Structures of Omicron spike complexes and implications for neutralizing antibody developmentOmicron 스파이크 복합체의 구조 및 중화 항체 개발에 대한 의미Article Published on 2022-05-032022-09-11 Journal: Cell Reports [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] ACE2 antibodies antibody Antibody binding Antibody structure binding biochemical complexes country CP: Immunology CP: Microbiology cryo Cryo-electron microscopy cryo-EM cryo-EM structures Delta dominant drugs electron microscopy Evidence explain Fab immune immune evasion immunology implication information interactions lead Microbiology Mutation mutations neutralization Neutralization antibody neutralization assays neutralizing antibody omicron provide required responsible SARS-CoV-2 spike spike mutation spike mutations Structure structures the SARS-CoV-2 therapeutic therapeutic antibodies Vaccine variant wild-type [DOI] 10.1016/j.celrep.2022.110770 PMC 바로가기 [Article Type] Article
Vaccine breakthrough infections with SARS-CoV-2 Alpha mirror mutations in Delta Plus, Iota, and OmicronDelta Plus, Iota 및 Omicron에서 SARS-CoV-2 알파 거울 돌연변이로 인한 백신 돌발 감염Article Published on 2022-05-022022-09-11 Journal: The Journal of Clinical Investigation [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] Alpha variant Amino acid amino acid substitution amino acid substitutions Amplicon amplicons Breakthrough infection COVID-19 deep deep sequencing Deep sequencing analysis defined Delta distribution distributions dominant epidemiologically examined Frequency Host human population identify Iota isolate Molecular biology mutant mutant spectra mutants Mutation nasopharyngeal omicron Omicron variants Patient Replication SARS-CoV-2 Sequencing Sequencing analysis Substitution the SARS-CoV-2 Vaccine variant variants Virology virus [DOI] 10.1172/JCI157700 PMC 바로가기 [Article Type] Article
Nosocomial Outbreak by Delta Variant From a Fully Vaccinated Patient완전 예방 접종을 받은 환자의 Delta 변이에 의한 병원 발병Article Published on 2022-05-022022-09-11 Journal: Journal of Korean medical science [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Admission Airborne transmission airflow Care Caregiver CCTV ChAdOx1 ChAdOx1 nCoV-19 close contact Contact contact with coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Delta delta variant diagnosed with COVID-19 Diagnosis dominant driven by equipment FIVE had no healthcare worker hospital index case individual Inpatient nosocomial occurred outbreak Patient performed polymorphism positive Sample SARS-CoV-2 severe acute respiratory syndrome Coronavirus single-nucleotide single-nucleotide polymorphism Symptom tested vaccinated individual vaccination variant virus ward WGS whole-genome sequencing [DOI] 10.3346/jkms.2022.37.e133 PMC 바로가기 [Article Type] Article
Generation time of the alpha and delta SARS-CoV-2 variants: an epidemiological analysis알파 및 델타 SARS-CoV-2 변종 생성 시간: 역학 분석Article Published on 2022-05-012022-09-11 Journal: The Lancet. Infectious Diseases [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] 95% CI Alpha alpha and delta variants Alpha variant analysed Analysis assumed B.1.1.529 B.1.617.2 Contact tracing Council credible interval decrease delta variant Delta variants determine dominant dominant variant effective Effectiveness Engineering epidemiological faster Generation Generation time genomic sequencing household Households index case Infection Innovation intrinsic Isolation less mathematical occur participant Participants positive PCR test posterior probability recruited reflect responsible SARS-CoV-2 SARS-CoV-2 variant Science security susceptible susceptible individual susceptible individuals Transmissibility Transmission Transmission model transmissions variant virus was used [DOI] 10.1016/S1473-3099(22)00001-9 PMC 바로가기 [Article Type] Article
Efficacy of Transfer Learning-based ResNet models in Chest X-ray image classification for detecting COVID-19 PneumoniaResearch article Published on 2022-05-012022-10-05 Journal: Chemometrics and Intelligent Laboratory Systems [Category] 진단, 치료기술, [키워드] Accuracy Analysis approach assist automatic detection build carried CNN complex computer COVID-19 COVID-19 diagnosis COVID-19 infection CPU CXR dataset datasets deep deep learning diagnostic dominant early diagnosis effective Effectiveness epidemiological evaluate facilitate FIVE fraction GPU highest individuals with COVID-19 Laboratory laboratory data laboratory measure learning network Neural PCR polymerase chain Precision problems Resnet ResNet model sensitivity specificity stages Symptom tissues transfer learning variant vision X-ray [DOI] 10.1016/j.chemolab.2022.104534 [Article Type] Research article
