Inhibition Potencies of Phytochemicals Derived from Sesame Against SARS-CoV-2 Main Protease: A Molecular Docking and Simulation StudyChemistry Published on 2021-10-082022-10-31 Journal: Frontiers in Chemistry [Category] COVID-19, [키워드] 3CL pro ADME Against binding caused Compound condition contagious COVID-19 COVID-19 pandemic disease distribution drug target enzyme evaluated FIVE Free energy calculation high mortality rate inhibition M pro main protease metabolism metabolite metabolites molecular molecular docking Molecular dynamics simulation molecular dynamics simulations molecular interaction natural compounds overcome phytochemical potency protease SARS-CoV-2 screened sesame sesamin Simulation Spread stability Therapeutics these compound treating COVID-19 Treatment viral replication Virtual screening was performed [DOI] 10.3389/fchem.2021.744376 PMC 바로가기 [Article Type] Chemistry
The cardiac molecular setting of metabolic syndrome in pigs reveals disease susceptibility and suggests mechanisms that exacerbate COVID-19 outcomes in patients돼지에서 대사 증후군의 심장 분자 설정은 질병 감수성을 나타내며 환자에서 Covid-19 결과를 악화시키는 메커니즘을 제안합니다.Article Published on 2021-10-052022-09-01 Journal: Scientific Reports [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] aggregation Analysis animal model Arterial thrombosis association Blood blood test blood tests capture cardiovascular disease cardiovascular diseases change Comorbidity Complement pathway component components computational analysis COVID-19 CVD deregulation develop diabete diabetes disease elevated enriched pathway enzyme exacerbate expressed greater hallmark hallmarks hypertension identity immune response investigated mechanism metabolic syndrome metabolite metabolites metabolomics molecular Myocardial Myocardium obese obesity outcome overexpressed pathophysiology Patient patients patients with COVID-19 PIGS Platelet platelet aggregation pro-inflammatory pro-inflammatory markers Protein proteomics reveal risk risk factor Risk factors RNA methylation susceptibility syndrome Therapeutic approach thrombosis transcriptomics virus viruses while [DOI] 10.1038/s41598-021-99143-w PMC 바로가기 [Article Type] Article
Neuropsychiatric Ramifications of COVID-19: Short-Chain Fatty Acid Deficiency and Disturbance of Microbiota-Gut-Brain Axis SignalingReview Article Published on 2021-10-052022-10-27 Journal: BioMed Research International [Category] [키워드] accompanied ACE-2 acid alleviate Altered Anti-inflammatory anti-inflammatory function axis Bacteria binding Brain changes in characterized commensal bacteria Complication components contribute COVID-19 COVID-19 patient Critical decrease deficiency described diagnostic disorders disturbance evaluate fatty favor fecal fiber gastrointestinal symptoms Gut gut microbiota gut microbiota composition implicated increase in Inflammation metabolite microbial Neurological disorder Neuropsychiatric Pathogens Prevent producing proinflammatory Psychiatric ramification receptor recommendation Research risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptors SCFA signaling pathway supported systemic inflammation Transport turn viral presence [DOI] 10.1155/2021/7880448 PMC 바로가기 [Article Type] Review Article
Neuropsychiatric Ramifications of COVID-19: Short-Chain Fatty Acid Deficiency and Disturbance of Microbiota-Gut-Brain Axis SignalingReview Article Published on 2021-10-052022-10-27 Journal: BioMed Research International [Category] COVID-19, MERS, SARS, [키워드] accompanied ACE-2 acid alleviate Altered Anti-inflammatory anti-inflammatory function axis Bacteria binding Brain changes in characterized commensal bacteria Complication components contribute COVID-19 COVID-19 patient Critical decrease deficiency described diagnostic disorders disturbance evaluate fatty favor fecal fiber gastrointestinal symptoms Gut gut microbiota gut microbiota composition implicated increase in Inflammation metabolite microbial Neurological disorder Neuropsychiatric Pathogens Prevent producing proinflammatory Psychiatric ramification receptor recommendation Research risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptors SCFA signaling pathway supported systemic inflammation Transport turn viral presence [DOI] 10.1155/2021/7880448 PMC 바로가기 [Article Type] Review Article
Plasma concentrations of remdesivir metabolite in a critical COVID-19 patient needing continuous venovenous haemodialysis지속적인 정맥혈투석이 필요한 중증 코로나19 환자의 렘데시비르 대사산물 혈장 농도Case Reports Published on 2021-10-012022-09-11 Journal: European Journal of Clinical Pharmacology [Category] 치료제, [키워드] Concentration COVID-19 patient Critical Haemodialysis metabolite Remdesivir [DOI] 10.1007/s00228-021-03128-7 PMC 바로가기 [Article Type] Case Reports
