Ookinete destruction within the mosquito midgut lumen explains Anopheles albimanus refractoriness to Plasmodium falciparum (3D7A) oocyst infection모기 중장 lumen 내에서의 오키네트 파괴는 Anopheles albimanus가 Plasmodium falciparum (3D7A) 포자 감염에 저항성을 보이는 이유를 설명합니다.Article Published on 2012-03-012024-08-26 Journal: International Journal for Parasitology [Category] 말라리아, [키워드] Bloodmeal malaria midgut Mosquito oocyst Ookinete Parasite–vector interaction susceptibility [DOI] 10.1016/j.ijpara.2011.12.005 PMC 바로가기 [Article Type] Article
SREBP Coordinates Iron and Ergosterol Homeostasis to Mediate Triazole Drug and Hypoxia Responses in the Human Fungal Pathogen Aspergillus fumigatusSREBP는 인간 곰팡이 병원체 Aspergillus fumigatus에서 트리아졸 약물 및 저산소증 반응을 중재하기 위해 철과 에르고스테롤 항상성을 조정합니다Research Article Published on 2011-12-012022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] A. fumigatus acquisition activated adaptation Adding addition advance Aspergillus fumigatus Author binding Candida albican Candida albicans caused cellular response class clinically condition conditions Coordinate Critical Cryptococcus neoforman Cryptococcus neoformans decrease dependent on drug drug susceptibility drugs ergosterol eukaryotes found foundation fungal fungal infections fungal pathogen Gene Genetic growth growth defect Health Human hypoxia hypoxic identify immunocompromised condition infections initial involved iron iron homeostasis Iron metabolism led to lethal disease majority mechanism metabolism microenvironment Most patients mRNA mutant mutants pathogenic Pathogens Patient phenotype Protein regulate Regulation regulatory element required response restoration Sterol Support susceptibility susceptible These data transcription factor transcription factors triazole virulence [DOI] 10.1371/journal.pgen.1002374 PMC 바로가기 [Article Type] Research Article
A Genome-Wide Meta-Analysis of Six Type 1 Diabetes Cohorts Identifies Multiple Associated Loci6개의 1형 당뇨병 코호트에 대한 게놈 전체 메타 분석으로 여러 관련 유전자좌 식별Research Article Published on 2011-09-292022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] ADCY3 affected association Author C6orf120 CENPO chromosomal combined cohort contributing to controls dataset diabete diabetes disease DLL1 DNAJC27 DNMT3A domain EFR3B examined excess FAM120B Follow-up Gene gene network gene networks Genes Genetic genetic component genetic loci genetic screening Genome Genome-wide association studies Genome-wide association study genome-wide significance genotyped GWAS homolog hypotheses identify Impact independent intergenic region intronic region investigator investigators Linkage disequilibrium LMO7 LOC154449 loci meta-analyses Meta-analysis Multiple NCOA1 Pathogenesis PHF10 POMC Protein PSMB1 reached recent finding Region replicated risk risk for disease significantly SNP SNPs susceptibility T1D TBP the disease Type Type 1 diabetes variant variants WDR27 [DOI] 10.1371/journal.pgen.1002293 PMC 바로가기 [Article Type] Research Article
Large-Scale Gene-Centric Analysis Identifies Novel Variants for Coronary Artery Disease대규모 유전자 중심 분석으로 관상동맥 질환에 대한 새로운 변종 식별Research Article Published on 2011-09-222022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] ABCG5 ABCG8 aetiology Affect allele Analysis array Artery Asians association association tests Author biochemical CAD candidate gene cardiovascular disease cellular characterized COL4A1 COL4A2 common variants complement conducted Control controls Coronary Coronary artery Coronary artery disease custom-designed array customised gene array CYP17A1 disease Effect European Europeans Evidence evidence of examined except for found Frequency function functional variant functional variants Gene Gene Expression Genes Genetic Genetic variant genome-wide association genotyped GWA heart disease help heterogeneity identify IL5 LIPA loci low frequency LPA majority mechanism not differ novel novel association novel associations Odds ratio Potential potential mechanism potential mechanisms replicate Replication reported risk risk factor South South Asian suggested supported susceptibility susceptibility loci target tested therapeutic interventions TRIB1 variant variants Vascular ZC3HC1 [DOI] 10.1371/journal.pgen.1002260 PMC 바로가기 [Article Type] Research Article
Increase in serotype 19A prevalence and amoxicillin non-susceptibility among paediatric Streptococcus pneumoniae isolates from middle ear fluid in a passive laboratory-based surveillance in Spain, 1997-2009스페인에서 1997년부터 2009년까지 수동 랩 기반 감시에서 중이염 환아 스트렙토코커스 폐렴균 분리물에서 세로타입 19A 유행과 아모시실린 미감수성 증가.Research Article Published on 2011-09-122024-08-04 Journal: BMC Infectious Diseases [Category] 폐렴구균 감염증, [키워드] middle ear isolates non-susceptibility time trends serotype 19A Surveillance susceptibility [DOI] 10.1186/1471-2334-11-239 PMC 바로가기 [Article Type] Research Article
Genetic Variation of the Human α-2-Heremans-Schmid Glycoprotein (AHSG) Gene Associated with the Risk of SARS-CoV InfectionResearch Article Published on 2011-08-172022-10-28 Journal: PLoS ONE [Category] Coronavirus, MERS, [키워드] 95% CI 95% confidence interval adjusted odds ratio affected After age and sex AHSG Analysis AOR association Beijing Cohort cohort study Concentration CYP4F3 cytochrome P450 demonstrated family found Gene Genotype genotype data genotyped Guangzhou HCW healthy control Human human neutrophil inflammation-associated gene Inflammatory investigated leukotriene Linkage disequilibrium liver LTB4 Macrophage nucleocapsid protein polymorphism promoter Protein regulated Regulation required SARS Coronavirus SARS virus SARS-CoV SARS-CoV infection selected serum Serum level significantly SNP statistical analysis supported susceptibility the patient transcriptional activity variant [DOI] 10.1371/journal.pone.0023730 PMC 바로가기 [Article Type] Research Article
