Teaching an old dog new tricks: A lipid membrane-based electric immunosensor for real-time probing of the spike S 1 protein subunit from SARS-CoV-2늙은 개에게 새로운 트릭 가르치기: SARS-CoV-2의 스파이크 S 1 단백질 소단위의 실시간 조사를 위한 지질막 기반 전기 면역 센서Article Published on 2022-03-012022-09-11 Journal: Proteomics [Category] SARS, 치료기술, [키워드] ACE2 Adsorption alteration amplitude Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antibody changes in core correlated Disease diagnosis early disease extraction followed by human serum in vitro Interaction ionic strength lipid membrane membrane membrane potential membrane potential. monoclonal antibody pathogen Pathogens point-of-care Protein Protein subunit Proteins receptor recorded SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike S1 serum proteins shown spectral analysis Spike protein subunit Teaching the SARS-CoV-2 transmembrane Transmembrane potential [DOI] 10.1002/pmic.202100047 PMC 바로가기 [Article Type] Article
Oxidative stress and inflammatory markers in patients with COVID-19: Potential role of RAGE, HMGB1, GFAP and COX-2 in disease severityCOVID-19 환자의 산화 스트레스 및 염증 표지자: 질병 중증도에서 RAGE, HMGB1, GFAP 및 COX-2의 잠재적 역할Observational Study Published on 2022-03-012022-09-11 Journal: International immunopharmacology [Category] SARS, 바이오마커, 임상, [키워드] Acidic addition All participants Blood blood sample Blood samples cellular response Clinical studies clinical study Control correlation COVID-19 COVID-19 pathogenesis COX-2 Critical cyclo-oxygenase cytokine Cytokines determine disease severity dysregulated end products evaluate form GFAp healthy controls HMGB1 hyperinflammatory state ICU immune implicated individual induce Inflammation Inflammatory marker intensive care intensive care unit lack lead marker Mild mild to moderate mild to moderate symptoms moderate Neurological dysfunction observational study Outpatient outpatients overexpression oxidative oxidative stress participant Patient patients with COVID-19 Potential Protein Proteins RAGE receptor receptor for advanced glycation end products respiratory respiratory viral infection respiratory viral infections risk of death SARS-COV-2 infection severity significant increase Stress Symptoms upregulation Viral viral infections was used western blot with COVID-19 [DOI] 10.1016/j.intimp.2021.108502 PMC 바로가기 [Article Type] Observational Study
The ChAdOx1 vectored vaccine, AZD2816, induces strong immunogenicity against SARS-CoV-2 beta (B.1.351) and other variants of concern in preclinical studiesChAdOx1 벡터화 백신 AZD2816은 SARS-CoV-2 베타(B.1.351) 및 전임상 연구에서 우려되는 기타 변이체에 대해 강력한 면역원성을 유도합니다.Article Published on 2022-03-012022-09-11 Journal: EBioMedicine [Category] COVID19(2023년), SARS, 변종, [키워드] addition animals antibodies AstraZeneca AZD1222 B.1.351 B.1.617.2 Beta binding booster booster dose Booster vaccine booster vaccines caused ChAdOx1 ChAdOx1-vectored vaccine clinical development clinically Course death Delta dose effort expresse funds Gamma hospitalisation Immunity immunogenic increase in induce MRC mutated Mutation nCoV Neutralising Antibodies neutralising antibody new SARS-CoV-2 omicron other variant over P.1 pandemic preclinical study Proteins reduced regimens Research SARS CoV2 SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV-2 virus single dose Spike protein Support T cell T cell response T cells the spike protein Vaccine Vaccines variants variants of concern vectored vaccine virus isolate was measured [DOI] 10.1016/j.ebiom.2022.103902 PMC 바로가기 [Article Type] Article
Proteomic profiling reveals a distinctive molecular signature for critically ill COVID-19 patients compared with asthma and chronic obstructive pulmonary diseaseProteomic profiling은 천식 및 만성 폐쇄성 폐 질환과 비교하여 중환자 COVID-19 환자를 위한 독특한 분자 서명을 나타냅니다Article Published on 2022-03-012022-09-11 Journal: International Journal of Infectious Diseases [Category] SARS, 유전자 메커니즘, [키워드] airway Airway mucus Analysis Anemia Asthma bronchoscopy cascades changes in chronic obstructive chronic obstructive pulmonary disease chronic obstructive pulmonary disease (COPD) Coagulation complement Control controls COPD COTL1 COVID-19 COVID-19 case COVID-19 patient COVID-19 patients Critically ill Critically ill COVID-19 differentially expressed expression FGB FGG groups HBA1 HBB healthy controls IGLV3-19 iron Iron metabolism metabolism molecular molecular target mortality rate obstructive pulmonary disease outcome overlapping Pathways Patient performed platelet activation Protein Proteins proteomic Proteomic sequencing. provide PRTN3 pulmonary disease quantified Research Respiratory disease respiratory diseases reveal Sequencing severe COVID-19 sputum therapy [DOI] 10.1016/j.ijid.2022.01.008 PMC 바로가기 [Article Type] Article
CRISPR/Cas12a-Derived electrochemical aptasensor for ultrasensitive detection of COVID-19 nucleocapsid proteinResearch article Published on 2022-03-012022-10-05 Journal: Biosensors & bioelectronics [Category] SARS, 치료기술, [키워드] activated aptamer cleaved COVID-19 CRISPR/Cas12a system Critical detect DNA sequence DPV early diagnosis Electrochemical aptasensor Interaction limit of detection nucleocapsid protein outbreak point-of-care probe Proteins pulse released reporter robust second serum Surveillance tap [DOI] 10.1016/j.bios.2021.113922 [Article Type] Research article