Machine Learning of Serum Metabolic Patterns Encodes Asymptomatic SARS-CoV-2 InfectionChemistry Published on 2021-10-012022-10-31 Journal: Frontiers in Chemistry [Category] COVID-19, [키워드] Algorithm approach Asymptomatic Asymptomatic COVID-19 Biomarker country COVID-19 COVID-19 outbreak demonstrated detect Diagnosis False positive healthy control high accuracy lack large cohort Lipid lipids machine learning MALDI-MS metabolic metabolic pathway metabolism metabolite pattern provided qRT-PCR Quantitative reagents resource reverse transcription PCR SARS-CoV-2 SARS-COV-2 infection serum Spread the SARS-CoV-2 time-consuming [DOI] 10.3389/fchem.2021.746134 PMC 바로가기 [Article Type] Chemistry
Cyanobacterial metabolites as promising drug leads against the M pro and PL pro of SARS-CoV-2: an in silico analysis유망한 약물로서 시아 노 박테리아 대사 산물은 SARS-COV-2의 M Pro 및 PL PRO에 대한 이끌어 낸다 : AN Silico AnalysisArticle Published on 2021-10-012022-08-31 Journal: Journal of biomolecular structure & dynamics [Category] MERS, SARS, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Analysis antiviral drug antiviral drugs approach binding energy binding pocket carrageenan causative agent Compound coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cryptophycin cyanobacterial metabolites cylindrospermopsin deoxycylindrospermopsin drug-likeness effective effort exhibited facilitate followed by foundation in silico in silico analysis in vitro in vivo inhibitor inhibitory lack M pro metabolite metabolites MM-PBSA molecular molecular docking molecular dynamics Molecular dynamics simulation molecular dynamics simulations pandemic Papain Papain-like protease Pathologies Physicochemical properties physicochemical property polyprotein present protease Proteases Research research finding respiratory robust SARS-CoV-2 SARS-CoV-2 protease the SARS-CoV-2 Toxicity Treatment Viral viral replication were assessed [DOI] 10.1080/07391102.2020.1794972 PMC 바로가기 [Article Type] Article
Group IIA secreted phospholipase A2 is associated with the pathobiology leading to COVID-19 mortality그룹 IIA 분비 포스포리파제 A2는 COVID-19 사망률로 이어지는 병리생물학과 관련이 있습니다Clinical Trial Published on 2021-10-012022-09-11 Journal: The Journal of Clinical Investigation [Category] MERS, SARS, 유전자 메커니즘, 임상, 진단, [키워드] Analysis biochemical analyses biochemical analysis Blood urea nitrogen catalytically active cellular and molecular Cellular and molecular mechanisms Cellular immune response central node circulating clinically Cohort COVID-19 COVID-19 disease COVID-19 disease severity COVID-19 mortality COVID-19 patient death Deceased Decision tree died disease severity elevated fatal COVID-19 group hypoxia identify immune independent Inflammation inhibitor kidney dysfunction machine learning mechanism median value metabolite Mild Mild disease mitochondrial mitochondrial dysfunction Molecular pathology multiple organ dysfunction nitrogen organ dysfunction pathology Patient performed Phospholipase A2 plasma plasma sample plasma samples Random forest reduce regression analysis responsible secreted severe COVID-19 significantly Stratification survivor tested the median therapeutic target urea variable with mild disease [DOI] 10.1172/JCI149236 PMC 바로가기 [Article Type] Clinical Trial
Eicosanoid Metabolomic Profile of Remdesivir Treatment in Rat Plasma by High-Performance Liquid Chromatography Mass SpectrometryPharmacology Published on 2021-09-292022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] Administered administration Analysis AUC baseline blood sample C max caused Chromatography collected Concentration correlated COVID-19 COVID-19 patients discrepancy dose eicosanoid Eicosanoids GS-441524 HPLC-MS/MS Immunity Inflammation Inflammatory initial intravenously investigated involved liquid mass metabolite metabolomics nucleotide parameter Pearson correlation PGE2 pharmacokinetic pharmacological profile RAT reduced Remdesivir reported robust SARS-CoV-2 SARS-CoV-2 virus infection significantly Spectrometry therapy Treatment Variation was performed [DOI] 10.3389/fphar.2021.747450 PMC 바로가기 [Article Type] Pharmacology
Untargeted Metabolic Profiling of Extracellular Vesicles of SARS-CoV-2-Infected Patients Shows Presence of Potent Anti-Inflammatory MetabolitesSARS-CoV-2 감염 환자의 세포외 소포에 대한 비표적 대사 프로파일링은 강력한 항염증 대사 산물의 존재를 보여줍니다Article Published on 2021-09-282022-09-10 Journal: International Journal of Molecular Sciences [Category] SARS, 진단, 치료기술, [키워드] 15-d-PGJ2 7-α,25-Dihydroxycholesterol Anti-inflammatory Antibiotics Antiviral Coagulation contribute controls COVID-19 COVID-19 infection COVID-19 patient COVID-19 patients Critical drugs EVs Exosome Exosomes Extracellular vesicles Foscarnet identify Indinavir Infection Inflammation inflammatory pathway inflammatory pathways lymecycline metabolic metabolite metabolites metabolomics Pathogenesis pathway patients treated potent Presence Profiling SARS-CoV-2 virus serum show Spread the SARS-CoV-2 virus thromboxane Vesicle Viral viral infections viruses [DOI] 10.3390/ijms221910467 PMC 바로가기 [Article Type] Article