The impact of viral hepatitis-related hepatocellular carcinoma to post-transplant outcomesArticle Published on 2016-01-012023-06-19 Journal: Journal of viral hepatitis [Category] B형 간염, [키워드] graft loss hepatitis B hepatitis C Hepatocellular carcinoma liver transplant survival [DOI] 10.1111/jvh.12449
The Effect of Therapeutic Lumbar Punctures on Acute Mortality From Cryptococcal Meningitis치료적 요추 천자가 크립토코커스 수막염으로 인한 급성 사망률에 미치는 영향HIV/AIDS Published on 2014-12-012022-09-06 Journal: Clinical Infectious Diseases: An Official Publicat [Category] Communicable Disease, [키워드] acute mortality adjusted relative risk Altered mental status ART association baseline cerebrospinal fluid COAT trial Conducting cryptococcal meningitis Cryptococcal Optimal ART Timing cryptococcosis CSF CSF fungal death diagnose Diagnosis Effect elevated Epidemiology Follow-up HIV Human immunodeficiency virus ICP immunodeficiency virus individual initial initial pressure intracranial pressure investigated Lumbar puncture lumbar punctures magnitude management Meningitis Mortality occurred Patient randomization Randomized receiving Relative risk risk screened South Africa sub-Saharan Africa subject subsequent survival Symptoms therapeutic LP therapeutic LPs therapeutic lumbar punctures time of death Trial Uganda was related [DOI] 10.1093/cid/ciu596 PMC 바로가기 [Article Type] HIV/AIDS
Beclin 1 Is Required for Neuron Viability and Regulates Endosome Pathways via the UVRAG-VPS34 ComplexBeclin 1은 뉴런 생존에 필요하고 UVRAG-VPS34 복합체를 통해 엔도솜 경로를 조절합니다Research Article Published on 2014-10-022022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activity addition animal model assembly autophagosome autophagy Beclin 1 Brain cause cell line cellular characterized Complete complex complexes conditions Coordinate deficiency disease Diseases Disruption distribution EEA1 endocytosis endosome Endosomes Evidence failure function Genetic human disease impair impairment implicated in addition to in vivo Infectious disease Interaction involved leads maintain mammalian maturation membrane molecular mechanism mutant neurodegeneration neurodegenerative Neuron neuronal neurons nucleation organelle overexpressed p40 pathway Pathways phosphatidylinositol phosphatidylinositol 3-kinase physiological PI3K Previous studies previous study Protein recent recruit recruitment regulate Regulation required rescued reveal RUBICON survival tumorigenesis UVRAG viability [DOI] 10.1371/journal.pgen.1004626 PMC 바로가기 [Article Type] Research Article
The PDZ-Binding Motif of Severe Acute Respiratory Syndrome Coronavirus Envelope Protein Is a Determinant of Viral PathogenesisResearch Article Published on 2014-08-142022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, MERS, [키워드] activate activating Activation acute respiratory syndrome addition administration analyses assays caused Cell cellular complementary confocal microscopy coronavirus cytoplasm decrease decreased expression Deleterious demonstrated determinant domain E protein Elimination envelope Epidemic exacerbated functional genetics highlight immune response immunopathology in vivo increase in induce infecting Infection Inflammation Inflammatory cytokine Inflammatory cytokines inhibitor interact Interaction interactions involved lung lung damage MAPK mice modulating Mortality motif nucleus overexpression parental pathway potential therapeutic target Protein Proteins proteomic recombinant reduce reduction in respiratory SARS-CoV SARS-CoV E SARS-CoV infected cells SARS-CoV infection siRNA survival triggered triggering virulence virus virus attenuation was reduced yeast [DOI] 10.1371/journal.ppat.1004320 PMC 바로가기 [Article Type] Research Article
Nontypeable Haemophilus influenzae inhibits autolysis and fratricide of Streptococcus pneumoniae in vitro비결핵성 헤모필루스 인플루엔자는 스트렙토코커스 폐렴의 자가소멸과 형제살해를 억제한다.journal-article Published on 2014-03-012024-08-04 Journal: Microbes and Infection [Category] 폐렴구균 감염증, [키워드] autolysis Fratricide inhibit Nontypeable Haemophilus influenzae Streptococcus pneumoniae survival [DOI] 10.1016/j.micinf.2013.11.006 [Article Type] journal-article
