Impact of the COVID-19 pandemic on patients with pre-existing anxiety disorders attending secondary careOriginal Research Published on 2020-06-082022-10-30 Journal: Irish Journal of Psychological Medicine [Category] COVID-19, MERS, SARS, [키워드] Anxiety Anxiety Disorder anxiety disorders anxiety symptom anxiety symptoms classification Comorbidity condition conducted COVID-19 COVID-19 pandemic Deleterious demonstrated described determine Diagnosis disorder Generalised anxiety disorder Impact impairment increase in increases in individual Likert scale objective obsessive compulsive obsessive compulsive disorder participant Patient physical Psychological Quality of life Result secondary care service Symptoms [DOI] 10.1017/ipm.2020.75 PMC 바로가기 [Article Type] Original Research
ACE2, Much More Than Just a Receptor for SARS-COV-2Cellular and Infection Microbiology Published on 2020-06-052022-10-31 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID-19, MERS, SARS, [키워드] ACE-2 ACE2 Activation acute injury acute respiratory syndrome alveolar alveolar epithelial cell amplify angiotensin Angiotensin converting enzyme-2 Anti-viral cardiovascular system Coagulopathy contribute coronavirus COVID-19 Deleterious drug dysregulation Host Infection inhibit inhibiting Invasion lung Lung injury Lungs modulation pandemic pathway Perspective physiological function protease protective effect Protein RAS receiving receptor reducing required SARS-CoV-2 SARS-COV-2 infection the SARS-CoV-2 viral entry [DOI] 10.3389/fcimb.2020.00317 PMC 바로가기 [Article Type] Cellular and Infection Microbiology
Innate Immune Signaling and Proteolytic Pathways in the Resolution or Exacerbation of SARS-CoV-2 in Covid-19: Key Therapeutic Targets?Immunology Published on 2020-05-282022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] “cytokine storm” ACE2 activating Activation Affect affecting alveolar epithelial cells angiotensin-converting enzyme 2 Anti-viral Cathepsins caused cellular entry cellular receptors cellular signaling pathway Community coronavirus CoV COVID-19 Deleterious dendritic cell downregulating downregulation DPP4 Epidemics event Exacerbation Factor furin glycoprotein H1N1 Haemagglutinin Health Host IL-8 infected patients Inflammation initial initial viral load Innate innate immune response innate immune responses involved Ligand ligands Like lung lung innate immunity Macrophage middle multiple organ failure outbreak pandemic Pandemics pro-inflammatory mediator promoted protease Proteases Protein Resolution respiratory RNA genome SARS-CoV SARS-CoV-2 serine 2 single-stranded survival syndrome T-cell TLR TMPRSS2 transmembrane serine protease triggering trimeric spike TTSP type I type III virus virus entry [DOI] 10.3389/fimmu.2020.01229 PMC 바로가기 [Article Type] Immunology
Metabolic Impacts of Confinement during the COVID-19 Pandemic Due to Modified Diet and Physical Activity HabitsReview Published on 2020-05-262022-10-30 Journal: Nutrients [Category] Coronavirus, MERS, SARS, [키워드] activity acute sedentary lifestyle arising cardiovascular disease Chronic diseases condition consequence Consequences COVID-19 COVID-19 pandemic Deleterious detrimental effect diabetes diet dietary intake energy balance Evidence exacerbate Factor fat habit Health help hypertension identify Impact increase increases in Inflammatory cytokines insulin resistance involved mechanism metabolic metabolic consequence metabolic consequences metabolic disorder metabolic syndrome mitigate physical activity Physical inactivity positive positive energy balance potential risk promoted reduce reduced reducing reduction in risk sarcopenia severe COVID-19 severely ill patient step reduction syndrome total body fat turn while with COVID-19 [DOI] 10.3390/nu12061549 PMC 바로가기 [Article Type] Review
COVID-19 pandemic: mental health and beyond – the Indian perspectivePerspective Piece Published on 2020-05-212022-10-30 Journal: Irish Journal of Psychological Medicine [Category] Coronavirus, MERS, SARS, [키워드] being benefit change consequence country COVID-19 Deleterious exacerbate global pandemic Health help India lockdown mental health outbreak pandemic Pandemics Perspective physical barrier Psychiatric disorders reduce screen time weighed [DOI] 10.1017/ipm.2020.63 PMC 바로가기 [Article Type] Perspective Piece
