Serum Amyloid P inhibits single stranded RNA-induced lung inflammation, lung damage, and cytokine storm in mice혈청 아밀로이드 P는 생쥐에서 단일 가닥 RNA 유발 폐 염증, 폐 손상 및 사이토카인 폭풍을 억제합니다Research Article Published on 2021-01-222022-09-10 Journal: PLoS ONE [Category] 치료법, [키워드] accumulation aggregate alveolar amyloid animal model animal models aspiration Blood clots cause clinical trials clot COVID-19 cytokine Cytokine storm D-dimer D-dimer level D-dimer levels disease Efficacy Extracellular female fibrosis Genome Hyperactivation IL-12p70 IL-1β IL-23 IL-27 IL-6 immune increase in induce Infection inflammatory cell inflammatory cells Inflammatory cytokine Inflammatory cytokines inflammatory immune cells inhibit innate immune system intraperitoneal injection Intraperitoneal injections lung lung alveolar lung damage Lung inflammation male mice mononuclear cells Peripheral blood Protein reduced RNA SARS-CoV-2 sequence serum serum amyloid serum cytokine serum cytokine levels Serum protein severe COVID-19 symptom severe symptom ssRNA Symptom Symptoms therapeutic upregulation virus women [DOI] 10.1371/journal.pone.0245924 PMC 바로가기 [Article Type] Research Article
Structural Mapping of Mutations in Spike, RdRp and Orf3a Genes of SARS-CoV-2 in Influenza Like Illness (ILI) Patients인플루엔자 유사 질병(ILI) 환자에서 SARS-CoV-2의 스파이크, RdRp 및 Orf3a 유전자 돌연변이의 구조적 매핑Article Published on 2021-01-192022-09-10 Journal: Viruses [Category] 치료기술, [키워드] Affect ambulatory patients Amino acid amino acid substitution Analysis binding site cause characterized China clade Clustering collected community transmission confirmation conformational change COVID-19 COVID-19 case COVID-19 illness D614G epidemiological link Extracellular followed by functional ILI illness incidence independent indicated Influenza influenza like illness influenza vaccine isolate Like mapping membrane mild COVID-19 illness mitigate Nasopharyngeal swab nasopharyngeal swabs next generation sequencing NGS oligomerization overlap P323L pandemic Patient PCR Public health interventions Q57H RdRP replaced SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 virus Sequencing silent silent transmission spike spike gene Substitution Surveillance thought Transcription Transmission transmission of SARS-CoV-2 virus virus replication [DOI] 10.3390/v13010136 PMC 바로가기 [Article Type] Article
Significance of NETs Formation in COVID-19Review Published on 2021-01-142022-10-31 Journal: Cells [Category] COVID-19, [키워드] ACE2 base cellular combating contagious coronavirus Course COVID-19 COVID-19 in patient COVID-19 pathogenesis elevated enzyme excessive inflammatory response Extracellular Formation IMPROVE Inflammation Interaction manuscript mechanism medication Metabolic diseases molecular NET NETs neutrophil Neutrophils Occurrence organs pathogenesis of COVID-19 Pathogens patients protease protein S reaction recruitment Regulatory Research Respiratory failure SARS-CoV-1 SARS-CoV-2 serine 2 Significance Spread Stress the SARS-CoV-2 therapeutic strategy therapy thromboembolic complication tissue TMPRSS2 Treatment [DOI] 10.3390/cells10010151 PMC 바로가기 [Article Type] Review
Upregulation of DUSP6 impairs infectious bronchitis virus replication by negatively regulating ERK pathway and promoting apoptosisResearch Article Published on 2021-01-112022-10-28 Journal: Veterinary Research [Category] Coronavirus, [키워드] activated antiviral drugs Apoptosis bronchitis cause Cell cell death component contagious disease Coronavirus infection correlated dominant negative DUSP6 ERK ERK1/2 expression Extracellular facilitate facilitated form IBV IBV infection impair Infectious Bronchitis Virus inhibitor Interaction investigated mutant negative regulation Pathogenesis pathway phosphatase Phosphorylation promoted reduced regulate Regulation Replication restrict shown Signaling signaling pathway siRNA suppressed target therapeutic These data Undetermined viral infection viral infections Viral load viral replication virus virus replication [DOI] 10.1186/s13567-020-00866-x PMC 바로가기 [Article Type] Research Article
Design and Rationale of a Randomized, Double-Blind, Placebo-Controlled, Phase 2/3 Study Evaluating Dociparstat in Acute Lung Injury Associated with Severe COVID-19Clinical Trial Published on 2021-01-012022-10-05 Journal: Advances in therapy [Category] SARS, 임상, [키워드] acute lung injury added advance anti-inflammatory properties approach Biomarker bleeding cause caused coagulation disorder Cohort contributed COVID-19 Critical care D-dimer determine Dexamethasone Dociparstat double-blind Efficacy Emergency use endpoints enrolled Evaluating Extracellular global pandemic HMGB1 hospital hospital ward Hospitalized hypercoagulable Hyperinflammatory Hypoxemia IL-6 Infection lung mechanical ventilation morbidity and mortality NETs Neutrophil extracellular traps New NIAID Novel coronavirus P-selectin participant pathology Patient patients patients with COVID-19 performed phase Phase 2 phase 2/3 trial Phase 3 Placebo placebo-controlled platelet factor 4 Platelet factor 4. positive primary endpoint proportion Randomized rationale reduced risk Respiratory failure robust SARS-CoV-2 sodium Standard of care subsequent supplemental oxygen treat with COVID-19 [DOI] 10.1007/s12325-020-01539-z PMC 바로가기 [Article Type] Clinical Trial
