Vaccination Decreases the Infectious Viral Load of Delta Variant SARS-CoV-2 in Asymptomatic PatientsArticle Published on 2022-09-182022-11-15 Journal: Viruses [Category] SARS, 변종, 진단, [키워드] affecting Anti-spike asymptomatic infection asymptomatic infections B.1.617.2 breakthrough Breakthrough infection caused collected COVID-19 decrease Delta delta variant IgA individual Infectious virus load nasal Nasopharyngeal swab nasopharyngeal swabs other variants patients quantified risk SARS-CoV-2 secretion significantly higher Symptomatic patients Transmission vaccinated individuals vaccination Vaccine vaccinee Viral load Viral RNA viral RNA genome while [DOI] 10.3390/v14092071 PMC 바로가기
The Omicron Variant BA.1.1 Presents a Lower Pathogenicity than B.1 D614G and Delta Variants in a Feline Model of SARS-CoV-2 InfectionArticle Published on 2022-09-142022-11-15 Journal: Journal of Virology [Category] SARS, 변종, 치료기술, [키워드] addition B.1 B.1.1.529 B.1.617.2 body temperature cats clinical COVID-19 D614G death Delta delta variant disease severity distribution effective Evidence evidenced histologic Hospitalization immunization immunofluorescence increased risk Infection infections Infectious virus Inflammation inoculated less lethargic log Lower lung Lung pathology Mild Model mutated nasal nasal turbinate observation omicron Pathogenesis pathogenic pathogenicity Pneumonia Postinfection present reduced remained Replication SARS-CoV-2 SARS-CoV-2 D614G SARS-CoV-2 variant secretion significant increase South Africa Spread staining suggested susceptible TCID tissue tissue tropism variant variant of concern variants Viral load viral replication Viral RNA viral titer Viral variants Virological virulence virus [DOI] 10.1128/jvi.00961-22 PMC 바로가기
Preclinical characterization of amubarvimab and romlusevimab, a pair of non-competing neutralizing monoclonal antibody cocktail, against SARS-CoV-2Article Published on 2022-09-142022-11-15 Journal: Frontiers in Immunology [Category] SARS, 변종, 진단, [키워드] acute respiratory syndrome amino acid substitution amubarvimab (BRII-196) antibody antibody cocktail Clinical efficacy Combination controls coronavirus coronavirus disease COVID-19 demonstrated Emergency use authorization epitope EUA Evolution half-maximal inhibitory concentration half-maximal inhibitory concentration (IC50) in vitro introduced less Lung pathology Lungs M252Y/S254T/T256E (YTE) mAb mAbs Modification monoclonal antibody monoclonal antibody (mAb) Mutation neutralize neutralized Neutralizing Post-infection Preclinical RBD receiving Receptor binding domain receptor binding domain (RBD) reduce reduced regions regulatory authority resulting retained romlusevimab (BRII-198) SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variants serum severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) significantly Spike protein Support susceptibility therapeutic option variant variant of concern (VOC) variants variants of concern Viral load virus VoC weight loss [DOI] 10.3389/fimmu.2022.980435 PMC 바로가기
Spike protein-independent attenuation of SARS-CoV-2 Omicron variant in laboratory miceArticle Published on 2022-09-132022-11-16 Journal: Cell Reports [Category] SARS, 변종, [키워드] accompanied ACE2 acute respiratory syndrome attenuation. BALB/c mice cause coronavirus CP: Microbiology disease disease severity Interaction K18-hACE2 Laboratory mice Mutation omicron Omicron variant pseudovirus responsible robust SARS-CoV-2 spike Spike protein the receptor-binding domain the spike protein variant variants of concern Viral load virus [DOI] 10.1016/j.celrep.2022.111359 PMC 바로가기
Detection and Kinetics of Subgenomic Severe Acute Respiratory Syndrome Coronavirus 2 RNA Viral Load in Longitudinal Diagnostic RNA-Positive SamplesArticle Published on 2022-09-132022-11-15 Journal: The Journal of Infectious Diseases [Category] SARS, 치료기술, [키워드] Above acute respiratory syndrome characterized collected coronavirus coronavirus 2 COVID-19 detectable detection diagnostic duration of illness identify independent Kinetics large sample linear load longitudinal nasal swab nucleic acid amplification participant peaking polymerase chain Postexposure Prophylaxis replicating virus Replication respiratory RNA RT-PCR Sample SARS-CoV-2 sgRNA sgRNAs subgenomic RNA swab sample Symptom threshold trajectory Treatment Viral load viral replication Viral RNA while [DOI] 10.1093/infdis/jiac048 PMC 바로가기
