Clinical guidance for navigating the QTc-prolonging and arrhythmogenic potential of pharmacotherapy during the COVID-19 pandemicCOVID-19 전염병 동안 약물 요법의 QTc 연장 및 부정맥 발생 가능성을 탐색하기 위한 임상 지침Review Published on 2021-02-012022-09-11 Journal: Irish Journal of Medical Science [Category] SARS, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Azithromycin cardiac death clinical clinical evidence contagious coronavirus coronavirus disease COVID-19 COVID-19 pandemic death deleterious effect disease drug drug-induced Drug-induced QTc prolongation focus Guidance guidelines Healthcare provider healthcare providers Healthcare system Healthcare systems help Hydroxychloroquine Kaletra lAbel Lopinavir Lopinavir/ritonavir medication medications mitigate Mortality Prevent public health QT interval QTc QTC prolongation respiratory responsible Ritonavir robust SARS-CoV-2 severe acute respiratory syndrome Coronavirus Spread sudden cardiac death torsades de pointes treat Treatment [DOI] 10.1007/s11845-020-02291-7 PMC 바로가기 [Article Type] Review
Insights of Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2) pandemic: a current reviewReview Published on 2021-02-012022-10-27 Journal: Biological Procedures Online [Category] COVID-19, [키워드] ACE-2 ACE-2 receptor ancestor antiviral drugs approaches approval Arbidol Azithromycin cause causes China chlorpromazine coronavirus country COVID-19 COVID-19 pandemic development domain drug Drug repurposing Evolution gastrointestinal systems group HCQ Health Organization Human human Angiotensin-converting enzyme insight Lopinavir membranes Novel coronavirus Oritavancin pandemic pandemic era rapid test kit receptors recommendation Research resource respiratory RT-PCR SARS-CoV-2 Support Treatment Trial Vaccine virulent WHO [DOI] 10.1186/s12575-020-00141-5 PMC 바로가기 [Article Type] Review
Clinical Outcomes and Plasma Concentrations of Baloxavir Marboxil and Favipiravir in COVID-19 Patients: An Exploratory Randomized, Controlled TrialCOVID-19 환자에서 Baloxavir Marboxil 및 Favipiravir의 임상 결과 및 혈장 농도: 탐색적 무작위 대조 시험Randomized Controlled Trial Published on 2021-02-012022-09-11 Journal: European journal of pharmaceutical sciences : offi [Category] SARS, 임상, 치료제, [키워드] addition antiviral activities antiviral activity antiviral drug antiviral drugs Arbidol Arm assigned baloxavir baloxavir acid baloxavir marboxil benefit Blood Chinese Chinese Clinical Trial Registry clinical clinical benefit clinical benefits Clinical improvement Clinical outcome clinical outcomes comparable Concentration conducted control group control groups Controlled COVID-19 COVID-19 patients Day dosage drug enrolled evaluate evaluated exploratory Favipiravir half-maximal effective concentration Hospitalized in vitro lack limitation Lopinavir medians Patient patients with COVID-19 pharmacokinetics plasma concentration plasma concentrations Primary outcome randomization Randomized reason for reduction Registered registry SARS-CoV-2 standard treatment subject symptom onset the half-maximal effective concentration (EC(50)). the median Treatment Trial Viral Virological [DOI] 10.1016/j.ejps.2020.105631 PMC 바로가기 [Article Type] Randomized Controlled Trial
Repeated COVID-19 relapse during post-discharge surveillance with viral shedding lasting for 67 days in a recovered patient infected with SARS-CoV-2SARS-CoV-2에 감염된 회복된 환자에서 67일 동안 지속되는 바이러스 배출과 함께 퇴원 후 감시 중 반복적인 COVID-19 재발Case Reports Published on 2021-02-012022-09-11 Journal: Journal of microbiology, immunology, and infection [Category] 치료기술, [키워드] Budesonide characteristic Chest radiography coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 discharge disease infected with SARS-CoV-2 Lopinavir Patient Prognosis recovered recovered patients Relapse ribavirin SARS-CoV-2 SARS-CoV-2 re-positive Surveillance Treatment Viral viral clearance viral shedding [DOI] 10.1016/j.jmii.2020.07.017 PMC 바로가기 [Article Type] Case Reports
Sex Differences in Lopinavir Concentrations and Occurrence of Marked QTc Prolongation Episodes in Patients with COVID-19COVID-19 환자에서 Lopinavir 농도의 성별 차이 및 현저한 QTc 연장 에피소드의 발생Comment Published on 2021-02-012022-09-11 Journal: Drug safety [Category] SARS, 치료제, [키워드] difference episode Lopinavir prolongation QTc with COVID-19 [DOI] 10.1007/s40264-020-01025-z PMC 바로가기 [Article Type] Comment
