Identification of 37 Heterogeneous Drug Candidates for Treatment of COVID-19 via a Rational Transcriptomics-Based Drug Repurposing ApproachArticle Published on 2021-01-252022-10-28 Journal: Pharmaceuticals [Category] COVID-19, [키워드] biological processe biosynthetic candidate caused cellular clinical trials Connectivity map COVID-19 COVID-19 pandemic dataset developmental processes Differentially expressed genes drug drug candidate drug candidates Drug repurposing enrichment analysis generate Health heterogeneous host cell host transcriptome identification identify Imatinib immune response Improvements include initial knowledge metabolic process outbreak pathway Pathways repurposing SARS-CoV-2 SARS-CoV-2 virus signaling pathways Study design Support transcriptomic transcriptomic alteration Treatment virus was performed [DOI] 10.3390/ph14020087 PMC 바로가기 [Article Type] Article
Network analysis of Down syndrome and SARS-CoV-2 identifies risk and protective factors for COVID-19다운 증후군 및 SARS-CoV-2의 네트워크 분석은 COVID-19에 대한 위험 및 보호 요인을 식별합니다.Article Published on 2021-01-212022-09-10 Journal: Scientific Reports [Category] 유전자 메커니즘, 임상, 치료기술, [키워드] acute respiratory distress acute respiratory distress syndrome Affect affected Analysis analyzed Anti-viral anti-viral response Bacterial infection clinical outcomes complications COVID-19 COVID-19 pandemic COVID-19 prognosis cytokine Cytokine storm datasets deregulated differentially expressed Down syndrome downregulation favor Gene regulatory networks General population Genes higher risk homeostasis host cells host protein host proteins identify individual Infection infections inflammatory gene inflammatory genes inhibiting initial interferon involved maintenance molecular multiple comorbidities multiple comorbidity network NLRP3 overlap Pathogenesis pathogenic pathway populations pro-inflammatory Prognosis Protective protective factor respiratory respiratory complication Respiratory complications respiratory distress Respiratory distress syndrome risk risk factor Risk factors risk of infection SARS-CoV-2 SARS-COV-2 infection SARS-CoV2 infection Signaling Spread susceptibility susceptible syndrome TMPRSS2 transcriptomic upregulated upregulation Viral viral genome Viral protein Viral proteins viral replication viral S viral S protein Vulnerable populations [DOI] 10.1038/s41598-021-81451-w PMC 바로가기 [Article Type] Article
Gene Expression Profiling Reveals the Shared and Distinct Transcriptional Signatures in Human Lung Epithelial Cells Infected With SARS-CoV-2, MERS-CoV, or SARS-CoV: Potential Implications in Cardiovascular Complications of COVID-19Cardiovascular Medicine Published on 2021-01-152022-10-31 Journal: Frontiers in Cardiovascular Medicine [Category] COVID-19, [키워드] acute inflammatory response acute respiratory syndrome Analysis Apoptosis cardiovasclar disease cardiovascular cardiovascular complication cellular response changes in Coagulation Complication contribute coronavirus coronavirus coronavirus disease Coronaviruses COVID-19 COVID-19 and transcriptome analysis CSF2 CXCL1 CXCL3 dataset DEGs differentially expressed gene effort epithelial cell FOXO1 gene expression dataset Gene Expression Omnibus Genes global pandemic Human human lung IL1A IL32 infected with SARS-CoV-2 initial ITGB3 lower expression lung damage MERS MERS-CoV Middle East Mild NLRP1 NR2F2 NRP1 Potential Profiling prognostic PROS1 SARS-CoV SARS-CoV-2 SARS-COV-2 infection signature single-stranded RNA virus syndrome TCF4 TFPI2 therapeutic TNF TP53INP1 transcriptional transcriptional response transcriptomic TYMP unique upper respiratory tract Vascular function VAV3 viral replication virus [DOI] 10.3389/fcvm.2020.623012 PMC 바로가기 [Article Type] Cardiovascular Medicine
Identifying Transcriptomic Signatures and Rules for SARS-CoV-2 InfectionCell and Developmental Biology Published on 2021-01-112022-10-31 Journal: Frontiers in Cell and Developmental Biology [Category] COVID-19, [키워드] acute respiratory illnesses acute respiratory syndrome airway analyzed Biomarker classification algorithms classification rule Classifier clinical testing conducted coronavirus COVID-19 diagnostic disease Diseases effective evaluated feature help identify identifying molecular Multiple new strain pandemic Pathogenesis pathogenesis of SARS-CoV-2 pathogenic mechanism Patient produced Quantitative reported rule SARS-CoV-2 SARS-COV-2 infection selected signature Spread target the disease therapeutic target tissue transcriptomic transcriptomics triggered Vaccine design virus widespread [DOI] 10.3389/fcell.2020.627302 PMC 바로가기 [Article Type] Cell and Developmental Biology
H2V: a database of human genes and proteins that respond to SARS-CoV-2, SARS-CoV, and MERS-CoV infectionDatabase Published on 2021-01-072022-10-27 Journal: BMC Bioinformatics [Category] COVID-19, [키워드] accelerate analysis Antiviral approved article caused cellular and molecular cellular pathway collected confirmed case coronavirus Coronavirus infection country COVID-19 pandemic database death develop expected Gene highly pathogenic human gene identify Impact impair Infection information measure MERS-CoV MERS-CoV infection molecular Novel coronavirus powerful tool Protein proteomic provide public health respond response Result SARS-CoV SARS-CoV-2 targets transcriptomic Treatment Vaccine viral infection viral pathogenesis viruses WHO [DOI] 10.1186/s12859-020-03935-2 PMC 바로가기 [Article Type] Database
