SARS-CoV-2 uses major endothelial integrin αvβ3 to cause vascular dysregulation in-vitro during COVID-19SARS-COV-2는 주요 내피 인테그린 αVβ3을 사용하여 COVID-19 동안 혈관 조절 조절을 유발합니다.Research Article Published on 2021-06-232022-08-13 Journal: PLoS ONE [Category] Biochemistry, COVID-19, MERS, SARS, [키워드] accelerate Anti-viral binding site bloodstream Candidates cardiovascular complications Characteristics cilengitide COVID-19 COVID-19 infection COVID-19 infections COVID-19 pandemic dysregulation Effect effort ENCODE endothelial endothelial cells Endothelium epithelium etiological expressed Final Host host protein in viral in-silico In-vitro infection rate integrin Integrins Interaction International leakage microbial motif Mutagenesis pathogen pathogenicity reproductive SARS-CoV-2 Spike protein Transmissibility unique Vascular vascular endothelial cell vascular endothelial cells vasculature Viral viral propagation [DOI] 10.1371/journal.pone.0253347 PMC 바로가기 [Article Type] Research Article
Sequence signatures of two public antibody clonotypes that bind SARS-CoV-2 receptor binding domainSARS-CoV-2 수용체 결합 도메인에 결합하는 2개의 공개 항체 클론형의 서열 서명Article Published on 2021-06-212022-09-12 Journal: Nature Communications [Category] MERS, SARS, 변종, 진단, [키워드] antibodies antibody Antibody Response association binding binding affinity binding domain CDR CDR H3 characterized complementarity-determining region COVID-19 COVID-19 pandemic Critical heavy chain identify identity light chain motif Public RBD Receptor binding domain recognize SARS-CoV-2 SARS-CoV-2 receptor SARS-CoV-2 spike protein sequence motif Sequence motifs specificity Spike protein the antibody response the spike protein X-ray crystallography [DOI] 10.1038/s41467-021-24123-7 PMC 바로가기 [Article Type] Article
Clinical Performance of Paraoxonase-1-Related Variables and Novel Markers of Inflammation in Coronavirus Disease-19. A Machine Learning ApproachArticle Published on 2021-06-212022-10-28 Journal: The Cochrane database of systematic reviews [Category] COVID-19, [키워드] alteration approach Biomarkers cause CCL2 chemokine chemokines circulating clinical clinical variable Comparisons COVID-19 COVID-19 negative death diagnosis of COVID-19 galectin-3 glycoprotein healthy individuals identify Inflammation inflammatory reaction innate immune system Interaction Ligand machine learning marker motif novel oxidative stress parameter parameters paraoxonase-1 Patient patients patients with COVID-19 performance PON1 positive positive patient Predictive pro-inflammatory mediator PROTECT recruited SARS-CoV-2 SARS-COV-2 infection serum synergy the disease variable was used [DOI] 10.3390/antiox10060991 PMC 바로가기 [Article Type] Article
Multiple Roles of SARS-CoV-2 N Protein Facilitated by Proteoform-Specific Interactions with RNA, Host Proteins, and Convalescent AntibodiesArticle Published on 2021-06-152022-10-30 Journal: JACS Au [Category] COVID-19, [키워드] antibodies antigenic approved bind C-terminal C-terminus convalescent convalescent plasma coronavirus COVID-19 cyclosporin A epitope exhibited functional highlight identify IgA antibody IgG IgM immunogenic Interaction mass spectrometry motif motifs Multiple N protein N-terminal nucleocapsid Protein Proteolytic processing Replication ribonucleoprotein RNA role SARS-CoV-2 SARS-CoV-2 N SARS-CoV-2 nucleocapsid significantly therapeutic intervention Therapies Viral protein virion assembly virus [DOI] 10.1021/jacsau.1c00139 PMC 바로가기 [Article Type] Article
Glycan reactive anti-HIV-1 antibodies bind the SARS-CoV-2 spike protein but do not block viral entryArticle Published on 2021-06-142022-10-29 Journal: Scientific Reports [Category] COVID-19, MERS, SARS, [키워드] ADE antibodies antibody Antibody titer Antibody-dependent enhancement Antigen binding block viral entry contribute COVID-19 Critical cross-reactive antibody cross-reactivity displaying ELISA experiment expressing glycan glycosylation gp120 HIV-1 immune response immunoassays immunoreactivity implication Infection interfere Interpretation Microbiology motif Neutralizing nine pseudovirus reactive receptor engagement SARS-CoV-2 SARS-CoV-2 S SARS-CoV-2 spike glycoprotein SARS-CoV-2 spike protein selected serological assays Spike protein Spike proteins the SARS-CoV-2 therapeutic unlikely vaccine immunogen Virology virus Virus neutralization [DOI] 10.1038/s41598-021-91746-7 PMC 바로가기 [Article Type] Article
