long-lasting – Page 16 – Communicable Diseases Research

Elicitation of Broadly Neutralizing Antibodies against B.1.1.7, B.1.351, and B.1.617.1 SARS-CoV-2 Variants by Three Prototype Strain-Derived Recombinant Protein Vaccines

3 개의 프로토 타입 변형 유래 재조합 단백질 백신에 의한 B.1.1.7, B.1.351 및 B.1.617.1 SARS-COV-2 변이체에 대한 광범위하게 중화 항체의 유도

Communication

Published on 2021-07-222022-09-01
Journal: Viruses [Category] SARS, 변종, 진단,

Interferon-armed RBD dimer enhances the immunogenicity of RBD for sterilizing immunity against SARS-CoV-2

인터페론-무기 RBD 이량 체는 SARS-COV-2에 대한 멸균 면역을위한 RBD의 면역 원성을 향상시킨다.

Clinical Trial

Published on 2021-07-152022-08-13
Journal: Cell Research [Category] Fulltext, SARS, 비임상, 임상, 진단, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus adjuvant Adults antigen processing antiviral immune responses appear Biological techniques breath caused Complete coronavirus COVID-19 dimerized DLNs draining lymph node effort elicit ENhance healthy High-dose human I-P-R-F vaccine I-P-R-F I-R-F immune responses Immunity Immunoglobulin induce initiated Innate immunity interferon long-lasting long-lasting neutralizing antibodies long-lasting neutralizing antibody low dose Lower respiratory tract lymph nodes NAbs overcome placebo-controlled protective immunity provide Randomized RBD RBD dimer Receptor-binding domain respiratory rhesus macaques Safe SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 T cell T cell response the receptor-binding domain the vaccine Trial Trigger upper and lower respiratory tracts V-01 vaccination Vaccine vaccine candidate
[DOI] 10.1038/s41422-021-00531-8 PMC 바로가기 [Article Type] Clinical Trial

Intranasal gene therapy to prevent infection by SARS-CoV-2 variants

SARS-CoV-2 변이체에 의한 감염을 예방하기 위한 비강내 유전자 요법

Research Article

Published on 2021-07-152022-09-10
Journal: PLoS Pathogens [Category] SARS, 변종,

[키워드] ACE2 administration affinity airway angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 animals Antiviral approach bind binding caused Cell combating coronavirus Coronaviruses countermeasure CoV COVID-19 COVID-19 pandemic CoVs demonstrated effective Efficacy evade expression Gene therapy human ACE2 humans immune response improvement infecting Infection Intervention intranasal intranasally less long-lasting monoclonal antibodies monoclonal antibody mouse model nasal Nasal spray neutralize Pandemics pathogenicity pathologic consequence Patient Population pre-existing immunity Prevent Prophylaxis Protein proximal receptor reduce respond SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2 viral secrete significantly Spread tested the patient therapeutic Transmissibility unlikely vaccination Vaccinations Vaccine Vaccines variant variants variants of SARS-CoV-2 Viral viral mutation Viral mutations viral particle Viral particles Viral vector virus Vulnerable populations zoonosis
[DOI] 10.1371/journal.ppat.1009544 PMC 바로가기 [Article Type] Research Article

Resveratrol and Pterostilbene Inhibit SARS-CoV-2 Replication in Air–Liquid Interface Cultured Human Primary Bronchial Epithelial Cells

레스베라트롤 및 피터 스틸 벤은 공기-액체 계면 배양 인간 1 차 기관지 상피 세포에서 SARS-COV-2 복제를 억제합니다.

Article

Published on 2021-07-102022-09-10
Journal: Viruses [Category] SARS, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 added African green monkey air–liquid interface Anti-inflammatory antioxidant Antiviral antiviral activity Antiviral compound Antiviral compounds Antiviral effect antiviral property antiviral therapy bronchial bronchial epithelial cells caused cells clinical trial clinical trials Compound conditions coronavirus COVID-19 COVID-19 pandemic COVID-19 treatment drug Economy epithelial cells Evidence FIVE green monkey Health healthy volunteers Human human primary bronchial epithelial cells in vitro infected cell infected cells Infection inhibit inhibit SARS-CoV-2 initial interface kidney Laboratory laboratory findings long-lasting Post-infection progeny pterostilbene reduced Replenishment Replication researcher respiratory resveratrol SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication second severe acute respiratory syndrome Coronavirus therapeutic options these cell These cells these compound these compounds Treatment upper respiratory tract virus virus replication
[DOI] 10.3390/v13071335 PMC 바로가기 [Article Type] Article

Shadow Burden of Undiagnosed Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) on Society: Retrospective and Prospective—In Light of COVID-19

Article

Published on 2021-07-062022-10-30
Journal: Journal of Clinical Medicine [Category] COVID-19,

