Large-scale serosurveillance of COVID-19 in Japan: Acquisition of neutralizing antibodies for Delta but not for Omicron and requirement of booster vaccination to overcome the Omicron’s outbreak일본의 대규모 COVID-19 혈청 감시: Delta에 대한 중화 항체 획득(Omicron에 대해서는 제외) 및 Omicron의 발병을 극복하기 위해 추가 백신 접종 필요Article Published on 2022-04-052022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] Analysis analyzed anti-S booster vaccination Cohort collected Concordance Continuous COVID-19 COVID-19 situation Delta delta variant Diagnosis effective Endemic Health Immunity individual Japan mass vaccination much lower Neutralizing activity neutralizing antibody omicron outbreak overcome reached SARS-CoV-2 variant SARS-CoV-2 variants sera seropositive vaccination vaccination rate [DOI] 10.1371/journal.pone.0266270 PMC 바로가기 [Article Type] Article
Recombinant VLPs empower RBM peptides showing no immunogenicity in native SARS-COV-2 protein to elicit a robust neutralizing antibody response재조합 VLP는 천연 SARS-COV-2 단백질에서 면역원성을 나타내지 않는 RBM 펩타이드를 강화하여 강력한 중화 항체 반응을 이끌어냅니다.Article Published on 2022-04-012022-09-11 Journal: Nanomedicine : nanotechnology, biology, and medici [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus affinity Antigen antigenicity Antisera candidate carrier protein core antigen coronavirus demonstrated effective delivery elicit epitope Epitopes HBcAg immunization in vitro inactivated indicate KLH linear mice motif Multi-epitope vaccine Neutralizing activity neutralizing antibody Neutralizing antibody response New overlapping Particle peptide peptide epitope peptides Protein RBM reactivity receptor binding motif receptor-binding motif Receptor-binding motif (RBM) recombinant respiratory robust S1 protein severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Vaccine variants virus virus infection virus mutation Virus-like particle virus-like particles Virus-like particles (VLPs) VLP VLPs [DOI] 10.1016/j.nano.2022.102527 PMC 바로가기 [Article Type] Article
Antibody evasion properties of SARS-CoV-2 Omicron sublineagesSARS-CoV-2 오미크론 하위 계통의 항체 회피 특성Article Published on 2022-04-012022-09-11 Journal: Nature [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 alteration antibody antigenic bebtelovimab caused comparable coronavirus Efficacy Evolution except for exhibited include lead monoclonal antibodies monoclonal antibody monoclonal antibody therapy mRNA vaccine Neutralizing activity neutralizing monoclonal antibodies neutralizing monoclonal antibody omicron Omicron variant Patient polyclonal sera Prevalence recipient recipients refs reported respiratory retained S309 SARS-CoV-2 sera severe acute respiratory syndrome Coronavirus Sotrovimab spike glycoprotein Surveillance tested therapy unique Vaccines variant wild-type SARS-CoV-2 [DOI] 10.1038/s41586-022-04594-4 PMC 바로가기 [Article Type] Article
Evasion of vaccine-induced humoral immunity by emerging sub-variants of SARS-CoV-2SARS-CoV-2의 새로운 하위 변종에 의한 백신 유도 체액 면역 회피Article Published on 2022-04-012022-09-11 Journal: Future Microbiology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] accelerate Beta Beta variant contributed COVID-19 dose Effectiveness Efficacy emergence escape mutant evaluate exhibited genomic global public health highest Humoral immunity Imdevimab immune Immune escape material mRNA vaccine Mu variant mutant mutants neutralization neutralization test Neutralizing activity Neutralizing antibodies no decrease omicron Pfizer/BioNTech Phenotypic analysis Receptor-binding domain retained SARS-CoV-2 SARS-CoV-2 variant selection pressure sera shown strain Strains Surveillance tested the receptor-binding domain vaccination Vaccine vaccine effectiveness were used [DOI] 10.2217/fmb-2022-0025 PMC 바로가기 [Article Type] Article
Immune treatment in COVID-19COVID-19의 면역 치료Review Published on 2022-04-012022-09-11 Journal: Revista española de quimioterapia : publicación [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] apparition bamlanivimab Casirivimab cells clinical benefit Combination convalescent plasma COVID-19 current doses etesevimab Evolution exhibited Imdevimab immune knowledge mAb mAbs Meta-analysis meta-analysis and systematic review monoclonal antibodies monoclonal antibody Neutralizing activity omicron Omicron variant Patient progression Recombinant protein recombinant proteins reduction in reported retained SARS-CoV-2 serological shown Sotrovimab Standard of care systematic review target population the disease Treatment variant variants Viral Viral load viral replication [DOI] 10.37201/req/s01.14.2022 PMC 바로가기 [Article Type] Review
