Coronaviruses Nsp5 Antagonizes Porcine Gasdermin D-Mediated Pyroptosis by Cleaving Pore-Forming p30 FragmentResearch Article Published on 2022-01-112022-10-29 Journal: mBio [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] addition Amino acid cleave cleaved coronavirus CoV CoV infection CoVs Critical epidemic diarrhea Evidence facilitate fragment gasdermin D GSDMD hepatic disease humans Infection inhibit initial MERS-CoV molecular mechanism nsp5 pathway PEDV protease pyroptosis Regulation Replication RNA virus SARS-CoV-2 viral replication virus [DOI] 10.1128/mbio.02739-21 PMC 바로가기 [Article Type] Research Article
COVID-19 Impact on Public Health, Environment, Human Psychology, Global Socioeconomy, and EducationReview Article Published on 2022-01-112022-10-29 Journal: The Scientific World Journal [Category] COVID-19, SARS, [키워드] addition boost China confirmed case coronavirus COVID-19 described disadvantage education Environment global pandemic Health highly pathogenic Human immune systems Impact infected patient management manuscript MERS-CoV pandemic pandemic of COVID-19 provided Psychology Public SARS-CoV WHO World Health Organization Wuhan [DOI] 10.1155/2022/5578284 PMC 바로가기 [Article Type] Review Article
Liposome-Mediated Delivery of MERS Antigen Induces Potent Humoral and Cell-Mediated Immune Response in MiceArticle Published on 2022-01-092022-10-30 Journal: Molecules [Category] COVID-19, [키워드] adjuvant Alanine ALT Antigen antigen-specific antibody Antiviral antiviral immunity Aspartate transaminase AST Blood Blood urea nitrogen Cell-mediated immune responses delivery DPPC effective exhibited Freund’ greater humoral IFN-γ IgG1 IgG2a immunization immunized immunized mice Incomplete induce lactate dehydrogenase LDH Liposome MERS MERS-CoV MERS-CoV infection mice Middle East notable Papain-like protease platform PLPro potent Prevent proliferation Prophylactic provided respiratory syndrome coronavirus response secreted serum shown significantly higher splenocyte switching the vaccine Toxicity vaccine delivery Vaccines Vesicle was used [DOI] 10.3390/molecules27020403 PMC 바로가기 [Article Type] Article
Inter-individual Variation in Receptor Expression Influences MERS-CoV Infection and Immune Responses in Airway EpitheliaPublic Health Published on 2022-01-042022-10-31 Journal: Frontiers in Public Health [Category] COVID-19, [키워드] airway epithelia appear Asymptomatic binding cause Cell Comorbidities contributing to coronavirus Defense Dipeptidyl peptidase 4 donors DPP4 ELISA epithelia expression greater HAE highlight Host humans Immunofluorescent staining include individual individual variation influence inter-individual Inter-individual variation interferon interferon-stimulated gene Male sex MERS MERS-CoV MERS-CoV infection Middle East middle east respiratory disease (MERS) Older age outcome Pathogenesis primary human airway receptor Replication respiratory infection Respiratory pathogens respiratory syndrome coronavirus response responses risk factor Risk factors robust severe pneumonia Spread susceptibility symptom severity Variability virus replication [DOI] 10.3389/fpubh.2021.756049 PMC 바로가기 [Article Type] Public Health
RNA structure-altering mutations underlying positive selection on Spike protein reveal novel putative signatures to trace crossing host-species barriers in BetacoronavirusArticle Published on 2022-01-012022-11-16 Journal: RNA Biology [Category] 변종, [키워드] analysed Analysis Antiviral bat bat virus bats Betacoronavirus build changes in coding complement conserved cross-species horizontal transmission D614G develop disrupt events Factor function Genome genome-wide analysis Health hosts hotspot Human Impact in viral information investigated jumping the species barrier MERS-CoV Missense mutation molecular molecular evolution Mutation natural selection overlap Positive selection Protein Proteins Research reservoir RNA RNA genome RNA structure RNA structures RNA viruses S protein SARS-CoV SARS-CoV-2 secondary RNA structures selected small RNA spike Surveillance the Betacoronavirus the S protein Therapeutic strategies Transmission viral genome Viral proteins viral RNA genome viral RNA genome. Viral transmission [DOI] 10.1080/15476286.2022.2115750 PMC 바로가기
Discovery of Highly Potent Fusion Inhibitors with Potential Pan-Coronavirus Activity That Effectively Inhibit Major COVID-19 Variants of Concern (VOCs) in Pseudovirus-Based AssaysArticle Published on 2021-12-312022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] activities activity acute respiratory syndrome ADME African Analysis B.1.1.7 B.1.351 B.1.617.2 bind Candidates Compound concern coronavirus COVID-19 Cytopathic effect delta variant demonstrated distribution facilitate fusion fusion inhibitor half-maximal inhibitory concentration in vivo India inhibited inhibitor inhibitors inhibitory lowest Major MERS-CoV metabolism Middle East Middle East respiratory syndrome (MERS) oral bioavailability pan-coronavirus potent Potential prefusion prevented respiratory syndrome coronavirus SARS-CoV SARS-CoV-2 SARS-CoV-2 spike protein Severe acute respiratory syndrome (SARS) small molecule South SPR surface plasmon resonance trimer variant variants of concern VOCs [DOI] 10.3390/v14010069 PMC 바로가기 [Article Type] Article
