Short-Course of Methylprednisolone Improves Respiratory Functional Parameters After 120 Days in Hospitalized COVID-19 Patients (Metcovid Trial): A Randomized Clinical TrialMedicine Published on 2021-11-302022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] acute phase Admission Analysis benefit Brazil carried clinical clinical trial conducted coronavirus Corticosteroid COVID-19 Day double-blind evaluated expiratory fibrosis Follow-up functions FVC group help Hospital admission hospitalized COVID-19 patient hospitalized patient ICU IIb IL-6 level impairment IMV Inflammation Invasive mechanical ventilation less long-COVID Methylprednisolone Older parameter participant Patient patients Placebo placebo-controlled Primary outcome pulmonary function parameters Pulmonary function test Pulmonary function testing Randomized respiratory Respiratory failure SARS-CoV-2 Seven severe COVID-19 significantly higher supplementary oxygen Supportive treatment survived surviving patient the cytokine storm Univariate analysis use of corticosteroid use of steroid Volume [DOI] 10.3389/fmed.2021.758405 PMC 바로가기 [Article Type] Medicine
Corticosteroid treatment and mortality in mechanically ventilated COVID-19-associated acute respiratory distress syndrome (ARDS) patients: a multicentre cohort studyResearch Published on 2021-11-262022-10-28 Journal: Annals of Intensive Care [Category] COVID-19, [키워드] 95% CI acute respiratory distress Admission age Analysis ARDS benefit Clinical effect cohort study collected data competing conducted Corticosteroid corticosteroid treatment Corticosteroids COVID-19 COVID-19-associated acute respiratory distress syndrome COVID-19-associated ARDS Effect Effectiveness hospital ICU ICU admission identify in-hospital mortality individual intensive care intensive care unit Invasive mechanical ventilation mechanically ventilated Mortality multicentre no significant difference non-survivor not differ outcome Patient patients patients treated performed propensity score matching question required Research Result Retrospective study risk secondary Secondary outcomes sensitivity analysis severe ARDS severe coronavirus disease Shock short-term survival Spanish Specific subgroup supplementary material survival syndrome Tocilizumab Treatment untreated patient ventilator-free day were excluded [DOI] 10.1186/s13613-021-00951-0 PMC 바로가기 [Article Type] Research
Use of Monoclonal Antibodies Therapy for Treatment of Mild to Moderate COVID-19 in 4 Patients with Rheumatologic Disorders4명의 류마티스 질환 환자에서 경증에서 중등도의 COVID-19 치료를 위한 단일클론항체 요법의 사용Case Reports Published on 2021-11-252022-09-12 Journal: Medical science monitor : international medical jo [Category] MERS, SARS, 진단, [키워드] adverse outcomes case sery conducted Coronavirus disease 2019 Corticosteroid COVID-19 disease Diseases effective therapy Efficacy EUA FDA form hospital illness immunosuppressive increase information MAT a Mild moderate monoclonal antibody Patient protocol receiving retrospective rheumatological rheumatological disorder risk Safe therapy treated treating COVID-19 [DOI] 10.12659/MSM.934267 PMC 바로가기 [Article Type] Case Reports
A new p65 isoform that bind the glucocorticoid hormone and is expressed in inflammation liver diseases and COVID-19Article Published on 2021-11-252022-10-04 Journal: Scientific Reports [Category] MERS, SARS, 변종, 진단, [키워드] affected amplifying antagonist anti-inflammatory agent anti-inflammatory response bind Cancer cause cirrhosis complex Corticosteroid COVID-19 Critical deregulation Dexamethasone disease Diseases expressed Factor gene expression level glucocorticoid HCC healthy subjects Hepatocellular carcinoma Human identify immunology IMPROVE Inflammation isoform knowledge liver Liver disease mice Molecular biology mRNA level NF-kB opposite p65 Patient PBMC physiological quantified receptor Regulation SARS-CoV-2 disease therapeutic target Transcription transcription factor transcription factors variant wild type [DOI] 10.1038/s41598-021-02119-z PMC 바로가기 [Article Type] Article
Increased Risk of Thrombosis in Patients with Myeloproliferative Neoplasms Compared with the General Population Hospitalized with COVID-19Conference abstract Published on 2021-11-232022-10-05 Journal: Blood [Category] 유전자 메커니즘, [키워드] 95% CI Admission age analyzed anticoagulation Aspirin baseline black bleeding blueprint board Boston categorical variable caused clinical clinically CML Cohort cohort analysis Complication consecutive patient constellation continuous variable Corticosteroid COVID COVID-19 critically ill patients D-dimer database death defined diabetes Diagnosis download figure funding General population Health heart failure Hispanic Hispanic ethnicity hospital Hospital admission Hospitalized hospitalized patient hypertension ICU ICU admission identify include Increased increased risk Incyte Infection Infectious disease Inflammatory less leukemia mass Medicine multivariable analysis multivariable logistic regression myelofibrosis myeloproliferative neoplasm Myocardial infarction occurred Older outcome Patient patient population patients PCR PCR testing Philadelphia Platelet polycythemia vera polymerase chain Population positive Primary outcome prognostic readmission Remdesivir required risk risk factor Seattle Sex significantly significantly increased smoking status Society steroid stroke t-test Test tested thrombosis thrombotic complication Thrombotic complications treated Treatment Venous Thromboembolism VTE white with COVID-19 [DOI] 10.1182/blood-2021-151801 [Article Type] Conference abstract