ACE2-Fc fusion protein overcomes viral escape by potently neutralizing SARS-CoV-2 variants of concernACE2-Fc 융합 단백질은 우려되는 SARS-CoV-2 변이체를 강력하게 중화하여 바이러스 탈출을 극복합니다Article Published on 2022-03-012022-09-11 Journal: Antiviral Research [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 진단, [키워드] ACE2-Fc Analysis antibodies Antibody drugs approved binding Biotechnology breakthrough infections caused Clinical data Comprehensive COVID-19 dominant variant drug drug design drug resistance Efficiency EMA experiment FDA fusion protein Glycoproteins increasingly Infectious disease Interaction mechanism monoclonal antibodies monoclonal antibody Mutation neutralization neutralize Neutralizing not compromised omicron overcome Protein binding Proteins public health remained SARS-CoV-2 variant SARS-CoV-2 virus spike variants tested the SARS-CoV-2 virus therapeutic therapeutic agent therapeutic antibodies Therapeutic antibody treat Treatment vaccinated individual vaccinated individuals Vaccine variant variants Viral viral escape viral infection [DOI] 10.1016/j.antiviral.2022.105271 PMC 바로가기 [Article Type] Article
A central role for amyloid fibrin microclots in long COVID/PASC: origins and therapeutic implications긴 코비드/PASC에서 아밀로이드 피브린 마이크로 클로트의 중심 역할 : 기원 및 치료 적 영향Review Published on 2022-02-252022-09-10 Journal: Biochemical Journal [Category] COVID19(2023년), Fulltext, MERS, SARS, 치료기술, 치료제, [키워드] acute COVID-19 amyloid anticoagulant therapy autoantibodies Blood Blood coagulation breathlessness Capillaries chronic fatigue syndrome clotting Coagulation Coagulopathies Coagulopathy COVID COVID-19 demographics disease entity disorders Encephalomyelitis fatigue fatigue syndrome FIBRIN fibrinogen fibrinolysis fluorescence microscope Health implication individual Infection Inflammation initial lead leads limit Long majority manifested Microscope PASC passage phenotype plasma Platelet platelet-poor plasma preliminary report Proteins proteolysis recognize red blood cell red blood cells referred to Regulatory removal SARS-COV-2 infection shown similarities similarity stain Symptom Symptoms syndrome terminology therapeutic these symptoms Thioflavin tissue damage Treatment [DOI] 10.1042/BCJ20220016 PMC 바로가기 [Article Type] Review
Emerging Glycation-Based Therapeutics—Glyoxalase 1 Inducers and Glyoxalase 1 Inhibitors새로운 당화 기반 치료제 - 글리옥살라제 1 유도제 및 글리옥살라제 1 억제제Review Published on 2022-02-232022-09-10 Journal: International Journal of Molecular Sciences [Category] 비임상, [키워드] Activation active against aging alleviate apoptotic appear Breast cancer breath cancer chemotherapy Cell cell line Chemotherapy clinical impact clinical trial clinically Combination Complication contribute correction diabetes dicarbonyl stress disease DNA double-blind dysfunction evaluated expression Glioblastoma glioblastoma multiforme Glo1 Glycation glyoxalase hesperetin IMPROVE in vitro in vivo inactivation Increased induce inducer inhibitor insulin insulin resistance low-grade inflammation malaria metabolism methylglyoxal mice multidrug-resistant National Cancer Institute obese outcome outcomes pathogenic Placebo placebo-controlled Protein Proteins prototype Randomized resveratrol SARS-CoV-2 small molecule spliceosome Stress subjects survival therapeutic therapy Treatment Tumor tumor cell line tumors type 2 diabete type 2 diabetes unfolded protein response Vascular [DOI] 10.3390/ijms23052453 PMC 바로가기 [Article Type] Review
Cooperative multivalent receptor binding promotes exposure of the SARS-CoV-2 fusion machinery core협력 다가 수용체 결합은 SARS-CoV-2 융합 기계 코어의 노출을 촉진합니다Article Published on 2022-02-222022-09-11 Journal: Nature Communications [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 ACE2 binding ACE2 receptor ACE2 receptors acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 binding binding affinity Cell conformational Cooperative coronavirus dissociation domains event induce Interaction membrane fusion molecular molecular dynamics Molecular dynamics simulation Population promote Protein Proteins receptor Receptor binding recognize S1 and S2 S1 and S2 domains S1 domain S1/S2 cleavage SARS-CoV-2 severe acute respiratory syndrome Coronavirus spike spike glycoprotein Spike proteins spike trimer spike trimers the SARS-CoV-2 therapeutic tomography variant virus [DOI] 10.1038/s41467-022-28654-5 PMC 바로가기 [Article Type] Article
COVIDomics: The Proteomic and Metabolomic Signatures of COVID-19Review Published on 2022-02-222022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, [키워드] addressed adopted biochemical COVID-19 COVID-19 disease COVID-19 pandemic COVID-19 research COVID-19 signature COVIDomics Data integration Diagnosis Disease progression drug target discovery dysregulated effort human cells include Infection knowledge mechanism metabolites metabolomics multiomics mutations pandemic pathophysiological pathway Perspective Proteins proteomics provided Replication Research SARS-CoV-2 Scientific community signature Spread the SARS-CoV-2 therapeutic Vaccine [DOI] 10.3390/ijms23052414 PMC 바로가기 [Article Type] Review