SARS-CoV-2 infection mediates differential expression of human endogenous retroviruses and long interspersed nuclear elementsSARS-CoV-2 감염은 인간 내인성 레트로바이러스와 긴 산재된 핵 요소의 차등 발현을 매개합니다Research Article Published on 2021-12-222022-09-10 Journal: JCI Insight [Category] SARS, 유전자 메커니즘, [키워드] activities activity binding site bioinformatics Bronchoalveolar lavage fluid Cell cell line cell lines cellular response Coronaviridae coronavirus COVID-19 differential expression differentially expressed distinctive features downregulation downstream Effect element expression feature host gene host gene expression host response human endogenous retrovirus human parainfluenza virus IAV immune response immune responses infection with SARS-CoV-2 Infectious disease Influenza influenza A influenza A virus innate immune Innate immunity investigated involved MERS MERS-CoV Middle East Middle East respiratory syndrome Coronavirus modulate modulating nuclear overexpression Patient patients with COVID-19 PBMCs promote Protein respiratory respiratory syncytial virus respiratory syndrome coronavirus RNA-seq data RSV SARS-CoV-2 SARS-COV-2 infection severity of COVID-19 subset Telescope transcription factor transcription factors Transcriptome transcripts unique upregulation Viral virus viruses [DOI] 10.1172/jci.insight.147170 PMC 바로가기 [Article Type] Research Article
Enhanced replication fitness of MERS-CoV clade B over clade A strains in camelids explains the dominance of clade B strains in the Arabian PeninsulaCoronaviruses Published on 2021-12-172022-10-31 Journal: Emerging Microbes & Infections [Category] COVID-19, [키워드] adaptive alpaca Amino acid amino acid substitution Analysis animal Antiviral Arabian Peninsula binding caused clade decrease difference double-stranded elicited enhanced Epidemic explain Frame hosts Human Hypothesis IFN IFN response immunological parameters in vivo infecting Infection inoculated interferon-stimulated gene ISGs MERS-CoV Middle East Middle East respiratory syndrome Coronavirus moderate motif nasal nasal mucosa orf4a post inoculation Protein Replication replicative reported respiratory syndrome coronavirus respiratory tract RNA S proteins strain subsequent Transcription Transmission variant viral loads viral shedding Virological virus while [DOI] 10.1080/22221751.2021.2019559 PMC 바로가기 [Article Type] Coronaviruses
A Yellow Fever 17D Virus Replicon-Based Vaccine Platform for Emerging CoronavirusesArticle Published on 2021-12-162022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] Antibody Response Antigen antigenic chimeric coronavirus Coronaviruses derivatives DNA E protein Effective vaccines Efficacy elicited expressing humans immunogenic infected cells MERS-CoV MHV mice mRNA-based Neutralizing Neutralizing antibodies outbreak Particle Pathogens platform Protein provided RBD Region replacing RNA S1 Safe SARS-CoV SARS-CoV spike protein SARS-CoV-2 SARS-CoV-2 pandemic Spike protein surface protein Vaccine vaccine platform Vaccines virus viruses yellow yellow fever YF17D YFV-17D [DOI] 10.3390/vaccines9121492 PMC 바로가기 [Article Type] Article
Molecular Characterization of Infectious Bronchitis Virus Strain HH06 Isolated in a Poultry Farm in Northeastern ChinaVeterinary Science Published on 2021-12-162022-11-01 Journal: Frontiers in Veterinary Science [Category] COVID-19, [키워드] Analysis bovine characterization characterized China clade clades coronavirus Coronaviruses CoV CoVs domain Epidemic Evolution explain farm Genetic Genome glycoprotein HCoV-OC43 Host IBV indicated Infectious Bronchitis Virus Isolated maintain mammalian MERS-CoV Molecular epidemiology motif Phylogenetic Phylogenetic relationship poultry protein sequence Recombination S gene S protein SARS CoV-2 SARS-CoV SARS-CoV-2 selected selection pressure sequence spike Spread strain variant virulent viruses zoonosis [DOI] 10.3389/fvets.2021.794228 PMC 바로가기 [Article Type] Veterinary Science
Comparison of Experimental Middle East Respiratory Syndrome Coronavirus Infection Acquired by Three Individual Routes of Infection in the Common MarmosetPathogenesis and Immunity Published on 2021-12-152022-10-30 Journal: Journal of Virology [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] Callithrix jacchus Acquired acute respiratory syndrome aerosol route Aerosols animal animal model breathing difficulties Callithrix caused challenge characterized common complications Concentration coronavirus cough demonstrated described disease emerging disease England Erasmus Fatality rate Fever Host host response Human Immunological response individual interstitial pneumonia intranasal Lung disease lung tissue Macrophage macrophages marmoset medical countermeasure MERS-CoV Middle East Middle East respiratory syndrome Mild neutrophil function Neutrophils Pneumonia Pyrexia renal respiratory respiratory syndrome coronavirus route SARS-CoV-2 severity Shortness of breath strain syndrome the disease throat swab upregulation Viable virus were used [DOI] 10.1128/jvi.01739-21 PMC 바로가기 [Article Type] Pathogenesis and Immunity
