Clinical characteristics and viral load dynamics of COVID-19 in a mildly or moderately symptomatic outpatient sample경증 또는 중등도의 증상이 있는 외래 환자 샘플에서 COVID-19의 임상 특성 및 바이러스 부하 역학Research Article Published on 2021-10-212022-09-12 Journal: PLoS ONE [Category] MERS, SARS, 진단, [키워드] 49 days age antibodies antibody tests association blood sample Blood samples Chain Reaction Characteristics clinical cohort study collected correlated COVID-19 COVID-19 outpatients cycle threshold enrolled females first positive initial initial viral load median median age Mild Moderate COVID-19 Nasopharyngeal swab nasopharyngeal swabs nine Outpatient outpatients participant Patient patients PCR test performed polymerase chain polymerase chain reaction positive positive RT-PCR remained reported Result reverse transcriptase Reverse transcriptase polymerase chain reaction RT-PCR RT-PCR test RT-PCR tests SARS-CoV-2 antibodies SARS-CoV-2 antibody significantly Symptom symptom duration symptom onset symptomatic tested transcriptase Viral load were used [DOI] 10.1371/journal.pone.0258970 PMC 바로가기 [Article Type] Research Article
Diagnostic Efficacy and Tolerability of Molded Plastic Nasopharyngeal Swab (FinSwab) Compared to Flocked Nylon Swab in Detection of SARS-CoV-2 and Other Respiratory VirusesSARS-CoV-2 및 기타 호흡기 바이러스의 검출에서 플록 나일론 면봉과 비교한 성형 플라스틱 비인두 면봉(FinSwab)의 진단 효능 및 내약성Comparative Study Published on 2021-10-202022-09-10 Journal: Microbiology Spectrum [Category] MERS, SARS, 진단, 치료기술, [키워드] age analyzed assays clinical setting collected comparable Copan coronavirus COVID-19 COVID-19 infection cycle threshold detection deviation diagnostic diagnostics discomfort Efficacy equipment evaluate Italy mRNA nasopharyngeal nasopharyngeal sample nasopharyngeal sampling Nasopharyngeal swab nasopharyngeal swabs no difference nostril Nylon OC43 Other Other respiratory viruses Patient patients plastic plastic injection molding positive Randomized respiratory respiratory virus respiratory viruses reverse transcriptase reverse transcriptase PCR rhinovirus RT-PCR sampling SARS-CoV-2 Spread subset supply Swab swabs symptomatic Tolerability virus β-actin [DOI] 10.1128/Spectrum.00736-21 PMC 바로가기 [Article Type] Comparative Study
Flower lose, a cell fitness marker, predicts COVID‐19 prognosis코로나19 예후를 예측하는 세포 건강 지표인 꽃 손실Observational Study Published on 2021-10-182022-09-11 Journal: EMBO Molecular Medicine [Category] MERS, SARS, 바이오마커, 임상, 진단, 치료기술, [키워드] acute lung injury age an area AUROC Biomarker Biomarkers C‐reactive protein Cell cell death cell fitness change characteristic Comorbidities Comorbidity COVID‐19 COVID‐19 patient COVID‐19 patients COVID‐19 D‐dimer death Deceased determine disease early phase evaluate expressed expression flower Gene Expression Hospitalization Host immune response Infection Inflammatory biomarker Lower respiratory tract Lung injury lung tissue management marker Microbiology, Virology & Host Pathogen Interaction Nasopharyngeal samples Nasopharyngeal swab nasopharyngeal swabs Negative predictive value neutrophil–lymphocyte ratio observational study outcome outperform pandemic pathway Patient patient age performed Positive predictive value positive predictive values predict Predictive value predictive values presenting Prognosis Prognostic value receiver operating characteristic receiver operating characteristic curve respiratory Serum ferritin significantly higher Stratification subsequent the cell tissue utility [DOI] 10.15252/emmm.202013714 PMC 바로가기 [Article Type] Observational Study
