Activation of the c-Jun NH 2 -terminal kinase pathway by coronavirus infectious bronchitis virus promotes apoptosis independently of c-JunArticle Published on 2017-12-132022-11-01 Journal: Cell Death & Disease [Category] Coronavirus, [키워드] activated Activation anti-apoptotic Apoptosis avian coronavirus B-cell lymphoma Cell cellular signaling pathways conserved coronavirus Coronaviruses demonstrated experiment host–virus interaction IBV IBV infection infections Infectious Bronchitis Virus Interaction investigated involved JNK JNK pathway kinase knockdown MAPK mitogen-activated protein kinase modulation N-terminal overexpression pathway pro-apoptotic activity pro-apoptotic protein promote Protein protein kinase regulate responsible shown upstream variety virus [DOI] 10.1038/s41419-017-0053-0 PMC 바로가기 [Article Type] Article
Porcine Hemagglutinating Encephalomyelitis Virus Enters Neuro-2a Cells via Clathrin-Mediated Endocytosis in a Rab5-, Cholesterol-, and pH-Dependent MannerVirus-Cell Interactions Published on 2017-09-272022-10-30 Journal: Journal of Virology [Category] Coronavirus, [키워드] Actin activated Activation Analysis antiviral drug approach cause Cell cells cellular entry Central nervous system China cholesterol clathrin Clathrin-mediated endocytosis CNS confocal microscopy contagious coronavirus death disease dissect dominant negative dysfunction Encephalomyelitis endocytic pathways endocytosis etiological agent Exocytosis GTPase Guidance Host infected cell Infection Invasion investigated involved knowledge mechanism molecular mechanism mutant nerve cell Neural neurological neurovirulent neurovirulent coronavirus occur overexpression Pathogenesis pathway performed pharmacological porcine hemagglutinating encephalomyelitis virus positive-sense positively correlated progression Rab required RNA coronavirus RNA interference single-stranded suggested target TEM Therapeutic strategies transfer transmission electron microscopy understanding viral endocytosis viral entry viral entry pathway virus virus particles were used [DOI] 10.1128/JVI.01083-17 PMC 바로가기 [Article Type] Virus-Cell Interactions
Disrupting the cortical actin cytoskeleton points to two distinct mechanisms of yeast [ PSI + ] prion formation피질의 액틴 세포골격을 교란하는 것은 효모 [PSI + ] 프리온 형성의 두 가지 뚜렷한 메커니즘을 나타냅니다.Research Article Published on 2017-04-032022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] abrogate abrogated Actin affected Affinity purification aggregate aggregates aggregation Analysis antioxidant component composed conditions cortical Deletion disease disrupt examined form forms fragmentation Frequency fungal identify implicated increase infectious agent infectious agents insoluble protein mass spectrometry mechanism misfolded protein misfolded proteins molecular MOST mutant mutants neurodegenerative occur overexpression oxidative oxidative damage oxidative stress oxidized Prevent Previous studies previous study prion Probability Protein Protein misfolding Proteins PSI reduced required thought transition translation Trigger undergo yeast yeast cell yeast cells [DOI] 10.1371/journal.pgen.1006708 PMC 바로가기 [Article Type] Research Article
Aminopeptidase N is not required for porcine epidemic diarrhea virus cell entryArticle Published on 2017-03-282022-11-01 Journal: Virus research [Category] Coronavirus, [키워드] alphacoronavirus aminopeptidase aminopeptidase N APN applied binding blocked cause Cell cell entry coronavirus diarrhea epidemic diarrhea examined exhibited expressed expressing expression functional gastroenteritis Genetic Genome had no HCoV-229E Hela host cell receptor Huh7 human cell line human coronavirus 229E indicated infect Infection intestinal epithelium knockout MDCK cell observation overexpression pathogenic coronavirus PEDV Porcine epidemic diarrhea virus preincubation Protein receptor reported required Result resulting S1 subunit Surface glycoprotein susceptibility susceptible TGEV these cell viral spike virus virus Virus cell entry viruses [DOI] 10.1016/j.virusres.2017.03.018 PMC 바로가기 [Article Type] Article
Nucleocapsid Interacts with NPM1 and Protects it from Proteolytic Cleavage, Enhancing Cell Survival, and is Involved in PEDV GrowthArticle Published on 2017-01-032022-10-29 Journal: Scientific Reports [Category] Coronavirus, MERS, [키워드] activities addition binding caspase-3 Cell components cytoplasm Degradation ENhance Enhancing epidemic diarrhea growth host cell independent indicated infected cells interact Interaction knockdown mechanism N protein NPM1 nuclear translocation nucleocapsid Nucleolus nucleophosmin nucleus overexpression PEDV Prevent promoted PROTECT Protein proteolytic proteolytic cleavage Regulation replicate Replication required suppressed survival the N protein virus [DOI] 10.1038/srep39700 PMC 바로가기 [Article Type] Article
