Messenger RNA – Page 17 – Communicable Diseases Research

Structure–function analysis of the nsp14 N7–guanine methyltransferase reveals an essential role in Betacoronavirus replication

423

Published on 2021-11-292022-10-29
Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19,

[키워드] acute respiratory syndrome affecting Analysis approach Betacoronavirus betacoronaviruses biochemical C-terminal catalytic cellular characterized conserved coronavirus CoV CoVs Critical defined Degradation develop domain drugs enzymatic activity enzyme Exoribonuclease feature genomes highlight host cell cytoplasm identify in silico in viral inhibitor innate immune involved MERS-CoV Messenger RNA methyltransferase Middle East MOST mRNA mRNA capping mRNAs Mutation N-terminal nonstructural protein 14 nsp14 nsp14-ExoN pandemic phenotype PROTECT replicate Replication replicative residue reveal RNA synthesis SARS-CoV SARS-CoV-2 selected Significance site-directed mutagenesis Substitution subunit syndrome targets tested translation unique viability Virological virus was used yielding
[DOI] 10.1073/pnas.2108709118 PMC 바로가기 [Article Type] 423

Mild Adverse Events of Sputnik V Vaccine in Russia: Social Media Content Analysis of Telegram via Deep Learning

Original Paper

Published on 2021-11-292022-10-30
Journal: Journal of Medical Internet Research [Category] COVID-19, MERS, SARS,

[키워드] addition Administered Adverse adverse event adverse events AEs age analyzed applied average caused chills chose clinical trial co-occurrence collected comparable concerning conducted content corpus COVID-19 COVID-19 vaccines database dataset deep deep learning diarrhea doses drugs elderly Euclidean distance fatigue Fever first dose frequencies Gam-COVID-Vac Gender headache information Insomnia Lancet learning lymph node enlargement media men Messenger RNA Mild nausea/vomiting objective Pain Pearson correlation performed Phase 3 pruritus reported representation Result resulting Russian language safety profile SARS-CoV-2 second dose sequence significantly more social media Sputnik V Symptom systemic AE Telegram transformer Trial unique vaccination Vaccine vaccine safety Vaccines vector
[DOI] 10.2196/30529 PMC 바로가기 [Article Type] Original Paper

Assessment of 4 Doses of SARS-CoV-2 Messenger RNA–Based Vaccine in Recipients of a Solid Organ Transplant

고형 장기 이식 환자에서 SARS-CoV-2 메신저 RNA 기반 백신 4회 용량 평가

Research

Published on 2021-11-242022-09-12
Journal: JAMA Network Open [Category] MERS, SARS, 진단,

[키워드] Antibody Response assessment case sery dose France messenger Messenger RNA recipient SARS-CoV-2 Solid solid organ solid organ transplant Transplant Vaccine
[DOI] 10.1001/jamanetworkopen.2021.36030 PMC 바로가기 [Article Type] Research

The Importance of RNA-Based Vaccines in the Fight against COVID-19: An Overview

Review

Published on 2021-11-172022-10-28
Journal: Vaccines [Category] COVID-19,

Comparative safety of mRNA COVID‐19 vaccines to influenza vaccines: A pharmacovigilance analysis using WHO international database

Research Article

Published on 2021-11-082022-10-04
Journal: Journal of medical virology [Category] Fulltext, MERS, 진단,

[키워드] 95% CI 95% confidence interval adjusted adverse event AEs Analysis cardiovascular complications Comparative COVID‐19 COVID‐19 database demonstrated detect Evidence fatigue hypertensive immunization individual Influenza influenza vaccine influenza vaccines injection International Loss of consciousness lower risk Messenger RNA Moderna mRNA mRNA vaccination mRNA vaccine mRNA vaccines myalgia Neurological complication Odds ratio Pfizer‐BioNTech post‐implementation surveillance prevalent previous study reaction reactogenicity event reported risk Safety safety profile significantly higher suggested supraventricular Syncope syndrome Tachycardia vaccinated individual Vaccine Vaccines VigiBase visual impairment Volume WHO
[DOI] 10.1002/jmv.27424 PMC 바로가기 [Article Type] Research Article