Proteasome Inhibitors as a Possible Therapy for SARS-CoV-2Review Published on 2020-05-202022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, SARS, [키워드] anti-inflammatory compounds Antibiotics antiparasitic agent Antiretrovirals bortezomib caused Cell cellular homeostasis compounds consequence Convalescent patients coronavirus COVID-19 CoVs Deleterious Effect effective endoplasmic stress global pandemic Immunological response in viral inflammatory conditions inhibitor MG132 off-label Oxygen administration Patient plasma proteasome proteasome inhibitors protein expression reduce Replication RNA SARS-CoV-2 subsequent supportive care the cytokine storm therapeutic therapy treated Treatment triggered UPR response virus entry virus replication [DOI] 10.3390/ijms21103622 PMC 바로가기 [Article Type] Review
The COVID-19 Pandemic during the Time of the Diabetes Pandemic: Likely Fraternal Twins?Review Published on 2020-05-192022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] accompanied adipose tissue dysfunction adverse outcomes affected circulating cytokines complex COVID-19 COVID-19 infection COVID-19 pandemic COVID-19 patients Critical cytokine Cytokine storm Deleterious develop developmental diabete diabetes diabetics Evidence explain GEMM family study hyperglycemia hyperinflammatory state hyperinsulinemia immune response Infection Infectious disease Inflammation insulin resistance manifestation mechanism meet morbidity multi-organ failure multifactorial Non-communicable disease pandemic pathogen pathology pathway Patient patients with diabete patients with diabetes prevalent proinflammatory prothrombotic recent risk factor severe COVID-19 subject suggested survival susceptibility symptoms of COVID-19 syndrome time triggering underlie [DOI] 10.3390/pathogens9050389 PMC 바로가기 [Article Type] Review
COVID-19: Pandemic Risk, Resilience and Possibilities for Aging ResearchArticle Published on 2020-05-192022-10-31 Journal: Canadian Journal on Aging [Category] Coronavirus, MERS, SARS, [키워드] affected age aging Analysis approach Community COVID-19 Deleterious Effects Endemic géro-pandémie gero-pandemic Health Infection infection risk morbidity and mortality Older Older adults outcome pandemic pathogenic Pathogens personnes âgées positive Psychological résilience Research Resilience risk significantly higher social isolation vieillissement vulnérabilité vulnerability [DOI] 10.1017/S0714980820000215 PMC 바로가기 [Article Type] Article
Creating COVID-19 Stigma by Referencing the Novel Coronavirus as the “Chinese virus” on Twitter: Quantitative Analysis of Social Media DataOriginal Paper Published on 2020-05-062022-10-30 Journal: Journal of Medical Internet Research [Category] COVID-19, MERS, SARS, [키워드] Adjusting average Characteristics coronavirus coronavirus disease COVID-19 Deleterious derivative foundation Frequency group heat map highest increase in knowledge National New Hampshire New York novel Novel coronavirus objective Prevalence public health Quantitative analysis Result social media South Stata 16 StataCorp Stigma the United State translation Twitter [DOI] 10.2196/19301 PMC 바로가기 [Article Type] Original Paper
Bioinformatic prediction of potential T cell epitopes for SARS-Cov-2Article Published on 2020-05-062022-10-04 Journal: Journal of Human Genetics [Category] MERS, SARS, 변종, 유전자 메커니즘, [키워드] addition allele frequency B-cell response Bioinformatic calculated CD4 CD8 Coverage COVID-19 pandemic Deleterious develop epitope high affinity High-throughput screening HLA HLA class I HLA molecules homology host immune responses immune immune system Immunogenetics induce information Japanese membrane nonstructural protein Novel coronavirus Nucleocapsid proteins other coronaviruses peptide epitope populations predicted Prevent Region SARS-CoV SARS-CoV-2 sequence significantly T cell epitope T-cell T-cell responses the SARS-CoV-2 Vaccine virus [DOI] 10.1038/s10038-020-0771-5 PMC 바로가기 [Article Type] Article