functional – Page 167 – Communicable Diseases Research

Surface vimentin is critical for the cell entry of SARS-CoV

Research

Published on 2016-01-222022-10-29
Journal: Journal of Biomedical Science [Category] Coronavirus,

Cleavage of a Neuroinvasive Human Respiratory Virus Spike Glycoprotein by Proprotein Convertases Modulates Neurovirulence and Virus Spread within the Central Nervous System

Research Article

Published on 2015-11-062022-10-29
Journal: PLoS Pathogens [Category] Coronavirus, MERS,

[키워드] affecting Amino acid amino acid change amino acid residue appear ATCC cDNA Central nervous system characterized cleavage cleavage site clone CNS colds contribute convertase coronavirus degenerative demonstrated dissemination Encephalitis etiologies feature functional functions furin-like cleavage site generate Genes glycoprotein HCoV-OC43 Human human respiratory tract identify Impact in viral Infection involved isolate isolates Laboratory less mechanism molecular Mutation nervous neurodegenerative Neuroinvasive neurologic neurological Neurological diseases neurotropic OC43 pathogenic Pathologies pathology Point mutation predominant proportion Proprotein Protein respiratory respiratory pathogen resulting retained S gene S glycoprotein S protein S1 and S2 sequence significantly spike System the S protein variant viral spike virulence virus virus spread while
[DOI] 10.1371/journal.ppat.1005261 PMC 바로가기 [Article Type] Research Article

The early immune response to infection of chickens with Infectious Bronchitis Virus (IBV) in susceptible and resistant birds

Research Article

Published on 2015-10-092022-10-28
Journal: BMC veterinary research [Category] Coronavirus,

[키워드] Affect analysed Bacterial infection biological pathway can be used candidate gene cause chicken contagious coronavirus disease Disease resistance Effect evaluated examined expression functional Gene Expression gene expression differences Genetic Genome help Host host response IBV IBV infection identify immune response Infection Infectious Bronchitis Virus innate immune response involved lesion Microarray Mortality occur Post-infection Potential reproductive resistance gene Respiratory disease responsible Result selective subsequent supplementary material susceptible target the disease tissue tracheal vaccination virus were used
[DOI] 10.1186/s12917-015-0575-6 PMC 바로가기 [Article Type] Research Article

Development of an indirect ELISA, blocking ELISA, fluorescent microsphere immunoassay and fluorescent focus neutralization assay for serologic evaluation of exposure to North American strains of Porcine Epidemic Diarrhea Virus

Methodology Article

Published on 2015-08-012022-10-28
Journal: BMC veterinary research [Category] Coronavirus,

[키워드] addition Analysis antibody Asia asked assays biotinylated calculated colostrum Coronaviruses correlation country cross-reactivity demonstrated described develop development diagnostic test Disadvantages ELISA epidemic diarrhea expressed fluorescent Fluorescent Focus Neutralization (FFN) Fluorescent microsphere immunoassay (FMIA) functional gastroenteritis highlight IFA Immune status immunoassay immunohistochemistry Interpretation kappa value Laboratory mAb mAbs magnetic bead measurement microsphere MONITOR monoclonal monoclonal antibody multiple antigen naïve Neutralization assay Neutralizing antibodies neutralizing antibody Neutralizing antibody response North North America outbreak pathogen PEDV porcine epidemic diarrhea virus (PEDV) protective immunity quantitation question receiver operating characteristic recent Respiratory Coronavirus Result ROC ROC analysis Sensitivity and specificity Seroconversion Serological assay serology serum serum sample significant level Spread staining strain TGEV vaccine candidate virus virus neutralizing antibodies was performed were used
[DOI] 10.1186/s12917-015-0500-z PMC 바로가기 [Article Type] Methodology Article

Protein-Protein Interactions of Viroporins in Coronaviruses and Paramyxoviruses: New Targets for Antivirals?