Structural basis of coronavirus E protein interactions with human PALS1 PDZ domainArticle Published on 2021-06-112022-10-31 Journal: Communications Biology [Category] COVID-19, [키워드] binding C-terminal Cell complex coronavirus coronavirus disease COVID-19 crystal structure disrupting domain E protein epithelial epithelial cells human epithelial cell Interaction interfere life-threatening MERS-CoV molecular basis motif motifs PALS1 platform Pneumonia Respiratory failure SARS-CoV-1 SARS-CoV-2 SARS-COV-2 infection sequence small molecule inhibitor suppress these symptom tissue X-ray crystallography [DOI] 10.1038/s42003-021-02250-7 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Envelope (E) protein interacts with PDZ-domain-2 of host tight junction protein ZO1SARS-COV-2 엔벨로프 (E) 단백질은 숙주 단단한 접합 단백질 ZO1의 PDZ- 도메인 -2와 상호 작용한다.Research Article Published on 2021-06-092022-08-13 Journal: PLoS ONE [Category] Biochemistry, MERS, SARS, 변종, 진단, [키워드] airway amplified approach approaches array binding Biotin C-terminal cell layer chloride complementary consolidation contribute contributing to COVID-19 patients disease severity domain dysfunction E protein ECT envelope epithelial epithelial cell epithelial cells epithelial tissues extreme Fluorescence fusion protein global pandemic homogenous Host HTRF humans interact Interaction Intervention lead Lungs membrane protein mitigate molecular morbidity motif multifunctional mutant Pathogenesis Pathologies peptide Protein reduce respiratory Respiratory disease respiratory tract SARS-CoV-1 SARS-CoV-2 screened secretion sequence severe pneumonia severe respiratory disease singular target the lungs a the SARS-CoV-2 tight junction tissues virus virus spread Zona [DOI] 10.1371/journal.pone.0251955 PMC 바로가기 [Article Type] Research Article
The Heterogeneous Landscape and Early Evolution of Pathogen-Associated CpG Dinucleotides in SARS-CoV-2SARS-CoV-2에서 병원체 관련 CpG 디뉴클레오티드의 이질적 풍경과 초기 진화Discoveries Published on 2021-06-082022-09-10 Journal: Molecular Biology and Evolution [Category] SARS, 치료법, [키워드] 3′UTR acting acute respiratory syndrome Amino acid Antiviral antiviral protein binding pattern binding patterns circulating coding region comparable COVID-19 COVID-19 pandemic CpG CpG motifs cytoplasm dinucleotide dinucleotides distribution dual dysregulated Evolution evolution of synonymous mutations expressed Genome greater HKU1 human host immune infected cell infected cells landscape lead loci MERS motif Mutation ORF outbreak pathogen-associated molecular pathogen-associated molecular patterns pathogenic Pattern recognition pattern recognition receptor Pattern recognition receptors pressure Protein Region Replication respiratory RNA SARS-CoV-2 SARS-CoV-2 genome Sequence motifs Signaling signature ssRNA viruses statistical synonymous the SARS-CoV-2 genome transcript transversion triggering Viral viral host mimicry Zinc zinc finger antiviral protein [DOI] 10.1093/molbev/msab036 PMC 바로가기 [Article Type] Discoveries
Structural basis for SARS-CoV-2 envelope protein recognition of human cell junction protein PALS1Article Published on 2021-06-082022-10-29 Journal: Nature Communications [Category] COVID-19, SARS, [키워드] addition C-terminal caused Cell complex COVID-19 pandemic Cryo-electron microscopy cryo-EM Cryoelectron microscopy determine domain E protein envelope protein facilitate Health human cell human protein human proteins hydrophobic residue inhibitor Interaction junctions lung epithelial motif observation occur PALS1 peptide promote Protein provide recognize recruit reduce Replication reported SARS-CoV-2 SARS-CoV-2 envelope SARS-CoV-2 viral SARS-CoV-2 virus Spread Structural analysis target targets the SARS-CoV-2 virus Viral protein viral-host protein virulence Virus structures Virus-host interactions [DOI] 10.1038/s41467-021-23533-x PMC 바로가기 [Article Type] Article
Circulating Cytokines and Coronavirus Disease: A Bi-Directional Mendelian Randomization StudyGenetics Published on 2021-06-072022-10-31 Journal: Frontiers in Genetics [Category] COVID-19, [키워드] 95% CI 95% confidence interval affected CCL4 conducted controls coronavirus disease COVID-19 cytokine Cytokines estimates GCSF genetic risk genetics Genome-wide association studies granulocyte hepatocyte growth factor HGF Hospitalized hospitalized COVID-19 immune response immune system Immunity Infection Inflammatory Intervention IVW Laboratory Ligand mendelian randomization motif multiple comparisons Prevent replicated Result risk sensitivity analysis was related Weighting with COVID-19 [DOI] 10.3389/fgene.2021.680646 PMC 바로가기 [Article Type] Genetics