Investigational Treatments for COVID-19 may Increase Ventricular Arrhythmia Risk Through Drug InteractionsCOVID-19에 대한 조사 치료는 약물 상호 작용을 통해 심실 부정맥 위험을 증가시킬 수 있습니다Article Published on 2021-02-012022-09-11 Journal: CPT: pharmacometrics & systems pharmacology [Category] 치료제, [키워드] action potential Analysis Arrhythmias Azithromycin cardiac adverse event cardiac adverse events cardiac electrophysiology caused cellular Chloroquine Combination combination therapy coronavirus disease Coronavirus disease 2019 COVID-19 disease drug drug combination drug combinations Drug interactions drugs Effect Factor greater healthy individual healthy individuals heart disease heart failure increase Isolation lead Lopinavir mathematical men molecular Myocyte Patient patient group pharmacokinetics potential benefits predict predicted QT prolongation Quantitative reported risk Ritonavir Sex Simulation statistical analysis susceptible Therapies treat Treatment ventricular ventricular arrhythmias women [DOI] 10.1002/psp4.12573 PMC 바로가기 [Article Type] Article
Can Zn Be a Critical Element in COVID-19 Treatment?Zn이 COVID-19 치료에서 중요한 요소가 될 수 있습니까?Review Published on 2021-02-012022-09-11 Journal: Biological trace element research [Category] 치료제, [키워드] adaptive addition anti-viral drug Anti-viral drugs Anti-viral treatment Antibiotics Azithromycin Can caused Chloroquine complement Course COVID-19 COVID-19 pandemic COVID-19 treatment doxycycline drugs effective Effectiveness element ENhance Evidence Immunity infected cell innate and adaptive immunity investigator investigators Ionophore Ivermectin Lopinavir Lopinavir/ritonavir parasite Perspective Pneumocytes Remdesivir ribavirin Ritonavir RNA RNA dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 replication suggested Treatment treatment of COVID-19 Viral viral infection Zinc zinc transporter [DOI] 10.1007/s12011-020-02194-9 PMC 바로가기 [Article Type] Review
Potential anti-COVID-19 activity of Egyptian propolis using computational modelingShort Communication Published on 2021-02-012022-10-31 Journal: Future Virology [Category] COVID-19, [키워드] addition Analysis Anti-COVID-19 Antiviral agents binding characterized collected computational modeling COVID-19 enzyme geographical area Lopinavir macromolecule material pandemic Potential predict Propolis protease Remdesivir Result RNA-dependent RNA polymerase spike protein S1 umifenovir [DOI] 10.2217/fvl-2020-0329 PMC 바로가기 [Article Type] Short Communication
Assessment of antiviral potencies of cannabinoids against SARS-CoV-2 using computational and in vitro approaches컴퓨터 및 시험관 접근법을 사용한 SARS-CoV-2에 대한 칸나비노이드의 항바이러스 효능 평가Article Published on 2021-01-312022-09-11 Journal: International journal of biological macromolecules [Category] SARS, 신약개발, 치료제, [키워드] absence acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Antiviral antiviral activity antiviral molecule antiviral potency approach assessment binding pocket cannabidiol cannabinoids Cannabinols carried Chloroquine Combination conformation coronavirus coronavirus SARS-CoV-2 Coronavirus-2 COVID-19 patients Density functional theory drug effective enzyme FIVE functional human coronavirus in silico in vitro In vitro antiviral assay in vitro experiment Interaction lead Lopinavir M pro molecular performed Remdesivir Research respiratory SARS-CoV-2 SARS-CoV-2 and M(pro) enzyme. Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus tetrahydrocannabinol the SARS-CoV-2 treat Treatment Viral viral infection viral infections Virtual screening [DOI] 10.1016/j.ijbiomac.2020.12.020 PMC 바로가기 [Article Type] Article
Comparative Evaluation of the Treatment of COVID-19 with Multicriteria Decision-Making Techniques다기준 의사결정 기법을 통한 코로나19 치료의 비교 평가Comparative Study Published on 2021-01-222022-09-10 Journal: Journal of Healthcare Engineering [Category] 진단, 치료제, [키워드] addition administration age alternatives Analysis applied assigned Comparative complex coronavirus disease Coronavirus disease 2019 COVID-19 criteria drug effective evaluate evaluated Favipiravir Fever followed by FPV global pandemic healthcare Hydroxychloroquine Immunoglobulin include interleukin Intravenous immunoglobulin IVIG Kidney function Lopinavir Lopinavir/ritonavir management New objective outbreak plasma plasma exchange Pregnancy problem qualitative data Quantitative reported Result Ritonavir Side effects technique the disease to define Treatment treatment methods [DOI] 10.1155/2021/8864522 PMC 바로가기 [Article Type] Comparative Study