Treatment of COVID-19 Patients: Insights into the Use of Bone Marrow-Derived Mesenchymal Stem CellsConference abstract Published on 2021-11-232022-10-05 Journal: Blood [Category] 유전자 메커니즘, [키워드] 24 hour acute phase acute respiratory distress Administered administration administration of methylprednisolone adverse effect adverse event adverse events affected age alveolar ARDS association benefit bone Cell chronic obstructive Clinical improvement clinical trial Complete consolidation contributed Corticosteroid COVID-19 COVID-19 complications COVID-19 disease criteria CRP level death decrease defined discharged distress dose doses download drug Efficacy ferritin figure glucocorticoid High dose high mortality rate High-dose Hypothesis immunomodulatory effect include Inclusion increased risk Infection Inflammatory marker inflammatory markers insight intravenous dose intubation large cohort lung male marker median median age median time Methylprednisolone MSC observational study one patient Organizing pneumonia outcomes PaCO2 paO2/fiO2 PaO2/FiO2 ratio parameter Patient patient survival patients died patients with COVID-19 PCO2 phase primary endpoint procalcitonin pulmonary disease Pulmonary infection Randomized controlled trial reactive reducing reported respiratory parameters SARS-CoV-2 second dose secondary endpoint secure Severe COVID-19 pneumonia severity STEM stem cell suggested syndrome therapeutic option therapy Thorax tissue treat treated Treatment Trial Two patient Ventilator-associated pneumonia worsening [DOI] 10.1182/blood-2021-154291 [Article Type] Conference abstract
ESCMID COVID-19 living guidelines: drug treatment and clinical managementGuidelines Published on 2021-11-222022-10-04 Journal: Clinical microbiology and infection : the official [Category] COVID19(2023년), MERS, SARS, 임상, 진단, 치료법, 치료제, [키워드] addressed Antibiotics approach Bacterial Clinical management clinician Colchicine Combination Committee convalescent plasma coronavirus disease Corticosteroid Corticosteroids COVID-19 COVID-19 guideline develop Disease progression etesevimab Evidence Favipiravir Guidance guidelines hospitalized patients Immunocompromised Infection Infectious disease intensive care Interferon β-1a Intervention involved Ivermectin majority management monoclonal antibody Mortality outcome Outpatient outpatients oxygen patients with COVID-19 performed pharmacological treatment PICO Population Prophylaxis provided question recommendation Remdesivir selected severe COVID-19 severity Tocilizumab Treatment use of hydroxychloroquine utility was used were given [DOI] 10.1016/j.cmi.2021.11.007 PMC 바로가기 [Article Type] Guidelines
COVID-19–associated mucormycosis: Evidence-based critical review of an emerging infection burden during the pandemic’s second wave in IndiaReview Published on 2021-11-182022-10-28 Journal: PLoS Neglected Tropical Diseases [Category] COVID-19, MERS, [키워드] Adding amphotericin B antifungal therapy caused clinical guideline code comorbid condition Comorbidity Corticosteroid country Course COVID-19 Critical diabete diagnose drugs Evidence Fungal infection groups Guidance Health hospital immune Immunity increased risk India Infection infection rate Inflammatory invasive involved mechanism Mucor Mucormycosis oxygen pandemic Pathogenesis patients with COVID-19 second wave secondary infections selected Severe case surgical the disease treat treatment strategy Vaccines [DOI] 10.1371/journal.pntd.0009921 PMC 바로가기 [Article Type] Review
Potential benefits of precise corticosteroid therapy for critical COVID-19Article Published on 2021-11-182023-06-15 Journal: Respiratory physiology & neurobiology [Category] MERS, SARS, [키워드] Corticosteroid COVID-19 Lymphocytes overall survival pulmonary fibrosis [DOI] 10.1016/j.resp.2021.103813 PMC 바로가기 [Article Type] Article
Riding the COVID Waves: Clinical Trends, Outcomes, and Remaining Pitfalls of the SARS-CoV-2 Pandemic: An Analysis of Two High-Incidence Periods at a Hospital in Northern ItalyArticle Published on 2021-11-112022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] age analysed change changes clinical clinical trends Comorbidities Corticosteroid country COVID death Deceased demographics Epidemic evaluate the effect Evidence hospital improvement Italy knowledge lack Older outbreak outcome Patient Period Prognosis remaining SARS-CoV-2 SARS-COV-2 infection selected Severe infection significant increase the disease the SARS-CoV-2 Treatment was recorded [DOI] 10.3390/jcm10225239 PMC 바로가기 [Article Type] Article