Safety and Immunogenicity of Newborn MVA85A Vaccination and Selective, Delayed Bacille Calmette-Guerin for Infants of Human Immunodeficiency Virus-Infected Mothers: A Phase 2 Randomized, Controlled Trial신생아 MVA85A 백신 접종 및 인간 면역결핍 바이러스에 감염된 산모의 유아를 위한 선택적 지연 Bacille Calmette-Guerin의 안전성 및 면역원성: 2상 무작위, 대조 시험Articles and Commentaries Published on 2018-02-152022-09-06 Journal: Clinical Infectious Diseases: An Official Publicat [Category] Communicable Disease, [키워드] acquisition Ag85A age appear ARMS bacille Calmette-Guérin BCG BCG vaccination boost candidate CD4 CD4+ T cell CD4+ T cells CD4+ T-cell clinical control arm Controlled Delayed disease double-blind ENhance enrolled excluded Follow-up followed by functional HIV HIV infection HIV-exposed infants HIV-uninfected Human Human immunodeficiency virus IFNγ immune response immunodeficiency virus immunogenicity Infant interfere interferon gamma life magnitude memory MVA85A New Newborn no significant difference Phase 2 phenotype potential risk profiles PROTECT randomized, controlled trial reactogenicity event Registration response Result Safe Safety selective Serious Adverse Events significantly higher subsequent T cells T-cell Response tested Tuberculosis tuberculosis disease tuberculosis vaccine vaccination Vaccination strategy vaccinees [DOI] 10.1093/cid/cix834 PMC 바로가기 [Article Type] Articles and Commentaries
Shared genetic regulatory networks for cardiovascular disease and type 2 diabetes in multiple populations of diverse ethnicities in the United States미국 내 다양한 민족의 여러 인구에서 심혈관 질환 및 제2형 당뇨병에 대한 공유 유전 조절 네트워크Research Article Published on 2017-09-282022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activity African Americans alterations American Americans Amino acid amino acid metabolism amino acids biological processe biological processes branched-chain amino acids cardiovascular cardiovascular disease cardiovascular diseases cause causes CAV1 Cell culture co-expression Cohort commonality complex disease connection Critical CVD data-driven death diabetes disease Diseases Diversity driven by driver ENCODE Epidemics eQTLs expression expression quantitative trait loci Extracellular matrix finding FIVE functional Functional genomics gene knockout gene network gene networks Genetic genetic risk Genome-wide association study Glucose graphical models GWAS GWAS hit help Hispanic HMGCR human population human populations hybrid identify IGF1 immune response in vitro in vivo information Integrative analysis knockdown lipids loci mechanism metabolism molecular molecular network mouse Mouse models multidimensional multiple tissues network models neuronal offer overlapping Panel Pathogenesis pathogenic pathogenic processe pathway Pathways PCOLCE Population populations Quantitative Regulatory regulatory network Risk factors shared pathway shared pathways siRNA Strains Support T2D the United State therapeutic therapeutic target tissues type 2 diabete type 2 diabetes [DOI] 10.1371/journal.pgen.1007040 PMC 바로가기 [Article Type] Research Article
PKA activity is essential for relieving the suppression of hyphal growth and appressorium formation by MoSfl1 in Magnaporthe oryzaePKA 활성은 Magnaporthe oryzae에서 MoSfl1에 의한 균사 성장 및 부착기 형성 억제를 완화하는 데 필수적입니다.Research Article Published on 2017-08-142022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Activation affinity Affinity purification Author C-terminal CAMP catalytic subunit cellular processe characterized co-IP conidia conidiation conserved Critical Deletion downstream eukaryotic cell eukaryotic cells Extracellular function functional functions Fusarium growth growth defect hyphal Infection insertion Interaction invasive involved IP assays loss-of-function mutation loss-of-function mutations Magnaporthe mutant mutants Mutation overlapping Pathogenesis pathway penetration Phosphorylation PKA produced purification reduced regulate regulated repressor residue response signaling pathway significantly strain Strains suppress suppressed suppression suppressor suppressors transcription factor transcriptional Treatment was reduced yeast [DOI] 10.1371/journal.pgen.1006954 PMC 바로가기 [Article Type] Research Article
Distinguishing functional polymorphism from random variation in the sequences of >10,000 HLA-A , -B and -C alleles10,000개 이상의 HLA-A, -B 및 -C 대립유전자 서열의 무작위 변이로부터 기능적 다형성 구별Research Article Published on 2017-06-262022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] allele alleles amino-acid Analysis Antigen applicability binding site bone-marrow transplant bone-marrow transplants breadth common allele common alleles core alleles Defense determined by develop distinguishing domain Donor donors effort engage exponential growth Facilitating Families family family member Frequency functional Genetic variation glycoprotein growth HLA HLA class I HLA class I alleles HLA class I glycoproteins HLA complex HLA gene HLA genes HLA type HLA variation HLA-A HLA-B HLA-C HLA-C alleles homologous human gene human genes Human genome human population human populations immune functions immune reaction immune system genes incidence individuals Infection kill lymphocyte majority MOST Mutation mutation rate nucleotide nucleotides Older Patient peptide peptides Point mutation polymorphism populations Positive selection predict produced random receptors recombinant recombinants registries required selected sequence sequenced Sequencing Single nucleotide polymorphism single nucleotide polymorphisms Spread subject Substitution the patient variant variants Variation Viral viral infections [DOI] 10.1371/journal.pgen.1006862 PMC 바로가기 [Article Type] Research Article