Repurposing of Drugs for SARS-CoV-2 Using Inverse Docking FingerprintsChemistry Published on 2021-12-282022-10-31 Journal: Frontiers in Chemistry [Category] COVID-19, [키워드] 3CL pro 3CLpro acute respiratory syndrome Antiviral approach approved cause caused claimed Cold Compound compound repurposing compounds conducted controls coronavirus COVID-19 database direct-acting disease docking drug examined FDA-approved drug fingerprint fingerprints FIVE Health humans in silico inhibitors inverse Inverse docking main protease MERS MERS-CoV methodology Middle East molecular docking outbreak pathogenic protease inhibitors Protein Remdesivir reported Repurposed drug repurposing respiratory syndrome coronavirus SARS-CoV virus SARS-CoV-2 SARS-CoV-2 main protease subset Support syndrome the Coronaviridae therapeutic option Viral protein Virtual screening virus was performed was used [DOI] 10.3389/fchem.2021.757826 PMC 바로가기 [Article Type] Chemistry
A genome-wide CRISPR screen identifies interactors of the autophagy pathway as conserved coronavirus targetsShort Reports Published on 2021-12-282022-10-28 Journal: PLoS Biology [Category] COVID-19, SARS, [키워드] approved approved drugs autophagy cell cultures cell line clinically Compound conducted conserved coronavirus coronavirus 2 Coronavirus replication coronavirus target CoV CoV replication CoVs demonstrated dependent on dose-dependent inhibition effective effective therapy epithelial Factor FKBP8 Genes genome-wide CRISPR screen HCoV-229E Health highlighting highly pathogenic Host Huh7 human coronavirus identify independent Infection inhibitor MERS-CoV Middle East MINAR1 nasal over pathway Protein Replication required respiratory SARS-CoV SARS-COV-2 infection Support survival target therapeutic intervention Tmem41b Treatment virus replication viruses [DOI] 10.1371/journal.pbio.3001490 PMC 바로가기 [Article Type] Short Reports
Molecular mechanisms for understanding the association between TMPRSS2 and beta coronaviruses SARS-CoV-2, SARS-CoV and MERS-CoV infection: scoping reviewTMPRSS2와 베타 코로나바이러스 SARS-CoV-2, SARS-CoV 및 MERS-CoV 감염 간의 연관성을 이해하기 위한 분자 메커니즘: 범위 검토Review Published on 2021-12-252022-09-11 Journal: Archives of Microbiology [Category] SARS, 유전자 메커니즘, [키워드] ACE2 Activation association beta coronavirus beta-CoVs Betacoronavirus cell surface receptor cell surface receptors CENTRAL cleaved Controlled controlled trials Critical DPP4 Evidence Gene host cells identify in viral infected cells Infection involved knowledge mechanism membrane fusion MERS MERS-CoV molecular molecular mechanism molecular mechanisms mRNA OVID Pathogenesis protease Protein Replication Research SARS-CoV SARS-CoV-2 searched Serine serine protease spike Spike protein Spread Syncytia the Spike TMPRSS2 virus entry virus propagation virus replication [DOI] 10.1007/s00203-021-02727-3 PMC 바로가기 [Article Type] Review
Microglia Do Not Restrict SARS-CoV-2 Replication following Infection of the Central Nervous System of K18-Human ACE2 Transgenic Mice소교세포는 K18-인간 ACE2 형질전환 마우스의 중추신경계 감염 후 SARS-CoV-2 복제를 제한하지 않습니다Pathogenesis and Immunity Published on 2021-12-222022-09-10 Journal: Journal of Virology [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단, [키워드] accompanied ACE2 Activation addition administration Antiviral causative agent CCL19 CCL2 CCL5 Central nervous system characterized chemokine CNS colony-stimulating factor consequence contribute contributing to COVID-19 COVID-19 patient COVID-19 patients Critical CXCL10 CXCL9 cytokine Defense determined by disease eIF2 evaluate Evidence exhibited expression hACE2 Host host defense human ACE2 IFN-λ Immune cell infiltration immune response immune responses immunological immunological mechanism increased expression infect infecting Infection infection with SARS-CoV-2 infiltration Inflammatory response inhibitor K18 K18-hACE2 Lung pathology macrophages MERS MERS-CoV mice microglia Mild mind Monocytes monocytes/macrophages nervous nervous system Neuroinvasive neurologic Neuron neurons Neuropathology not affect PLX5622 Pro-inflammatory genes proinflammatory Proinflammatory cytokine receptor reduction in replicate responsible RNA sequencing SARS-CoV-1 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication severity Signaling survival Symptom System TNF-α transcript transgenic mice understanding Viral viral infection viral pathogen viral replication virus viruses [DOI] 10.1128/jvi.01969-21 PMC 바로가기 [Article Type] Pathogenesis and Immunity