Systematic assessment of SARS-CoV-2 virus in wastewater, rivers and drinking water – A catchment-wide appraisal폐수, 강 및 식수에서 SARS-CoV-2 바이러스의 체계적인 평가 - 집수 전체 평가Article Published on 2021-12-152022-09-11 Journal: The Science of the total environment [Category] SARS, 치료기술, [키워드] acute respiratory syndrome Aerosols African appear attenuation caused Chain Reaction contagious coronavirus COVID-19 Detection limit downstream drinking water evaluated faece Faeces global pandemic HCoVs Human human coronaviruses infective MERS MERS-CoV Middle East Middle East respiratory syndrome Migration mortality rate Municipal wastewater offer outbreak patients PCR polymerase chain polymerase chain reaction potential risk Probability Quality monitoring Quantitative Real-time quantitative reverse transcription polymerase chain reaction (RT-qPCR) receiving reservoir of infection retention time reverse transcription RT-qPCR SARS-CoV SARS-CoV virus SARS-CoV-2 SARS-CoV-2 migration SARS-CoV-2 viral RNA SARS-CoV-2 virus Severe acute respiratory syndrome South stages status syndrome temperature the SARS-CoV-2 virus Transmission Treatment virus viruses wastewater water water bodies water body water quality Water quality monitoring. [DOI] 10.1016/j.scitotenv.2021.149298 PMC 바로가기 [Article Type] Article
Production of SARS-CoV-2 N Protein-Specific Monoclonal Antibody and Its Application in an ELISA-Based Detection System and Targeting the Interaction Between the Spike C-Terminal Domain and N ProteinMicrobiology Published on 2021-12-072022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] anti-SARS-CoV-2 N antibody antibody application bait and prey C-terminal domain cell lysate clade coronavirus culture media detect detection diagnose ELISA fusion protein human-to-human transmission infected cell interact Interaction MERS-CoV monoclonal antibody N protein pfu produced Production Proteins recognize reported SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 N sensitivity spike Spike protein Spread System targeting the N protein the SARS-CoV-2 the Spike the spike protein this system Vero Cell Vero cells virus detection [DOI] 10.3389/fmicb.2021.726231 PMC 바로가기 [Article Type] Microbiology
A Review of SARS-CoV2: Compared With SARS-CoV and MERS-CoVMedicine Published on 2021-12-072022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] acute respiratory syndrome Characteristics characterized China Chinese concern coronavirus disease COVID-19 curtail Cytokine storm Emergency Evidence genomic Government Health hospital limit lymphocyte lymphopenia measure MERS-CoV outbreak pandemic PHEIC PHEIC 3 Pneumonia Public public health review SARS-CoV SARS-CoV2 severe COVID-19 similarity Spread the epidemic transmission pattern were used WHO World Health Organization [DOI] 10.3389/fmed.2021.628370 PMC 바로가기 [Article Type] Medicine
Strategies for drug repurposing against coronavirus targetsCOVID-19 therapy edited by Isabella Zanella & Simon Pitchford Published on 2021-12-042022-10-04 Journal: Current Research in Pharmacology and Drug Discovery [Category] 신약개발, [키워드] agency approved drug ARDS attrition Compound coronavirus coronavirus target de novo drug Drug discovery Drug repurposing Epidemic hospital human coronaviruses Impact in silico screening in viral involved MERS-CoV pandemic Patient Proteases public health Regulatory repurposing safety profile SARS-CoV SARS-CoV-2 significantly Strategy target Treatment viral replication viral-induced virus widespread [DOI] 10.1016/j.crphar.2021.100072 PMC 바로가기 [Article Type] COVID-19 therapy edited by Isabella Zanella & Simon Pitchford
The NSP14/NSP10 RNA repair complex as a Pan-coronavirus therapeutic targetArticle Published on 2021-12-032022-10-31 Journal: Cell Death and Differentiation [Category] COVID-19, COVID19(2023년), SARS, [키워드] Antiviral Antiviral effect antivirals cellular complex DNA repair enzymes Efficacy ENhance exonuclease human coronavirus OC43 in silico in vitro Infectious diseases inhibit inhibitor MERS-CoV Microbiology pandemic Proofreading provide Remdesivir replication of SARS-CoV-2 risk RNA SARS-CoV SARS-CoV-2 Screening sofalcone the SARS-CoV-2 therapeutic target Zoonotic coronavirus [DOI] 10.1038/s41418-021-00900-1 PMC 바로가기 [Article Type] Article