protective role – Page 16 – Communicable Diseases Research

COVID-19 and rheumatic autoimmune systemic diseases: report of a large Italian patients series

Original Article

Published on 2020-08-272022-10-31
Journal: Clinical Rheumatology [Category] COVID-19, MERS, SARS,

[키워드] absence Arthritis Autoimmune Autoimmune systemic diseases comparison condition conditions Connective tissue diseases COVID-19 develop Diagnosis disease disease-modifying anti-rheumatic drug Disease-modifying anti-rheumatic drugs General population generally mild geographical area impairment Infection Inflammatory Interaction investigated Italian Italian patient manifestation Manifestations measure medium methotrexate multicenter overlapping pandemic Patient Point positive Prevalence protective role Region Result Rheumatic diseases SARS-CoV-2 significantly higher stimulate susceptibility Swab test symptomatic COVID-19 Symptoms systemic disease systemic diseases tissue Treatment Tuscany Virological virus
[DOI] 10.1007/s10067-020-05334-7 PMC 바로가기 [Article Type] Original Article

Harnessing Memory NK Cell to Protect Against COVID-19

Pharmacology

Published on 2020-08-202022-10-31
Journal: Frontiers in Pharmacology [Category] COVID-19,

[키워드] adaptive adaptive NK cell addition Against Allogeneic antiviral activity approach Cell chemokine chimeric antigen receptor coronavirus disease COVID-19 cytotoxicity early stage effective antiviral treatment Evidence exhibit function globe HCMV Human Cytomegalovirus hyper inflammation immune system immunization immunopathology Immunotherapy imperative Infection infections Inflammatory cytokine innate immune system Interaction lung tissue memory memory NK cell MERS natural NK cell NK cells offer pathogen-specific Perspective Prevalence progression Proinflammatory cytokine protective role public health crisis residue respiratory infection Responder responses SARS-CoV-2 severe lung pathology subset suppresse therapeutic potential Treatment vaccination Vaccine vaccine-induced immune response viral infections virus viruses
[DOI] 10.3389/fphar.2020.01309 PMC 바로가기 [Article Type] Pharmacology

Sequence-based prediction of SARS-CoV-2 vaccine targets using a mass spectrometry-based bioinformatics predictor identifies immunogenic T cell epitopes

질량 분석 기반 생물정보학 예측자를 사용한 SARS-CoV-2 백신 표적의 서열 기반 예측으로 면역원성 T 세포 에피토프 식별

Research

Published on 2020-08-132022-08-13
Journal: Genome Medicine [Category] MERS, 유전자 메커니즘,

[키워드] allele alleles Antigen applied Asian binding bioinformatics CD4 CD8 Cell-mediated immunity characterized Computational biology Coronaviridae family Coverage COVID-19 COVID-19 pandemic database demonstrated Donor elicit epitope Epitopes European expression expression of SARS-CoV-2 healthy HLA allele HLA binding HLA-I binding prediction HLA-II binding prediction human leukocyte antigen humoral identify immune Immunity immunogenic infected cell leukocyte mass mass spectrometry mononuclear cell mononuclear cells Open reading frame open reading frames ORFs other coronavirus other coronaviruses PBMCs peptide peptides Peripheral blood platform populations positive predict predicted predictor protective immunity protective role Protein protein expression reported Result SARS-CoV-2 SARS-CoV-2 proteins SARS-CoV-2 T cell epitopes SARS-CoV-2 vaccine subset T cell T cell assay T cell epitope T cell epitopes T cell response T cell responses T cells target the Coronaviridae urgency Vaccine Vaccine design Validity Viral viral genome viral genomes
[DOI] 10.1186/s13073-020-00767-w PMC 바로가기 [Article Type] Research

Coronavirus Disease-2019 Conundrum: RAS Blockade and Geriatric-Associated Neuropsychiatric Disorders

Medicine

Published on 2020-08-112022-10-31
Journal: Frontiers in Medicine [Category] COVID-19,

[키워드] ACE inhibitor ACE2 ACEi ACEIs acute respiratory syndrome Adults angiotensin receptor blocker ARB ARBs caused clinical decompensation contribute coronavirus coronavirus disease-2019 COVID-19 COVID-19 pandemic critical appraisal death disorders Effect epithelial cell Evidence Geriatrics high-risk patient High-risk patients Host kidney metabolic disease Metabolic diseases neurodegenerative Neuropsychiatric neuropsychiatric disorders Older organ outcomes positive progression protective role Psychiatric disorders RAS receptor renin-angiotensin system Respiratory system SARS-CoV-2 severe pneumonia target the SARS-CoV-2 therapy Treatment
[DOI] 10.3389/fmed.2020.00515 PMC 바로가기 [Article Type] Medicine

Crosstalk between COVID-19 and prostate cancer

Reviews

Published on 2020-07-242022-10-05
Journal: Prostate cancer and prostatic diseases [Category] SARS, 신약개발, 임상,

Distinct conformational states of SARS-CoV-2 spike protein

Research Article

Published on 2020-07-212022-10-28
Journal: Science (New York, N.y.) [Category] COVID-19,

Glucocorticoids improve severe or critical COVID-19 by activating ACE2 and reducing IL-6 levels

Research Paper

Published on 2020-06-272022-10-29
Journal: International Journal of Biological Sciences [Category] COVID-19, MERS, SARS,

[키워드] ACE2 ACE2 expression activate activating Activation acute respiratory distress addition agonist analyzed angiotensin-converting enzyme 2 ARDS bioinformatics cell line cell lines Chest CT images clinical evidence clinical parameter clinician Cohort country COVID-19 COVID-19 cases Critical Critical case Cytokine storm Dexamethasone digestive system digestive tract dose drug Drug repurposing Effect effective Efficacy engage epithelial cell line glucocorticoid Glucocorticoids IL-6 IL-6 level IMPROVE inhibit Macrophage medium Methylprednisolone molecular target monocyte Mortality nine Patient Prednisolone protective role provide public health emergency reducing regions riboside SARS-CoV-2 screened spread to syndrome therapeutic therapeutic efficacy THP-1 Treatment treatment regimen Wuhan
[DOI] 10.7150/ijbs.47652 PMC 바로가기 [Article Type] Research Paper

Cannabinoid Receptor Type 2: A Possible Target in SARS-CoV-2 (CoV-19) Infection?

Review

Published on 2020-05-272022-10-29
Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, SARS,

[키워드] Anti-inflammatory cannabinoid cannabinoid receptor type 2 cause cells circulating COVID-19 COVID-19 pandemic Cytokine storm death endocannabinoids system ENhance Estrogen Estrogens exacerbated excessive inflammation global pandemic immune cells immune response immune responses Inflammation Inflammatory limit Lung fibrosis Macrophage macrophage phenotype Mild modulating molecular target Novel coronavirus Patient Prevalence pro-inflammatory pro-inflammatory cytokines protective role receptor respiratory tract SARS-CoV-2 SARS-COV-2 infection small vessel susceptibility target Therapeutic strategies therapeutic target thrombosis Type women Wuhan, China
[DOI] 10.3390/ijms21113809 PMC 바로가기 [Article Type] Review

Psychological well-being among older adults during the COVID-19 outbreak: a comparative study of the young–old and the old–old adults

Brief Report

Published on 2020-05-222022-10-29
Journal: International Psychogeriatrics [Category] Coronavirus, MERS, SARS,

Does Vitamin D play a role in the management of Covid-19 in Brazil?

Comment

Published on 2020-05-222022-10-29
Journal: Revista de Saúde Pública [Category] Coronavirus, MERS, SARS,