RNA-induced liquid phase separation of SARS-CoV-2 nucleocapsid protein facilitates NF-κB hyper-activation and inflammationSARS-CoV-2 뉴클레오캡시드 단백질의 RNA 유도 액체 상 분리는 NF-κB 과활성화 및 염증을 촉진합니다Article Published on 2021-04-242022-09-10 Journal: Signal Transduction and Targeted Therapy [Category] MERS, SARS, 치료법, [키워드] 1,6-hexanediol 2019 novel coronavirus Activation attenuate binding caused complex coronavirus disease COVID-19 cytokine Cytokine storms disease ENhance facilitate function global public health hexanediol host inflammatory response host inflammatory responses IKK induce Infection Inflammation Inflammatory response inhibitor Innate immunity kinase kinases Mortality N protein NF-κB NF-κB activation NF-κB signaling Novel coronavirus novel coronavirus disease platform Pneumonia potential therapeutic target promote Protein provide recruit Regulatory restrict SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 nucleocapsid severe pneumonia severity structural protein TAK1 Viral Viral RNA virion worldwide pandemic [DOI] 10.1038/s41392-021-00575-7 PMC 바로가기 [Article Type] Article
SARS CoV-2 Nucleoprotein Enhances the Infectivity of Lentiviral Spike ParticlesSARS CoV-2 핵단백질은 렌티바이러스 스파이크 입자의 감염성을 향상시킵니다Cellular and Infection Microbiology Published on 2021-04-232022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] MERS, SARS, 변종, 치료법, [키워드] ACE2 ACE2-Fc BSL-2 cells cellular entry D614G enhancer Entry inhibitor entry inhibitors fused Genes implication Infectivity Interpretation lentiviral less mutant N protein Neutralizing neutralizing effect nucleocapsid nucleoprotein ORF Particle particle infectivity Particles pathogen performed produced SARS CoV SARS CoV-2 SARS-CoV-2 spike spike lentiviral pseudotyping Spike protein the spike protein virion virions Virus neutralization while wild-type [DOI] 10.3389/fcimb.2021.663688 PMC 바로가기 [Article Type] Cellular and Infection Microbiology
A trans-complementation system for SARS-CoV-2 recapitulates authentic viral replication without virulenceSARS-CoV-2에 대한 트랜스 보완 시스템은 독성 없이 진정한 바이러스 복제를 요약합니다.Article Published on 2021-04-152022-09-11 Journal: Cell [Category] MERS, SARS, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antiviral biosafety level Biosafety Level 3 BSL-2 laboratory BSL-3 can be used Cell cell line Complementation component coronavirus COVID-19 Culture deleted deletions detectable Diagnosis disease dose envelope gene exhibited expressing gene deletions generate Genes genomic hamster hamsters highest infect inoculated K18-hACE2 transgenic mice level 3 mutated naive cells neutralization ORF3 platform Research respiratory SARS-CoV-2 severe acute respiratory syndrome Coronavirus trans transcriptional regulator Vaccine Viral viral replication Viral RNA virion virions virulence wild-type SARS-CoV-2 [DOI] 10.1016/j.cell.2021.02.044 PMC 바로가기 [Article Type] Article
Glycans of SARS-CoV-2 Spike Protein in Virus Infection and Antibody ProductionMolecular Biosciences Published on 2021-04-132022-10-31 Journal: Frontiers in Molecular Biosciences [Category] COVID-19, [키워드] acute respiratory syndrome antibody production coronavirus COVID-19 pandemic death Defense epitope glycan glycosylation Host Host immune response immune response in viral indication Infection interactions Modification Neutralizing antibodies Production Protein Proteins reported resulting S protein SARS-CoV-2 SARS-CoV-2 (2019-nCoV) spike Structure Vaccine Vaccine development viral entry viral peptide virion [DOI] 10.3389/fmolb.2021.629873 PMC 바로가기 [Article Type] Molecular Biosciences
High-throughput, single-copy sequencing reveals SARS-CoV-2 spike variants coincident with mounting humoral immunity during acute COVID-19높은 처리량, 단일 사본 시퀀싱은 급성 COVID-19 동안 체액 면역 증가와 일치하는 SARS-CoV-2 스파이크 변이체를 보여줍니다Clinical Trial Published on 2021-04-082022-08-13 Journal: PLoS Pathogens [Category] MERS, SARS, 변종, 유전자 메커니즘, 임상, 치료기술, 치료제, [키워드] acute COVID-19 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 acute respiratory syndrome coronavirus-2 Analysis Antibody binding Antiviral antiviral drug antiviral therapies antiviral therapy applied approach arising autologous antibodies binding Cell culture clearance Clinical outcome Clustering contribute coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 cross-sectional analysis detect detectable domain epitope evade Evolution exhibit Frame furin furin cleavage site Genetic genetic diversity Genome genomic RNA Haplotype help Humoral immunity immune response immune responses Immune-mediated in vitro in vivo increase in independent individual individuals with COVID-19 infected individual infected individuals infecting initial intra-individual longitudinal analysis Mutation mutations Non-synonymous mutation NTD one individual participant Pathogenesis predominant regions respiratory reveal SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 genome SARS-CoV-2 genomes SARS-CoV-2 replication SARS-CoV-2 spike protein SARS-CoV-2 spike variant SARS-CoV-2 variant SARS-CoV-2 variants selected selection of variant sequence Sequencing sequencing technology serum serum sample Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 Spike protein study participant surface protein surface proteins susceptibility the SARS-CoV-2 Time frame upper respiratory sample variant variants Variation virion virus virus RNA virus variants viruses WA-1 reference with COVID-19 [DOI] 10.1371/journal.ppat.1009431 PMC 바로가기 [Article Type] Clinical Trial