Bioinformatics and system biology approaches to identify the diseasome and comorbidities complexities of SARS-CoV-2 infection with the digestive tract disorders

소화관 장애와 SARS-CoV-2 감염의 질병 및 동반 질환 복잡성을 식별하기 위한 생물정보학 및 시스템 생물학 접근

Article

Published on 2021-11-052022-09-12
Journal: Briefings in Bioinformatics [Category] MERS, SARS, 진단,

[키워드] Analysis approach association bioinformatics CEL Comorbidity complex interplay coronavirus 2 correlation COVID-19 COVID-19 pandemic COVID-19 positive patient COVID-19 positive patients Critical CRO differentially expressed differentially expressed gene Differentially expressed genes digestive digestive disorders digestive tract diseasome disorder disorders Effect enrichment analysis Evidence expression faece Faeces functional functional enrichment Gastrointestinal symptom gene regulatory network gene regulatory networks. Genes Health identify infected patient Infection influence Interaction live SARS-CoV-2 Messenger RNA overlap overlapping pathophysiology patients with COVID-19 protein-protein interaction raised Regulatory respiratory respiratory symptoms risk factor RNA-seq dataset SARS-CoV-2 SARS-COV-2 infection shown Symptom System biology therapeutic tissue tissues ulcerative colitis virus with COVID-19
[DOI] 10.1093/bib/bbab126 PMC 바로가기 [Article Type] Article

BNT162b2 and mRNA-1273 COVID-19 vaccine effectiveness against the SARS-CoV-2 Delta variant in Qatar

Research

Published on 2021-11-022022-10-05
Journal: Nature Medicine [Category] SARS, 임상,

Upregulation of FOXP3 is associated with severity of hypoxia and poor outcomes in COVID-19 patients

FOXP3의 상향 조절은 COVID-19 환자의 저산소증 및 불량한 결과와 관련이 있습니다

Article

Published on 2021-11-012022-09-12
Journal: Virology [Category] MERS, 바이오마커, 진단,

Important Insights into Myopericarditis after the Pfizer mRNA COVID-19 Vaccination in Adolescents

Editorial

Published on 2021-11-012022-10-05
Journal: The Journal of pediatrics [Category] SARS, 유전자 메커니즘,

[키워드] Adolescent COVID-19 insight Messenger RNA mRNA mRNAMessenger RNA Pfizer SARA-CoV-2Severe acute respiratory syndrome coronavirus 2 severe acute respiratory syndrome coronavirus 2
[DOI] 10.1016/j.jpeds.2021.07.057 [Article Type] Editorial

A live measles-vectored COVID-19 vaccine induces strong immunity and protection from SARS-CoV-2 challenge in mice and hamsters

홍역 매개 코로나19 생백신은 생쥐와 햄스터에서 SARS-CoV-2 공격으로부터 강력한 면역과 보호를 유도합니다

Article

Published on 2021-11-012022-09-10
Journal: Nature Communications [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, 치료기술, 치료법,

[키워드] Adenovirus animals antibody Antibody titers Antigen approach circulating variant circulating variants Coverage COVID-19 vaccine develop Efficacy elicited expressing full-length S generate hamster hamsters Immunity immunogenicity in vitro induce intranasal Live attenuated vaccines measles vaccine measles virus Messenger RNA mice neutralization neutralize neutralizing antibody titers pandemic pediatric prefusion PROTECT response SARS-CoV-2 SARS-CoV-2 pandemic SARS-CoV-2 vaccine SARSCoV-2 Spike protein T-cell Response T-cell responses tested the SARS-CoV-2 Vaccine variants viral infection world population
[DOI] 10.1038/s41467-021-26506-2 PMC 바로가기 [Article Type] Article