COVID-19 Morbidity and Severity in Patients With Age-Related Macular Degeneration: A Korean Nationwide Cohort StudyArticle Published on 2022-07-012023-07-06 Journal: American journal of ophthalmology [Category] COVID19(2023년), [키워드] Age-related macular degeneration COVID-19 exudative age-related macular degeneration severity susceptibility [DOI] 10.1016/j.ajo.2021.05.024 PMC 바로가기
Large-scale study on virological and serological prevalence of SARS-CoV-2 in cats and dogs in Spain스페인의 고양이와 개에서 SARS-CoV-2의 바이러스 및 혈청학적 유행에 대한 대규모 연구Article Published on 2022-07-012022-09-11 Journal: Transboundary and emerging diseases [Category] COVID19(2023년), SARS, 치료기술, [키워드] acute respiratory syndrome analyzed animals cats compatible symptom compatible symptoms condition Contact contact with coronavirus COVID-19 Critical disease dogs eight Evidence evidenced Human Inclusion Isolation Neutralizing Neutralizing antibodies neutralizing antibody pandemic PCR performed positive Prevalence produced qPCR quantitative PCR random reverse transcription Reverse transcription quantitative PCR RT-qPCR Sample SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RNA detection serological Severe acute respiratory syndrome Severe acute respiratory syndrome-related coronavirus source of infection Spain Surveillance susceptibility susceptible the disease viral infection Viral isolation Virological with COVID-19 zoonotic origin [DOI] 10.1111/tbed.14366 PMC 바로가기 [Article Type] Article
Encouraging COVID-19 vaccination via an evolutionary theoretical approach: A randomized controlled study in JapanRandomized Controlled Trial Published on 2022-07-012022-10-04 Journal: Patient education and counseling [Category] 임상, [키워드] ANOVA approach assigned avoidance Care children conducted COVID-19 COVID-19 vaccination disease Efficacy Encouraging health communication immunization Intention Intervention Japan pandemic participant Practice professional randomized controlled study Randomly receive recommendation recommendations severity of COVID-19 significantly increased susceptibility vaccinated against COVID-19 vaccination Vaccine Vaccine hesitancy Vaccines [DOI] 10.1016/j.pec.2022.02.013 PMC 바로가기 [Article Type] Randomized Controlled Trial
Effect of vaccination on household transmission of SARS-CoV-2 Delta variant of concern우려되는 SARS-CoV-2 Delta 변이체의 가정 전염에 대한 예방접종의 효과Article Published on 2022-06-302022-09-11 Journal: Nature Communications [Category] COVID19(2023년), SARS, 변종, [키워드] Breakthrough infection breakthrough infections concern Contact Delta delta variant Effect Effective vaccines Effectiveness exhibited household contacts household transmission individual Infection infectiousness National PROTECT public health reduce reducing SARS-CoV-2 SARS-COV-2 infection secondary case seeking susceptibility susceptibility to infection the vaccine transmission of SARS-CoV-2 vaccination Vaccinations Vaccine Viral load [DOI] 10.1038/s41467-022-31494-y PMC 바로가기 [Article Type] Article
Human ACE2 Polymorphisms from Different Human Populations Modulate SARS-CoV-2 Infection다양한 인간 집단의 인간 ACE2 다형성이 SARS-CoV-2 감염을 조절합니다Article Published on 2022-06-302022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 ACE2 variant ACE2 variants acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Affect Asian caused cell entry receptor cells contrary coronavirus COVID-19 COVID-19 mortality COVID-19 pandemic COVID-19 symptom COVID-19 symptoms death determinant E35K ENCODE environmental factor Ethnic groups expression Genetic genetic determinant hACE2 high variability Host Human human ACE2 Human genome human population Infection modulate pandemic polymorphism Polymorphisms Population populations PROTECT Protective protective effect reduced risk SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe COVID-19 severity of COVID-19 surface expression susceptibility Symptoms two allele Two alleles variant virus infection wild-type [DOI] 10.3390/v14071451 PMC 바로가기 [Article Type] Article
Epidemiological and virological surveillance of influenza viruses in China during 2020-20212020-2021년 동안 중국에서 인플루엔자 바이러스의 역학 및 바이러스 감시Article Published on 2022-06-292022-09-11 Journal: Infectious Diseases of Poverty [Category] COVID19(2023년), SARS, 치료제, [키워드] accompanied acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition analyses Analysis analyzed antigenic antigenic diversity Antiviral antiviral medication Antiviral medications B/Victoria lineage viruses caused Characteristics characterized China Chinese circulating collected component components conducted coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic declined Diversity Epidemic epidemiological Epidemiology flu Genetic genetic diversity Hemisphere hospital Influenza influenza like illness Influenza virus influenza viruses inhibitors isolate Laboratory Lineage mainland molecular Mutation network neuraminidase inhibitor neuraminidase inhibitors Next-generation sequencing outbreak pandemic phenotypic Phylogenetic analysis preventive measure preventive measures reduced Region remained representing respiratory respiratory specimens respond SARS-CoV-2 Seasonal influenza sensitivity Sequencing severe acute respiratory syndrome Coronavirus specimen study period Surveillance susceptibility tested the vaccine unique Virological Virological. virus viruses was performed was used Winter [DOI] 10.1186/s40249-022-01002-x PMC 바로가기 [Article Type] Article
