Multidisciplinary Approaches Identify Compounds that Bind to Human ACE2 or SARS-CoV-2 Spike Protein as Candidates to Block SARS-CoV-2–ACE2 Receptor Interactions다학제적 접근 방식으로 SARS-CoV-2–ACE2 수용체 상호작용을 차단하는 후보로서 인간 ACE2 또는 SARS-CoV-2 스파이크 단백질에 결합하는 화합물 식별Research Article Published on 2021-03-302022-09-10 Journal: mBio [Category] SARS, 신약개발, 치료제, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 Antiviral bind binding block blockade candidate causative agent cause caused cellular receptor Compound compounds coronavirus COVID-19 death demonstrated Diseases Dissociation constant dose-dependent drug Drug development Drug screening dual entry inhibitors enzyme evaluate Evans blue Human human ACE2 identify in vitro Infection Infectious disease inhibitor Interaction interfere Intervention library lifitegrast lumacaftor molecular docking Protein RBD RBD binders RBD-ACE2 receptor Receptor binding domain Registered repurposing respiratory SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 RBD SARS-CoV-2 spike glycoprotein SARS-CoV-2 spike protein SARS-CoV-2 spike protein receptor binding domain severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 sodium spike spike glycoprotein Spike protein SPR surface plasmon surface plasmon resonance targets the RBD the SARS-CoV-2 these compounds VERO-E6 virus was used [DOI] 10.1128/mBio.03681-20 PMC 바로가기 [Article Type] Research Article
Repurposing of approved drugs with potential to interact with SARS-CoV-2 receptorResearch Article Published on 2021-03-292022-10-04 Journal: Biochemistry and Biophysics Reports [Category] 신약개발, [키워드] Abstract ACE ACE1 ACE2 addition Amino acid Analysis angiotensin approved drug binding Cell comparable coronavirus 2 COVID-19 distribution domain Drug repurposing entry of SARS-CoV-2 enzyme epithelial expression homolog host cells host-virus interaction human cells human lung Image Infection Interaction interfere low expression organized peptidase predict primary sequence Proteins RBD receptor Receptor binding domain Region reported repurposing respiratory S protein same order SARS-CoV-2 SARS-CoV-2 receptor SARS-CoV-2 spike protein similarities similarity spike glycoprotein Spike protein the SARS-CoV-2 tissue Transmission variety viral spike protein X-ray crystallographic structure [DOI] 10.1016/j.bbrep.2021.100982 PMC 바로가기 [Article Type] Research Article
Thyroid and COVID-19: a review on pathophysiological, clinical and organizational aspectsReview Published on 2021-03-252022-10-30 Journal: Journal of Endocrinological Investigation [Category] COVID-19, [키워드] activity Adequate Affect analyzed Atypical baseline Care Chronic lymphocytic thyroiditis Clinical course collected consequence COVID-19 defined deteriorate detrimental diagnostic procedure disease dysfunction endocrine disease Evidence Google Scholar Graves’ disease healthcare healthcare service higher risk Hyperthyroidism Hypothyroidism In-hospital in-person visit induce Infection interfere management measure nodule objective pandemic pathophysiological Patient patients with COVID-19 Prognosis progression recognize reducing Result SARS-CoV-2 searched secretion seriously ill patient Severe case Subclinical thyroiditis subject Telemedicine the disease therapeutic therapeutic intervention Thyroid thyroid dysfunction thyroid nodules Thyroiditis triiodothyronine with COVID-19 [DOI] 10.1007/s40618-021-01554-z PMC 바로가기 [Article Type] Review
Epigenetic Lens to Visualize the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) Infection in COVID-19 PandemicGenetics Published on 2021-03-222022-10-31 Journal: Frontiers in Genetics [Category] COVID-19, [키워드] Alter alteration assist association chromatin coronavirus Coronaviruses COVID COVID-19 deaths develop DNA Epidemics Epigenetic epigenetic modulation epigenetics evade Factor Genetic global infection highlight Host host cell host gene expression Host immune response host-pathogen interaction human populations immune response immune sensing Immunopathogenesis Infection interactions interfere intrinsic involved kill knowledge Len mechanism MERS-CoV Methylation miRNA Modification modulate modulated Mortality Non-coding RNAs pandemic Pathogenesis pathway phenotypic prevent disease progression provide regulate Replication researchers respiratory respiratory RNA viruses RNA virus SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARSCoV2 SARSCoV2 pathogenesis Spread the disease treat Treatment Variation virus widespread [DOI] 10.3389/fgene.2021.581726 PMC 바로가기 [Article Type] Genetics