H2V: a database of human genes and proteins that respond to SARS-CoV-2, SARS-CoV, and MERS-CoV infectionDatabase Published on 2021-01-072022-10-27 Journal: BMC Bioinformatics [Category] Coronavirus, COVID-19, Fulltext, MERS, [키워드] accelerate analysis Antiviral approved article caused cellular and molecular cellular pathway collected confirmed case coronavirus Coronavirus infection country COVID-19 pandemic database death develop expected Gene highly pathogenic human gene identify Impact impair Infection information measure MERS-CoV MERS-CoV infection molecular Novel coronavirus powerful tool Protein proteomic provide public health respond response Result SARS-CoV SARS-CoV-2 targets transcriptomic Treatment Vaccine viral infection viral pathogenesis viruses WHO [DOI] 10.1186/s12859-020-03935-2 PMC 바로가기 [Article Type] Database
H2V: a database of human genes and proteins that respond to SARS-CoV-2, SARS-CoV, and MERS-CoV infectionH2V: SARS-CoV-2, SARS-CoV, MERS-CoV 감염에 반응하는 인간 유전자 및 단백질 데이터베이스Database Published on 2021-01-072022-09-01 Journal: BMC Bioinformatics [Category] 유전자 메커니즘, 진단, [키워드] accelerate analysis Antiviral antiviral agent approved article caused cellular and molecular cellular pathway cellular pathways collected confirmed case coronavirus Coronavirus infection Coronavirus infections country CoV infection COVID-19 pandemic database death develop Economy expected Gene highly pathogenic human body human gene human genes identify Impact impair Infection information measure MERS MERS-CoV MERS-CoV infection molecular Novel coronavirus powerful tool Protein proteomic provide public health respond response Result SARS-CoV SARS-CoV-2 Society targets these viruses transcriptomic Treatment Vaccine Viral viral infection viral infections viral pathogenesis viruses WHO [DOI] 10.1186/s12859-020-03935-2 PMC 바로가기 [Article Type] Database
Interleukin-38 ameliorates poly(I:C) induced lung inflammation: therapeutic implications in respiratory viral infectionsArticle Published on 2021-01-072022-10-04 Journal: Cell Death & Disease [Category] 진단, [키워드] Activation administration alleviate anti-inflammatory property biological processe Bronchoalveolar lavage fluid chemokine circulating co-culture co-cultured Concentration correlated counteract COVID-19 patients disease severity Effect Host implication in viral in vitro indicate Inflammation Inflammatory diseases Inflammatory response Influenza inhibiting innate immune response Interleukins lung Lung injury Lymphocytes Macrophage MAPK microenvironment mitigate neutrophil NF-κB signaling Pathways Pneumonia pro-inflammatory cytokine pulmonary inflammation reduced respiratory epithelial cell Respiratory tract diseases respiratory viral infection respiratory viral infections shown significantly Stat1 STAT3 therapeutic therapeutic target transcriptomic virus [DOI] 10.1038/s41419-020-03283-2 PMC 바로가기 [Article Type] Article
Public Database-Driven Insights Into Aging Stress-Associated Defective Gut Barrier With Low SARS-CoV-2 ReceptorsMedicine Published on 2020-12-222022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] abdominal pain acute respiratory syndrome addition aging barrier Biomarker Biomarkers caused Cell clearance contributing to coronavirus COVID-19 COVID-19 severity Defense diarrhea downregulation expression expression of SARS-CoV-2 fecal Gastrointestinal symptom global pandemic Gut Gut barrier gut barrier integrity include increasing age insight integrated stress responses metabolic stress novel coronavirus disease Public pulmonary system receptor response responses SARS-CoV-2 SARS-CoV-2 receptor Stress susceptibility transcriptomic viral entry virus vomiting [DOI] 10.3389/fmed.2020.606991 PMC 바로가기 [Article Type] Medicine
Host transcriptomic profiling of COVID-19 patients with mild, moderate, and severe clinical outcomesResearch article Published on 2020-12-182022-10-05 Journal: Computational and Structural Biotechnology Journal [Category] 유전자 메커니즘, [키워드] Analysis approach cascades CCL2 CCL22 cellular pathway chemokine Clinical outcome Coagulation complement COVID-19 COVID-19 patient CXCL12 CXCL9 cytokine disease disease severity dysregulated Expression signature Gene expression analysis Host human RNA identify Ifi44 IFIH1 IFIT1 IL10 immune interferon involved Jak-STAT management Mild moderate molecular Nasopharyngeal swab nasopharyngeal swabs outcome pathophysiology Pathways Patient patients with COVID-19 predictor Prognosis receptor signaling Regulatory severe symptoms signaling pathway significantly higher TGF Transcriptome transcriptome sequencing transcriptomic [DOI] 10.1016/j.csbj.2020.12.016 [Article Type] Research article