Recombination events are concentrated in the spike protein region of Betacoronaviruses재조합 이벤트는 Betacoronaviruses의 스파이크 단백질 영역에 집중되어 있습니다.Research Article Published on 2020-12-172022-08-13 Journal: PLoS Genetics [Category] Biochemistry, COVID-19, SARS, [키워드] accumulate Alter Analysis analyzed approach Author betacoronaviruses change circulating Coronaviral disease severity engage event events gene flow Genome genomic region genomic variation high mutation rate high mutation rates homoplasies homoplasy host cells host tropism human disease implicated include Interaction likelihood limit limits MERS Mutation mutation rate Mutation rates mutations null model occur polymorphism Polymorphisms Population Positive selection random Recombination recombination event Region RNA virus RNA viruses SARS-CoV-2 sequence similarities sequence similarity shown Spike protein strain Strains subject tested the Sarbecovirus the spike protein variant Viral viruses [DOI] 10.1371/journal.pgen.1009272 PMC 바로가기 [Article Type] Research Article
Genomic recombination events may reveal the evolution of coronavirus and the origin of SARS-CoV-2게놈 재조합 사건은 코로나바이러스의 진화와 SARS-CoV-2의 기원을 밝힐 수 있습니다Article Published on 2020-12-102022-09-10 Journal: Scientific Reports [Category] MERS, SARS, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptation Analysis analyzed bat bats cause collected Computational biology and bioinformatics coronavirus coronavirus disease Coronavirus disease 2019 coronavirus genomes COVID-19 directional estimate Evolution Genetic genetic diversity Genome Host hosts human coronavirus humans independent introduced isolate pangolin-CoV pangolins pool Population RaTG13 RBD Receptor-binding domain Recombination recombination event respiratory S protein SARS-CoV-2 SARS-CoV-2 strains sequence severe acute respiratory syndrome Coronavirus spike glycoprotein statistical significance strain Strains subclade the RBD the receptor-binding domain virus [DOI] 10.1038/s41598-020-78703-6 PMC 바로가기 [Article Type] Article
Predicting the recombination potential of severe acute respiratory syndrome coronavirus 2 and Middle East respiratory syndrome coronavirusResearch Article Published on 2020-12-092022-10-30 Journal: The Journal of General Virology [Category] COVID-19, SARS, [키워드] ACE2 acute respiratory syndrome analysed analyses anatomical cause cellular receptor co-expression Co-infection coronavirus develop diagnostic DPP4 emergence facilitate Fatality rate genomic region high-risk area homologous humans identify Infection interacting residues investigated Kingdom Laboratory MERS-CoV MERS-CoV RNA Middle East ORF1ab outbreak Patient predictions public health Recombination recombination event reported respiratory syndrome coronavirus S gene SARS-CoV-2 SARS-COV-2 infection Saudi Arabia susceptibility Virus spike widespread [DOI] 10.1099/jgv.0.001491 PMC 바로가기 [Article Type] Research Article
Global analysis of more than 50,000 SARS-CoV-2 genomes reveals epistasis between eight viral genes530 Published on 2020-12-082022-10-29 Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome Analysis assumption caused Complete coronavirus COVID-19 pandemic Cutoff direct coupling analysis Effect eight epistasis Genome genome sequence GISAID in viral initiative Interaction interactions investigated loci locus microbial Mutation natural selection Nonsynonymous mutations Nsp12 nsp13 nsp14 NSP2 nsp4 ORF3a ORF8 Pathogenesis Pathogens powerful tool public health emergency Recombination Repository reveal SARS-CoV-2 SARS-CoV-2 genome sequence Significance starting point synonymous Vaccine development viral gene viral pathogens Whole-genome sequence [DOI] 10.1073/pnas.2012331117 PMC 바로가기 [Article Type] 530
Structural diversity, natural selection and intragenic recombination in the Plasmodium vivax merozoite surface protein 9 locus in Thailandarticle Published on 2020-11-302024-09-01 Journal: Infection, Genetics and Evolution [Category] 말라리아, [키워드] Complete coding sequence malaria Merozoite surface protein 9 natural selection Plasmodium vivax Recombination Thailand [Article Type] article
