Colchicine use in patients with COVID-19: A systematic review and meta-analysisCovid-19 환자의 콜히친 사용 : 체계적인 검토 및 메타 분석Meta-Analysis Published on 2021-12-282022-09-10 Journal: PLoS ONE [Category] SARS, 유전자 메커니즘, 치료제, [키워드] 95% CI Admissions analyzed Care Clinical outcome Colchicine COVID-19 COVID-19 patient COVID-19 pneumonia Cytokines determine Efficacy hazard ratio ICU ICU admission ICU admissions identify individuals with COVID-19 inflammasome signaling inhibit intensive care intensive care unit Long-term care lower risk mechanical ventilation mechanism Meta-analysis Mortality no statistical difference Odds ratio outcome Patient patients patients with COVID-19 Pneumonia proinflammatory cytokines RCT RECOVERY trial reduce reference reported Result risk risk ratio screened searched systematic review the disease Treatment Trial [DOI] 10.1371/journal.pone.0261358 PMC 바로가기 [Article Type] Meta-Analysis
Final Results of a Randomized, Placebo-Controlled, Two-Arm, Parallel Clinical Trial of Proxalutamide for Hospitalized COVID-19 Patients: A Multiregional, Joint Analysis of the Proxa-Rescue AndroCoV TrialEndocrinology/Diabetes/Metabolism Published on 2021-12-252022-10-31 Journal: Cureus [Category] COVID-19, [키워드] 1:1 95% CI 95% confidence interval ACE2 addition all-cause mortality androgen Androgen receptor angiotensin-converting enzyme 2 antiandrogens Arm ARMS baseline Brazil clinical clinical trial COVID COVID-19 Day demonstrated discharge Drug efficacy effective Efficacy evaluate expression female Final highest hospital Hospital stay Hospitalization hospitalized COVID-19 patient hospitalized COVID-19 patients improvement Inflammatory response interquartile range IQR joint material median mortality rate mortality rates North outcome outcomes oxygen pandemic performed Placebo placebo group preliminary report Prevent proxalutamide randomization randomized clinical trial RCT RCTs reduced reduction in Region Regulation Result risk ratio SARS-CoV-2 score Sepsis South statistical analysis statistically statistically significant stratified by sex study population subject the placebo group TMPRSS2 transmembrane protease serine 2 Trial usual care was performed WHO [DOI] 10.7759/cureus.20691 PMC 바로가기 [Article Type] Endocrinology/Diabetes/Metabolism
Protocol of investigation into reporting quality of RCT abstracts on COVID-19 pursuant to CONSORT (CoCo study)—a reviewCONSORT(CoCo 연구)에 따른 COVID-19에 대한 RCT 초록의 보고 품질에 대한 조사 프로토콜 - 검토Study Protocol Published on 2021-12-242022-09-10 Journal: Trials [Category] SARS, 임상, [키워드] Abstract abstracts accelerated activity checked Cochrane Library Completeness comprehensive analysis CONSORT CONSORT checklist CONSORT statement contribute coronavirus COVID-19 COVID-19 pandemic COVID-19 RCT COVID-19 RCTs criteria criticism debate emergency situation English examined expected Frequency include information investigated less manuscript Medical research object offer peer review primary endpoint RCT RCTs Registration reported Reporting Reporting quality required Research RTC SARS-CoV-2 Study design subject Support Therapies Transparency urgency [DOI] 10.1186/s13063-021-05937-8 PMC 바로가기 [Article Type] Study Protocol
Impact of potential modifications to Alzheimer’s disease clinical trials in response to disruption by COVID-19: a simulation studyCOVID-19에 의한 혼란에 대한 반응으로 알츠하이머 병 임상 시험에 대한 잠재적 수정의 영향 : 시뮬레이션 연구Research Published on 2021-12-202022-09-10 Journal: Alzheimer's Research & Therapy [Category] SARS, 치료기술, [키워드] accounted adaptive affected Alzheimer Alzheimer disease Alzheimer’s disease Analysis assessments biases change changes changes in Changing clinical trial clinical trials completion COVID-19 COVID-19 pandemic datasets detect disease Disease modification Effect effect size Enrollment examined expected idea Impact investigator investigators linear maintain Mild cognitive impairment Modification outcome outcomes pandemic performed randomized clinical trial RCT RCTs Result risk Simulation Simulations Sponsor Statistical power Support symptomatic Symptomatic treatment threat Threats Treatment treatment period Trial trials Validity was determined [DOI] 10.1186/s13195-021-00938-w PMC 바로가기 [Article Type] Research
The physiological and psychological effects of cognitive behavior therapy on patients with inflammatory bowel disease before COVID-19: a systematic reviewResearch Published on 2021-12-152022-10-27 Journal: BMC Gastroenterology [Category] Coronavirus, Fulltext, SARS, [키워드] Anxiety C-reactive protein CBT CINAHL clinical trial cognitive Cognitive behavior therapy cognitive behavioral therapy Consensus Crohn's disease Depression Disease activity Effect eligible evaluate Evidence IBD IMPROVE inclusion criteria Inflammatory bowel disease initial Mental objective outcome Patient patients physical physiological positive post-intervention Psychological psychological improvement PsycINFO Quality of life Randomized controlled trial RCT reduce Result searched shown supplementary material sustained systematic review therapy Treatment ulcerative colitis Web of Science [DOI] 10.1186/s12876-021-02003-0 PMC 바로가기 [Article Type] Research
