New Metrics for Evaluating Viral Respiratory PathogenesisResearch Article Published on 2015-06-262022-10-28 Journal: PLoS ONE [Category] Coronavirus, 신종인플루엔자, [키워드] change changes in clinically connection evaluate Evaluating highlight human disease Infection marker Measures methodology Metrics mice New Pathogenesis Pulmonary function respiratory Respiratory function respiratory viral infections respiratory virus responses SARS-CoV severe systemic disease utility viral pathogenesis virus was used [DOI] 10.1371/journal.pone.0131451 PMC 바로가기 [Article Type] Research Article
Dendritic cells as Achilles’ heel and Trojan horse during varicella zoster virus infectionarticle Published on 2015-05-082024-09-02 Journal: Frontiers in Microbiology [Category] 대상포진, [키워드] dendritic cells herpesviruses Varicella zoster virus Viral immune evasion viral pathogenesis [DOI] 10.3389/fmicb.2015.00417 PMC 바로가기 [Article Type] article
Canine Enteric Coronaviruses: Emerging Viral Pathogens with Distinct Recombinant Spike ProteinsReview Published on 2014-08-222022-10-28 Journal: Viruses [Category] Coronavirus, MERS, [키워드] addition Canine coronavirus caused Clinical signs coronavirus disease severity dissemination domain enteric Evidence Host increase in infecting Infection Infectious disease Mild NTDs occur recombinant Recombination serotype spike spike gene Spike protein Strains variant viral pathogenesis while [DOI] 10.3390/v6083363 PMC 바로가기 [Article Type] Review
Interferon induction of IFITM proteins promotes infection by human coronavirus OC43Article Published on 2014-05-062023-06-15 Journal: Proceedings of the National Academy of Sciences of [Category] MERS, [키워드] evasion of IFN response proviral function of IFITM viral pathogenesis [DOI] 10.1073/pnas.1320856111 PMC 바로가기
The YXXΦ motif within the severe acute respiratory syndrome coronavirus (SARS-CoV) 3a protein is crucial for its intracellular transportResearch Published on 2014-04-242022-10-28 Journal: Virology Journal [Category] Coronavirus, [키워드] absence accumulated acute respiratory syndrome Apoptosis Aprotinin association Brefeldin A carried Cell coronavirus Degradation detect distribution expressed function Golgi immunofluorescence Increased induce lipid droplets lysosomal marker motif mRNA mutant Mutation plasma membrane Protein protein level protein synthesis Proteins residue Result reversed RT-PCR SARS Coronavirus SARS-CoV significantly lower staining subcellular distribution Transcription transfected with translation Transport transported tyrosine viral pathogenesis was performed while wild type [DOI] 10.1186/1743-422X-11-75 PMC 바로가기 [Article Type] Research
A Network Integration Approach to Predict Conserved Regulators Related to Pathogenicity of Influenza and SARS-CoV Respiratory VirusesResearch Article Published on 2013-07-252022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] approach both virus component conserved Critical dataset disease pathology effort epithelial cell event Factor feature Gene Host host response human lung identify Infection influence Influenza virus integration Interaction Intervention involved lung epithelial Metrics network Pandemics pathogen pathogenicity predict predicted proteome public health threat Regression model regulator Regulatory related respiratory respiratory virus SARS-CoV severe therapeutic target transcriptome dataset utility viral pathogenesis virus [DOI] 10.1371/journal.pone.0069374 PMC 바로가기 [Article Type] Research Article
Differentiated phenotypes of primary murine alveolar epithelial cells and their susceptibility to infection by respiratory virusesArticle Published on 2013-04-292022-11-01 Journal: Virus research [Category] Coronavirus, 신종인플루엔자, [키워드] activating alveolar cell alveolar epithelial cell alveolar epithelial cells ATII Cell cell type cells contribute coronavirus correlated Critical Culture cytokine cytokine expression cytokine response Cytokines determine determined different disease severity epithelial cell exhibited Express expression Factor H1N1 Host IAV identify IL-1β immune responses in vitro model in vivo increased expression Infected Infection influenza A influenza A virus lung Lungs maintain Mouse-adapted SARS-coronavirus mouse-adapted SARS-CoV mRNA murine murine coronavirus murine model Pathogenesis pathology phenotype quantified respiratory viral infection respiratory virus respiratory viruses response robust SARS-CoV severe spread to susceptibility susceptible target type I Type I pneumocyte Type II pneumocyte v2163 viral infection viral infections viral pathogenesis virus viruses while [DOI] 10.1016/j.virusres.2013.04.008 PMC 바로가기 [Article Type] Article
Ready, Set, Fuse! The Coronavirus Spike Protein and Acquisition of Fusion CompetenceReview Published on 2012-04-122022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] activate angiotensin converting enzyme 2 antiviral therapies Carcinoembryonic antigen cathepsin cofactor competence coronavirus Coronavirus infection endocytosis Endosomes fusion highlight Interaction interactions membrane fusion other protease protease Proteins receptor response S protein S proteins spike Spike protein transmembrane protease transmembrane serine protease triggers TTSPs viral pathogenesis viral spike virus virus entry virus-cell membrane fusion [DOI] 10.3390/v4040557 PMC 바로가기 [Article Type] Review
SARS-CoV Pathogenesis Is Regulated by a STAT1 Dependent but a Type I, II and III Interferon Receptor Independent MechanismResearch Article Published on 2010-04-082022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, MERS, [키워드] acute lung injury acute respiratory syndrome affecting alveolar inflammation ARDS Author BALB/c mice caused cell proliferation clinical disease coronavirus death demonstrated Dependent died Diffuse alveolar damage ENhance Epidemic evaluated highly pathogenic I, II independent Infected Infection innate immune innate immune response Innate immunity interferon interferon signaling knockout mice lack liver Lung disease Lung injury Lung pathology MA15 mechanism mice molecular mechanism Mortality Mouse models other tissue outcomes Pathogenesis Pathways Post-infection PROTECT Protein pulmonary fibrosis pulmonary lesion question receptor regulated respiratory respiratory virus SARS Coronavirus SARS pathogenesis SARS-CoV SARS-CoV infection severe severe disease Signaling spleen Stat1 the epidemic Type type I type III interferon viral pathogenesis virus virus pathogenesis virus titer Virus-host interaction viruses weight loss wildtype [DOI] 10.1371/journal.ppat.1000849 PMC 바로가기 [Article Type] Research Article
Preparation and characterization of a novel monoclonal antibody specific to severe acute respiratory syndrome-coronavirus nucleocapsid proteinArticle Published on 2006-08-302022-11-01 Journal: Virus research [Category] Coronavirus, [키워드] Antigen assays C-terminus Cell coronavirus cross-reactivity Diagnosis diagnostic early diagnosis epitope expressed FIVE found generate Host IgG immune Infection insect cell linear epitopes mAb modulation monoclonal antibody N protein N proteins N-terminus nucleocapsid nucleocapsid protein pathology phosphorylated preparation Protein reactivity related SARS-CoV SARS-CoV N selected severe Severe acute respiratory syndrome suggested viral pathogenesis virus replication [DOI] 10.1016/j.virusres.2006.07.004 PMC 바로가기 [Article Type] Article