peptides – Page 16 – Communicable Diseases Research

Cryo-EM structures of human bradykinin receptor-G q proteins complexes

Article

Published on 2022-02-072022-10-04
Journal: Nature Communications [Category] 변종,

Identification of cytotoxic T cells and their T cell receptor sequences targeting COVID-19 using MHC class I-binding peptides

MHC 클래스 I 결합 펩타이드를 사용하여 COVID-19를 표적으로 하는 세포독성 T 세포 및 T 세포 수용체 서열 확인

Article

Published on 2022-02-022022-09-10
Journal: Journal of Human Genetics [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 치료기술, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alpha Antigen Brazil CD8 cellular immunity characterized China clone conserved coronavirus COVID-19 CTL CTLs Cytotoxic T cell cytotoxic T lymphocyte cytotoxic T lymphocytes elicited Epitopes glycoprotein histocompatibility complex HLA-A HLA-A*02:01 HLA-A*02:06 human leukocyte antigen identification identify Immunity India individual individuals induce investigated leukocyte Lymphocytes maintain major histocompatibility complex membrane membrane glycoprotein MERS-CoV MHC MHC class Neutralizing antibodies neutralizing antibody nine non-infected ORF1 ORF1ab other coronavirus other coronaviruses pandemic peptide peptide epitope peptide epitopes peptides Peripheral blood peripheral blood samples polyprotein Protein recognize reported respiratory SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variants SARS-CoV-2 viral sequence Sequencing severe acute respiratory syndrome Coronavirus South Africa Spike protein T cell T cell receptor T cell response T cell responses T cells TCR sequence TCR sequences TRA TRB unique United Kingdom Vaccinations variant Viral proteins
[DOI] 10.1038/s10038-022-01013-4 PMC 바로가기 [Article Type] Article

Antibodies to the N-Terminal Domain of Angiotensin-Converting Enzyme (ACE2) That Block Its Interaction with SARS-CoV-2 S Protein

SARS-CoV-2 S 단백질과의 상호작용을 차단하는 안지오텐신 전환 효소(ACE2)의 N-말단 도메인에 대한 항체

Article

Published on 2022-02-012022-09-11
Journal: Doklady. Biochemistry and biophysics [Category] COVID19(2023년), SARS, 치료기술, 치료제,

Screening and identification of B cell epitope of the nucleocapsid protein in SARS-CoV-2 using the monoclonal antibodies

단일클론항체를 이용한 SARS-CoV-2의 뉴클레오캡시드 단백질 B 세포 에피토프의 스크리닝 및 동정

Article

Published on 2022-02-012022-09-11
Journal: Applied Microbiology and Biotechnology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, 치료법, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Amino acid amino acids antibody antibody affinity Antibody titer Antibody titers Antigen B cell B-cell B-cell epitope cause cells Characteristics codon coronavirus coronavirus disease COVID-19 ELISA epitope expressed expression Guidance high affinity Host immune response insect cell insect cells linear mAb mAbs modulation monoclonal antibodies monoclonal antibody N gene N protein nucleocapsid nucleocapsid protein overlapped peptide peptides Protein reactivity Replication respiratory RNA SARS-CoV-2 SARS-CoV-2 N protein Screening sequence severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 shown strain targets the N protein the SARS-CoV-2 Transcription variants variants of concern variants of interest Viral viral pathogenesis virus virus detection VOCs VOIs were used
[DOI] 10.1007/s00253-022-11769-6 PMC 바로가기 [Article Type] Article

Three Specific Potential Epitopes That Could Be Recognized by T Cells of Convalescent COVID-19 Patients Were Identified From Spike Protein

회복기 COVID-19 환자의 T 세포가 인식할 수 있는 3개의 특정 잠재적 에피토프가 스파이크 단백질에서 확인되었습니다

Immunology

Published on 2022-01-282022-09-11
Journal: Frontiers in Immunology [Category] 치료기술, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Amino acid amino acids antibody Antigen Chinese convalescent Convalescent patients coronavirus coronavirus disease Coronavirus disease 2019 Coverage COVID-19 COVID-19 convalescent patient COVID-19 convalescent patients COVID-19 patient COVID-19 vaccine COVID-19 vaccines cross-reaction detect disease disease susceptibility Efficacy epitope Epitopes flow cytometry Frequency frequency of occurrence Genotype HLA HLA allele HLA alleles Identified IFN-γ Infection information mononuclear cell neutralizing antibody nonspecific Occurrence peptide peptides Peripheral blood positive Potential Prevent provide provided reaction rate Reactions Research respiratory SARS-CoV-2 SARS-CoV-2 S protein screened Seven severe acute respiratory syndrome Coronavirus severity of COVID-19 Specific spike Spike protein subsequent susceptibility T cell T cells T-cell T-cell epitope T-cell epitopes T-cell immunity Vaccine Viral viral infection
[DOI] 10.3389/fimmu.2022.752622 PMC 바로가기 [Article Type] Immunology

Molecular Docking and Dynamics Studies to Explore Effective Inhibitory Peptides Against the Spike Receptor Binding Domain of SARS-CoV-2

Molecular Biosciences

Published on 2022-01-272022-10-31
Journal: Frontiers in Molecular Biosciences [Category] COVID-19,

[키워드] acute respiratory syndrome addition affected Against allergenicity antimicrobial peptide binding binding energy binding free energy calculate complexes coronavirus deviation docked docking docking result docking scores domain drug candidate Dynamics effective exacerbated fluctuation Future Health host cell HPEPDOCK Hydrogen bond in vitro in vivo inhibit lack molecular molecular dynamics mortality rate non-allergenic non-toxic pandemic peptide peptide-protein docking peptides predicted radius of gyration RBD RMSD RMSF SARS-CoV-2 selected Spike protein Spread suggested the RBD the SARS-CoV-2 the Spike Toxicity Transmission Vaccines virus
[DOI] 10.3389/fmolb.2021.791642 PMC 바로가기 [Article Type] Molecular Biosciences