Detection of alpha- and betacoronaviruses in rodents from Yunnan, ChinaResearch Published on 2017-05-262022-10-28 Journal: Virology Journal [Category] Coronavirus, MERS, [키워드] Alpha alphacoronavirus alphacoronaviruses Analysis Apodemus Betacoronavirus characterized China collected conserved coronavirus Coronaviruses detection domains Eothenomy Evolution expected feature full-length genome functional genetic diversity Genome help Host infect intestinal investigated Lineage mammal much higher nucleocapsid protein nucleotide ORF3 ORF8 gene other coronavirus Pathogens Phylogenetic Rattus reservoir Result rodent S gene sequence similarity supplementary material Surveillance transcription regulatory sequence TRS upstream variant [DOI] 10.1186/s12985-017-0766-9 PMC 바로가기 [Article Type] Research
miR-142-5p Disrupts Neuronal Morphogenesis Underlying Porcine Hemagglutinating Encephalomyelitis Virus Infection by Targeting Ulk1Microbiology Published on 2017-05-032022-10-31 Journal: Frontiers in Cellular and Infection Microbiology [Category] Coronavirus, MERS, [키워드] cause caused Central nervous system CNS Control cortical demonstrated dendritic disease disrupting dysfunction Encephalomyelitis functional Host increased survival Infection inhibitor Injury mice microenvironment microRNA miR-142-5p morphogenesis mRNA neurodegeneration neurodegenerative neurological Neuron neuronal neuronal morphogenesis neurotropic virus PHE phenotype porcine hemagglutinating encephalomyelitis virus provided regulate Relieving significantly spatiotemporal targeting Ulk1 viral replication virus [DOI] 10.3389/fcimb.2017.00155 PMC 바로가기 [Article Type] Microbiology
Allosteric inhibition of aminopeptidase N functions related to tumor growth and virus infectionArticle Published on 2017-04-102022-10-29 Journal: Scientific Reports [Category] Coronavirus, [키워드] addition aminopeptidase N APN approach bind binding blocking Cancer Cell cell entry cell entry receptor cell surface coronavirus crystal structure defined drug ectodomain envelope protein function functional functions hydrolysis inhibit inhibited Ligand membrane-bound occur offered peptide prevented progression Protein regulate Structure suppress Therapies tumor cell tumor growth virus virus infection [DOI] 10.1038/srep46045 PMC 바로가기 [Article Type] Article
Further Evidence for Bats as the Evolutionary Source of Middle East Respiratory Syndrome CoronavirusResearch Article Published on 2017-04-042022-10-29 Journal: mBio [Category] Coronavirus, [키워드] Amino acid amino acid substitution Analysis approach bat binding clone competent coronavirus CoV Critical current described determine DPP4 driving ecological effort epithelial cells Evidence Evolution Express expressing Factor functional Genome humans Hypothesis identity infect infect cell Infection investigated MERS MERS coronavirus MERS-CoV Middle East novel virus pandemic phenotype Pipistrellus predicted primary human airway primary mechanism receptor Receptor binding recombinant Recombination Replication residue respiratory risk sequence Source spike spike gene Spike protein Spread Surveillance syndrome the S1 subunit the spike protein Uganda unlikely Variation Vero Cell Vespertilionidae virus viruses zoonoses zoonotic zoonotic threat [DOI] 10.1128/mBio.00373-17 PMC 바로가기 [Article Type] Research Article
Aminopeptidase N is not required for porcine epidemic diarrhea virus cell entryArticle Published on 2017-03-282022-11-01 Journal: Virus research [Category] Coronavirus, [키워드] alphacoronavirus aminopeptidase aminopeptidase N APN applied binding blocked cause Cell cell entry coronavirus diarrhea epidemic diarrhea examined exhibited expressed expressing expression functional gastroenteritis Genetic Genome had no HCoV-229E Hela host cell receptor Huh7 human cell line human coronavirus 229E indicated infect Infection intestinal epithelium knockout MDCK cell observation overexpression pathogenic coronavirus PEDV Porcine epidemic diarrhea virus preincubation Protein receptor reported required Result resulting S1 subunit Surface glycoprotein susceptibility susceptible TGEV these cell viral spike virus Virus cell entry viruses [DOI] 10.1016/j.virusres.2017.03.018 PMC 바로가기 [Article Type] Article
Overlapping SETBP1 gain-of-function mutations in Schinzel-Giedion syndrome and hematologic malignanciesSchinzel-Giedion 증후군 및 혈액 악성 종양에서 중복 SETBP1 기능 획득 돌연변이Research Article Published on 2017-03-272022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] accumulation activating affecting alteration alterations Author Cancer caused cell proliferation cellular characterized clinical information clinical phenotype Clustering Cohort collected de novo de novo mutation Degradation developmental developmental disorder developmental disorders disrupt Disruption distribution Drawing driven by driving Effect event events ExoN functional gain-of-function genetics Genotype genotype-phenotype correlation germline Hematologic malignancy hotspot implicated in silico in vitro incidence increase in increased risk individual lead leukemia magnitude malformation malignancy Mendelian disorder Mendelian disorders molecular Mutation mutations neurological occur overlap Patient phenotype prenatal development Previous studies previous study Protein protein level protein levels Regulation required residue risk SETBP1 signal significantly more somatic mutation somatic mutations stability subject Substitution substitutions Support syndrome threshold [DOI] 10.1371/journal.pgen.1006683 PMC 바로가기 [Article Type] Research Article