Monitoring of the SARS-CoV-2 Omicron BA.1/BA.2 lineage transition in the Swedish population reveals increased viral RNA levels in BA.2 casesArticle Published on 2022-09-092022-11-16 Journal: Med (New York, N.Y.) [Category] SARS, 변종, [키워드] airway analyzed BA.1 BA.2 CDC collected contagious COVID-19 cases dominant feasibility help Lineage monitoring nasopharyngeal occurred omicron pandemic populations reliability reveal RT-PCR RT-PCR assay SARS-CoV-2 Swedish the SARS-CoV-2 Translation to population health Transmissibility unique upper airways variant variants of concern Viral load Viral RNA [DOI] 10.1016/j.medj.2022.07.007 PMC 바로가기
Different clinical features of children and adults in regional outbreak of Delta COVID-19Article Published on 2022-09-082022-11-16 Journal: BMC Infectious Diseases [Category] SARS, 변종, [키워드] Adult Adults analyzed Child children clinical clinical chemistry clinical feature collected college coronavirus disease COVID-19 Delta delta variant diarrhea Different clinical feature drug Hospitalized incidence Inflammatory Injury interleukin-6 less Liver injury Lymphocyte count Mild mild patient nasopharyngeal swabs no significant difference outbreak proportion SARS-CoV-2 serum creatinine significantly Symptom Symptom assessment Symptoms two groups Viral load [DOI] 10.1186/s12879-022-07707-6 PMC 바로가기
Quantifying the Relationship between SARS-CoV-2 Wastewater Concentrations and Building-Level COVID-19 Prevalence at an Isolation Residence: A Passive Sampling ApproachArticle Published on 2022-09-072022-11-15 Journal: International Journal of Environmental Research an [Category] SARS, 치료기술, 치료제, [키워드] approach association baseline collected college campus monitoring complex concentrations correlated covariate COVID-19 demonstrated Epidemiology excreta fecal Fecal shedding help highlight individuals with COVID-19 Infection infections Isolation Laboratory maintain majority median MONITOR multivariable model N1 and N2 Passive Passive sampling polymerase chain positive correlation Prevalence processed public health Public health responses quantified Quantitative relationship remained RNA load RT-qPCR Sample sampling SARS-CoV-2 SARS-CoV-2 RNA specimen Surveillance susceptible the mean Variation Viral load viral shedding wastewater Wastewater-based epidemiology yielding [DOI] 10.3390/ijerph191811245 PMC 바로가기
A dual-antigen self-amplifying RNA SARS-CoV-2 vaccine induces potent humoral and cellular immune responses and protects against SARS-CoV-2 variants through T cell-mediated immunityArticle Published on 2022-09-072022-11-15 Journal: Molecular therapy : the journal of the American So [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] addition amplified Antibody Response antigen expression attenuate B.1.351 B.1.617.2 Beta caused CD3 CD4 CD8 cell-mediated immune Cell-mediated immunity Cellular immune response Convalescent patients COVID-19 COVID-19 vaccine cytokine response Delta disease severity displaying dual-antigen saRNA vaccine elicit hamsters humoral immune response induce lower dose mice mRNA vaccine mutated N antigen Neutralizing antibody response Neutralizing antibody titer PROTECT Proteins RNA RNA vaccine S-RBD SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV-2 variant SARS-CoV-2 variants self-amplifying RNA spike T cell Th1 vaccination variant variants of concern Viral load [DOI] 10.1016/j.ymthe.2022.04.014 PMC 바로가기
Impaired activation of transposable elements in SARS-CoV-2 infectionArticle Published on 2022-09-052022-11-15 Journal: EMBO Reports [Category] SARS, 유전자 메커니즘, 치료제, [키워드] activate activated Activation Cell cellular changes in Chromatin structure correlation COVID-19 Defense drug target element elements Epigenetic epigenetics Evidence explain expression expression level functional Genes Host host immune system identify immune Impaired Infection interferon interferon response mechanism primary cells Proteins provide regulate robust SARS-CoV-2 SARS-COV-2 infection suggested the SARS-CoV-2 Transcription transposable elements. upregulation variable viral infections Viral load viruses [DOI] 10.15252/embr.202255101 PMC 바로가기