Toward a Practical, Nonenzymatic Process for Investigational COVID-19 Antiviral Molnupiravir from Cytidine: Supply-Centered SynthesisReview article Published on 2021-12-092022-10-05 Journal: Organic Process Research & Development [Category] 치료제, [키워드] acetone antivirals approach average carried COVID-19 cytidine described EIDD-2801 HPLC isopropanol MK-4482 molnupiravir Process purification reagent solvent synthesis [DOI] 10.1021/acs.oprd.1c00219 [Article Type] Review article
A novel model of molnupiravir against SARS-CoV-2 replication: accumulated RNA mutations to induce error catastropheSARS-CoV-2 복제에 대한 몰누피라비르의 새로운 모델: 오류 재앙을 유발하는 축적된 RNA 돌연변이Comment Published on 2021-12-022022-09-10 Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 변종, [키워드] accumulated Chemical biology Drug discovery induce molnupiravir Mutation RNA SARS-CoV-2 [DOI] 10.1038/s41392-021-00837-4 PMC 바로가기 [Article Type] Comment
Thermodynamic and structural insights into the repurposing of drugs that bind to SARS-CoV-2 main proteaseChemistry Published on 2021-11-182022-10-29 Journal: Molecular Systems Design & Engineering [Category] COVID-19, [키워드] 3CL pro antiviral drug approach approved binding binding site clinical trials Compound compounds continuum country COVID-19 outbreak COVID-19 pandemic disease drug Drug discovery drug library Drug repurposing drugs emergency situation molecular Molecular dynamics simulation molnupiravir predicted protease provide Remdesivir researcher SARS-CoV-2 main protease solvent subset the SARS-CoV-2 the SARS-CoV-2 virus turn urgency was performed X-ray [DOI] 10.1039/d1me00124h PMC 바로가기 [Article Type] Chemistry
Combined treatment of molnupiravir and favipiravir against SARS-CoV-2 infection: One + zero equals two?SARS-CoV-2 감염에 대한 몰누피라비르와 파비피라비르의 병용 치료: 1+0은 2인가요?Commentary Published on 2021-11-092022-09-11 Journal: EBioMedicine [Category] SARS, 치료제, [키워드] Combined Favipiravir molnupiravir SARS-CoV-2 Treatment [DOI] 10.1016/j.ebiom.2021.103663 PMC 바로가기 [Article Type] Commentary
Molnupiravir in COVID-19: A systematic review of literatureReview Published on 2021-10-302023-06-16 Journal: Diabetes & metabolic syndrome [Category] MERS, SARS, [키워드] COVID-19 EIDD-2801 MK-4482 molnupiravir SARS-CoV-2 [DOI] 10.1016/j.dsx.2021.102329 PMC 바로가기 [Article Type] Review
Molnupiravir—A Novel Oral Anti-SARS-CoV-2 AgentPerspective Published on 2021-10-232022-10-27 Journal: Antibiotics [Category] COVID-19, [키워드] acute respiratory syndrome agent antiviral agent Antiviral agents benefit clinical trial coronavirus COVID-19 COVID-19 patient death deaths demonstrated Efficacy EIDD-1931 EIDD-2801 eliminating Enrollment evidenced expected global pandemic Hospitalization inhibitor Mild Moderate COVID-19 molnupiravir nasopharyngeal novel oral Patient Prevent progression Prophylactic public health reduced released risk RNA polymerase inhibitor RNA-dependent RNA polymerase Safe SARS-CoV-2 SARS-CoV-2 transmission significantly therapeutic doses therapy treat Trial trials virus [DOI] 10.3390/antibiotics10111294 PMC 바로가기 [Article Type] Perspective
Viral polymerase binding and broad-spectrum antiviral activity of molnupiravir against human seasonal coronavirusesArticle Published on 2021-10-022023-06-14 Journal: Virology [Category] MERS, [키워드] Drug repurposing molnupiravir RdRP seasonal coronavirus [DOI] 10.1016/j.virol.2021.09.009 PMC 바로가기 [Article Type] Article
[Plitidepsin, an inhibitor of the cell elongation factor eEF1a, and molnupiravir an analogue of the ribonucleoside cytidine, two new chemical compounds with intense activity against SARS-CoV-2][세포신장인자 eEF1a 억제제 플리티뎁신과 리보뉴클레오시드 시티딘 유사체 몰누피라비르, SARS-CoV-2에 대한 강력한 활성을 가진 두 가지 새로운 화합물]Review Published on 2021-10-012022-09-11 Journal: Revista española de quimioterapia : publicación [Category] SARS, 치료제, [키워드] Administered administration analogues animals Cell cellular Compound Culture cytidine decrease determine elongation factor English human cell human clinical trials inhibiting inhibitor Interaction intravenously knowledge lethal mutagenesis molnupiravir molnupiravir (MK-4482/EIDD-2801) Mutagenesis oral administration oropharynx phase Plitidepsin potency Prevent Prophylaxis Protein pulmonary viral Remdesivir replicative Ribonucleoside SARS-CoV-2 SARS-CoV-2 sntiviral Spanish therapeutic Transmission virus [DOI] 10.37201/req/042.2021 PMC 바로가기 [Article Type] Review
Discovery, Development, and Patent Trends on Molnupiravir: A Prospective Oral Treatment for COVID-19Molnupiravir에 대한 발견, 개발 및 특허 동향: COVID-19에 대한 유망한 경구 치료제Review Published on 2021-09-242022-09-10 Journal: Molecules [Category] SARS, 임상, 치료제, [키워드] Baricitinib Clinical data clinical trial Combination COVID-19 COVID-19 pandemic demonstrated develop development disease dosage drug effective EIDD-1931 EIDD-2801 Favipiravir forms humans Influenza inhalers market meet MK-4482 molnupiravir oral oral bioavailability pandemic Patent patents Patient pharmaceutical industry Phase 3 phase 3 clinical trial present Prospective RdRP RdRp inhibitor Remdesivir researcher Safe safety profile SARS-CoV-2 Tolerability tolerable treat Treatment treatment of influenza treatments for COVID-19 trend university USA variety viruses [DOI] 10.3390/molecules26195795 PMC 바로가기 [Article Type] Review
The combined treatment of Molnupiravir and Favipiravir results in a potentiation of antiviral efficacy in a SARS-CoV-2 hamster infection model몰누피라비르와 파비피라비르의 병용 치료는 SARS-CoV-2 햄스터 감염 모델에서 항바이러스 효능을 강화합니다Research paper Published on 2021-09-242022-09-11 Journal: EBioMedicine [Category] MERS, 치료기술, 치료제, [키워드] animals antiviral activity Antiviral effect antiviral efficacy antiviral potency antivirals Clinical studies clinical study Combination combined treatment compounds control group COVID-19 COVID-19 patients dose drug Efficacy Endpoint explain Favipiravir Favipiravir, hamsters, coronavirus finding Frequency funding hamster hamsters Infection Infectious virus infectious virus titers lung Lungs molnupiravir Mutation prevented reduced reduction reported SARS-CoV-2 titers Transmission treated Treatment treatment group treatment of COVID-19 vehicle Viral Viral RNA virus titer virus titers [DOI] 10.1016/j.ebiom.2021.103595 PMC 바로가기 [Article Type] Research paper