Association between biomarkers and COVID-19 severity and mortality: a nationwide Danish cohort study바이오마커와 COVID-19 심각도 및 사망률 사이의 연관성: 덴마크 전국 코호트 연구Article Published on 2020-12-022022-09-11 Journal: BMJ Open [Category] MERS, SARS, 바이오마커, [키워드] adjusted Admission adult intensive & age and gender Analysis association baseline level baseline levels Biochemistry Biomarker Biomarkers Bootstrapping C reactive protein cohort study Composite composite endpoint COVID-19 severity Critical Critical care CRP D-dimer death Denmark died Diseases EGFR elevated evaluate filtration rates general medicine (see internal medicine) glomerular filtration rate hospital ICU Infectious diseases Intensive intensive care intensive care unit internal medicine leucocyte leucocytes median age National normal outcome Patient patients with COVID-19 procalcitonin registry data retrospective cohort study risk significantly higher troponin urea ureas with COVID-19 [DOI] 10.1136/bmjopen-2020-041295 PMC 바로가기 [Article Type] Article
Remdesivir Is Effective in Combating COVID-19 because It Is a Better Substrate than ATP for the Viral RNA-Dependent RNA PolymeraseArticle Published on 2020-11-282022-10-30 Journal: iScience [Category] COVID-19, [키워드] acute respiratory syndrome Analysis ATP Better Biochemistry Biological Biological sciences Biology caused chaperone competing complex coronavirus COVID-19 Efficiency enzyme expression Genome inhibit inhibitor inhibitors kinetic analysis mechanism Molecular biology Molecular Biology Experimental Approach polymerase polymerization provide purification RdRP replicate RNA robust SARS-CoV-2 specificity substrate the SARS-CoV-2 treated [DOI] 10.1016/j.isci.2020.101849 PMC 바로가기 [Article Type] Article
Architecture of a SARS-CoV-2 mini replication and transcription complexArticle Published on 2020-11-182022-10-04 Journal: Nature Communications [Category] SARS, 변종, [키워드] architecture atomic Biochemistry cofactor complex component composed conformation Cryo-electron microscopy cryo-EM structure Cryoelectron microscopy determine facilitate form group Helicase Interaction Mutation non-structural protein Nsp12 nsp13 Orientation polymerase Protein RdRP Replication RNA RNA-dependent RNA polymerase RTC SARS-CoV-2 SARS-CoV-2 virus Transcription virus replication [DOI] 10.1038/s41467-020-19770-1 PMC 바로가기 [Article Type] Article
Clinical and radiographic characteristics, management and short-term outcomes of patients with COVID-19 in Wenzhou, ChinaResearch Article Published on 2020-11-132022-10-28 Journal: BMC Infectious Diseases [Category] COVID-19, SARS, [키워드] Admission antiviral drugs Biochemistry C-reactive protein Characteristics Chest China clinical Clinical characteristics Clinical features Computerized tomography confirmed COVID-19 case Coronavirus disease 2019 cough COVID-19 COVID-19 patient demographics Department Diagnosis diarrhea discharged distress Dizziness epidemiological history Epidemiology examined Fever headache hospital Hospitalization Infectious disease Isolation Laboratory tests management muscular nucleic acid tests observation outcome outcomes Oxygen therapy Patient patients patients with COVID-19 Prognosis Radiographic Radiographic characteristics recruited Result routine test SARS-CoV-2 severe cases Shortness of breath sore throat Symptom transferred treated Treatment viral disease was performed Wuhan [DOI] 10.1186/s12879-020-05528-z PMC 바로가기 [Article Type] Research Article
Ensemble description of the intrinsically disordered N-terminal domain of the Nipah virus P/V protein from combined NMR and SAXSArticle Published on 2020-11-112023-08-29 Journal: Scientific Reports [Category] E형 간염, [키워드] Biochemistry Biophysics structural biology [DOI] 10.1038/s41598-020-76522-3 PMC 바로가기 [Article Type] Article