[키워드] aetiology affected affecting Analysis approach assumed assumption burden cause CFS chronic conditions Chronic diseases chronic fatigue syndrome complex Complication consequence Consequences COVID-19 COVID-19 pandemic COVID-19 patient Diagnosis diagnostic disease disorder distress epidemiological Factor fatigue FIVE functional hypothetical impact on society increase increase in induce initial Interaction lack Latvia LIGHT literature review long-lasting ME/CFS myalgic encephalomyelitis Patient patients predict predominant Prevalence Prevent preventive measure problem problems progression Quality of life reduce reported Research severe fatigue severity shadow significantly significantly lower significantly more statistical Study design substantial reduction Symptom Symptoms syndrome Treatment were used
[DOI] 10.3390/jcm10143017 PMC 바로가기 [Article Type] Article

Fusion Protein of Rotavirus VP6 and SARS-CoV-2 Receptor Binding Domain Induces T Cell Responses

Communication

Published on 2021-07-022022-10-28
Journal: Vaccines [Category] COVID-19,

[키워드] antibodies antigen-presenting cells antigenic B cell B cell epitope BALB/c mice caused Cell cell-mediated immune response conditions conformational COVID-19 cross-reactive delivery platform displaying domain fusion fusion protein hACE2 human Angiotensin-converting enzyme humoral immune response Immunity immunize in vitro investigated long-lasting mRNA N-terminus pandemic platform populations produced RBD receptor respiratory response rotavirus S-specific antibody SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 spike protein T cell T cell epitope T cells Vaccine vaccine candidate Vaccines Viral vector VP6 was used
[DOI] 10.3390/vaccines9070733 PMC 바로가기 [Article Type] Communication

SARS-CoV-2-specific T cell memory is sustained in COVID-19 convalescent patients for 10 months with successful development of stem cell-like memory T cells

SARS-CoV-2 특이 T 세포 기억은 줄기 세포 유사 기억 T 세포의 성공적인 개발로 COVID-19 회복기 환자에서 10개월 동안 지속됩니다.

Article

Published on 2021-06-302022-09-12
Journal: Nature Communications [Category] MERS, SARS, 진단, 치료기술,

[키워드] activation-induced markers Antimicrobial responses CD4 CD8 Cell cells contribute convalescent COVID-19 patients COVID-19 COVID-19 convalescent patient COVID-19 pandemic detectable development differentiation effective evaluate Ex vivo feasibility immune responses Immunity Immunological memory long-lasting Longevity measure memory memory T memory T cell memory T cells MHC-I observé pathogen peaking post-symptom onset proliferation proportion protective immune response Re-infection response responsible SARS-CoV-2 SARS-CoV-2-specific T cell SARS-CoV-2-specific T cells severity of COVID-19 staining stem cell study period Support sustained T cell T cell memory T cell response T cell responses T cells vaccination viral clearance viral infection
[DOI] 10.1038/s41467-021-24377-1 PMC 바로가기 [Article Type] Article

Persistence and baseline determinants of seropositivity and reinfection rates in health care workers up to 12.5 months after COVID-19

Covid-19 후 최대 12.5 개월까지 의료 종사자의 혈청 양성 및 재감염의 지속성 및 기준 결정 요인

Correspondence

Published on 2021-06-282022-09-01
Journal: BMC Medicine [Category] MERS, SARS, 진단, 치료기술,

[키워드] allergies Anosmia anosmia/hypogeusia antibodies antibody antibody level antibody levels Antibody Response Antibody responses Antigen baseline Baseline determinants Care Cohort correlated COVID-19 COVID-19 symptom COVID-19 symptoms COVID-19 vaccine determinant domain Duration Fever first episode Health Health care Health care worker health care workers Hope Hospitalization Hypogeusia IgA IgG IgG response IgG responses IgM Immunity individual Kinetics long-lasting Occurrence Patient Primary Health Care prospective cohort raise Reinfection SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike antigen seronegative Seropositivity significantly smoking Spanish Spike antigen STABLE subset supplementary material symptoms onset
[DOI] 10.1186/s12916-021-02032-2 PMC 바로가기 [Article Type] Correspondence

Intravenous immunoglobulin as a therapeutic option for patients with worsening COVID-19 under rituximab

리툭시맙 투여로 COVID-19가 악화된 환자를 위한 치료 옵션으로서 정맥 면역글로불린

Case Reports

Published on 2021-06-282022-09-12
Journal: BMJ case reports [Category] MERS, SARS, 진단,

Oropharyngeal Dysphagia After Hospitalization for COVID-19 Disease: Our Screening Results

Original Article

Published on 2021-06-242022-10-31
Journal: Dysphagia [Category] COVID-19, COVID19(2023년), MERS, SARS,