monocyte – Page 16 – Communicable Diseases Research

Differential dynamics of peripheral immune responses to acute SARS-CoV-2 infection in older adults

Research

Published on 2021-10-282022-10-05
Journal: Nature Aging [Category] SARS, 임상,

Comprehensive investigations revealed consistent pathophysiological alterations after vaccination with COVID-19 vaccines

Article

Published on 2021-10-262022-10-04
Journal: Cell Discovery [Category] 바이오마커, 치료제,

[키워드] alteration biological assay CD8 clinical conditions Coagulation coagulation disorders Comprehensive country COVID-19 pandemic COVID-19 patients COVID-19 vaccination diabetes Gene Expression healthy volunteer hemoglobin immune cell types immunology inactivated increase in Infection monocyte mononuclear cell mRNA Neutralizing antibodies NF-κB signaling occur pathophysiological PBMCs Peripheral blood Potassium profiles reduced renal dysfunction renal function reported responses SARS-COV-2 infection SARS-CoV-2 vaccine scRNA-seq Sequencing serum sodium Similar change Symptoms T cell transcriptomics type I interferon vaccination Vaccine with COVID-19
[DOI] 10.1038/s41421-021-00329-3 PMC 바로가기 [Article Type] Article

Induction of trained immunity by influenza vaccination – impact on COVID-19

인플루엔자 예방접종을 통한 훈련된 면역 유도 - 코로나19에 미치는 영향

Observational Study

Published on 2021-10-252022-09-10
Journal: PLoS Pathogens [Category] MERS, 유전자 메커니즘, 임상,

[키워드] affected anti-SARS-CoV-2 assays caused claimed COVID-19 COVID-19 incidence COVID-19 vaccine cross-protection decrease distribution Effects epidemiological Epidemiological study fine-tune flu healthcare worker help hospital identify Immune cell immune cells immune responses Immunity immunological inactivated induction Influenza influenza vaccination influenza vaccine innate immune response innate immune responses Innate immunity investigated less lower risk mechanism mind monocyte Monocytes observation pandemic potential benefit potential benefits protective effect proteomics randomized trial reduced Relative risk reported reveal risk reduction Safe SARS-CoV-2 SARS-COV-2 infection Seasonal influenza Single-cell RNA sequencing suggested systemic inflammation transcriptional vaccination vaccination against COVID-19 Vaccine variant Viral virus
[DOI] 10.1371/journal.ppat.1009928 PMC 바로가기 [Article Type] Observational Study

Sex-Related Differences in Innate and Adaptive Immune Responses to SARS-CoV-2

Immunology

Published on 2021-10-202022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS,

[키워드] Activation addition CD86 chemokine complications Coronavirus disease 2019 COVID-19 CTLs CXCL-10 DCs dendritic cell dendritic cells difference exhibit expression female females healthy HLA-DR Hospitalization IFN-α immune responses in vitro individual Infection initial Innate innate immune response interferon-α lung male males mDC mDCs mechanism monocyte Monocytes mononuclear cell morbidity and mortality not significant PBMC PBMCs pDC pDCs Peripheral blood response responsible reversed SARS-CoV-2 secreted secretion severe disease Sex sex differences significantly higher stimulated Symptoms the patient these cell Treatment upregulated virus
[DOI] 10.3389/fimmu.2021.739757 PMC 바로가기 [Article Type] Immunology

Early prediction of in-hospital death of COVID-19 patients: a machine-learning model based on age, blood analyses, and chest x-ray score

Research Article

Published on 2021-10-182022-10-31
Journal: eLife [Category] COVID-19, MERS, SARS,

Presence of Antibodies to SARS-CoV-2 in Domestic Cats in Istanbul, Turkey, Before and After COVID-19 Pandemic

Veterinary Science

Published on 2021-10-122022-11-01
Journal: Frontiers in Veterinary Science [Category] COVID-19,

Dynamic alterations in monocyte numbers, subset frequencies and activation markers in acute and convalescent COVID-19 individuals

급성 및 회복기 COVID-19 개인의 단핵구 수, 하위 집합 빈도 및 활성화 마커의 동적 변경

Article

Published on 2021-10-122022-09-10
Journal: Scientific Reports [Category] Coronavirus, MERS, 바이오마커, 치료기술, 치료제,

[키워드] Activation alteration classical monocyte classical monocytes convalescent COVID-19 COVID-19 patient COVID-19 patients CRP Cytokines Day decrease dynamic elevated ELISA Evidence evidence of examined Factor Frequency group Host immunology increase individual individuals intermediate and non-classical monocytes marker Mild disease monocyte Monocyte activation monocyte subsets Monocytes Monocytes and macrophages non-classical monocyte Non-classical monocytes Pathogenesis pathogenesis of COVID-19 performed plasma Plasma levels plateau provide RT-PCR SARS-CoV2 infection Seven severe disease subset thought with mild disease
[DOI] 10.1038/s41598-021-99705-y PMC 바로가기 [Article Type] Article