Plasma Proteomics of COVID-19–Associated Cardiovascular Complications: Implications for Pathophysiology and TherapeuticsResearch article Published on 2022-05-012022-10-05 Journal: JACC: Basic to Translational Science [Category] 바이오마커, 유전자 메커니즘, [키워드] ADAMTS13 cardiovascular cardiovascular complication Case-control cause Cohort COVID-19 COVID-19 patient COVID-19 patients disease severity dominant driving finding FSTL3 identify Implications Injury loss-of-function marker mechanism Microvascular thrombosis Myocardial myocardial injury pathophysiology performed phenotype plasma proteomics protease Protein proteomics senescence Signaling Stress therapeutic Therapeutics [DOI] 10.1016/j.jacbts.2022.01.013 [Article Type] Research article
Relative instantaneous reproduction number of Omicron SARS-CoV-2 variant with respect to the Delta variant in Denmark덴마크 Delta 변종에 대한 Omicron SARS-CoV-2 변종 상대적 순시 번식 수Article Published on 2022-05-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, [키워드] 95% CI 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 conditions coronavirus Delta delta variant Denmark dominant effective epidemiological Epidemiology Evolution expected GISAID database greater Infection instantaneous introduced less measure nucleotide nucleotide sequence omicron Omicron variant Omicron variants Preparing proportion rapid increase Registered relative Reproduction number SARS Coronavirus SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 variant severe acute respiratory syndrome Coronavirus Transmission variant variants virus widespread [DOI] 10.1002/jmv.27560 PMC 바로가기 [Article Type] Article
Molecular signature of postmortem lung tissue from COVID-19 patients suggests distinct trajectories driving mortalityCOVID-19 환자의 사후 폐 조직의 분자 서명은 사망률을 이끄는 뚜렷한 궤적을 시사합니다Article Published on 2022-05-012022-09-12 Journal: Disease Models & Mechanisms [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] absence Activation acute respiratory syndrome Autopsy can be used CCL19 characteristic classical complement controls coronavirus COVID-19 COVID-19 patient CRS cytokine cytokine release dominant driving in silico infections Infectious disease lung lung abnormality lung damage Lung microbiome Lung pathology lung tissue majority Metatranscriptomics Microbiome molecular molecular mechanism Mortality Pasteurella pathogen Patient patients performed SARS-CoV-2 SARS-COV-2 infection secondary infections Sequencing severe COVID-19 severe COVID-19 patients Staphylococcus suffered supported syndrome therapy trajectory unfolded protein response uninfected upregulation Whole-transcriptome sequencing. [DOI] 10.1242/dmm.049572 PMC 바로가기 [Article Type] Article
Impact of SARS-CoV-2 Mutations on PCR Assay Sequence AlignmentSARS-CoV-2 돌연변이가 PCR 분석 시퀀스 정렬에 미치는 영향Article Published on 2022-04-282022-09-11 Journal: Frontiers in Public Health [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, 치료제, [키워드] alignment Analysis analyzed assays biosurveillance blind Chain Reaction clinical samples COVID-19 creating diagnosis of COVID-19 diagnostic diagnostics dominant Evidence evidence of failure False negative false negatives functional consequence functional consequences Genome genomic RNA growth highlight identify Impact in silico in viral molecular test Molecular tests Mutation mutations occurred pandemic PCR PCR assay PCR assays polymerase chain polymerase chain reaction preserved proportion Real-time monitoring Real-Time Reverse Transcription Polymerase Chain Reaction Region reverse transcription RT-PCR SARS-CoV-2 SARS-CoV-2 sequences Sensitivity and specificity sequence sequence identity Sequencing signature statistically sustained therapeutic unique Vaccine variant Viral viral genomes whole genome whole genome sequence Whole genome sequencing [DOI] 10.3389/fpubh.2022.889973 PMC 바로가기 [Article Type] Article
Specific Detection of SARS-CoV-2 Variants B.1.1.7 (Alpha) and B.1.617.2 (Delta) Using a One-Step Quantitative PCR Assay1단계 정량적 PCR 분석을 사용한 SARS-CoV-2 변이체 B.1.1.7(알파) 및 B.1.617.2(델타)의 특이적 검출Article Published on 2022-04-272022-09-11 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adjust Alpha Alpha (B.1.1.7) analyzed B.1.1.7 B.1.617.2 classification clinical sample clinical samples Community consequence coronavirus Delta Delta (B.1.617.2) demonstrated described detect detection diagnostic diagnostic assay. dominant epidemiological examined global health Health highlight identify IMPROVE Mutation mutations N gene ORF8 gene PCR provide qPCR quantitative PCR reaction Research respond reverse transcription RNA RT-qPCR SARS-CoV-2 SC-2 surveillance sensitivity severe acute respiratory syndrome Coronavirus Specific spike gene target variant variants variants of concern whole-genome sequencing [DOI] 10.1128/spectrum.02176-21 PMC 바로가기 [Article Type] Article