Senescent endothelial cells are predisposed to SARS-CoV-2 infection and subsequent endothelial dysfunction노화 내피 세포는 SARS-CoV-2 감염 및 후속 내피 기능 장애에 걸리기 쉽습니다.Article Published on 2022-07-252022-09-12 Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] acute respiratory syndrome affected Alter Analysis association cause caused cell damage characterized contribute coronavirus coronavirus disease COVID-19 COVID-19 patients disease dysfunction Endothelial cell Endothelial dysfunction event exacerbated expression high mortality infect Infection Inflammation Injury investigated lung Lungs molecular pathogenesis of COVID-19 performed Post-infection Post-mortem replicate replicative reported SARS-CoV-2 SARS-COV-2 infection senescent Spread subsequent susceptible sustained systemic the SARS-CoV-2 thrombosis [DOI] 10.1038/s41598-022-15976-z PMC 바로가기 [Article Type] Article
PTP1B inhibitors protect against acute lung injury and regulate CXCR4 signaling in neutrophilsArticle Published on 2022-07-222022-11-15 Journal: JCI Insight [Category] 진단, [키워드] Activation acute lung injury acute respiratory distress administration ameliorated antibody ARDS cause Cell Biology Chemokine receptor collateral tissue damage COVID-19 CXCR4 death dysregulated Effects etiologies highlight homeostasis implicated increased survival Inflammation inhibitor Lung injury mice Migration myeloperoxidase NET neutrophil Neutrophil extracellular trap neutrophil function Neutrophils phenotype Prevent prevented PROTECT Protein reduced regulate Sepsis Signaling signaling pathway survival syndrome Treatment tyrosine phosphatase [DOI] 10.1172/jci.insight.158199 PMC 바로가기
Role of pepper mild mottle virus as a tracking tool for fecal pollution in aquatic environments수중 환경에서 분변 오염에 대한 추적 도구로서의 후추 연한 반점 바이러스의 역할Review Published on 2022-07-222022-09-11 Journal: Archives of Microbiology [Category] COVID19(2023년), SARS, 치료기술, [키워드] aquatic environment aquatic environments cause Concentration coronavirus difficulty excreta fecal Fecal contamination feces genus humans incidence Indicator indicator organism microbial Mild MONITOR normalized Outbreaks pathogen Pathogens pathway Pepper mild mottle virus (PMMoV) persistence plant processed public health reduction reported Research reuse RNA virus role SARS-CoV-2 Surrogates the SARS-CoV-2 Tobamovirus Treatment virus Waste treatment wastewater water Water indicator. water quality Water treatment [DOI] 10.1007/s00203-022-03121-3 PMC 바로가기 [Article Type] Review
A diagnostic classifier for gene expression-based identification of early Lyme disease Research Published on 2022-07-222022-10-05 Journal: Communications Medicine [Category] 바이오마커, 진단, [키워드] Accuracy Algorithm association Bacteremia Borrelia cause Cell culture Classifier clinical investigation clinical utility controls database described Diagnosis diagnostic diagnostic test differentially expressed gene evaluated false-discovery rate Gene Expression highlight identify in vitro independent Infection Influenza lack Lyme disease mononuclear cell New Patient patients Peripheral blood positive Result RNA sequencing selected sensitivity Sensitivity and specificity serologic testing seronegative patient specificity subject subjects The United States Transcriptome Tuberculosis uninfected control [DOI] 10.1038/s43856-022-00127-2 [Article Type] Research
Effectiveness of 2, 3, and 4 COVID-19 mRNA Vaccine Doses Among Immunocompetent Adults During Periods when SARS-CoV-2 Omicron BA.1 and BA.2/BA.2.12.1 Sublineages Predominated – VISION Network, 10 States, December 2021-June 2022SARS-CoV-2 Omicron BA.1 및 BA.2/BA.2.12.1 하위 계통이 우세한 기간 동안 면역적격 성인 중 2, 3 및 4 COVID-19 mRNA 백신 용량의 효과 - VISION Network, 10개 주, 2021년 12월 -2022년 6월Article Published on 2022-07-222022-09-11 Journal: Morbidity and Mortality Weekly Report [Category] COVID19(2023년), SARS, 변종, [키워드] 95% CI accounted B.1.1.529 BNT162b2 booster dose booster doses Care cause conditions COVID-19 COVID-19 case COVID-19 vaccine Diagnosis dose Effectiveness eligible estimate evade evaluate examined Hospitalization initial median moderate moderate to severe mRNA mRNA COVID-19 vaccine mRNA COVID-19 vaccines mRNA-1273 network omicron Omicron variant pattern Period Pfizer-BioNTech Prevent real-world data receipt receive reduced SARS-CoV-2 SARS-COV-2 infection severe COVID-19 the United State United States vaccination Vaccine-induced immunity variant virus [DOI] 10.15585/mmwr.mm7129e1 PMC 바로가기 [Article Type] Article
Risk assessment in COVID-19 patients: A multiclass classification approachResearch article Published on 2022-07-192022-10-05 Journal: Informatics in Medicine Unlocked [Category] 유전자 메커니즘, 치료기술, [키워드] Accuracy age Algorithm applied approach artificial cause Comorbidity Complication component COVID-19 COVID-19 disease COVID-19 patient dataset death determine diabete Dyspnea elapsed Factor Factors Feature importance forest hypertension intelligence machine learning Ministry of Health Multiclass classification pandemic performed receiving risk Risk assessment risk factor SARS-COV-2 infection Severe case severity Sex Symptom Symptoms Treatment understanding [DOI] 10.1016/j.imu.2022.101023 [Article Type] Research article
