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[키워드] alterations Amino acid analysed antibiotic Antibiotic resistance Antibiotic treatment Antibiotics approach arise association Bacteria Beta-lactam beta-lactam antibiotics block blocks carried cause change children clinical setting collected Comprehensive description determinant determinants Diseases distribution DNA fragment explain Frequency Genetic genetic association genetic determinant genetic determinants Genome Genome sequencing Genome-wide association study genomes Haplotype identification identify INDEL indels independent dataset independent datasets introduced isolate isolates large sample leads lineages loci mechanism Meningitis morbidity morbidity and mortality more difficult mosaic Mutation nasopharyngeal non-susceptibility nucleotide organism performed pneumococcal Pneumonia pneumoniae populations predict Previous studies previous study raise Recombination reported resistance responsible sensitivity sequence single nucleotide Single nucleotide polymorphism single nucleotide polymorphisms SNPs Spread strain Strains Streptococcus pneumoniae susceptible Traditional Treatment understanding USA variant variants while
[DOI] 10.1371/journal.pgen.1004547 PMC 바로가기 [Article Type] Research Article