Bypass of Candida albicans Filamentation/Biofilm Regulators through Diminished Expression of Protein Kinase Cak1단백질 키나제 Cak1의 발현 감소를 통한 칸디다 알비칸스 필라멘트/생물막 조절기 우회Research Article Published on 2016-12-092022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] absence activating Activation antimicrobial Antimicrobials bacterial pathogen biofilm bypass Candida Candida albican Candida albicans Cell cell cycle cell growth cell proliferation contribute coupling dependence determinant diminished Effectiveness Express expresse expression Filamentous functional Gene Expression Genes growth implicated induce Infection infections information inhibition invasive kinase leads Medical devices Mutation occur organism pathogen Pathogens proliferation property Protein protein kinase reduced regulator Regulatory required Screen Stimulation strain Strains Target genes the cell transcription factor transcription factors wild-type [DOI] 10.1371/journal.pgen.1006487 PMC 바로가기 [Article Type] Research Article
Design, Synthesis and Biological Evaluation of Novel Primaquine-Cinnamic Acid Conjugates of the Amide and Acylsemicarbazide TypeArticle Published on 2016-11-282022-10-30 Journal: Molecules [Category] Coronavirus, [키워드] 229E acid Activation activities Alter amide amide bond anticancer Antioxidative antioxidative activity Antiviral antiviral activity binding Biological CAD Cell cell line chloride cinnamic acid derivative Compound compounds Concentration concentrations conjugate Conjugates coronavirus cytostatic activity derivative DPPH evaluated Evidence functional group Hela highest inhibitor inhibitory activity LOX MCF-7 morphology motif novel performed primaquine reducing reported selective spacer synthesis Type [DOI] 10.3390/molecules21121629 PMC 바로가기 [Article Type] Article
Distinct Prion Domain Sequences Ensure Efficient Amyloid Propagation by Promoting Chaperone Binding or Processing In Vivo고유한 프리온 도메인 서열은 생체 내 샤페론 결합 또는 처리를 촉진하여 효율적인 아밀로이드 증식을 보장합니다Research Article Published on 2016-11-042022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] acting aggregate Alter Amino acid amyloid assembly binding change chaperone chaperones complementary composed conformation conformational conformational flexibility contribute creating efficient element elements Ensure functional in vitro in vivo inheritance Interaction maintain mechanism molecular observation occur open persistence physical physical properties predict prion processing promote Promoting Propagation Protein Protein misfolding Proteins proximal PSI question Regulation required resulting sequence Spectrum stability Transmission yeast [DOI] 10.1371/journal.pgen.1006417 PMC 바로가기 [Article Type] Research Article
Signaling through Lrg1, Rho1 and Pkc1 Governs Candida albicans Morphogenesis in Response to Diverse CuesLrg1, Rho1 및 Pkc1을 통한 신호는 다양한 신호에 대한 응답으로 Candida albicans 형태 형성을 제어합니다Research Article Published on 2016-10-272022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] absence Activation adenylyl cyclase allele Analysis blocked CAMP Candida Candida albican Candida albicans canonical cascade Cell cell growth concert Critical defined Deletion developmental disease downstream example form function functional fungal fungal pathogens Genetic growth GTPase healthy homozygous hosts Human humans hyphal identify Immunocompromised implicated inactive independent independent of Infection insertion invasive leads Lrg1 morphogenesis Morphological morphology mutant Mutation not impaired pathogen Pathogenesis Pathogens pathway positive promoted reduced regulate represse repression required response screened serum signaling pathway skin infections strain Strains transition transposon virulence yeast [DOI] 10.1371/journal.pgen.1006405 PMC 바로가기 [Article Type] Research Article
Widespread Shortening of 3’ Untranslated Regions and Increased Exon Inclusion Are Evolutionarily Conserved Features of Innate Immune Responses to Infection3' 번역되지 않은 영역의 광범위한 단축 및 증가된 엑손 포함은 감염에 대한 타고난 면역 반응의 진화적으로 보존된 특징입니다Research Article Published on 2016-09-302022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] 3’ UTR accompanied activated adaptive immune responses Bacteria Bacterial infection Bacterial infections cellular response Cellular responses change changes in characterized collected complementary conserved evade example ExoN expression Factor feature functional Gene Expression Gene regulation human macrophage human macrophages idea identify immune immune response immune responses Inclusion increase in Increased individuals Infection Innate innate immune response innate immune responses involved isoform less Listeria monocytogene Listeria monocytogenes Macrophage macrophages mechanism microRNA miRNAs mRNA non-human primates polyadenylation sites Post-infection pre-mRNA primates reduced Region regulate regulated Regulation repression response RNA Salmonella Typhimurium sequenced Sequencing shortening significantly Support tandem transcriptional response transcriptional responses upstream Usage UTRs Variation while whole blood sample [DOI] 10.1371/journal.pgen.1006338 PMC 바로가기 [Article Type] Research Article