Molecular Insights into the MAPK Cascade during Viral Infection: Potential Crosstalk between HCQ and HCQ AnaloguesReview Published on 2020-12-312022-10-27 Journal: BioMed Research International [Category] [키워드] analogue analogues antimalarial approach approved attacks cascade cause claimed Combination country COVID-19 COVID-19 pandemic Critical Crosstalk deaths Defense disease Diseases drugs Efficacy Extracellular HCQ highlight Host Hydroxychloroquine in viral indicated Infection inhibitor insight MAPK mechanism molecular mechanisms molecular pattern Pandemics pathway Potential Protein receptor respiratory SARS-CoV-2 specific treatment Transcription transducing Treatment variety viral infection viral infections [DOI] 10.1155/2020/8827752 PMC 바로가기 [Article Type] Review
Molecular Insights into the MAPK Cascade during Viral Infection: Potential Crosstalk between HCQ and HCQ AnaloguesReview Published on 2020-12-312022-10-27 Journal: BioMed Research International [Category] COVID-19, MERS, SARS, [키워드] analogue analogues antimalarial approach approved attacks cascade cause claimed Combination country COVID-19 COVID-19 pandemic Critical Crosstalk deaths Defense disease Diseases drugs Efficacy Extracellular HCQ highlight Host Hydroxychloroquine in viral indicated Infection inhibitor insight MAPK mechanism molecular mechanisms molecular pattern Pandemics pathway Potential Protein receptor respiratory SARS-CoV-2 specific treatment Transcription transducing Treatment variety viral infection viral infections [DOI] 10.1155/2020/8827752 PMC 바로가기 [Article Type] Review
Molecular Insights into the MAPK Cascade during Viral Infection: Potential Crosstalk between HCQ and HCQ Analogues바이러스 감염 중 MAPK 캐스케이드에 대한 분자적 통찰력: HCQ와 HCQ 유사체 간의 잠재적인 누화Review Published on 2020-12-312022-09-10 Journal: BioMed Research International [Category] 유전자 메커니즘, [키워드] acute respiratory syndrome coronavirus analogue analogues antimalarial approach approved attacks cascade cause claimed Combination coronavirus country COVID-19 COVID-19 pandemic Critical Crosstalk deaths Defense disease Diseases drugs Efficacy Extracellular HCQ highlight Host host defense Hydroxychloroquine in viral indicated Infection inhibitor insight MAPK mechanism mitogen mitogen-activated protein kinase molecular mechanisms molecular pattern molecular patterns Pandemics pathway Potential Protein quinoline receptor respiratory SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 specific treatment Transcription transducing Treatment variety Viral viral infection viral infections Virus Disease [DOI] 10.1155/2020/8827752 PMC 바로가기 [Article Type] Review
Extracellular RNA as a Versatile DAMP and Alarm Signal That Influences Leukocyte Recruitment in Inflammation and InfectionCell and Developmental Biology Published on 2020-12-182022-10-31 Journal: Frontiers in Cell and Developmental Biology [Category] COVID-19, [키워드] Activation activity administration alarm arteriogenesis Bacteria Blood cells bypasses cardiovascular disease circulating cofactor condition Contact COVID-19 DAMP DAMPs danger-associated molecular patterns defense process demonstrated dissemination docking edema effective endothelial endothelial cells Endothelium ENhance Extracellular extracellular nucleic acids growth help histone host cell immune defense implicated in vitro in vivo include Inflammation Inflammatory inflammatory macrophages inflammatory vascular diseases influence initiate innate immune response Interaction intracellular material Invasion investigated Ischemia leukocyte limit microbial microbial infection microRNA molecular Non-coding RNAs non-toxic nucleic acid pro-thrombotic promote provide provoke Reactions recruitment regimen RNA RNase1 Safe signal subsequent therapeutic thrombosis tissue damage Vascular Vascular injury VEGF vessel vessel wall viral infection viral particle virus virus infection while wound healing [DOI] 10.3389/fcell.2020.619221 PMC 바로가기 [Article Type] Cell and Developmental Biology
Recombinant SARS-CoV-2 Spike Protein Mediates Glycolytic and Inflammatory Activation in Human MonocytesAbstracts Published on 2020-12-162022-10-30 Journal: Innovation in Aging [Category] COVID-19, [키워드] ACE2 receptor activate Activation acute respiratory syndrome cause caused cell lysate Contamination coronavirus disease Coronavirus-2 COVID-19 cytokine production Cytokine storm Donor Efficacy ELISA endotoxin Evidence Extracellular facilitate Glycolysis healthy human monocyte human monocytes Immune cell increase in Inflammation Inflammatory Inflammatory response Interaction interleukin-6 investigated marrow-derived macrophage metabolic monocyte mouse processed Protein protein expression qPCR Rapamycin recombinant SARS-CoV-2 SARS-CoV-2 spike protein Seahorse spike stimulated subunit the spike protein treating COVID-19 upregulation [DOI] 10.1093/geroni/igaa057.3493 PMC 바로가기 [Article Type] Abstracts