Increased Abundance of Achromobacter xylosoxidans and Bacillus cereus in Upper Airway Transcriptionally Active Microbiome of COVID-19 Mortality Patients Indicates Role of Co-Infections in Disease Severity and OutcomeCOVID-19 사망률 환자의 상부 기도에서 증가된 Achromobacter xylosoxidans 및 Bacillus cereus는 질병 심각도 및 결과에서 공동 감염의 역할을 나타냅니다.Article Published on 2022-06-292022-09-11 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] abundance Achromobacter Actinomyce Alter Analysis Antibiotic therapy approaches Bacillus cereus Bacterial bacterial species bacterial specy Care clinical manifestation Co-infection complementary complications of COVID-19 contribute COVID-19 COVID-19 patient current disease disease outcome disease pathology disease severity disease sub-phenotype Exacerbation Factor feature functional groups highlight Holo-Seq hospital host-pathogen interactions Increased Inflammatory response Inflammatory responses Integrative analysis investigated involved isolate isolates Leptotrichia mechanism Medical care metabolic pathways microbe microbial Mild mild COVID-19 patients moderate modulate modulating Mortality nasopharyngeal nasopharyngeal RNA outcome parameters pathogen pathogen genomics Patient patients phenotype Phenotypes Phylogenetic analysis progression provide question recovered patient recovered patients reported respiratory virus respiratory virus oligo panel (RVOP) role SARS-CoV-2 SARS-CoV-2 infected patients SARS-CoV-2 pathogenesis Sequencing severe COVID-19 severe disease severity susceptibility Symptoms the disease the patient transcript transcriptionally transcriptionally active microbial isolates. Transmissibility upper vaccination variants variants of concern VoC window [DOI] 10.1128/spectrum.02311-21 PMC 바로가기 [Article Type] Article
The genetic architecture of pneumonia susceptibility implicates mucin biology and a relationship with psychiatric illness Research Published on 2022-06-292022-10-05 Journal: Nature Communications [Category] 신약개발, 유전자 메커니즘, [키워드] Analysis association cause clinically correlation death Diagnosis Evidence Genetic genetic architecture genetics histocompatibility complex region identify implicated mapped Meta-analysis MUC5AC Necrosis overlap pathway phenotype Pneumonia Precision Psychiatric receptor risk risk score smoking Support susceptibility target targets TNFRSF1A Treatment utilised variant widespread [DOI] 10.1038/s41467-022-31473-3 [Article Type] Research
Serine Protease Inhibitors Restrict Host Susceptibility to SARS-CoV-2 Infections세린 프로테아제 억제제는 SARS-CoV-2 감염에 대한 숙주 감수성을 제한합니다Article Published on 2022-06-282022-09-11 Journal: mBio [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료제, [키워드] A1AT acute respiratory syndrome Administered Affect affecting age Alpha alpha-1-antitrypsin antithrombin III antitrypsin Antiviral antiviral drug antiviral intervention approach asymptomatic infection asymptomatic infections ATIII can be used cellular cellular protease ciliated cleavage club Comorbidities Comorbidity complex coronavirus disease Coronavirus disease 2019 COVID-19 deficiency determinant determinants disease disease severity Donor door expression expression level Factor Genetic Genetic variation Genetic variations goblet cells highlight Host human donors identification identify identity immune response individual Infection inhibitor inhibitors less lung cell mechanism mechanism of action outcome PAI1 Patient patients plasminogen activator inhibitor 1 Potential potential treatments primary cell primary cells reduce reducing regulate restrict risk risk factor Risk factors SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 susceptibility Serine serine protease serine protease inhibitor serine protease inhibitors serpin serpin. SERPINA1 SERPINE1 SERPINE2 serpins Severe acute respiratory syndrome severe COVID-19 severe infections Sex Single-cell RNA sequencing Spike protein susceptibility susceptible Symptom target cells TMPRSS2 Treatment Usage Variation viral burden viral entry viral spike protein [DOI] 10.1128/mbio.00892-22 PMC 바로가기 [Article Type] Article
Mediators of Obesity Do Not Influence SARS-CoV-2 Infection or Activation of Primary Human Lung Microvascular Endothelial Cells In Vitro비만 매개체는 SARS-CoV-2 감염 또는 시험관 내 1차 인간 폐 미세혈관 내피 세포 활성화에 영향을 미치지 않습니다Article Published on 2022-06-282022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료기술, [키워드] activated Activation addition Adhesion Molecule adipokines adipose Adipose tissue Alter Cell cells clinical clinical observations COVID-19 Critically ill driving dysfunction E-selectin endothelial endothelial activation Endothelial cell endothelial cells Endothelial dysfunction evidenced exacerbate excess exposure to expression fat Human human lung ICAM-1 IL-6 Incubation individuals induce Infection Inflammation Inflammatory Inflammatory cytokine Inflammatory response Inflammatory responses influence initiated lack Leptin lung Lungs mechanism mediator mounted obese obese COVID-19 patients obesity observation other organs outcome phenotype plasma pro-inflammatory produced virus required response SARS-CoV-2 SARS-CoV-2 entry receptor SARS-COV-2 infection selectin severe disease shown susceptibility susceptibility to infection susceptible systemic level tested tissue VCAM-1 Viral protein Viral proteins virus visceral with COVID-19 [DOI] 10.3389/fimmu.2022.879033 PMC 바로가기 [Article Type] Article