Mitigating Coronavirus Induced Dysfunctional Immunity for At-Risk Populations in COVID-19: Trained Immunity, BCG and “New Old Friends”Immunology Published on 2020-09-042022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] Mycobacterium obuense animal anti-SARS-CoV-2 vaccine BCG Characteristics Combined contagious coronavirus SARS-CoV-2 coronavirus vaccine Coronaviruses COVID-19 cytokine dysfunctional immune response effective effort hallmark help high risk highly pathogenic IMM-101 immune cells immune response Immunity immunological immunopathological induced infectious agents knowledge Mycobacterium Novel coronavirus observation overcome pandemic patients with COVID-19 Population PROTECT representing Respiratory illness response risk Safe SARS severe COVID-19 disease Spread systemic level trained immunity Vaccine Vaccine development Vaccines [DOI] 10.3389/fimmu.2020.02059 PMC 바로가기 [Article Type] Immunology
Immunoregulation with mTOR inhibitors to prevent COVID-19 severity: A novel intervention strategy beyond vaccines and specific antiviral medicinesCOVID-19 중증도를 예방하기 위한 mTOR 억제제를 사용한 면역 조절: 백신 및 특정 항바이러스제를 넘어선 새로운 개입 전략Article Published on 2020-09-012022-09-12 Journal: Journal of medical virology [Category] 진단, [키워드] Activation acute respiratory syndrome ADE Antibody-dependent enhancement antiviral medicine Characteristics clinical trial coronavirus Coronavirus disease 2019 COVID-19 CoVs Critical Critically ill patient cross-reactive cross-reactive antibody cytokine Cytokine storm Cytokine storms death develop drug early stage effective global public health high-risk patient highly pathogenic human coronavirus Immunity inhibited inhibitor Intervention mammalian memory B cell more difficult Mortality mortality rate mTOR inhibitor mTOR inhibitors Occurrence Prevent prevented Rapamycin reduce reducing severe symptom severity severity of COVID-19 the disease Vaccine virus [DOI] 10.1002/jmv.26009 PMC 바로가기 [Article Type] Article
Non‐steroidal anti‐inflammatory drugs, prostaglandins, and COVID‐19Review Article Published on 2020-08-272022-10-28 Journal: British Journal of Pharmacology [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome alleviate article coronavirus COVID‐19 COVID‐19 patients COVID‐19 Cytokine storm drug drugs Effect effective Enzymes Fever global pandemic highly pathogenic Inflammation Inflammatory Medicine novel coronavirus disease NSAID NSAIDS Pain PGs Pharmacology progression proinflammatory prostaglandin Respiratory disease responsible SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 Symptom treatment strategy Vaccine [DOI] 10.1111/bph.15206 PMC 바로가기 [Article Type] Review Article
From SARS and MERS to COVID-19: a brief summary and comparison of severe acute respiratory infections caused by three highly pathogenic human coronavirusesReview Published on 2020-08-272022-10-28 Journal: Respiratory Research [Category] COVID-19, MERS, [키워드] Acute respiratory infection Biological features cause caused Clinical characteristics coronavirus death effective feature global infection HCoV Health highly pathogenic human coronavirus human coronaviruses illness infodemic information knowledge lesson medical countermeasure MERS MERS-CoV outbreak Panic SARS-CoV SARS-CoV-2 SARS-CoV-2 pandemic similarity Spread threat virus [DOI] 10.1186/s12931-020-01479-w PMC 바로가기 [Article Type] Review
Molecular Pathogenesis, Immunopathogenesis and Novel Therapeutic Strategy Against COVID-19Molecular Biosciences Published on 2020-08-112022-10-31 Journal: Frontiers in Molecular Biosciences [Category] COVID-19, [키워드] ACE2 ACE2 receptor Activation acute lung injury Against airway epithelial cells antibody appear approach can be used caused cell receptor cellular cleavability complement contagious coronavirus coronavirus disease correlated COVID-19 cytokine Cytokine storm disease disease severity docking drug candidate early phase Effect enzyme excessive inflammatory response expressed expression Factor followed by help highlight highly pathogenic host cells Host immune response host tropism humans IL-6 immune dysregulation immunomodulator immunomodulators inflammatory mediator Innate immunity Interaction involved Lung inflammation mannose-binding lectin mechanism MERS-CoV molecular novel Occurrence pathogenic Proinflammatory cytokine Protein proteolytic recombinant Research respiratory epithelial cell Respiratory tract infections S protein SARS-CoV SARS-CoV-2 SARS-COV-2 infection secreted spike Strategy targeted therapy Therapeutic approach TMPRSS2 understanding Vaccine viral infection Viral pneumonia virulence virus with COVID-19 [DOI] 10.3389/fmolb.2020.00196 PMC 바로가기 [Article Type] Molecular Biosciences