Effect of Ivermectin and Atorvastatin on Nuclear Localization of Importin Alpha and Drug Target Expression Profiling in Host Cells from Nasopharyngeal Swabs of SARS-CoV-2- Positive PatientsSARS-COV-2- 양성 환자의 비 인두 면봉으로부터의 숙주 세포에서 수입 알파 및 약물 표적 발현 프로파일 링에 대한 Ivermectin 및 Atorvastatin의 효과Article Published on 2021-10-152022-09-10 Journal: Viruses [Category] SARS, 신약개발, 유전자 메커니즘, 치료법, 치료제, [키워드] Actin Affect alteration analyzed antihelmintic drug atorvastatin Cdc42 cellular Combination concentrations confocal microscopy COVID-19 COVID-19 patient COVID-19 patients cytoplasmic distribution drug Drug repurposing drug target drugs Effect expression function Gene Expression host cell host cell antiviral response host cells impair Importin in vitro model Infection inhibit involved Ivermectin KPNA3 KPNA5 KPNA7 KPNB1 lipophilic statin Localization mechanism Nasopharyngeal swab nasopharyngeal swabs NF-κB NF-κB activation Non-COVID-19 patients nuclear Nuclear localization Pathogenesis Patient pleiotropic effect poly(I:C) Profiling Result Rho GTPase Rho GTPases RHOA RNA viruses SARS-CoV-2 SARS-COV-2 infection Signaling target transcriptional Transport Treatment triggered Vesicle Viral viral double-stranded RNA [DOI] 10.3390/v13102084 PMC 바로가기 [Article Type] Article
Concordance between PCR-based extraction-free saliva and nasopharyngeal swabs for SARS-CoV-2 testingResearch Article Published on 2021-10-152022-10-31 Journal: HRB Open Research [Category] COVID-19, [키워드] 95% CI Accuracy acute respiratory syndrome analysed Analysis Asymptomatic Cohort Concordance coronavirus correlation COVID-19 testing demonstrated detect extraction-free method gene target gold standard greater hospital invasive less matching Nasopharyngeal swab nasopharyngeal swabs NPs nucleic acid participant Population positive processed protocol RdRP recruited Result RNA RT-qPCR Saliva saliva specimens saliva test SalivaDirect SARS-CoV-2 SARS-CoV-2 testing SARS-CoV2 sensitivity significant difference specificity specimens symptomatic Symptomatic patients [DOI] 10.12688/hrbopenres.13353.2 PMC 바로가기 [Article Type] Research Article
Feasibility and Effectiveness Assessment of SARS-CoV-2 Antigenic Tests in Mass Screening of a Pediatric Population and Correlation with the Kinetics of Viral Loads소아 집단의 대량 스크리닝 및 바이러스 부하의 동역학과의 상관 관계에서 SARS-COV-2 항원 시험의 타당성 및 효과 평가Article Published on 2021-10-142022-09-01 Journal: Viruses [Category] MERS, SARS, 진단, 치료기술, [키워드] 95% CI Accuracy AFIAS COVID-19 Ag Ag-RDT Ag-RDTs Antigen antigen detection antigen tests assessment baseline children Clinicians Cohort COVID-19 diagnosis of SARS-CoV-2 effective Emergency feasible gold gold standard infected children Infection IRCCS Kinetics late phase load mass Mass screening minutes molecular test NAAT Nasopharyngeal swab nasopharyngeal swabs nucleic acid nucleic acid amplification nucleic acid amplification tests offer Patient patients Pediatric patient Pediatric patients POC point-of-care Polyclinic Population positive rapid antigenic test RDTs real time RT-PCR Result SARS-CoV-2 SARS-COV-2 infection screened Screening sensitivity specificity Test unit Viral Viral load viral loads [DOI] 10.3390/v13102071 PMC 바로가기 [Article Type] Article
Impact of baseline SARS-CoV-2 antibody status on syndromic surveillance and the risk of subsequent COVID-19—a prospective multicenter cohort study기준 SARS-COV-2 항체 상태의 증후군 감시 및 후속 COVID-19의 위험-전향 적 다기관 코호트 연구에 미치는 영향Multicenter Study Published on 2021-10-142022-09-10 Journal: BMC Medicine [Category] MERS, SARS, 치료법, [키워드] 95% CI 95% confidence interval analyzed Anti-nucleocapsid antibodies anti-nucleocapsid antibody Antigen Asymptomatic baseline Baseline serology baseline serostatus best chill chills Cohort coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 symptoms Follow-up HCW healthcare healthcare worker Healthcare workers Impact Impaired information less median multicenter cohort study muscle pain nasopharyngeal Nasopharyngeal swab nasopharyngeal swabs occurrence of COVID-19 Pain participant participated performed positive positive result provide questionnaire Re-infection reported Result risk risk ratio SARS-CoV-2 SARS-CoV-2 antibody SARS-COV-2 infection SARS-CoV-2 test Screening serology seronegative participants seropositive seropositive individual seropositive individuals subsequent supplementary material Surveillance Symptom symptomatic [DOI] 10.1186/s12916-021-02144-9 PMC 바로가기 [Article Type] Multicenter Study