Virtual reality-based rehabilitation in patients following total knee arthroplasty: a systematic review and meta-analysis of randomized controlled trials슬관절 전치환술 후 환자의 가상 현실 기반 재활: 무작위 대조 시험의 체계적인 검토 및 메타 분석Meta-Analysis Published on 2021-12-132022-09-11 Journal: Chinese medical journal [Category] SARS, 임상, [키워드] 95% CI 95% confidence interval Arthroplasty Care China Cochrane Handbook Controlled controlled trials coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic effective Effectiveness Handbook Health Health care identify inaccessible inception increasingly index Infrastructure item knee Meta-analysis no significant difference outcome Pain pandemic Patient Physical therapy Physiotherapy promote PsycINFO Randomized controlled trial Randomized controlled trials RCT RCTs rehabilitation Reporting review score searched Seven significant difference significantly standardized mean difference surgery systematic review systematic reviews university virtual reality Web of Science [DOI] 10.1097/CM9.0000000000001847 PMC 바로가기 [Article Type] Meta-Analysis
Feasibility of remote neurocognitive assessment: pandemic adaptations for a clinical trial, the Cognition and Obstructive Sleep Apnea in Parkinson’s Disease, Effect of Positive Airway Pressure Therapy (COPE-PAP) studyLetter Published on 2021-12-112022-10-29 Journal: Trials [Category] Coronavirus, SARS, [키워드] 95%CI Administered administration agreement assessment baseline clinical trial Cognition cognitive Cognitive function Complete control arm COVID-19 pandemic COVID19 disease course domain Effect expected Exploratory analyses feasible Follow-up group ICC Intraclass correlation coefficient MoCA Montreal Neurocognitive testing obstructive sleep apnea OSA outcome pandemic Parkinson’s disease Parkinson’s disease participant Patient pressure protocol randomized clinical trial RCT remote Result retrieved Sample size significantly Sleep Sleep disordered breathing supplementary material t -test telephone Treatment [DOI] 10.1186/s13063-021-05879-1 PMC 바로가기 [Article Type] Letter
An eHealth Intervention for Promoting COVID-19 Knowledge and Protective Behaviors and Reducing Pandemic Distress Among Sexual and Gender Minorities: Protocol for a Randomized Controlled Trial (#SafeHandsSafeHearts)Protocol Published on 2021-12-102022-10-29 Journal: JMIR Research Protocols [Category] COVID-19, [키워드] Anxiety Behavior Canada Care center conducted Control control groups Controlled COVID-19 COVID-19 knowledge COVID-19 pandemic Depression effective Effectiveness Efficacy eHealth evaluate Evidence exit expected Gender Generalized Health HIV Identifier identity include India individual Intervention intervention effect lack LGBT LGBT+ loneliness Measures media men mental health Mumbai n=36 objective Older organizations outcome participant Population populations prevention Primary outcome Promoting Protective Protective behaviors Psychological distress Randomized controlled trial RCT recruited recruitment reduce Registration report Result risk SARS-COV-2 infection secondary selected severe disease Sex sexual social determinant stratified Stress subgroup subgroups Tablet Thailand Toronto Trial US CDC women World Health Organization [DOI] 10.2196/34381 PMC 바로가기 [Article Type] Protocol
A randomised controlled trial testing the efficacy of Fit after COVID, a cognitive behavioural therapy targeting severe post-infectious fatigue following COVID-19 (ReCOVer): study protocolCOVID-19(ReCOVer) 이후 심각한 감염 후 피로를 표적으로 하는 인지 행동 요법인 Fit after COVID의 효능을 테스트하는 무작위 대조 시험: 연구 프로토콜Study Protocol Published on 2021-12-022022-09-10 Journal: Trials [Category] SARS, 임상, [키워드] 1:1 acute phase addition behavioural benefit both groups Care CBT changes in checklist cognitive Cognitive behavioural therapy conditions consequence contribute coronavirus disease Coronavirus disease 2019 COVID COVID-19 determine effective Efficacy eligible fatigue fatigued Follow-up follow-up assessment follow-up assessments Health in both group individual infection with SARS-CoV-2 Internet therapy Intervention lead Long COVID Long-Haul COVID-19 Fatigue Long-term follow-up multicentre Netherland other conditions participant PASC performed physical Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) Post-COVID-19 syndrome prevalent Primary outcome problem problems proportion protocol randomisation randomised randomised controlled trial RCT reduce reducing referred to SARS-CoV-2 SARS-COV-2 infection Secondary objective Secondary objectives severe fatigue severity shown significantly lower strength Study protocol subgroup of patients supplementary material Symptom Symptoms treat Treatment trial testing [DOI] 10.1186/s13063-021-05569-y PMC 바로가기 [Article Type] Study Protocol
Efficacy of Interferon-β in Moderate-to-Severe Hospitalised Cases of COVID-19: A Systematic Review and Meta-analysis중등도 내지 중증 COVID-19 입원 사례에서 인터페론-β의 효능: 체계적인 검토 및 메타 분석Meta-Analysis Published on 2021-12-012022-09-11 Journal: Clinical drug investigation [Category] SARS, 치료제, [키워드] 95 % CI anti-viral agents benefit calculate categorical variable categorical variables Clinical improvement continuous variable Controlled trial controlled trials COVID-19 determine Effect Efficacy eligible hazard ratio Hospital stay IFN-β indicated interferon investigated mean difference Meta-analysis moderate-to-severe COVID-19 patients Mortality no statistically significant difference Odds ratio outcome measures RCT reducing reduction in reduction in mortality review Seven Standard of care statistically significant difference systematic literature search systematic review Treatment was done was performed [DOI] 10.1007/s40261-021-01092-9 PMC 바로가기 [Article Type] Meta-Analysis