The SARS-CoV-2 Conserved Macrodomain Is a Mono-ADP-RibosylhydrolaseStructure and Assembly Published on 2020-11-062022-10-30 Journal: Journal of Virology [Category] COVID-19, [키워드] activity acute respiratory syndrome addition ADP-ribose ADP-ribosylation affinity animal model Antiviral approved bind binding Biochemistry caused complex Compound conserved coronavirus CoV CoV infection COVID-19 Critical death demonstrated domain ELISAs enzyme enzyme activity enzyme-linked immunosorbent assay functions host response hydrolysis increasingly Mac1 macrodomain MAR MERS-CoV Middle East Modification mono-ADP-ribose nonstructural protein 3 Nsp3 Pathogenesis poly-ADP-ribose potential therapeutic target potential therapy Protein Proteins reagent regulate respiratory syndrome coronavirus SARS-CoV SARS-CoV-2 SARS-related CoV target proteins the SARS-CoV-2 therapeutic strategy therapeutic target unique viral infection viral infections virulence worldwide pandemic [DOI] 10.1128/JVI.01969-20 PMC 바로가기 [Article Type] Structure and Assembly
Selection, biophysical and structural analysis of synthetic nanobodies that effectively neutralize SARS-CoV-2Article Published on 2020-11-042022-10-29 Journal: Nature Communications [Category] COVID-19, SARS, [키워드] ACE2 binding ACE2 binding site Analysis antibody production approach bind Biochemistry Biophysics coronavirus SARS-CoV-2 costly COVID-19 COVID-19 pandemic cryo-EM cryo-EM structure high affinity Infectious diseases Isolation Molecular medicine nanobody nanomolar affinity neutralization activity neutralize neutralized Neutralizing activity neutralizing antibody Pseudotyped viruses pseudovirus RBD SARS-CoV-2 SARS-CoV-2 spike protein Selection spike Spike protein Structural analysis structural biology sybody synthetic nanobody the receptor-binding domain the SARS-CoV-2 viruses [DOI] 10.1038/s41467-020-19204-y PMC 바로가기 [Article Type] Article
Characteristics and outcomes of hospitalised patients with acute kidney injury and COVID-19급성신장손상 및 코로나19로 입원한 환자의 특징 및 결과Research Article Published on 2020-11-032022-08-13 Journal: PLoS ONE [Category] Biochemistry, COVID-19, MERS, [키워드] Acute kidney injury Admission Adult patients AKI association baseline characteristics Biochemistry Comorbidities COVID-19 Critical care death Deprivation Deterioration diagnosis of COVID-19 disease Escalation foundation hospital hospitalised patient Initially laboratory data mechanical ventilation medications Mortality multiple organ involvement observations outcome overall mortality P-value pandemic Patient patients patients with AKI patients with COVID-19 presenting Prevent Record renal renal disease renal function renal replacement therapy replacement therapy required respiratory Result retrospective retrospective review risk shown Spread the disease Trust university with COVID-19 World Health Organisation [DOI] 10.1371/journal.pone.0241544 PMC 바로가기 [Article Type] Research Article
Teaching biochemistry and molecular biology online in Nigeria: Missed opportunities during the COVID-19 pandemic나이지리아에서 온라인으로 생화학 및 분자 생물학 교육: COVID-19 전염병 동안 놓친 기회Article Published on 2020-11-012022-09-11 Journal: Biochemistry and Molecular Biology Education [Category] SARS, 유전자 메커니즘, [키워드] Biochemistry COVID-19 pandemic Missed Molecular biology Teaching [DOI] 10.1002/bmb.21463 PMC 바로가기 [Article Type] Article
Using student-centered approaches to teach the biochemistry of SARS-CoV-2Article Published on 2020-11-012023-07-05 Journal: Biochemistry and Molecular Biology Education [Category] SARS, [키워드] active learning Biochemistry COVID-19 online teaching [DOI] 10.1002/bmb.21462 PMC 바로가기