Association of Genetic Variants in Complement Factor H and Factor H-Related Genes with Systemic Lupus Erythematosus Susceptibility보체 인자 H 및 인자 H 관련 유전자의 유전적 변이체와 전신성 홍반성 루푸스 감수성의 연관성Research Article Published on 2011-05-262022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Activation addition African American African Americans allelic American amplification Analysis Asian Asians association Author Autoimmune disease Case-control causal variant CFH CFHR1 CFHR3 CFHR4 CFHR5 chromosome chromosome 1q32 complement Complement activation complex contribute datasets Deletion described detected disease-associated downstream dysregulated Ethnic groups European Evidence exonic exonic SNPs Factor FIVE Gene genes encoding Genetic variant genetic variants genotypic haplotype analysis heterozygous higher risk homozygous human disease human diseases impair intron Intronic locus Lupus lupus erythematosus multiplex Pathogenesis populations Previous studies previous study probe Protein provide provided Regulation Significant SLE SNP SNPs subject suggested susceptibility systemic systemic lupus erythematosus tested variant variants [DOI] 10.1371/journal.pgen.1002079 PMC 바로가기 [Article Type] Research Article
A Decline in p38 MAPK Signaling Underlies Immunosenescence in Caenorhabditis elegansCaenorhabditis elegans에서 p38 MAPK 신호 전달의 감소는 면역 노화의 기초가 됩니다Research Article Published on 2011-05-192022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] addressed age aging amplify Author Bacteria Bacterial Bacterial infection Caenorhabditis Caenorhabditis elegan Caenorhabditis elegans change conserved cycle death Decline declines Defense defined Deterioration elegan examined exhibit Genetic Host host defense human pathogen humans immune function immunosenescence impair implicated increase in Infection innate immune Innate immunity intestinal intestinal tissue involved leads MAPK mice mitogen mitogen-activated protein kinase molecular basis molecular mechanism motion pathogen pathway phenomenon PMK-1 proliferation promote Protein protein kinase Pseudomonas aeruginosa regulate signaling pathway susceptibility tissue damage turn [DOI] 10.1371/journal.pgen.1002082 PMC 바로가기 [Article Type] Research Article
A −436C>A Polymorphism in the Human FAS Gene Promoter Associated with Severe Childhood MalariaA −436C>심각한 아동기 말라리아와 관련된 인간 FAS 유전자 프로모터의 다형성Research Article Published on 2011-05-192022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, 말라리아, [키워드] 95% confidence interval A allele a major activated affected allele Analysis Anemia Apoptosis applied assigned association Author carried Case-control caused CD69 Cell cell surface receptor cerebral malaria childhood children Community compared complex interplay complications Control Donor ENCODE Endemic Express expression FACS analysis FAS fatality found functional Genetic variant genetic variants genetics Health healthy individual help heterozygote homozygote homozygous Human Human genetics immune regulation immune response immune responses increased expression individual Infection investigated involved life-threatening locus lymphocyte Lymphocytes malaria molecule mononuclear cell mononuclear cells naïve nucleotide Occurrence Odds ratio outcome Pediatric case Peripheral blood Peripheral blood mononuclear cells phenotypic Plasmodium Plasmodium falciparum predisposition programmed cell death promoter promoter region proportion PROTECT Protective protective immune response Replication risk severe severe malaria significantly significantly higher Single nucleotide variant sub-Saharan Africa subgroup surface receptor susceptibility susceptible syndrome T-lymphocyte the disease Transmission dynamics variant West [DOI] 10.1371/journal.pgen.1002066 PMC 바로가기 [Article Type] Research Article
Avian coronavirus infectious bronchitis virus susceptibility to botanical oleoresins and essential oils in vitro and in vivoArticle Published on 2010-01-212022-11-01 Journal: Virus research [Category] Coronavirus, MERS, [키워드] addition Administering Botanical extracts Clinical sign Compound coronavirus CPE, cytopathic effects Dilution disease effective EID50, 50% embryo infectious dose ELISA, enzyme linked immunosorbent assay essential oils examined expected greater HMA, hexamethylene amiloride Host IBV IBV, infectious bronchitis virus in vitro in vivo Infection Infectious Bronchitis Virus investigated knowledge Laboratory lesion Massachusett MHV, mouse hepatitis virus Natural ingredients Oleoresins PBS, phosphate buffered saline protection reduced RFLP, restriction fragment length polymorphism RT-PCR, Reverse transcriptase-polymerase chain reaction SARS-CoV, Severe Acute Respiratory Syndrome virus serotype severity SPF, specific pathogen free susceptibility TCID50, 50% tissue culture infectious dose Transmission Treatment Vero E6 cell Viral RNA virucidal virus Virus challenge virus inactivation virus titer viruses was determined [DOI] 10.1016/j.virusres.2010.01.006 PMC 바로가기 [Article Type] Article