Porcine epidemic diarrhea virus nucleoprotein contributes to HMGB1 transcription and release by interacting with C/EBP-βResearch Paper Published on 2016-11-152022-10-28 Journal: Oncotarget [Category] Coronavirus, [키워드] C/EBP-β caused co-immunoprecipitation contribute demonstrated disease epidemic diarrhea experiment HMGB1 immunoprecipitation in vitro induce Infection motif NF-κB nucleoprotein overexpression Pathogenesis PEDV Porcine epidemic diarrhea virus proinflammatory cytokines Proinflammatory response promotor region Protein regulated release of HMGB1 reporter gene assay SIRT1 subsequent Transcription various inflammatory diseases virus [DOI] 10.18632/oncotarget.11991 PMC 바로가기 [Article Type] Research Paper
Amplification of TLO Mediator Subunit Genes Facilitate Filamentous Growth in Candida Spp .TLO 중재자 소단위 유전자의 증폭은 칸디다 종에서 필라멘트 성장을 촉진합니다.Research Article Published on 2016-10-142022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Activation amplification amplitude ascomycete ascomycetes binding domain bloodstream infection Bloodstream infections Candida Candida albican Candida albicans candidiasis cause cell physiology complex death DNA domain Engineering ENhance environmental cues eukaryotic exhibit facilitated Filamentous fungal fungi gene family Genome genomes genomic growth hallmark individual Infection infections Interaction less mediator mortality rate multitude murine mutant Nuclear localization nuclear localization signal nucleus ortholog overexpressed overexpression pathogenicity phenotype Phenotypes phenotypic plasticity Protein provide reduced regulate subunit Support systemic Candidiasis systemic infection target targets The United States Transcription transcription factor transcription factors transcriptional transcriptional activation unique United States virulence [DOI] 10.1371/journal.pgen.1006373 PMC 바로가기 [Article Type] Research Article
TGEV infection up-regulates FcRn expression via activation of NF-κB signalingArticle Published on 2016-08-242022-10-29 Journal: Scientific Reports [Category] Coronavirus, [키워드] activated Activation addition Analysis binding site caused Cell characterized chromatin immunoprecipitation Degradation disease down-regulation electromobility shift assay Evidence expressed expression gastroenteritis IgG Infection inhibitor intestinal epithelial cell Neonatal Newborn NF-κB NF-κB signaling overexpression p65 pathogenic pathway Plasmid plasmids promoter promoter region PROTECT receptor regulated reported reporter Research TGEV transcription factor Transient Transport Treatment up-regulate up-regulated virus [DOI] 10.1038/srep32154 PMC 바로가기 [Article Type] Article
Glucose-6-Phosphate Dehydrogenase Enhances Antiviral Response through Downregulation of NADPH Sensor HSCARG and Upregulation of NF-κB SignalingArticle Published on 2015-12-172022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] activity Alpha Analysis Antiviral antiviral response Cell cells coronavirus Degradation dehydrogenase DNA binding downregulated enterovirus examined Exogenous expression G6PD glucose-6-phosphate dehydrogenase GTPase HCoV-229E HSCARG human coronavirus 229E IDH1 increased expression Infection inhibited IκB mechanism MX1 NADPH Necrosis NF-κB NF-κB signaling nicotinamide adenine dinucleotide overexpression phosphate promoter Protein reduced response resulting sensor siRNA suppressed susceptibility susceptible TNF- α upregulated viral gene expression viral infection virus infection [DOI] 10.3390/v7122966 PMC 바로가기 [Article Type] Article
Heterologous Aggregates Promote De Novo Prion Appearance via More than One Mechanism이종 골재는 하나 이상의 메커니즘을 통해 De Novo Prion 모양을 촉진합니다.Research Article Published on 2015-01-082022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] absence aggregate aggregates aggregation appear appearance asparagine Cell cells cellular chaperone characteristic Colocalization conformational cytoplasm de novo detect disease domains eukaryotic form Glutamine Heterologous Interaction lack mechanisms molecular MOST neurodegenerative no interaction open overexpressed overexpression pathway periphery phenotypic phenotypic traits physical Polymer prevalent prion promote Protein Proteins PSI required seed stimulated the cell traits vacuole variant while yeast [DOI] 10.1371/journal.pgen.1004814 PMC 바로가기 [Article Type] Research Article