Survival of Salmonella enterica in poultry feed is strain dependent살모넬라 엔테리카의 가금류 사료에서의 생존은 균주에 따라 다릅니다.journal-article Published on 2014-02-012024-07-31 Journal: Poultry Science [Category] 살모넬라증, [키워드] Gene regulation poultry feed Salmonella survival virulence [DOI] 10.3382/ps.2013-03401 [Article Type] journal-article
Age, Gender, and Cancer but Not Neurodegenerative and Cardiovascular Diseases Strongly Modulate Systemic Effect of the Apolipoprotein E4 Allele on Lifespan연령, 성별 및 암은 아니지만 신경퇴행성 및 심혈관 질환은 수명에 대한 아포지단백 E4 대립유전자의 전신 효과를 강력하게 조절합니다Research Article Published on 2014-01-302022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] adverse effect age allele Analysis ApoE APOE gene ApoE4 allele ApoE4 carrier APOE4 carriers Apolipoprotein Apolipoprotein e association Author Cancer cardiovascular cardiovascular and neurodegenerative diseases cardiovascular disease carriers Cohort cohorts compared CVD death deaths disease Diseases e4 allele e4 allele carrier e4 allele carriers e4 carrier e4 carriers Effect Enduring ENhance explain extreme family Family Study genetic origin genetic origins genotyped ApoE polymorphism Geriatrics Gerontology healthy heart Human human disease human diseases increase interfere large sample lead life Life expectancy lifespan Long Longitudinal studies Major mechanism mechanisms men moderate Mortality neurodegenerative neurodegenerative disorder neurodegenerative disorders Non-skin cancer offspring old ages participant polymorphism Population populations Relative risk resulting risk risk of death sensitivity skin cancer survival systemic women [DOI] 10.1371/journal.pgen.1004141 PMC 바로가기 [Article Type] Research Article
Influenza A virus survival in water is influenced by the origin species of the host cellOriginal Article Published on 2014-01-232023-06-08 Journal: Influenza and Other Respiratory Viruses [Category] 신종인플루엔자, [키워드] host cell Influenza lipid bilayer survival [DOI] 10.1111/irv.12179 PMC 바로가기 [Article Type] Original Article
The Transcription Factor BcLTF1 Regulates Virulence and Light Responses in the Necrotrophic Plant Pathogen Botrytis cinerea전사 인자 BcLTF1은 괴사성 식물 병원체 Botrytis cinerea에서 독성과 빛 반응을 조절합니다Research Article Published on 2014-01-092022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] absence accumulation addition Affect alternative oxidase alternative respiration enzymes antioxidants AOX apothecia applied approach arising Aspergillus nidulan Aspergillus nidulans Author BcLTF1 bctlf1 Botrytis cinerea caused characterized circadian rhythm conditions conidia continuous light Deletion dependent on detoxification detrimental effect detrimental effects dicotyledonous plant differentiation dispersal ecological ecological niche equilibrium Evidence exogenously exposure to expression expression level expression levels expression of gene Factor fertilization filamentous fungi fruiting bodies function fungal fungal pathogen fungi fungus GATA transcription factor Gene gene encoding Genes gray mold disease gray mold diseases growth rate growth rates homoeostasis homologue Host host infection hypersensitivity illumination impair Increased increased expression induce Infection LIGHT macroconidia macromolecule macromolecules majority metabolism Microarray analyses microarray analysis microconidia mitochondrial mitochondrial dysfunction modulated mutant mutants necrotrophic pathogen necrotrophic pathogen Botrytis cinerea Neurospora crassa NsdD Organisms Orientation over-expression overexpression oxidative stress oxygen Pathogens photomorphogenesis photoreceptor phototropism pigments plant plants predicted propagule propagules PROTECT random mutagenesis reactive oxygen species reactive oxygen specy Regulation reproductive required respiration enzymes respond response restoration ROS scavenging sclerotia Secondary metabolism sexual reproduction singlet oxygen spores Structure structures SUB-1 survival TF 1 transcription factor transcriptional level virulence [DOI] 10.1371/journal.pgen.1004040 PMC 바로가기 [Article Type] Research Article
Evaluation of novel lipid based formulation of β-Artemether and Lumefantrine in murine malaria modelArticle Published on 2013-10-152024-08-28 Journal: International Journal of Pharmaceutics [Category] 말라리아, [키워드] Artemether Lipid Lumefantrine Parasitemia recrudescence survival