CDC25B promotes influenza A virus replication by regulating the phosphorylation of nucleoproteinArticle Published on 2018-12-012023-06-23 Journal: Virology [Category] 신종인플루엔자, [키워드] CDC25B influenza A virus nuclear export nucleoprotein Phosphorylation Self-oligomerization. [DOI] 10.1016/j.virol.2018.09.005
Differentially expressed non-coding RNAs induced by transmissible gastroenteritis virus potentially regulate inflammation and NF-κB pathway in porcine intestinal epithelial cell lineResearch Article Published on 2018-10-122022-10-28 Journal: BMC Genomics [Category] Coronavirus, [키워드] activate Activation Analysis analyzed binding cell line cells circular RNA differentially expressed Effects epithelial epithelial cell line expressed gastroenteritis Infection Inflammation inhibited Interaction intestinal intestinal epithelial cell KEGG Kyoto microRNA miRNA miRNAs mitochondrial mRNA mRNAs ncRNA ncRNAs Next-generation sequencing NF-κB NF-κB pathway NGS non-coding RNA nucleus opposite overexpression p65 pathway Pathways Phosphorylation profile promoted Protein receptor reduction regulate reporter Result RNA severe inflammation supplementary material TGEV TNF translated transmissible gastroenteritis virus viral infection virus was used [DOI] 10.1186/s12864-018-5128-5 PMC 바로가기 [Article Type] Research Article
VSIG4 inhibits proinflammatory macrophage activation by reprogramming mitochondrial pyruvate metabolismArticle Published on 2017-11-062022-10-29 Journal: Nature Communications [Category] Coronavirus, MERS, [키워드] activate cell metabolism contribute Exacerbation expressed expression Forced Hepatitis Inflammation Inflammatory inflammatory function inhibit insulin resistance Macrophage macrophage activation macrophages metabolism mice mitochondrial modulating murine hepatitis virus obesity Pathogenesis pathway PDK2 Phosphorylation proinflammatory promote Protein pyruvate reactive oxygen specy reduction in regulate Regulation secretion subsequent susceptible upregulation various inflammatory diseases Viral hepatitis VSIG4 [DOI] 10.1038/s41467-017-01327-4 PMC 바로가기 [Article Type] Article
PKA activity is essential for relieving the suppression of hyphal growth and appressorium formation by MoSfl1 in Magnaporthe oryzaePKA 활성은 Magnaporthe oryzae에서 MoSfl1에 의한 균사 성장 및 부착기 형성 억제를 완화하는 데 필수적입니다.Research Article Published on 2017-08-142022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Activation affinity Affinity purification Author C-terminal CAMP catalytic subunit cellular processe characterized co-IP conidia conidiation conserved Critical Deletion downstream eukaryotic cell eukaryotic cells Extracellular function functional functions Fusarium growth growth defect hyphal Infection insertion Interaction invasive involved IP assays loss-of-function mutation loss-of-function mutations Magnaporthe mutant mutants Mutation overlapping Pathogenesis pathway penetration Phosphorylation PKA produced purification reduced regulate regulated repressor residue response signaling pathway significantly strain Strains suppress suppressed suppression suppressor suppressors transcription factor transcriptional Treatment was reduced yeast [DOI] 10.1371/journal.pgen.1006954 PMC 바로가기 [Article Type] Research Article
Targeting Coronaviral Replication and Cellular JAK2 Mediated Dominant NF-κB Activation for Comprehensive and Ultimate Inhibition of Coronaviral ActivityArticle Published on 2017-06-222022-10-29 Journal: Scientific Reports [Category] Coronavirus, [키워드] activities activity approach block cells cellular combination treatment Compound Comprehensive Coronaviral Coronaviruses dominant effective feasible host cell Infection inhibit inhibition inhibitor IκBα Jak JAK2 mechanisms Mediated MERS-CoV NF-κB NF-κB activation p65 pathway Pathways Phosphorylation pro-inflammatory response Regulation Replication SARS-CoV target targeting TGEV Treatment viral infection Viral RNA virus [DOI] 10.1038/s41598-017-04203-9 PMC 바로가기 [Article Type] Article