Review

Published on 2015-06-042022-10-28
Journal: Viruses [Category] Coronavirus,

Extensive Copy-Number Variation of Young Genes across Stickleback Populations

스틱백 개체군에 걸친 젊은 유전자의 광범위한 복사 수 변이

Research Article

Published on 2014-12-042022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] adaptive Analysis candidate Candidates category CNV CNV gene CNV genes CNVs Comparative genomics complexity copy-number variation copy-number variations disparate distribution duplicate gene Duplicate genes duplication duplications eco-genomic model ecological Effect elevated evaluate Evolution Extensive fixed Frequency function functional Genes Genetic genetic diversity Genome highlight identify individual Innovation interactions joint lineage-specific gene lineage-specific genes Local locus low frequencies molecular natural populations occur over Population population genomics population level populations prevalent producing selective pressure selective pressures Stage structural polymorphism subset teleost genome teleost genomes three-spined stickleback three-spined sticklebacks Variation whole genome sequence
[DOI] 10.1371/journal.pgen.1004830 PMC 바로가기 [Article Type] Research Article

Epigenome-Guided Analysis of the Transcriptome of Plaque Macrophages during Atherosclerosis Regression Reveals Activation of the Wnt Signaling Pathway

죽상경화증 퇴행 동안 플라크 대식세포의 전사체에 대한 후성유전체 분석은 Wnt 신호 전달 경로의 활성화를 보여줍니다

Research Article

Published on 2014-12-042022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] activated Affect Analysis annotations approach arterial plaque macrophage arteries Atherosclerosis binding site canonical Cell cell motility cell type chromatin circulating condition control group demonstrated detect differentially expressed drug treatments eight element enrichment epigenomic eQTL Evidence expression foam cell functional Gene Expression humans identify in vitro in vivo increase Inflammation inflammatory disease inflammatory state innate immune system less Lipoproteins lowering Macrophage Macrophage response macrophage responses macrophages mice Migration molecular mouse model network overlap plaque plaque macrophage plaque macrophage response plaque macrophage responses plaque macrophages plaque regression plaques plasma lipoprotein plasma lipoproteins power promoter promoters reducing regressing plaque regressing plaques Regression Regression model regression models regulatory region response reversed risk significantly SNPs statins statistically Stimulation Systems biology TCF/LEF therapeutic target transcription factor transcription factors transcriptional change Transcriptome upregulated upregulated gene upregulated genes upstream validation study while Wnt Wnt signaling Wnt signaling pathway β-catenin
[DOI] 10.1371/journal.pgen.1004828 PMC 바로가기 [Article Type] Research Article

Coronavirus nonstructural protein 1: Common and distinct functions in the regulation of host and viral gene expression

Article

Published on 2014-11-262022-11-01
Journal: Virus research [Category] Coronavirus,

CD26/DPP4 Cell-Surface Expression in Bat Cells Correlates with Bat Cell Susceptibility to Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Infection and Evolution of Persistent Infection

Research Article

Published on 2014-11-192022-10-28
Journal: PLoS ONE [Category] Coronavirus, MERS,

Selection on a Variant Associated with Improved Viral Clearance Drives Local, Adaptive Pseudogenization of Interferon Lambda 4 ( IFNL4 )

개선된 바이러스 제거와 관련된 변이체에 대한 선택은 인터페론 람다 4(IFNL4)의 국소적 적응형 가성화를 유도합니다.

Research Article

Published on 2014-10-162022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] ABC adaptive allele America Antiviral antiviral activity approach Approximate Asia Asian association Bayesian clearance complex conserved disease drive driving East Elimination ENCODE environmental force Europe European Evidence evidence of fixation Frame Frequency functional Genetic genetic association Genetic variant Genetic variation groups HCV hepatitis C hepatitis C virus heterogeneity Human human populations IFN-λ IFNL4 Improved inactivation Infection insertion Interferon lambda Lambda mammal mammals Migration moderate Mutation Open reading frame phenotype phenotypic diversity Population populations positive Positive selection Protein provide pseudogene raise raising reached resulting Selection selective SNP SNPs strength susceptibility the strongest turn variant virus
[DOI] 10.1371/journal.pgen.1004681 PMC 바로가기 [Article Type] Research Article