Neutralization or enhancement of SARS-CoV-2 infection by a monoclonal antibody targeting a specific epitope in the spike receptor-binding domain스파이크 수용체 결합 도메인의 특정 에피토프를 표적으로 하는 단일클론항체에 의한 SARS-CoV-2 감염의 중화 또는 증강Article Published on 2022-04-012022-09-11 Journal: Antiviral Research [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] abrogated ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alanine Alpha angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antibody Antibody-dependent enhancement binding binding epitope caused cellular contrary coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cross-reactivity Delta demonstrated dose-dependent manner ELISA epitope Epitopes Epsilon exhibited exhibiting experiment Gamma HEK293T cells Infection lentivirus MERS-CoV monoclonal antibodies monoclonal antibody mouse monoclonal antibody NAbs Neutralizing activity Neutralizing antibodies neutralizing antibody Prophylactic Protein pseudotyped RBD receptor Receptor binding domain Receptor-binding domain reduction Region reported residue residues respiratory S protein S proteins SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 variant SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus spike Spike receptor binding domain Spike receptor binding domain. spike receptor-binding domain the RBD the receptor-binding domain the S protein Therapeutic treatment variant variants of SARS-CoV-2 wild-type [DOI] 10.1016/j.antiviral.2022.105290 PMC 바로가기 [Article Type] Article
Combined Subcutaneous-Intranasal Immunization With Epitope-Based Antigens Elicits Binding and Neutralizing Antibody Responses in Serum and Mucosae Against PRRSV-2 and SARS-CoV-2에피토프 기반 항원과 결합된 피하-비강내 면역화는 PRRSV-2 및 SARS-CoV-2에 대한 혈청 및 점막의 결합 및 중화 항체 반응을 유도합니다Article Published on 2022-03-312022-09-12 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, [키워드] Administered Against animal antibodies antibody Antigen antigens Antiviral approaches asymptomatic infection baculovirus binding binding antibody Combination Combined Concentration conserved elicit emerging and re-emerging viruses envelope protein epitope epitope-based antigens evaluate evaluated expressed fluids generate GP5 Humoral response immunization immunization strategy immunized induce Infection inhibited inoculated Interaction intranasal intranasally investigated Local memory response mucosal mucosal antibodies Mucosal immunization nasal Neutralizing Neutralizing activity Neutralizing antibodies neutralizing antibody New Prevent produced promoted Protein RBD-ACE2 receptor-binding motif recombinant baculovirus recombinant proteins recombinant proteins. reduce response responses SARS-CoV-2 serum serum antibody serum sample subcutaneously the S protein Transmission vaccinated individuals Vaccine design vaginal swabs virus [DOI] 10.3389/fimmu.2022.848054 PMC 바로가기 [Article Type] Article
Isolation of human monoclonal antibodies with neutralizing activity to a broad spectrum of SARS-CoV-2 viruses including the Omicron variantsArticle Published on 2022-03-242023-07-02 Journal: Antiviral Research [Category] COVID19(2023년), SARS, [키워드] escape mutants mAb Neutralizing activity Omicron variants SARS-CoV-2 Spike protein [DOI] 10.1016/j.antiviral.2022.105297 PMC 바로가기 [Article Type] Article
Serum neutralization of SARS-CoV-2 Omicron sublineages BA.1 and BA.2 in patients receiving monoclonal antibodies Research Published on 2022-03-232022-10-05 Journal: Nature Medicine [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome administration analyzed antibody antibody treatment coronavirus country delta variant elevated immunocompromised individual individual individuals Infection inhibited mAbs monoclonal antibody Mutation neutralization neutralized Neutralizing activity Neutralizing titer nine not neutralize noticeable difference omicron Patient Prevent receiving recipient recipients reduced SARS-CoV-2 sensitivity sera therapeutic treated [DOI] 10.1038/s41591-022-01792-5 [Article Type] Research
Characterization of Serum and Mucosal SARS-CoV-2-Antibodies in HIV-1-Infected Subjects after BNT162b2 mRNA Vaccination or SARS-CoV-2 InfectionBNT162b2 mRNA 백신 접종 또는 SARS-CoV-2 감염 후 HIV-1 감염 대상에서 혈청 및 점막 SARS-CoV-2-항체의 특성화Article Published on 2022-03-212022-09-11 Journal: Viruses [Category] SARS, 치료기술, [키워드] all subject all subjects analysed Anti-spike anti-Spike IgG antibody Antiretroviral therapy BNT162b2 BNT162b2 mRNA BNT162b2 mRNA vaccine characterization convalescent detectable dose ELISA Frequency HIV-1 humoral humoral immune response IgA IgA antibodies IgA antibody IgG immune Immunity immunogenicity indicate induce investigated mRNA vaccination mRNA vaccine mucosal mucosal immunity neutralization activity Neutralization assay Neutralizing activity Neutralizing antibodies neutralizing antibody neutralizing capacity no significant difference of BNT162b2 Patient patients Saliva saliva samples SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike-specific SARS-CoV-2-specific antibodies SARS-CoV-2-specific antibody serum serum levels significantly higher significantly lower specific antibodies spike IgA spike-specific antibody response subject subjects uninfected vaccination Vaccine vaccine response vaccinee vaccinees while [DOI] 10.3390/v14030651 PMC 바로가기 [Article Type] Article