MoCAP proteins regulated by MoArk1-mediated phosphorylation coordinate endocytosis and actin dynamics to govern development and virulence of Magnaporthe oryzaeMoArk1 매개 인산화에 의해 조절되는 MoCAP 단백질은 세포내이입과 액틴 역학을 조정하여 Magnaporthe oryzae의 발병 및 독성을 제어합니다Research Article Published on 2017-05-252022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Actin addition Analysis Author cellular conidia conidiation connection conserved Deletion endocytosis eukaryotic cells Evidence exhibited F-actin function functions fungi growth homolog host cells host infection hyphal in vivo invasive lead Magnaporthe mechanism modulate mutant mutants mycelial participated pathogenic pathogenicity penetration phosphatidylinositol phospholipid Phosphorylation PIP previous study Protein protein phosphorylation provided reduced regulate regulated Regulation required residue Signaling subject subunit type strain virulence wild-type strain [DOI] 10.1371/journal.pgen.1006814 PMC 바로가기 [Article Type] Research Article
The Eukaryote-Like Serine/Threonine Kinase STK Regulates the Growth and Metabolism of Zoonotic Streptococcus suisOriginal Research Published on 2017-03-072023-05-31 Journal: Frontiers in Cellular and Infection Microbiology [Category] Fulltext, 조류인플루엔자, [키워드] eukaryote-like serine/threonine kinase growth metabolism phosphoproteome Phosphorylation RNA-Seq Streptococcus suis virulence [DOI] 10.3389/fcimb.2017.00066 PMC 바로가기 [Article Type] Original Research
Characterization of pneumococcal Ser/Thr protein phosphatase phpP mutant and identification of a novel PhpP substrate, putative RNA binding protein Jag폐렴구균 Ser/Thr 단백질 인산가수분해효소 phpP 돌연변이의 특성화 및 새로운 PhpP 기질, 추정 RNA 결합 단백질 Jag의 확인Research Article Published on 2016-10-242024-08-01 Journal: BMC Microbiology [Category] 폐렴구균 감염증, [키워드] cell division Jag Phosphorylation protein kinase Protein phosphatase Signal transduction Streptococcus [DOI] 10.1186/s12866-016-0865-6 PMC 바로가기 [Article Type] Research Article
Middle East respiratory syndrome coronavirus M protein suppresses type I interferon expression through the inhibition of TBK1-dependent phosphorylation of IRF3Original Article Published on 2016-04-202022-10-31 Journal: Emerging Microbes & Infections [Category] Coronavirus, [키워드] Activation antiviral response association C-terminal C-terminal domain characterized chimeric claimed conserved contribute evade ex vivo models expression highly pathogenic Host IFN induce infected patient Infection inhibitory effect innate antiviral response interferon IRF3 IRF3 activation M protein mechanism MERS coronavirus MERS-CoV Middle East mutants N-terminal nuclear Pathogenesis Phosphorylation Protein reduced Regulatory respiratory syndrome coronavirus resulting RIG-I-like receptors SARS-CoV Saudi Arabia Sendai virus suppress suppresse suppressed TRAF3 transmembrane domain Type I IFN type I interferon type I interferons [DOI] 10.1038/emi.2016.33 PMC 바로가기 [Article Type] Original Article
Diminished COX-2/PGE 2 -Mediated Antiviral Response Due to Impaired NOX/MAPK Signaling in G6PD-Knockdown Lung Epithelial CellsResearch Article Published on 2016-04-202022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] A549 cell A549 cells addition Affect antiviral activity antiviral response Cell cellular chloride coronavirus 229E decrease decreased expression deficiency diminished downstream DPI dysregulated expression G6PD glucose-6-phosphate dehydrogenase homeostasis Impaired Infection Inflammatory response inhibitor MAPK NADPH NADPH oxidase NF-κB occurred oxidative stress PGE Phosphorylation provide reduced reducing Regulation response Signaling subunit susceptibility These data TNF-α transcriptional level Treatment tumor necrosis factor-α up-regulated viral infections viral replication was determined [DOI] 10.1371/journal.pone.0153462 PMC 바로가기 [Article Type] Research Article