Hepatitis C virus NS3/4A inhibitors and other drug-like compounds as covalent binders of SARS-CoV-2 main proteaseSARS-CoV-2 주요 프로테아제의 공유 결합제로서의 C형 간염 바이러스 NS3/4A 억제제 및 기타 약물 유사 화합물Article Published on 2022-07-162022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, 신약개발, 치료제, [키워드] 3CL pro active site Antiviral antiviral inhibitor approved binding catalytic cause clinical trials clinically Compound compounds coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 therapeutics Cys145 derivative derivatives drug drug target Evidence global public health hepatitis C hepatitis C virus higher affinity inhibitor M pro maturation molecular docking studies Molecular docking study pandemic polyproteins protease Protein residue SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 main protease Severe acute respiratory syndrome Spread the SARS-CoV-2 genome Vaccine variants virus [DOI] 10.1038/s41598-022-15930-z PMC 바로가기 [Article Type] Article
Effect of cannabidiol on apoptosis and cellular interferon and interferon-stimulated gene responses to the SARS-CoV-2 genes ORF8, ORF10 and M proteinSARS-CoV-2 유전자 ORF8, ORF10 및 M 단백질에 대한 세포 사멸 및 세포 인터페론 및 인터페론 자극 유전자 반응에 대한 칸나비디올의 효과Article Published on 2022-07-152022-09-11 Journal: Life sciences [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료제, [키워드] 2′-5′-oligoadenylate synthetase (OAS) family activating acute respiratory syndrome acute respiratory syndrome coronavirus anti-viral response Apoptosis cannabidiol cause Cell cellular Combination component control cell control cells coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus disease 2019 (COVID-19) COVID-19 Effect expressing expression HEK293 cell HEK293 cells IFNγ immune responses Innate innate immune response innate immune system Innate immunity interferon interferon-stimulated gene interferons M protein marker membrane protein OAS OAS1 OAS2 OAS3 OASL ORF10 ORF8 Plasmid plasmids Prophylaxis Protein readiness respond response SARS-CoV-2 SARS-CoV-2 gene SARS-CoV-2 genes severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) the SARS-CoV-2 transfected cells transfected with treated Treatment vehicle viral gene viral genes viral infection [DOI] 10.1016/j.lfs.2022.120624 PMC 바로가기 [Article Type] Article
Infection Rate of Respiratory Viruses in the Pandemic SARS-CoV-2 Period Considering Symptomatic Patients: Two Years of Ongoing Observations유행성 SARS-CoV-2 기간 동안 증상 환자를 고려한 호흡기 바이러스 감염률: 2년 동안 계속 관찰Article Published on 2022-07-152022-09-11 Journal: Biomolecules [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] acute respiratory infections Analysis carried cause change changes in Characteristics clinically suspected Coinfection collected COVID-19 decrease Department detect drastic reduction Emergency emergency medicine epidemiological Factors HCoV human behavior Infectious disease Infectious diseases laboratory feature Masks median age Medicine men Missing data nasopharyngeal swabs new SARS-CoV-2 observation observational study pandemic pathogen Pathogens Patient patients performed Period physical distancing positive patients positive rate Rate receptor reflected Research respiratory respiratory infections Respiratory pathogens respiratory tract respiratory viral respiratory viral pathogens respiratory virus respiratory viruses SARS-CoV-2 SARS-CoV-2 pandemic SARS-CoV-2 variants SARS-CoV-2 virus Self-isolation social isolation socialization Surveillance surveillance research. Swab the patient the SARS-CoV-2 vaccination variant variants virus viruses were excluded women Year [DOI] 10.3390/biom12070987 PMC 바로가기 [Article Type] Article
The GUIDE-HF trial of pulmonary artery pressure monitoring in heart failure: impact of the COVID-19 pandemicRandomized Controlled Trial Published on 2022-07-142022-10-05 Journal: European heart journal [Category] Fulltext, MERS, 임상, [키워드] all-cause mortality cause change changes changes in clinical Compliance Contact Control control group coronavirus disease COVID-19 COVID-19 pandemic decrease event rate events examined Factor Frequency group groups Haemodynamics heart heart failure in both groups management medication not different outcome outcomes pandemic Patient primary endpoint primary event rate pulmonary artery pulmonary artery pressure Pulmonary artery pressure. Randomized remained reported resulting Study protocol the primary endpoint Treatment treatment group Trial [DOI] 10.1093/eurheartj/ehac114 PMC 바로가기 [Article Type] Randomized Controlled Trial