mouse model – Page 16 – Communicable Diseases Research

Combining Quantitative Genetic Footprinting and Trait Enrichment Analysis to Identify Fitness Determinants of a Bacterial Pathogen

정량적 유전 발자국과 특성 강화 분석을 결합하여 세균성 병원체의 적합성 결정 요인 식별

Research Article

Published on 2013-08-222022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] a major abundance Affect Algorithm Antibiotic resistance approach approach approaches array assortment Author Bacterial bacterial gene bacterial genes benefit bioinformatics candidate gene changes in Combination conjunction conserved dataset deep sequencing deleted determinant determinants Determining diagnostic dissect Diversity DNA binding E. coli effective effort enrichment Escherichia Escherichia coli Factor fitness Follow-up analysis Footprinting found Gene Genes Genetic Genome genomes highest highlight homologue homologues Host hypothetical identify increasingly independent Infection infections insertion investigator investigators isolates Meningitis molecular mouse model Mutagenesis mutant novel observation observations pathogen Pathogenesis pathogenic pathogenic strain pathogenic strains Pathogens phenotypic phenotypic variation phylogenetic distribution promote Quantitative reported required Research resource saturated Sepsis Sequencing shown strain Strains suggested therapeutic therapeutic targets Therapies Tn-seq to define trait transcriptional repressor transposon urinary tract infections variant Variation virulence virulence gene widespread zebrafish
[DOI] 10.1371/journal.pgen.1003716 PMC 바로가기 [Article Type] Research Article

miR-199a-5p Is Upregulated during Fibrogenic Response to Tissue Injury and Mediates TGFbeta-Induced Lung Fibroblast Activation by Targeting Caveolin-1

miR-199a-5p는 조직 손상에 대한 섬유성 반응 동안 상향 조절되고 카베올린-1을 표적으로 하여 TGF베타 유도 폐 섬유아세포 활성화를 매개합니다

Research Article

Published on 2013-02-142022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] a major Activation addition Author best Bile duct Biology Bleomycin CAV1 Cell cell type cellular cellular processes characterized chronic class complex diseases contributing to controls Critical current therapy demonstrated deregulation develop different differentiation disease Disease progression Diseases disorder driving dysregulation ectopic expression Effect expression failure fibroblast fibroblasts fibrosis final common pathway foci form found histologic identify idiopathic Invasion investigated IPF kidney led to life liver Liver fibrosis lung Lung diseases Lung fibrosis Lungs mechanism mediator MicroRNAs Migration miRNA miRNA expression miRNAs morbidity morbidity and mortality mouse model Myofibroblast non-coding RNA Organ failure organ function pathogenic pathogenic mechanism pathogenic mechanisms Patient patients performed poor prognosis proliferation promote pulmonary fibrosis reducing response response rate responsible scar scar tissue Signaling significantly increased strain susceptibility targeting TGFβ therapeutic potency therapeutic strategy thought tissue treat ureteral obstruction
[DOI] 10.1371/journal.pgen.1003291 PMC 바로가기 [Article Type] Research Article

A Genome-Scale RNA–Interference Screen Identifies RRAS Signaling as a Pathologic Feature of Huntington’s Disease

게놈 규모의 RNA-간섭 스크린은 헌팅턴병의 병리학적 특징으로 RRAS 신호를 식별합니다

Research Article

Published on 2012-11-292022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] Activation addition Amino acid amino-terminus Analysis Author cascade caused Cell cellular cellular processe cellular processes component disease disorder Drosophila dysfunction effective ENCODE enzyme excitotoxicity farnesyltransferase FNTA found functional Glutamate Glutamine huntingtin Huntington's disease identify implicated in addition to increase in inhibitor Interaction Intervention involved Localization loss-of-function mammalian mechanism mechanisms mitochondrial mitochondrial dysfunction motor dysfunction mouse model mutant Mutation observé occur pathogenic pathway Pathways pharmacological PIN1 PLK1 Protein proteolysis RAF1 reduce reduced reducing repeated RNA interference RRAS Screen Signaling signaling pathway small molecule solubility suppress suppressed suppressor Therapeutic benefit These data Toxicity was performed
[DOI] 10.1371/journal.pgen.1003042 PMC 바로가기 [Article Type] Research Article

Signature patterns revealed by microarray analyses of mice infected with influenza virus A and Streptococcus pneumoniae

Article

Published on 2006-06-022023-06-14
Journal: Microbes and infection
[Category] Fulltext, 신종인플루엔자,

[키워드] Streptococcus pneumoniae; Host response influenza virus A Intracellular signaling pathways Microarray profiles mouse model Signature patterns
[DOI] 10.1016/j.micinf.2006.04.018 PMC 바로가기 [Article Type] Article