stem cell – Page 16 – Communicable Diseases Research

How Do We Manage Hematopoietic Cell Transplant during the SARS-CoV-2 Pandemic?

SARS-CoV-2 전염병 동안 조혈 세포 이식을 어떻게 관리합니까?

Review

Published on 2021-01-012022-09-11
Journal: Acta haematologica [Category] 치료기술,

Clinical analysis and pluripotent stem cells-based model reveal possible impacts of ACE2 and lung progenitor cells on infants vulnerable to COVID-19

임상 분석 및 만능 줄기 세포 기반 모델은 COVID-19에 취약한 유아에 대한 ACE2 및 폐 전구 세포의 가능한 영향을 보여줍니다

Multicenter Study

Published on 2021-01-012022-09-01
Journal: Theranostics [Category] 진단, 치료기술,

[키워드] ACE2 ACE2 expression age Alveolar Type II analysed Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 biopsies Cell cells children children with COVID-19 clinical clinical feature Clinical features Cohort Combination contributing to cooperation coronavirus disease Coronavirus disease 2019 COVID-19 derivative develop developmental developmental stages disease severity distribution double positive cell double positive cells Ex vivo examined expressed expression expression level expression levels expression pattern expression patterns immune response immune system Impact Infant Infants infections lung lung biopsies lung cell lung cells lung development lung injuries Lung injury lung progenitor cells Lungs number of children Older pluripotent stem cells Pneumonia positive profiles progenitor cell progenitor cells reported risk factor Risk factors RNA-sequencing SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pseudovirus SARS-CoV-2 virus severe coronavirus disease significantly single cell RNA sequencing SOX9 Spectrum Stage stem cell Type vulnerability with COVID-19
[DOI] 10.7150/thno.53136 PMC 바로가기 [Article Type] Multicenter Study

The Systematic Effect of Mesenchymal Stem Cell Therapy in Critical COVID-19 Patients: A Prospective Double Controlled Trial

중증 코로나19 환자에서 중간엽 줄기세포 치료의 체계적인 효과: 전향적 이중 대조 시험

Controlled Clinical Trial

Published on 2021-01-012022-09-11
Journal: Cell transplantation [Category] 유전자 메커니즘, 임상,

[키워드] Analysis anti-inflammatory cytokine anti-inflammatory cytokines Apoptosis Biochemical parameters CD16 CD19 CD3 CD4 CD45 CD56 CD8 Cell cellular chemokines clinical manifestation clinical manifestations clinical trial Controlled COVID-19 COVID-19 patient COVID-19 patients Critical critical cases Critically ill critically ill COVID-19 patients critically ill patients CRP level CRP levels cytokine Cytokine storm Cytokines demonstrated died dose Effect evaluate evaluated fibrinogen group groups growth growth factor Growth factors HLA-DR IFNγ IL-10 IL-12 IL-13 IL-17A IL-1ra IL-2 IL-6 immunomodulatory effect immunomodulatory effects intravenously investigated KGF lymphocyte Lymphocyte subsets marker matrix metalloproteinases mechanism of action mesenchymal stem cell Mesenchymal stem cells moderate MSC MSCs Neutrophils NGF overall mortality Patient positive proinflammatory proinflammatory cytokines Prospective reducing mortality separated Serum ferritin significantly statistical STEM stem cell TGF-β the cytokine storm therapy tissue regeneration treated Treatment VEGF
[DOI] 10.1177/09636897211024942 PMC 바로가기 [Article Type] Controlled Clinical Trial

Current Status and Future Prospects of Perinatal Stem Cells

주산기 줄기세포 현황 및 향후 전망

Review

Published on 2020-12-232022-09-10
Journal: Genes [Category] MERS, SARS, 임상,

[키워드] Allogeneic amniotic fluid/membrane Birth Blood candidate carried Cell Cell therapy cell type cell types Characteristics chorion circulatory systems clinical settings clinical trial clinical trials contribute Cord blood COVID-19 COVID19 pneumonia current decidua described feature fetus Future gestation growth hematological immunological disorder independent individual intrinsic Mesenchymal stromal cells mother nanomedicine non-hematopoietic cell non-hematopoietic cells organ Other Pathologies Perinatal perinatal tissue perinatal tissues phenotypical Placenta Pneumonia primary source regenerative regenerative medicine status STEM stem cell stem cells stromal cell stromal cells therapeutic therapy these cell These cells tissue tissue engineering tissues treat trials umbilical cord tissue/blood unique
[DOI] 10.3390/genes12010006 PMC 바로가기 [Article Type] Review