Comparative Performance of a New SARS-CoV-2 Rapid Detection System새로운 SARS-CoV-2 신속 탐지 시스템의 비교 성능Comparative Study Published on 2021-10-132022-09-10 Journal: Microbiology Spectrum [Category] MERS, SARS, 진단, 치료기술, [키워드] Accuracy acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Administered affected collected colonize Comparative comparator complex coronavirus COVID-19 detection develop Diagnosis diagnosis of SARS-CoV-2 diagnostic diagnostic platform diagnostic procedures drug evaluated examined false-positive result False-positive results Finder gold gold standard Infection interfere Interpretation less medium microorganism microorganisms molecular Molecular diagnosis molecular test Nasopharyngeal swab nasopharyngeal swabs New NPSs overcome parameter performance positive provide qualitative detection Rapid Rapid test reagent reagents Real-time PCR real-time PCR system real-time RT-PCR required respiratory Respiratory disease respiratory diseases retrospective risk SARS-CoV-2 SARS-CoV-2 detection SARS-COV-2 infection sensitivity Sensitivity and specificity severe acute respiratory syndrome Coronavirus specificity Swab System tested Transport transport medium Universal Transport Medium upper respiratory tract UTM [DOI] 10.1128/Spectrum.00205-21 PMC 바로가기 [Article Type] Comparative Study
Response to BNT162b2 mRNA COVID-19 vaccine among healthcare workers in Italy: a 3-month follow-up이탈리아 의료 종사자들의 BNT162b2 mRNA COVID-19 백신에 대한 반응: 3개월 추적 관찰Im - Original Published on 2021-10-122022-09-10 Journal: Internal and Emergency Medicine [Category] MERS, SARS, 치료기술, [키워드] administration Adverse adverse events anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody BNT162b2 BNT162b2 mRNA BNT162b2 vaccine COVID-19 COVID-19 vaccine cut-off Effectiveness event exceeded first dose focus Follow-up HCW HCWs healthcare worker Healthcare workers high risk hospital immunization immunoglobulins Infection investigated Italian Nasopharyngeal swab nasopharyngeal swabs nucleic acid offer participant Participants positive reactivity recipients reported Research response RT-PCR assay SARS-CoV-2 SARS-CoV-2 nucleic acid serology testing tested the vaccine Vaccine vaccine response [DOI] 10.1007/s11739-021-02857-y PMC 바로가기 [Article Type] Im - Original
Comparison of 11 respiratory pathogens among hospitalized children before and during the COVID-19 epidemic in Shenzhen, China중국 심천의 Covid-19 전염병 전과 중에 입원 어린이들 사이에서 11 개의 호흡기 병원체의 비교Comparative Study Published on 2021-10-092022-09-10 Journal: Virology Journal [Category] MERS, SARS, 치료기술, [키워드] Acute respiratory infection acute respiratory infections Adenovirus analyzed children China circulation collected COVID-19 COVID-19 epidemic detection rate enrolled Epidemic Hospitalized Human human metapneumovirus human parainfluenza virus Human respiratory syncytial virus Human rhinovirus Influenza influenza A measure Multiplex PCR Mycoplasma pneumoniae nasopharyngeal swabs outbreak parainfluenza virus pathogen Pathogens Patient pneumoniae Prevalence preventive measure preventive measures remains uncertain respiratory respiratory pathogen Respiratory pathogens respiratory syncytial virus respiratory tract infection Result rhinovirus SARS-CoV-2 Seasonal influenza Shenzhen significantly lower Swab virus [DOI] 10.1186/s12985-021-01669-y PMC 바로가기 [Article Type] Comparative Study