Nucleocapsid protein-dependent assembly of the RNA packaging signal of Middle East respiratory syndrome coronavirusResearch Published on 2018-05-242022-10-29 Journal: Journal of Biomedical Science [Category] Coronavirus, [키워드] addition assembly C-terminal domain coexpressed Culture dependent on expression functional GFP help Heterologous HUH7 cells indicated membrane MERS MERS-CoV MERS-CoV genome Microscopy Middle East mRNA N-terminal domain nucleocapsid protein nucleotide Particle positive-sense Protein respiratory syndrome coronavirus Result RNA RNA fragment RNA genome RNA packaging signal RNA structure SARS-CoV sequence single-stranded structural protein structural proteins the viral nucleocapsid viral genome virus virus infection virus particle VLP VLPs was determined [DOI] 10.1186/s12929-018-0449-x PMC 바로가기 [Article Type] Research
Role of Severe Acute Respiratory Syndrome Coronavirus Viroporins E, 3a, and 8a in Replication and PathogenesisResearch Article Published on 2018-05-222022-10-29 Journal: mBio [Category] Coronavirus, MERS, SARS, [키워드] absence activities acute respiratory syndrome antiviral therapy Cell cellular coronavirus CoV CoVs demonstrated domain E protein ENCODE full-length functional homologous mice motif Mutation Pathogenesis pathogenicity PBM PDZ Protein Proteins Replication required respiratory restored role SARS-CoV target Vaccines viability Viral protein viroporins virulence virus virus replication was performed while [DOI] 10.1128/mBio.02325-17 PMC 바로가기 [Article Type] Research Article
Machine learning identifies signatures of host adaptation in the bacterial pathogen Salmonella enterica기계 학습은 박테리아 병원체 Salmonella enterica에서 숙주 적응의 신호를 식별합니다Research Article Published on 2018-05-082022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, 살모넬라증, [키워드] analyses Analysis approach architecture Atypical bacterial pathogen Bacterial pathogens bacterial specy build captures change changes in Classifier complex interaction continuum convergence data sets Degradation detect disease disease phenotype Disease surveillance dissect enrichment Epidemic epidemiological purposes functional Gastrointestinal infection Genes genome sequence genomic data high mortality HIV host adaptation host range identify Immunocompromised implementation Inclusion Infection input invasive invasive disease lead Lineage lineages machine member metabolic pathway metabolic pathways Mortality Mutation New outcome pathogen pathogenic Pathogens phenotype Population predict Predictive protein coding gene protein coding genes public health random Random forest rare variant Rare variants required Salmonella Salmonella Enteritidis scaled sequence Sequencing shift species strain Strains sub-Saharan Africa Surveillance [DOI] 10.1371/journal.pgen.1007333 PMC 바로가기 [Article Type] Research Article
Early events during human coronavirus OC43 entry to the cellArticle Published on 2018-05-082022-10-29 Journal: Scientific Reports [Category] Coronavirus, MERS, [키워드] Actin Affect Cell cellular receptor Cluster confocal microscopy Coronaviridae family determine entry routes event Features functional human coronavirus OC43 Infection infection process Molecular biology recognize Research RNA viruses specificity susceptible cell Vesicle virulence virus [DOI] 10.1038/s41598-018-25640-0 PMC 바로가기 [Article Type] Article
Cryo-EM structure of infectious bronchitis coronavirus spike protein reveals structural and functional evolution of coronavirus spike proteinsResearch Article Published on 2018-04-232022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] bronchitis C-terminal domain comparison Comparisons complex coronavirus coronavirus spike protein Critical cryo-EM structure domain ectodomain Evolution evolutionary relationship feature function functional host cells IBV membrane fusion molecular N-terminal domain provided receptor reveal S1-NTD spike Spike protein spikes Structure trimeric unique viral entry viral evolution while γ-coronavirus [DOI] 10.1371/journal.ppat.1007009 PMC 바로가기 [Article Type] Research Article
Cyclic di-AMP regulation of osmotic homeostasis is essential in Group B Streptococcus삼투성 항상성의 순환 di-AMP 조절은 B군 연쇄상 구균에서 필수적입니다Research Article Published on 2018-04-162022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] absence accumulating accumulation assumed Bacteria Bacterial betaine bind binding cellular cellular physiology compensatory mutations conditions conserved Control cyclic dacA Deletion demonstrated dependent on enzyme etiological agent expression function functional glycine glycine betaine group growth homeostasis host cell host cells host-pathogen interactions hyperosmotic identification identify Infection involved leads Loss loss-of-function loss-of-function mutation maintain mechanism medium Meningitis monophosphate mutant Mutation Neonatal nucleotide nucleotides opportunistic pathogen osmolyte osmoregulation osmotic osmotic regulation pathogen pathway phenotype Potassium predominant promoter Protein regulate Regulation second messenger second messengers secondary messenger septicaemia Streptococcus Streptococcus agalactiae susceptibility Transcription transcriptional viability [DOI] 10.1371/journal.pgen.1007342 PMC 바로가기 [Article Type] Research Article
