Favipiravir and/or nitazoxanide: a randomized, double-blind, 2×2 design, placebo-controlled trial of early therapy in COVID-19 in health workers, their household members, and patients treated at IMSS (FANTAZE)Favipiravir 및/또는 nitazoxanide: IMSS(FANTAZE)에서 치료를 받는 의료 종사자, 가족 구성원 및 환자를 대상으로 한 COVID-19 조기 치료에 대한 무작위, 이중 맹검, 2x2 설계, 위약 대조 시험Randomized Controlled Trial Published on 2022-07-222022-09-11 Journal: Trials [Category] COVID19(2023년), SARS, 임상, 치료제, [키워드] 1:1 2×2 design absence Admission antimicrobial Antimicrobials Antiviral effect antiviral therapy Antiviral treatment antivirals appear assigned Asymptomatic blinded to treatment combination therapy Comorbidities Comorbidity Controlled trial COVID-19 COVID-19 disease disease double-blind early disease early phase early treatment example Favipiravir followed by Gender Genetic genetic mutation Health high risk Hospitalization Hypothesis in some include individuals Infection Inflammatory Influenza intensive care investigator investigators later phase morbidity and mortality Mutation mutation rate nitazoxanide obesity older patient outcome pandemic participant patients treated pharmacokinetics phase phase IIa Placebo placebo-controlled placebo-controlled clinical trial placebo-controlled trial positive presence or absence Prevent Primary outcome progression protocol randomised randomised controlled trial Randomized receive replicates SARS-CoV-2 secondary Secondary outcomes security Sepsis severe disease smoking status Social Security Stratification symptomatic symptomatic COVID-19 Symptoms tested the disease therapy those with comorbidity Toxicity treatment allocation Trial upper respiratory tract Viral load virus [DOI] 10.1186/s13063-022-06533-0 PMC 바로가기 [Article Type] Randomized Controlled Trial
COVID-19 in patients with hematologic malignancy혈액암 환자의 코로나19Article Published on 2022-07-212022-09-11 Journal: Blood [Category] Coronavirus, COVID19(2023년), SARS, 변종, 치료제, [키워드] active immunization acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 advanced age Antibody Response Antiviral antiviral drug antiviral drugs Clinical efficacy contribute coronavirus COVID-19 COVID-19 in patient develop early treatment early treatment of COVID-19 hematologic Hematologic malignancy heterogeneity high risk illnesses immune response immune system Infectious disease malignancy MONITOR monoclonal antibodies monoclonal antibody mortality rate offered outcome pandemic Patient patients hospitalized Postexposure Prophylaxis predict Prevent reduced risk factor SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 vaccine SARS-CoV-2 vaccines severe acute respiratory syndrome Coronavirus severe COVID-19 significantly subtype symptomatic therapy Treatment vaccination Vaccine variants virus [DOI] 10.1182/blood.2021012251 PMC 바로가기 [Article Type] Article
Limitations of Molecular and Antigen Test Performance for SARS-CoV-2 in Symptomatic and Asymptomatic COVID-19 Contacts증상 및 무증상 COVID-19 접촉자에서 SARS-CoV-2에 대한 분자 및 항원 테스트 성능의 한계Article Published on 2022-07-202022-09-12 Journal: Journal of Clinical Microbiology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] acute respiratory syndrome Antigen antigen test Asymptomatic individuals Cell culture close contact Contact coronavirus COVID-19 Culture diagnostics enrolled identify in viral individual Infection limitation Molecular assay nasopharyngeal NAT nucleic acid test pandemic participant performance performed PerkinElmer platform positive positive sample Probability rapid diagnostics recruited reference Repeat reverse transcription-PCR RT-PCR RT-PCR assay Saliva SARS-CoV-2 SARS-CoV-2 testing SARS-CoV-2-positive individual Swab Symptom symptomatic Test test performance tested Transport media VTM [DOI] 10.1128/jcm.00187-22 PMC 바로가기 [Article Type] Article
A Hybrid Epidemic Model to Explore Stochasticity in COVID-19 DynamicsCOVID-19 역학에서 확률을 탐색하기 위한 하이브리드 전염병 모델Article Published on 2022-07-202022-09-11 Journal: Bulletin of Mathematical Biology [Category] COVID19(2023년), SARS, 치료기술, [키워드] adopted approaches Canada Clinical data confirmed case contributed COVID-19 COVID-19 outbreak COVID-19 pandemic death death rates determine differential equation disease disease transmission Dynamics e parameters Environmental variability Face masks hybrid Impact initiated Measures Model outbreak parameter Parameter estimation Probability public health Public health intervention Public health interventions reducing severity of COVID-19 shown silent Silent spreader social distancing Stage stochastic Stochastic models. subpopulations Symptom symptomatic Transmission transmission rate transmission rates USA Variability virus [DOI] 10.1007/s11538-022-01030-6 PMC 바로가기 [Article Type] Article