Coronavirus Interplay With Lipid Rafts and Autophagy Unveils Promising Therapeutic TargetsMicrobiology Published on 2020-08-112022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] agent anti-viral role approach autophagic autophagy cell entry Cluster Contact coronavirus Coronavirus infection Coronavirus infections Coronaviruses COVID-19 Degradation disrupt drugs Health highly pathogenic host cell Host immune response hosts induce infect Infection inhibit inhibitor investigated involved Lipid Lipid rafts Mild occur pandemic pathogen plasma membrane positive-sense potential therapeutic target raft recent receptor regions Replication reported representing researcher respiratory diseases responsible RNA virus SARS-CoV-2 shown single-stranded target this new coronavirus treat Treatment Vaccine variant viral infections viral products virus viruses [DOI] 10.3389/fmicb.2020.01821 PMC 바로가기 [Article Type] Microbiology
Wide Diversity of Coronaviruses in Frugivorous and Insectivorous Bat Species: A Pilot Study in Guinea, West AfricaArticle Published on 2020-08-052022-10-28 Journal: Viruses [Category] COVID-19, Fulltext, MERS, 조류인플루엔자, [키워드] acute respiratory syndrome Africa Alpha bat beta coronavirus circulation coronavirus Coronaviruses country CoV COVID-19 pandemic CoVs Diversity evaluate FIVE Guinea highly pathogenic hosts human coronaviruses human populations humans public health risk SARS-CoV2 sequence Spread tested Virus diversity West Zoonotic coronavirus zoonotic CoV [DOI] 10.3390/v12080855 PMC 바로가기 [Article Type] Article
Sequence analysis and pathogenicity of Avian Orthoavulavirus 1 strains isolated from poultry flocks during 2015–2019Research Article Published on 2020-07-222022-10-28 Journal: BMC veterinary research [Category] Coronavirus, [키워드] Amino acid residue substitution Analysis Avian Orthoavulavirus 1 cause Co-infection decrease Delta disease examined F protein fusion protein gene sequence genetic analysis Genotype glycosylation high mortality highly pathogenic IBV indicated Infectious Bronchitis Virus Influenza Intensive Intracerebral isolate isolates Isolation molecular motif neutralizing epitopes newcastle disease virus pathogenic pathogenicity positive Prevalence primer qRT-PCR ranged RBCs reduce residue respiratory viral disease Result selected sequenced Sequencing Seven Spread strain submitted suffered tested vaccination Vaccines [DOI] 10.1186/s12917-020-02470-9 PMC 바로가기 [Article Type] Research Article
Protective Immunity against SARS Subunit Vaccine Candidates Based on Spike Protein: Lessons for Coronavirus Vaccine DevelopmentReview Article Published on 2020-07-182022-10-29 Journal: Journal of Immunology Research [Category] COVID-19, MERS, SARS, [키워드] against SARS-CoV animal model Antigen candidate coronavirus Coronavirus infection coronavirus spike protein coronavirus vaccine COVID-19 develop development effective facilitate Genetic global health security help highly pathogenic induce lesson neutralizing antibody novel coronavirus disease outbreak pathogenic coronavirus protective immunity respiratory SARS-CoV SARS-CoV-2 similarity spike subunit the vaccine Vaccine vaccine candidate virus [DOI] 10.1155/2020/7201752 PMC 바로가기 [Article Type] Review Article
Cryo-EM analysis of the post-fusion structure of the SARS-CoV spike glycoproteinArticle Published on 2020-07-172022-10-04 Journal: Nature Communications [Category] SARS, 변종, 치료제, [키워드] acute respiratory syndrome Analysis Antigen caused Cell conserved contribute coronavirus Coronaviruses Cryo-electron microscopy cryo-EM structure Cryoelectron microscopy form glycoprotein Health Hepatitis highly pathogenic Host information linker mechanism membrane membrane fusion MERS-CoV MHV motif mouse Protein Proteins receptor respiratory syndrome coronavirus responsible S2 subunit SARS virus SARS-CoV SARS-CoV S SARS-CoV-2 SARS-like coronaviruses significantly spike glycoprotein Structure target therapeutic therapy trimer upstream Vaccine viral entry viral membrane virus [DOI] 10.1038/s41467-020-17371-6 PMC 바로가기 [Article Type] Article