Obesity Correlates With Pronounced Aberrant Innate Immune Responses in Hospitalized Aged COVID-19 Patients

비만은 입원한 노인 COVID-19 환자의 비정상적인 선천성 면역 반응과 관련이 있습니다

Comparative Study

Published on 2021-10-112022-09-11
Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, 치료기술,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adaptive immune response Admission Admissions advanced age age aging Antibody titers BMI caused changes in Chronic low-grade inflammation circulating Concentration coronavirus coronavirus disease Coronavirus disease 2019 correlated COVID-19 cytokine cytokine response Cytokines death defined dysregulated elevated Frequency hospitalizations hospitalized COVID-19 patient hospitalized COVID-19 patients host response IgG antibody IgG antibody titers immune Immune cell immune cells immune responses individual Infection Inflammatory cytokine inflammatory cytokine production Innate Innate immunity innate response intensive care intensive care unit mediators mitogen monocyte Monocytes obesity occur patients Prevalence respiratory response responsible risk risk factor Risk factors SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe coronavirus disease severe disease significant negative correlation subset These data
[DOI] 10.3389/fimmu.2021.760288 PMC 바로가기 [Article Type] Comparative Study

Impaired function and delayed regeneration of dendritic cells in COVID-19

코로나19에서 손상된 수지상 세포의 기능 장애 및 재생 지연

Clinical Trial

Published on 2021-10-062022-09-10
Journal: PLoS Pathogens [Category] MERS, SARS, 바이오마커, 임상,

[키워드] accompanied activated acute illness acute phase adaptive Adaptive immune response adaptive immune responses alteration analyzed antibody antibody-secreting cells antiviral immunity Blood CD14 CD14+ cell CD14+ cells CD163 CD4 CD86 Cell cells circulating classical monocyte classical monocytes Clinical management consequence contribute correlated COVID-19 COVID-19 patient COVID-19 patients COVID-19 severity DCs dendritic cell dendritic cells Depletion disease disease severity downregulation dysregulated dysregulated innate immune response expansion follicular Frequency functional healthy controls helper cells HLADR hospitalized COVID-19 patient Host immune response identify immune responses immunopathology Impaired impairment Increased Inflammatory response Inflammatory responses inhibitory innate immune response long-lasting manifestation Mild modulation monocyte monocyte subsets Monocytes naïve Patient PD-L1 persistent recognize reduced reduction regeneration SARS-COV-2 infection Secondary infection secondary infections severe disease stimulate subpopulation subset susceptibility systemic inflammation T cell T cells T follicular helper cells the disease therapy these cell These cells Trigger upregulation Viral viral infection viral infections
[DOI] 10.1371/journal.ppat.1009742 PMC 바로가기 [Article Type] Clinical Trial

Upregulation of Human Endogenous Retroviruses in Bronchoalveolar Lavage Fluid of COVID-19 Patients

COVID-19 환자의 기관지폐포 세척액에서 인간 내인성 레트로바이러스의 상향 조절

Research Article

Published on 2021-10-062022-09-10
Journal: Microbiology Spectrum [Category] MERS, SARS, 유전자 메커니즘, 진단, 치료기술, 치료제,

[키워드] activated addition age analyzed BALF bronchial cell bronchial cells bronchial epithelial cell Bronchoalveolar lavage fluid Cancer cellular senescence changes in characterized China conditions controls Course COVID-19 COVID-19 patient COVID-19 patients COVID-19 pneumonia COVID-19 severity Disease progression disease severity dysregulated dysregulation element endogenous endogenous retroviruses epithelial cells examined explain exploration expression Families global pandemic groups HBEC HBECs healthy control healthy controls HERV HERVs Human human bronchial epithelial cells human endogenous retrovirus human endogenous retroviruses identify immune senescence increase in increasing age Infection Inflammation Inflammatory inflammatory pathway Inflammatory response Inflammatory responses Intensive lavage Local lung Lungs mechanism monocyte Monocytes Mortality Older age oncogene outcomes pathophysiological Patient PBMC PBMCs Peripheral blood peripheral blood monocytes Pneumonia populations Potential biomarker potential biomarkers potential therapeutic target provide recognize retroviral retrovirus risk factor SARS-CoV-2 senescent severe COVID-19 Severe COVID-19 pneumonia shown Transcriptome transcriptomes upregulated upregulation
[DOI] 10.1128/Spectrum.01260-21 PMC 바로가기 [Article Type] Research Article