Temporal trends and differences of SARS-CoV-2-specific antibody responses in symptomatic and asymptomatic subjects: a longitudinal study from Umbria in Italy증상이 있는 대상과 무증상 대상에서 SARS-CoV-2 특이 항체 반응의 시간적 경향과 차이점: 이탈리아 Umbria의 종단 연구Article Published on 2022-07-182022-09-11 Journal: BMJ Open [Category] COVID19(2023년), MERS, SARS, 진단, 치료법, [키워드] anti-S anti-S antibody antibody Antibody Response Antibody responses Antibody titre antibody titres Asymptomatic Clinical severity clinically Cohort correlation COVID-19 Decline Diagnosis discharged Dynamics eligible first visit Follow-up follow-up study group hospital Immunity immunology Infectious diseases Italy longitudinal overtime participant Participants PCR test persistence positive Protein recruited reduced Reinfection remained SARS-CoV-2 SARS-COV-2 infection serological Serological testing significant difference significantly higher Signs and symptoms spike Spike proteins subject subjects Symptom symptomatic symptomatic and asymptomatic Temporal the median three group three groups threshold titre titres Treatment two groups U/mL Variation Virology while without symptom [DOI] 10.1136/bmjopen-2021-056370 PMC 바로가기 [Article Type] Article
Alterations in the molecular composition of COVID-19 patient urine, detected using Raman spectroscopic/computational analysis라만 분광/전산 분석을 사용하여 감지한 COVID-19 환자 소변의 분자 구성 변화Article Published on 2022-07-182022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] Abnormalities Accuracy affected alteration Analysis analyzed Bladder cancer Care Chain Reaction Chromatography Clinical pathology collected complex component components computational analysis Contact contact with contributing to correlation correlations COVID-19 COVID-19 disease COVID-19 patient creatinine defined detect determine disease disease severity EGFR elevated fingerprint gas chromatography Gas Chromatography-Mass Spectrometry GC-MS glomerular filtration rate healthy healthy individual healthy individuals Hospitalized HPLC identify in urine include Infection Inflammatory liquid Liquid chromatography Long mass spectrometry metabolomic analysis Mild moderate molecular Negative predictive value pathology Patient patients performance Peritoneal dialysis positive Positive predictive value Predictive value Raman spectroscopy random ranged reaction representing respiratory RT-PCR SARS-CoV-2 virus sensitivity serum creatinine severity specificity specimen specimens Spectrometry Symptom symptomatic tested Urinalysis Urine urine specimens Viral Volunteer with COVID-19 [DOI] 10.1371/journal.pone.0270914 PMC 바로가기 [Article Type] Article
Urban monitoring, evaluation and application of COVID-19 listed vaccine effectiveness: a health code blockchain studyCOVID-19 등재 백신 효과의 도시 모니터링, 평가 및 적용: 건강 코드 블록체인 연구Article Published on 2022-07-132022-09-11 Journal: BMJ Open [Category] 변종, [키워드] aggravate Algorithm analysed Analysis Asymptomatic average basic reproduction number calculate city Complete conditions Contact cooperation country COVID-19 decrease deviation Effectiveness eight ENhance epidemiological Epidemiological investigation Epidemiology evaluate greater Health Health policy herd immunity Immunity increase Incubation period index infection rate information measure MONITOR mutant virus not decreased outcome Patient Primary outcome Primary outcomes promote promoted proportion protective effect reduced regions respond second significantly Simulation statistical symptomatic the vaccine this system transmitted urban urban population vaccination vaccination rate Vaccination strategy Vaccine Vaccines variant Variation virus weight [DOI] 10.1136/bmjopen-2021-057281 PMC 바로가기 [Article Type] Article