Professionalism revisited during the pandemics of our time: COVID-19 and racismEye-Opener Published on 2021-03-182022-10-28 Journal: Perspectives on Medical Education [Category] Coronavirus, MERS, SARS, [키워드] Burnout Care COVID-19 Critical hcp Health Health care ethics Health professionals highlighting impacted interfere Pandemics Patient PPE Prevent principle professionalism sick Social Justice treat [DOI] 10.1007/s40037-021-00657-w PMC 바로가기 [Article Type] Eye-Opener
Bepridil is potent against SARS-CoV-2 in vitroBepridil은 시험관 내 SARS-CoV-2에 강력합니다.410 Published on 2021-03-092022-08-13 Journal: Proceedings of the National Academy of Sciences of [Category] Biochemistry, COVID-19, SARS, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis animal model animal models Antiviral bepridil Cell characterized Clinical tests Clinical use Concentration coronavirus COVID-19 COVID-19 patients docking dose-dependent manner drug Drug administration dual ebastine effective endosomal pH food function Host human cell in vitro indicated infected cells inhibit inhibiting interfere Live virus main protease mammalian cell medication Medicine microneutralization pathogen pimozide protease raising respiratory SARS-CoV-2 SARS-CoV-2 entry severe acute respiratory syndrome Coronavirus Significance small molecule Small molecules tested Vero E6 [DOI] 10.1073/pnas.2012201118 PMC 바로가기 [Article Type] 410
Polyunsaturated ω-3 fatty acids inhibit ACE2-controlled SARS-CoV-2 binding and cellular entryArticle Published on 2021-03-042022-10-29 Journal: Scientific Reports [Category] COVID-19, SARS, [키워드] addition affected anti-SARS-CoV-2 Antiviral compound antiviral efficacy binding cathepsin L cellular entry Compound COVID-19 Efficacy entry of SARS-CoV-2 expression Fatty acid fatty acids hACE2 hACE2 receptor in vivo experiment inhibit interfere Ligand linolenic acid Lipid Microbiology pandemic Polyunsaturated Proteases protein level provide pseudo-virus receptor reducing reduction SARS-CoV-2 saturated screened sequence shown significantly Spike protein the SARS-CoV-2 TMPRSS2 Treatment Virology vitamins WHO [DOI] 10.1038/s41598-021-84850-1 PMC 바로가기 [Article Type] Article
Therapeutic Potential of EGCG, a Green Tea Polyphenol, for Treatment of Coronavirus DiseasesCommunication Published on 2021-03-042022-10-29 Journal: International Review of Cell and Molecular Biology [Category] COVID-19, [키워드] 3CL addition Antiviral Bioavailability cleaved coronavirus coronavirus disease coronavirus diseases Coronaviruses COVID-19 demonstrated EGCG enzymatic activity epigallocatechin gallate Evidence green green tea inhibit interfere maturation polyphenol polyprotein Potential protease regulate Replication reported Research RNA-dependent RNA polymerase SARS-CoV-2 targets tea Treatment viral spike protein [DOI] 10.3390/life11030197 PMC 바로가기 [Article Type] Communication
Lung Protection vs. Infection Resolution: Interleukin 10 Suspected of Double-Dealing in COVID-19Immunology Published on 2021-03-032022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] absence acute respiratory syndrome age cellular clinical phenotype contribute coronavirus coronavirus disease COVID-19 cytokine Defense Deterioration endotype etiological feature Genotype hallmark Health High-risk patients identifying IL-10 immune Immune-mediated increase increases in independent Infection infections Injury interfere interleukin Interleukin 10 lung outcome Patient Peripheral blood PROTECT protection Regulatory SARS-CoV infection SARS-CoV-2 severity Suspected thought underlie viral clearance Viral load viral spread virus while [DOI] 10.3389/fimmu.2021.602130 PMC 바로가기 [Article Type] Immunology
COVID-19: Is reinfection possible?Review Article Published on 2021-03-022022-10-31 Journal: EXCLI Journal [Category] COVID-19, [키워드] adopted Complete concerning COVID-19 COVID-19 pandemic criteria cured Diagnosis discharge effective Epidemiology Factor Follow-up health system hospitals impacts Infection information interfere MOST pandemic Patient patients positive positive RT-PCR presenting recover recurrence Reinfection released robust SARS-CoV-2 Spread subject Treatment Viral RNA virus [DOI] 10.17179/excli2021-3383 PMC 바로가기 [Article Type] Review Article