Neocentromeres Provide Chromosome Segregation Accuracy and Centromere Clustering to Multiple Loci along a Candida albicans Chromosome네오센트로미어는 칸디다 알비칸스 염색체를 따라 여러 유전자좌에 염색체 분리 정확도 및 중심체 클러스터링을 제공합니다Research Article Published on 2016-09-232022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Accuracy adaptation addition approach assembly benefit Cancer cancer cell Cancer cells cancers Candida Candida albican Candida albicans caused Cell cell division centromere change Chemotherapy chromosome chromosome 5 chromosome segregation chromosomes Cluster Clustering complexes consequence Contact copy number de novo defined disease DNA DNA sequence drug resistance error rate exhibit function functional functions Gene Expression Genes Genome greater independent independent of instance kinetochore leads Like loci maintain mechanisms Multiple nuclear nucleus observation occur organism protein complex Proteins provide recent reduced Region reorganization required segregation speciation stability Support the cells three-dimensional structure Transcription yeast [DOI] 10.1371/journal.pgen.1006317 PMC 바로가기 [Article Type] Research Article
Human Management of a Wild Plant Modulates the Evolutionary Dynamics of a Gene Determining Recessive Resistance to Virus Infection야생 식물의 인간 관리는 바이러스 감염에 대한 열성 내성을 결정하는 유전자의 진화 역학을 조절합니다Research Article Published on 2016-08-042022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] allele alleles analysed Analysis assays Capsicum coding sequence cultivation Defense Determining Diseases Diversity Dynamics Effect electrostatic Evidence evidence of Evolution full-length functional gene encode Genetic variation genetics host-pathogen interaction host-pathogen interactions Human impairing Infection infection assay infection assays initiation factor Interaction involved loci management mapping Mutation Neutral no evidence of pathogen phenotypic Phylogeny physical plant plant virus plants Population populations Positive selection Potyvirus Proteins R genes recessive recognize resistance resistance gene resistance mutations Result resulting severity supported susceptibility translation initiation triggering Variation variety Viral viruses [DOI] 10.1371/journal.pgen.1006214 PMC 바로가기 [Article Type] Research Article
Cellular entry of the porcine epidemic diarrhea virusArticle Published on 2016-06-152022-11-01 Journal: Virus research [Category] Coronavirus, MERS, [키워드] Americas aminopeptidase N Asia binding binding activity carbohydrate Cell coronavirus Culture determine diarrhea domain East epidemic diarrhea epithelial cell Factor functional glycoprotein host cell in vitro in vivo Infection initial Interaction medium membrane fusion N-terminal observation outbreak PED PEDV Porcine epidemic diarrhea virus protease Protein proteolytic activation receptor receptor interaction replicate reported resulting S protein S proteins sialic acid Sialic acid binding small intestine spike subsequent target cell the S protein tissue tropism trimer villus virus virus entry virus infection virus tropism [DOI] 10.1016/j.virusres.2016.05.031 PMC 바로가기 [Article Type] Article
Comparative Genomic Analysis of Drechmeria coniospora Reveals Core and Specific Genetic Requirements for Fungal Endoparasitism of NematodesDrechmeria coniospora의 비교 게놈 분석을 통해 선충류의 곰팡이 내부 기생충에 대한 핵심 및 특정 유전적 요구 사항이 밝혀졌습니다.Research Article Published on 2016-05-062022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] acquisition adhesion Analysis arms race branch Caenorhabditis elegan Caenorhabditis elegans can be used characterisation characterized Comparative core Dissection elegan elegans Endoparasitism Evolution evolutionary arms race expresse expressed fluorescent reporter genes functional fungal Fungal infection fungi fungus Gene Expression Gene expression analysis gene families gene family Genes Genetic genetic engineering genetic transformation Genome genomic growth Host in silico infect Infection initial Interaction Interference involved kill killing knock-out knowledge lifecycle mechanism Modification molecular mycelia nematode nematodes NETs opens parasitic nematodes parasitism pathogen pathogen’ Phylogenetic analysis probe regulated reported reporter genes Requirement sequenced Specific spore Stage Tolypocladium transformation TRAP virulence [DOI] 10.1371/journal.pgen.1006017 PMC 바로가기 [Article Type] Research Article
The Caenorhabditis elegans Protein FIC-1 Is an AMPylase That Covalently Modifies Heat-Shock 70 Family Proteins, Translation Elongation Factors and HistonesCaenorhabditis elegans 단백질 FIC-1은 Heat-Shock 70 계열 단백질, 번역 연장 인자 및 히스톤을 공유적으로 수정하는 AMPylase입니다Research Article Published on 2016-05-032022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] approach ATP bacterial pathogen biochemical Caenorhabditis Caenorhabditis elegan Caenorhabditis elegans connection consequence conserved core histone domain elegan elegans elongation elongation factors Endoplasmic reticulum Factor Factors family family members functional Heat shock heat shock protein heat-shock protein histone identify in vitro in vivo innate immune response Innate immunity modify novel nuclear ortholog P . aeruginosa pathogen phenotype post-translational modification Previous studies previous study Protein Proteins Pseudomonas aeruginosa sequence identity substrate susceptibility target protein target proteins three-dimensional structure translation unfolded protein response UPR [DOI] 10.1371/journal.pgen.1006023 PMC 바로가기 [Article Type] Research Article