Genetic variation analyses indicate conserved SARS-CoV-2-host interaction and varied genetic adaptation in immune response factors in modern human evolution유전적 변이 분석은 현대 인간 진화의 면역 반응 요인에서 보존된 SARS-CoV-2-숙주 상호작용과 다양한 유전적 적응을 나타냅니다.Review Published on 2021-04-012022-09-11 Journal: Development, growth & differentiation [Category] SARS, 변종, [키워드] absence ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 allele frequency Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 appear caused Chemokine receptor chromosome chromosome 3 conducted conserved coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 effectors Evolution Factor Factors Genes genes encoding Genetic genetic risk factor genetic risk factors Genetic variant genetic variants Genome-wide association study Haplotype host cell host cells Host immune response human evolution. immune immune response individual individuals Infection Interaction investigated molecular pandemic pathogen Pathogens Population populations recent receptor Research risk SARS-CoV-2 SARS-COV-2 infection segment severe acute respiratory syndrome Coronavirus severe COVID-19 severity of COVID-19 stimulate Variation virion [DOI] 10.1111/dgd.12717 PMC 바로가기 [Article Type] Review
A Whole Virion Vaccine for COVID-19 Produced via a Novel Inactivation Method and Preliminary Demonstration of Efficacy in an Animal Challenge ModelArticle Published on 2021-04-012022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] animal animal model antibody approach cellular fraction challenge clinical evaluation COVID-19 COVID-19 pandemic demonstration disease Diseases effective Efficacy flow cytometric hamster histopathological immune responses immune stimulation Immunological response Inactivated vaccine Inactivated virus vaccine Infection live SARS-CoV-2 many cases Model neutralizing antibody novel photochemical Prevent produced promote RBD Riboflavin SARS-CoV-2 SARS-CoV-2 virus single cell sequencing Spike protein spread of COVID-19 Th1 tissue utility UV light vaccination Vaccine vaccine candidate vaccine for COVID-19 vaccine production viral shedding virion [DOI] 10.3390/vaccines9040340 PMC 바로가기 [Article Type] Article
Effect of Inactivation Methods on SARS-CoV-2 Virion Protein and StructureSARS-CoV-2 비리온 단백질 및 구조에 대한 비활성화 방법의 영향Article Published on 2021-03-262022-09-01 Journal: Viruses [Category] SARS, 진단, 치료기술, [키워드] Antibody detection assays best biosafety biosafety level Biosafety Level 3 BSL3 comparable conditions conducted coronavirus detectable Effect electron microscopy ELISA Genome heat inactivation impacted inactivated inactivation Incubation Infection investigator investigators less level 3 meet protocol purification reduction Research respiratory resulting risk SARS-CoV-2 severe acute respiratory syndrome Coronavirus Severe Acute Respiratory Syndrome Coronavirus -2 Structure Treatment ultraviolet ultraviolet irradiation UV inactivation Viral Viral protein Viral proteins Viral RNA viral RNA quantification viral stocks virion virions virus western blot working [DOI] 10.3390/v13040562 PMC 바로가기 [Article Type] Article
Severe Acute Respiratory Syndrome Coronavirus 2 Spike Protein Based Novel Epitopes Induce Potent Immune Responses in vivo and Inhibit Viral Replication in vitroImmunology Published on 2021-03-262022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, SARS, [키워드] ACE2 acute respiratory syndrome Analysis angiotensin-converting enzyme 2 antiviral activity binding candidate cellular immune responses coronavirus coronavirus 2 develop domain domains effort epitope functional heptad repeat host cell humoral immune response implication in vitro in vivo Infection inhibit inhibitors inhibitory effect initiate murine model N-terminal domain novel NTD peptide peptides potent RBD receptor receptors Region replication of SARS-CoV-2 respiratory response responsible S glycoprotein S1 subunit SARS-CoV-2 shown spike spike (S) glycoprotein spike glycoprotein Spike-based vaccine subunits the receptor-binding domain the SARS-CoV-2 therapeutic Trimers Vaccine virion virus virus entry wild-type virus [DOI] 10.3389/fimmu.2021.613045 PMC 바로가기 [Article Type] Immunology
Computational characterization of inhaled droplet transport to the nasopharynxArticle Published on 2021-03-232022-10-29 Journal: Scientific Reports [Category] COVID-19, SARS, [키워드] airway biomedical engineering COVID-2019 determine distribution domain droplet Fluid dynamics help hospitalized COVID-19 patient Infection infectious dose Inhaled initial nasopharyngeal nasopharynx proceed question Respiratory tract diseases reveal sputum subject susceptibility the disease the SARS-CoV-2 Translational research Transmission transmission of SARS-CoV-2 Transport virion [DOI] 10.1038/s41598-021-85765-7 PMC 바로가기 [Article Type] Article