Immunological imprint of COVID‐19 on human peripheral blood leukocyte populations인간 말초 혈액 백혈구 개체군에 대한 COVID-19의 면역학적 각인Original Article Published on 2020-11-222022-09-01 Journal: Allergy [Category] SARS, 진단, 치료법, [키워드] activated Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive addition antibody antibody levels B cells CD25 CD3 CD31 CD38 CD4 CD45 CD45RA CD8 Cell cells cellular Cellular immune response cellular immune responses central memory clinical immunology Cohort convalescent patient Convalescent patients coronavirus coronavirus disease Coronavirus disease 2019 correlated COVID‐19 COVID‐19 patient COVID‐19 patients determined by disease domain effector memory elevated ELISA expression flow cytometry FOXP3 healthy control HLA‐DR immune responses immune system immunological immunological change immunological changes immunosorbent Infection infections innate immune system investigated leukocyte population Lymphocytes Mild Mild disease multiparametric flow cytometry neutrophil Neutrophils nucleocapsid pandemic parameters Patient patients Peripheral blood qPCR Quantitative quantitative PCR RBD receptor receptor‐binding domain Recombination reduction reflected regression analysis respiratory responses Result SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‑CoV2 SARS‐CoV‐2 sense sense of taste severe acute respiratory syndrome Coronavirus significantly Spike protein subject T cell T cells T regulatory cell T regulatory cells T‐cell Taste thymic emigrant thymic emigrants transitional B cell transitional B cells triggered Viral [DOI] 10.1111/all.14647 PMC 바로가기 [Article Type] Original Article
Stability of SARS-CoV-2 phylogeniesSARS-CoV-2 계통발생의 안정성Research Article Published on 2020-11-182022-08-13 Journal: PLoS Genetics [Category] COVID-19, Medicine and Health Sciences, SARS, [키워드] Affect building clade collected Community comparison Comparisons develop discourse effort Evolutionary inference evolutionary inferences evolutionary relationship evolutionary relationships excess facilitate feature genome sequence Genome sequences groups Host host viral genome editing identified variant Inclusion lab local lineage tracing molecular molecular and bioinformatic techniques mutations natural selection phylogenetic inference phylogenies Phylogeny primer binding site primer binding sites problematic variant problematic variants processing produced protein-coding sequence protein-coding sequences provided real-time genetic tracing Recombination recurrent mutation reported SARS-CoV-2 evolution SARS-CoV-2 genome sequence SARS-CoV-2 genome sequences SARS-CoV-2 pandemic SARS-CoV-2 phylogenies SARS-CoV-2 phylogeny Scientific community screened sequence Sequencing sequencing error stable clade structure systematic errors the SARS-CoV-2 These data toolkit variant variants variety Viral viral genome viral lineages viral recombination viral sample viral samples Visualization [DOI] 10.1371/journal.pgen.1009175 PMC 바로가기 [Article Type] Research Article
The genetic structure of SARS‐CoV‐2 does not rule out a laboratory origin SARS‐COV‐2 chimeric structure and furin cleavage site might be the result of genetic manipulationProblems & Paradigms Published on 2020-11-172022-10-27 Journal: Bioessays [Category] COVID-19, [키워드] Analysis backbone binding ability BtCov/4991 chimeric cleavage site coronavirus Coronaviruses CoV CoVs cross evaluate furin cleavage site Gain‐of‐function studies Genetic genetic manipulation Host human cell Intervention Laboratory Mutagenesis Pandemics pangolin pangolin CoV performed RaTG13 RBD Receptor binding domain Recombination researcher resulting SARS‐CoV‐2 SARS‐CoV‐2 sequence the spike protein tissue virus [DOI] 10.1002/bies.202000240 PMC 바로가기 [Article Type] Problems & Paradigms
The genetic structure of SARS‐CoV‐2 does not rule out a laboratory origin SARS‐COV‐2 chimeric structure and furin cleavage site might be the result of genetic manipulationProblems & Paradigms Published on 2020-11-172022-10-27 Journal: Bioessays [Category] Coronavirus, COVID-19, SARS, [키워드] Analysis backbone binding ability BtCov/4991 chimeric cleavage site coronavirus Coronaviruses CoV CoVs cross evaluate furin cleavage site Gain‐of‐function studies Genetic genetic manipulation Host human cell Intervention Laboratory Mutagenesis Pandemics pangolin pangolin CoV performed RaTG13 RBD Receptor binding domain Recombination researcher resulting SARS‐CoV‐2 SARS‐CoV‐2 sequence the spike protein tissue virus [DOI] 10.1002/bies.202000240 PMC 바로가기 [Article Type] Problems & Paradigms
Recombination and Positive Selection Differentially Shaped the Diversity of Betacoronavirus SubgeneraArticle Published on 2020-11-162022-10-28 Journal: Viruses [Category] COVID-19, Fulltext, 조류인플루엔자, [키워드] analyzed Betacoronavirus Betacoronavirus genus Cluster contributing to coronavirus Diversity Evolution Genome evolution genomic region Host hotspot human coronaviruses include less Positive selection preference Recombination sarbecovirus SARS-CoV-2 Selection the Betacoronavirus Trajectories virus Virus evolution widespread zoonotic [DOI] 10.3390/v12111313 PMC 바로가기 [Article Type] Article