Generation of SARS-CoV-2 reporter replicon for high-throughput antiviral screening and testing
고처리량 항바이러스 스크리닝 및 테스트를 위한 SARS-CoV-2 리포터 복제 생성
423
Published on
Journal: Proceedings of the National Academy of Sciences of [Category] MERS, SARS, 유전자 메커니즘, 치료제,
Journal: Proceedings of the National Academy of Sciences of [Category] MERS, SARS, 유전자 메커니즘, 치료제,
[키워드] accelerate
acute respiratory syndrome
acute respiratory syndrome coronavirus
adopted
Antiviral
Antiviral compound
Antiviral compounds
antivirals
biology of SARS-CoV-2
biosafety level
Biosafety Level 3
BSL-3
Cell culture
cell line
cell lines
cells
competent
Compound
construction
coronavirus
costly
COVID-19
COVID-19 pandemic
effective
effort
expand
Generation
Genome
high-throughput antiviral screening
highlight
implementation
in vivo
Infectious virus
inhibited
inhibiting viral replication
inhibitor
investigator
Laboratory
lack
level 3
limitations
mechanism
overcome
platform
producing
progeny virions
provide
RdRP
RdRp mutation
RdRp mutations
Replication
replicon
reporter
Research
respiratory
SARS-CoV-2
SARS-COV-2 infection
severe acute respiratory syndrome Coronavirus
severe acute respiratory syndrome coronavirus 2
Significance
Significant
significant differences
this system
Treatment
urgency
Viral
viral replication
virus
virus replication
[DOI] 10.1073/pnas.2025866118 PMC 바로가기 [Article Type] 423
[DOI] 10.1073/pnas.2025866118 PMC 바로가기 [Article Type] 423