Exploring the Immunomodulatory Aspect of Mesenchymal Stem Cells for Treatment of Severe Coronavirus Disease 19중증 코로나바이러스 질환 치료를 위한 중간엽 줄기세포의 면역조절 측면 탐색 19Review Published on 2022-07-122022-09-11 Journal: Cells [Category] COVID19(2023년), SARS, 치료법, [키워드] ACE-2 acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 acute respiratory syndrome coronavirus-2 administration affected Alpha alveolar epithelial cell alveolar epithelial cells angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 anti-apoptotic Anti-inflammatory anti-oxidative aspect Asymptomatic average Betacoronavirus breathlessness cause cellular characterized chemokines chest pain Clinical outcome Clinical symptoms colony-stimulating factor coronavirus 2 COVID-19 COVID-19 patient Critically ill critically ill COVID-19 patients curative cytokine Cytokine storm Cytokine storms damaged dependent on Deterioration disease severity dry cough Effectiveness Effects elicited endothelial engage enzyme epithelial cells excessive inflammation family Coronaviridae fatigue Fever fibroblast fibroblast growth factor functional GCSF genus genus Betacoronavirus granulocyte granulocyte colony-stimulating factor growth factor Growth factors Health healthy histological IL-6 IL-7 IL-8 IL-9 immune cells immune response immune responses immunomodulation immunomodulatory immunomodulatory capabilities immunomodulatory capability Incubation period individual infected individual infected individuals infiltrating immune cells Inflammatory Inflammatory cytokines inflammatory protein inhalation Injury Intention interferon interleukin intravenous intravenous infusion Invasion IP10 lung Lungs Macrophage majority MCP1 Mesenchymal stem cells MIP1A mitigate monocyte monocyte chemotactic protein-1 MSC MSCs multitude myriad Necrosis organ PDGFB persistence Platelet platelet-derived growth factor positioned positive Protein receptor reduce respiratory Respiratory droplets RNA SARS-CoV-2 SARS-COV-2 infection secretion Secretome Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 sore throat STEM stem cell stem cells subunit supportive therapy symptomatic therapeutic therapy tissue TNF-α translational transmitted Treatment Tumor tumor necrosis tumor necrosis factor tumor necrosis factor alpha undergo Vascular virus widespread [DOI] 10.3390/cells11142175 PMC 바로가기 [Article Type] Review
COVID-19 vaccine effectiveness against symptomatic SARS-CoV-2 infection and severe COVID-19 outcomes from Delta AY.4.2: Cohort and test-negative study of 5.4 million individuals in ScotlandDelta AY.4.2의 증상이 있는 SARS-CoV-2 감염 및 심각한 COVID-19 결과에 대한 COVID-19 백신 효과: 스코틀랜드의 540만 개인에 대한 코호트 및 테스트 음성 연구Article Published on 2022-07-092022-09-11 Journal: Journal of Global Health [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] 95% CI 95% confidence interval accounted acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adults age BNT162b2 ChAdOx1 Chain Reaction cohort study Community conditions conducted confounders contributed coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 admission COVID-19 hospitalisation COVID-19 vaccine Cox proportional hazard Cox proportional hazards model death Delta Effectiveness enhanced Good hazard ratio Hospital admission increased risk individual individuals Infection Lineage mRNA mRNA-1273 mRNA-1273 vaccine mRNA-1273 vaccines offered omicron Omicron variant outcome performed platform polymerase chain polymerase chain reaction proportional hazards model provided reverse transcriptase Reverse transcriptase polymerase chain reaction RT-PCR SARS-CoV-2 SARS-COV-2 infection second vaccination security severe acute respiratory syndrome Coronavirus severe COVID-19 Sex socioeconomic status spline splines symptomatic symptomatic COVID-19 symptomatic infection symptomatic SARS-CoV-2 infection transcriptase United Kingdom vaccination Vaccine vaccine dose Vaccines variant variant of SARS-CoV-2 were infected [DOI] 10.7189/jogh.12.05025 PMC 바로가기 [Article Type] Article
Effects of Previous Infection and Vaccination on Symptomatic Omicron Infections증상이 있는 오미크론 감염에 대한 이전 감염 및 예방 접종의 영향Article Published on 2022-07-072022-09-11 Journal: The New England Journal of Medicine [Category] COVID19(2023년), SARS, 변종, [키워드] 95% CI 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis B.1.1.529 BNT162b2 booster vaccination case-control study conducted coronavirus coronavirus disease Coronavirus disease 2019 Critical dose Effect Effectiveness evaluate hybrid Immunity Infection Moderna mRNA mRNA-1273 National natural immunity of BNT162b2 omicron Pfizer-BioNTech resulting SARS-CoV-2 second dose symptomatic vaccination variant variants [DOI] 10.1056/NEJMoa2203965 PMC 바로가기 [Article Type] Article