Heterologous Immunity Between SARS-CoV-2 and Pathogenic Bacteria

Immunology

Published on 2022-01-272022-11-01
Journal: Frontiers in Immunology [Category] COVID-19,

[키워드] Activation acute respiratory syndrome Asymptomatic Bacterial bacterial pathogen bystander CD69 Cell co-culture coronavirus coronavirus disease COVID-19 cross-reactive cross-reactivity cytokine production Donor Effect elicited explain extension Heterologous heterologous immunity high variability IFN-γ IL-2 Immunity in silico in vitro individual induce mechanism memory T memory T cell non-structural protein offered outcome outcomes pathogen pathogenic bacteria peptide peptides proliferation recall recognize response SARS-CoV-2 SARS-CoV-2 peptide SARS-CoV-2 vaccination SARS-CoV-2 vaccine sequence homology severity Spike protein T cell T cell response tested the SARS-CoV-2 the spike protein TNF vaccination
[DOI] 10.3389/fimmu.2022.821595 PMC 바로가기 [Article Type] Immunology

Comprehensive characterization of the antibody responses to SARS-CoV-2 Spike protein finds additional vaccine-induced epitopes beyond those for mild infection

SARS-CoV-2 스파이크 단백질에 대한 항체 반응의 포괄적인 특성화는 경증 감염에 대한 것 이외의 추가 백신 유도 에피토프를 찾습니다.

Comparative Study

Published on 2022-01-242022-09-10
Journal: eLife [Category] 변종, 치료기술, 치료제,

[키워드] Affect affected age Alter Analysis antibodies antibody Antibody binding antibody epitope Antibody Response Antigen Bacteria binding C-terminal domain cause chair changes in complicate Comprehensive computing conserved Control covariate COVID-19 COVID-19 pandemic disease DNA fragment dose education effective epitope Epitopes escape escape mutations experiment exposure to faculty FAM feature finding focus foundation funding fusion peptide genetic code help Howard Hughe Howard Hughes Human Humoral response humoral responses identify immune Immune escape immune system implication individual infect infected individuals Infection Infrastructure interfere Laboratory Lower majority mild infection mRNA vaccination mRNA vaccine mutant Mutation mutations NIH not affect not altered occur offered overlapping pandemic pathway Pathways pattern peptide peptides phage phages population level portion Principal component principal component analysis produced producing PROTECT Protein RBD Region regions Research residue route S1 subunit S2 subunit SARS-CoV-2 SARS-CoV-2 spike protein Scholar selected severe disease Severe infection shape small molecule Small molecules specific antibodies specific protein spike Spike protein spike-specific antibodies Spike-specific antibody Spread stick subsequent Support supported target the antibody the antibody response the RBD the S1 subunit the SARS-CoV-2 the Spike the spike protein thought triggering unique vaccinated individual vaccinated individuals vaccination Vaccine Vaccine development vaccine-induced antibodies vaccine-induced antibody variant Variation virus was performed while wild-type
[DOI] 10.7554/eLife.73490 PMC 바로가기 [Article Type] Comparative Study

SARS-CoV-2-Specific T Cell Responses Are Stronger in Children With Multisystem Inflammatory Syndrome Compared to Children With Uncomplicated SARS-CoV-2 Infection

SARS-CoV-2-특이적 T 세포 반응은 단순 SARS-CoV-2 감염 아동에 비해 다기관 염증 증후군 아동에서 더 강력합니다

Comparative Study

Published on 2022-01-182022-09-11
Journal: Frontiers in Immunology [Category] 진단, 치료법,

[키워드] acute infection acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Adults antibody Antigen Blood children collected convalescent Coronavirus-2 COVID-19 CST cytokine cytokine production evaluated finding flow cytometry Immunity Infection LIPS luciferase Luciferase immunoprecipitation system magnitude manifestation MIS-C morbidity and mortality nucleocapsid Patient patients pediatric peptides Presence rates of infection respiratory response risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-specific peptides seropositive Seropositivity serum/plasma Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus significantly higher specificity Stimulation surface markers T cell was measured
[DOI] 10.3389/fimmu.2021.793197 PMC 바로가기 [Article Type] Comparative Study

B- and T-Cell Responses After SARS-CoV-2 Vaccination in Patients With Multiple Sclerosis Receiving Disease Modifying Therapies: Immunological Patterns and Clinical Implications

Clinical Trial

Published on 2022-01-172022-10-04
Journal: Frontiers in Immunology [Category] 임상, 치료기술,

[키워드] acute respiratory syndrome administration age and sex All the patient Analysis anti-S anti-S antibody Antibody detection Antibody titers B-lymphocyte blood lymphocyte count CD20 cell-mediated response characterized circulating clinical Cohort comparable coronavirus Coronavirus-2 correlation COVID COVID-19 disease dose effective enrolled evaluate fingolimod General population GraphPad Prism healthy donor help Humoral response IFN-gamma IGRA Immunological response increase in lymphocyte Modifying mRNA vaccine Multiple multiple sclerosis Natalizumab NK-cell Ocrelizumab Patient pattern peptide peptides peripheral Peripheral blood Population protective role raised reduced reduction reported response Result SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccination SARS-CoV-2 vaccine sclerosis second dose severe COVID-19 Spread symptoms of COVID-19 T-cell T-cell Response T-cell responses T-lymphocyte Treatment Vaccination strategy Vaccine vaccine immunogenicity was performed were assessed while
[DOI] 10.3389/fimmu.2021.796482 PMC 바로가기 [Article Type] Clinical Trial