Efficacy and safety of mesenchymal stem cells for the treatment of patients infected with COVID-19: a systematic review and meta-analysis protocol

코로나19 환자 치료를 위한 중간엽줄기세포의 효능 및 안전성: 체계적 고찰 및 메타분석 프로토콜

Article

Published on 2020-12-182022-08-31
Journal: BMJ Open [Category] MERS, meta-analysis, SARS,

[키워드] academic conference adverse events antivirus drug assessment bias risk Biomarker Biomarkers Case series case sery CBM Cell Cell Biology changes in chest pain China Chinese CINAHL CNKI Cochrane Library collected conducted Controlled trial COVID-19 pandemic critical cases data extraction database development Dexamethasone difficulty difficulty breathing dose duration of fever Efficacy and safety eligibility criteria Ethical approval Ethics evaluate Evidence high mortality immunology inception incidence include Infectious diseases Infrastructure journal Laboratory laboratory examination life literature mesenchymal stem cell Meta-analysis Mild moderate moderate to severe Mortality movement MSC MSC therapy Patient patients with COVID-19 peer-reviewed performed pressure Prevent Primary outcome Primary outcomes progression PROSPERO protocol public health Quality of life Randomised controlled trials reduce registration number respiratory searched secondary outcome Secondary outcomes sensitivity analysis service severity Shortness of breath SinoMed speech stem cell strength Symptom System systematic review Therapeutic approach therapy treat Treatment Vaccine ventilator VIP Web of Science
[DOI] 10.1136/bmjopen-2020-042085 PMC 바로가기 [Article Type] Article

Host metabolism dysregulation and cell tropism identification in human airway and alveolar organoids upon SARS-CoV-2 infection

SARS-CoV-2 감염 시 인간의 기도 및 폐포 오르가노이드에서 숙주 대사 조절 장애 및 세포 친화성 식별

Research Article

Published on 2020-12-122022-09-10
Journal: Protein & Cell [Category] MERS, SARS, 유전자 메커니즘, 진단,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition airway alveolar animals AT2 Cancer cells caused Cell cell line cell lines cell tropism cells cellular metabolism ciliated club Complete coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Culture distal downregulation Drug discovery dysregulation embryonic embryonic stem cells human airway human lung organoid human lung organoids humans immune response in vitro infect infected cell infected cells Infection inhibited lipid metabolism lung organoids Lungs mechanism metabolic processes metabolism neutralizing antibody Organoid organoids organs pandemic pathophysiological physiological condition physiological conditions proximal Remdesivir replicated respiratory respiratory droplet Respiratory droplets RNA-Seq route SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication severe acute respiratory syndrome Coronavirus Spread stem cell supplementary material therapeutic drug upregulation virus infection
[DOI] 10.1007/s13238-020-00811-w PMC 바로가기 [Article Type] Research Article

COVID-19 and graft-versus-host disease: a tale of two diseases (and why age matters)

Reviews

Published on 2020-12-092022-10-05
Journal: Laboratory Investigation [Category] SARS, 바이오마커,

Infection of human Nasal Epithelial Cells with SARS-CoV-2 and a 382-nt deletion isolate lacking ORF8 reveals similar viral kinetics and host transcriptional profiles

SARS-CoV-2 및 ORF8이 결여된 382-nt 결실 분리주에 의한 인간 비강 상피 세포의 감염은 유사한 바이러스 동역학 및 숙주 전사 프로필을 나타냅니다

Research Article

Published on 2020-12-072022-08-13
Journal: PLoS Pathogens [Category] Biochemistry, MERS, SARS, 유전자 메커니즘, 치료기술,