Contribution of porcine aminopeptidase N to porcine deltacoronavirus infectionArticle Published on 2018-04-112022-10-31 Journal: Emerging Microbes & Infections [Category] Coronavirus, [키워드] adopted alphacoronavirus amino acid sequence aminopeptidase N Analysis antibody BHK-21 cell blocked C-terminal domain Cell Cluster Contact coronavirus CoV CoVs Critical effort Evolution explain expression functional gastroenteritis Infection information inhibitor Interaction intestinal epithelial cells involved Porcine deltacoronavirus Protein receptor receptors recognize residue Support susceptible TGEV Treatment turn Variation virus [DOI] 10.1038/s41426-018-0068-3 PMC 바로가기 [Article Type] Article
Functional diversification accompanies gene family expansion of MED2 homologs in Candida albicans기능적 다양화는 칸디다 알비칸스에서 MED2 상동체의 유전자 패밀리 확장을 수반합니다Research Article Published on 2018-04-092022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] 3’ end accompany addressed affected aggregation biological function Biological functions buffer Candida Candida albican Candida albicans Cell Combination commensal complex component conserved contribute contributed correlated did not produce difficulty domain duplication Effect entire gene example expansion expression facilitate family members function functional functions Gene duplication gene families gene family generate Genes genetic diversity greater growth homolog identify INDEL individual gene individual genes induced Infection influence involved killing Macrophage mapped mechanism mediator Mutation natural selection neofunctionalization occurred opportunistic pathogen organism overlap pathogen pathogenic phenotype Phenotypes phenotypic phenotypic effect polymorphic site Positive selection promoter provide question regulate regulated Regulation Regulatory repeated selective pressure sequence sequence similarity Specific strain Strains subfunctionalization subunit sucrose traits transcriptional transcriptional regulator unique Variability variant virulence were assessed yeast [DOI] 10.1371/journal.pgen.1007326 PMC 바로가기 [Article Type] Research Article
High-throughput interaction screens illuminate the role of c-di-AMP in cyanobacterial nighttime survival높은 처리량 상호 작용 화면은 시아노박테리아 야간 생존에서 c-di-AMP의 역할을 조명합니다.Research Article Published on 2018-04-022022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] adaptation addition Affect Analysis approach approaches Bacteria biochemical cdaA cells cellular characterization characterized conducted conserved cyanobacteria cyclase cyclic darkness death determine DNA ENCODE enzyme expand fitness function functional Genes Genetic genetic interaction genetic interactions growth identify implicated IMPROVE Interaction interactions involved management metabolism microorganisms molecule monophosphate mutant mutants Mutation nucleotide occur organism Organisms oxidative stress pathway Pathways phylum Potassium produced proteomic Quantitative Research responsible resulting Signaling Stress management survival Synechococcus synthesis technique Transport viability [DOI] 10.1371/journal.pgen.1007301 PMC 바로가기 [Article Type] Research Article
Tuning Hsf1 levels drives distinct fungal morphogenetic programs with depletion impairing Hsp90 function and overexpression expanding the target spaceHsf1 수준을 조정하면 고갈이 Hsp90 기능을 손상시키고 과발현이 대상 공간을 확장하여 독특한 곰팡이 형태 발생 프로그램을 구동합니다.Research Article Published on 2018-03-282022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] absence bypassing Candida albican Candida albicans cellular changes in chaperone complex conserved Control Critical defend Depletion developmental dose-dependent driving elevated temperature environmental cue environmental cues Fever fluctuation form functional fungal fungal pathogen Gene Expression growth Heat shock highlight Host host response hosts Hsf1 Hsp90 Human impairing induce Infection mammalian mechanism microorganism microorganisms modulate molecular morphogenesis observé overexpression pathogen Pathogens physiological temperature positive provide regulate Regulation required respond survival target temperature transcription factor transcriptional tuning virulence yeast [DOI] 10.1371/journal.pgen.1007270 PMC 바로가기 [Article Type] Research Article