Cleavage of the SARS Coronavirus Spike Glycoprotein by Airway Proteases Enhances Virus Entry into Human Bronchial Epithelial Cells In VitroResearch Article Published on 2009-11-172022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] 16HBE ACE2 ACE2 binding Activation acute respiratory syndrome against SARS-CoV airway Amino acid Analysis arginine residue bronchial bronchial epithelial cell cell entry Chromatography cleavage cleaved coronavirus demonstrated dependent on different Efficacy Efficiency exhibited expand expressing expression Extracellular finding full-length glycoprotein host cell HPLC Human implication in vitro investigated lack liquid mechanism molecular basis mutant not affect performance potential therapeutic agent protease Proteases Protein R667 R797 Receptor binding regulate Respiratory system S-protein SARS-CoV SARS-CoV infection Sequencing shown spike susceptibility susceptible Treatment trimer trypsin viral entry viral envelope virus virus entry [DOI] 10.1371/journal.pone.0007870 PMC 바로가기 [Article Type] Research Article
Type I interferon receptor-independent and -dependent host transcriptional responses to mouse hepatitis coronavirus infection in vivoResearch Article Published on 2009-08-032022-10-28 Journal: BMC Genomics [Category] Coronavirus, MERS, [키워드] Analysis Antiviral association BALB/c BALB/c mice Brain brains compared coronavirus Coronavirus infection correlated CoV CoV infection Culture days post infection demonstrated detected different differentially expressed effector expression profiling Fold change Gene Gene Expression gene expression profile Host transcriptional response identify IFN response IFN-inducible gene IFN-γ in vivo inducer Infected Infection infections interferon knowledge less MHV mice mouse hepatitis performed Profiling Protective protective role receptor response responses Result robust shown significantly Strains susceptibility susceptible tissue transcriptional responses Type type I Type I IFN type I interferon type II IFN Viral load virus were used while whole-genome [DOI] 10.1186/1471-2164-10-350 PMC 바로가기 [Article Type] Research Article
Lack of association between polymorphisms of MASP2 and susceptibility to SARS coronavirus infectionResearch Article Published on 2009-05-012022-10-28 Journal: BMC Infectious Diseases [Category] Coronavirus, [키워드] acute respiratory disease Algorithms allele Analysis analyzed association Beijing case-control study China control subjects downstream Evidence Frequency genetic parameters Genotype genotyping group Guangzhou homogeneous individual Infection MASP2 mean Pathogenesis PCR platform polymorphism populations Protein reported Result SARS Coronavirus SARS patient SARS-CoV Sequencing Serine Single nucleotide polymorphism SNP statistically significant susceptibility syndrome Tag throughput variant [DOI] 10.1186/1471-2334-9-51 PMC 바로가기 [Article Type] Research Article
Plaque assay for human coronavirus NL63 using human colon carcinoma cellsMethodology Published on 2008-11-122022-10-28 Journal: Virology Journal [Category] Coronavirus, [키워드] African green monkey Antiviral Avicel carboxymethyl-cellulose Cell Cell culture colds Colon coronavirus cytopathogenic effect days post infection demonstrated different disease Drug screening Effects HCoV HCoV-NL63 Human human pathogen humans Infection kidney log NL63 plaque Plaque assay plaque assays produced purification quantification replicated Result Support susceptibility tested utility viral infectivity virus virus infectivity virus replication virus stock [DOI] 10.1186/1743-422X-5-138 PMC 바로가기 [Article Type] Methodology
Failure to respond to the surface of Plasmodium falciparum infected erythrocytes predicts susceptibility to clinical malaria amongst African children플라스모디움 팔시파룸에 감염된 적혈구 표면에 대한 반응 실패는 아프리카 어린이들 사이에서 임상 말라리아에 대한 취약성을 예측합니다.Article Published on 2008-10-012024-08-26 Journal: International Journal for Parasitology [Category] 말라리아, [키워드] Antibody responses children Epidemiology immunology malaria Plasmodium falciparum sub-Saharan Africa susceptibility [DOI] 10.1016/j.ijpara.2008.03.009 PMC 바로가기 [Article Type] Article
Roles of TNF -α gene polymorphisms in the occurrence and progress of SARS-Cov infection: A case-control studyResearch Article Published on 2008-02-292022-10-28 Journal: BMC Infectious Diseases [Category] Coronavirus, [키워드] 95% CI acute respiratory syndrome adjusted Analysis association carried case-control study collected data compared conducted cured determine discharged fibrosis found Genetic polymorphism Genotype glucocorticoid Health care worker healthy controls Host genetic factor Infection interstitial locus Logistic lung Lung fibrosis manifested Necrosis not affect Occurrence PCR polymorphism prognosis of patient promoter region protective effect relationship Result risk risk factor role SARS patient SARS patients SARS-CoV infection Sequencing SNP susceptibility TNF TNF-α was used [DOI] 10.1186/1471-2334-8-27 PMC 바로가기 [Article Type] Research Article
The association of RANTES polymorphism with severe acute respiratory syndrome in Hong Kong and Beijing ChineseResearch Article Published on 2007-06-012022-10-28 Journal: BMC Infectious Diseases [Category] Coronavirus, MERS, [키워드] acute respiratory syndrome Admission Affect antiviral action association Beijing Chinese controls death examined G allele Genotype Hong Kong increased risk individual Inflammation intensive care unit IP-10 outcome Pathogenesis polymorphism RANTES Replication Result risk of death SARS patient susceptibility tested [DOI] 10.1186/1471-2334-7-50 PMC 바로가기 [Article Type] Research Article
Feline aminopeptidase N is not a functional receptor for avian infectious bronchitis virusResearch Published on 2007-02-262022-10-28 Journal: Virology Journal [Category] Coronavirus, [키워드] acute respiratory syndrome aminopeptidase N arch BHK-21 cell canine Cell cells chick compared coronavirus Coronaviruses Efficiency expression functional gastroenteritis GT HCoV-229E host cells host range human coronavirus 229E humans IBV identity Infected Infection infectious Infectious Bronchitis Virus Infectious disease Interaction kidney many cases mass Miguel notable receptor Result Strains suggested susceptibility susceptible TGEV transient transfection virus [DOI] 10.1186/1743-422X-4-20 PMC 바로가기 [Article Type] Research
SARS–associated Coronavirus Replication in Cell LinesResearch Published on 2006-01-012022-10-31 Journal: Emerging Infectious Diseases [Category] Coronavirus, [키워드] absence After Cell cell line cell lines cell susceptibility, cytopathic effects, research coronavirus Cytopathic effect cytopathic effects diagnostic immunofluorescence assay Infection infections investigated LINE polymerase chain Quantitative replicate Replication reported Research SARS-CoV susceptibility susceptible viral replication virus virus isolation was used [DOI] 10.3201/eid1201.050496 PMC 바로가기 [Article Type] Research
In vitro susceptibility of 10 clinical isolates of SARS coronavirus to selected antiviral compoundsShort Communication Published on 2004-05-182022-11-01 Journal: Journal of Clinical Virology [Category] Coronavirus, [키워드] acute respiratory syndrome antiviral activity antiviral agent Antiviral compound Antiviral compounds assay cell line cell lines Checkerboard Chinese Combination Compound different drug Epidemics glycyrrhizin interferon interferon-alpha isolate neutralisation test performed placebo controlled trial plaque reduction assays profile Prophylaxis randomised Result ribavirin SARS Coronavirus screened selected Severe acute respiratory syndrome susceptibility synergistic synergy Toxicity Treatment [DOI] 10.1016/j.jcv.2004.03.003 PMC 바로가기 [Article Type] Short Communication