[키워드] absence airway airway epithelial cells anti-viral gene up-regulation anti-viral signaling pathway anti-viral signaling pathways apical side basolateral secretion causative agent cell type cell types comparable conserved expression coronavirus disease Coronavirus disease 2019 CoV COVID-19 COVID-19 patients CXCL10 CXCL10 production cytokine cytokine production Cytokines differentiated NEC differentiated NECs distinct gene subset distinct gene subsets Duration of infection early response elevated elicited epithelial epithelial cell epithelial cells examined genomes global healthcare greater magnitude H3N2 healthy nasal-tissue highlight Host host gene expression Host immune response Host transcriptional response host-response hours post-infection hpi IL-6 Immune cell infiltration immune cells immune response impair in vitro In-vitro infancy infected cells infected NEC infected NECs Infection Infection of NEC Infection of NECs Infection with Δ382 infiltrating immune cell infiltrating immune cells Inflammatory response Influenza influenza strain late time-point late time-points less modulating Nasal Epithelial cells NECs Novel coronavirus novel coronavirus SARS-CoV-2 ORF8 other SARS-CoV-2 genes Pathogenesis patient sera patients plasticity post-infection time-point pro-inflammatory cytokine pro-inflammatory cytokines released reported reveal SARS-CoV-2 SARS-CoV-2 and Δ382 infection SARS-CoV-2 genes SARS-COV-2 infection Screening severe disease significantly similar replication kinetics similarities similarity Singapore stem cell stem cells subsequent cytokine production temporal up-regulation therapeutic node TNFα transcriptional transcriptional profile Transcriptome transcriptome analysis transcripts transcripts mapping understanding Viral viral clearance viral kinetics virus particle virus particles wild-type and Δ382 wild-type SARS-CoV-2 Δ382 Δ382 infected cell Δ382 infected cells Δ382 infection
[DOI] 10.1371/journal.ppat.1009130 PMC 바로가기 [Article Type] Research Article

Androgen Signaling Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men

안드로겐 신호는 SARS-CoV-2 수용체 수준을 조절하고 남성의 심각한 COVID-19 증상과 관련이 있습니다

Article

Published on 2020-12-032022-09-11
Journal: Cell Stem Cell [Category] Fulltext, MERS, 변종, 신약개발, 유전자 메커니즘, 치료제,

[키워드] 5-alpha reductase inhibitors ACE2 ACE2 expression ACE2 regulation Analysis androgen androgen signaling angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 binding Cell cell membrane Clinical data Compound COVID-19 COVID-19 patient COVID-19 risk factors COVID-19 sex bias deep learning demonstrated disease disease severity disease susceptibility Diseases drug drug re-purposing elevated embryonic embryonic stem cell enzyme Genetic variant genetic variants Health Health crisis high content screening hPSC-based disease modeling identify Infection Level lung organoid lung organoids mechanism men occur offer potential treatment option Prostate reduce reduced risk risk factor SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infection model screening strategy Sex stem cell susceptibility target the cell the disease virtual drug screen. virus
[DOI] 10.1016/j.stem.2020.11.009 PMC 바로가기 [Article Type] Article

Three-Dimensional Human Alveolar Stem Cell Culture Models Reveal Infection Response to SARS-CoV-2

3차원 인간 폐포 줄기 세포 배양 모델, SARS-CoV-2에 대한 감염 반응 밝혀

Article

Published on 2020-12-032022-09-11
Journal: Cell Stem Cell [Category] MERS, SARS, 유전자 메커니즘,

[키워드] 3D cultures acute respiratory syndrome acute respiratory syndrome coronavirus alveolar alveolar stem cells Analysis Cell cells cellular cellular physiology change condition conditions coronavirus COVID-19 Culture defined develop electron microscopy exhibited Human human alveolar type 2 cells human lung human lung tissue identify increased expression individual cell individual cells infect Infection innate immune innate immune response interferon interferon-stimulating genes lack limit Model pandemic Pathogenesis pathogenesis of SARS-CoV-2 pathology phenotype proinflammatory gene proinflammatory genes provide respiratory respiratory diseases response resulting reveal RNA-Seq robust SARS-CoV-2 SARS-CoV-2 entry severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 single-cell single-cell RNA-seq STEM stem cell stem cells Therapeutics Transcriptome Transmission Vaccine Viral viral entry viral mutation Viral mutations viral replication
[DOI] 10.1016/j.stem.2020.10.004 PMC 바로가기 [Article Type] Article