Therapeutic efficacy of an oral nucleoside analog of remdesivir against SARS-CoV-2 pathogenesis in mice
마우스에서 SARS-CoV-2 발병에 대한 렘데시비르의 경구 뉴클레오시드 유사체의 치료 효능
Article
[키워드] administration
Antiviral
antiviral activity
antivirals
Breakthrough infection
breakthrough infections
breath
conserved
COVID-19
COVID-19 pandemic
Culture
develop
dose-dependent
drug
effective
Efficacy
exhibited
exploration
GS-441524
human clinical trial
humans
IMPROVE
in vitro
in vivo
increasingly
infected with SARS-CoV-2
Infection
lung cell
lung cell line
lung cell lines
Lung pathology
mice
molnupiravir
monoclonal antibodies
monoclonal antibody
nucleoside
oral administration
outcome
outpatients
parental
pharmacokinetic
Pulmonary function
reduced
Remdesivir
RNA-dependent RNA polymerase
Safe
SARS-CoV-2
SARS-CoV-2 pathogenesis
SARS-CoV-2 vaccines
SARS-CoV-2 variant
SARS-CoV-2 variants
significantly
Support
target
therapeutic
therapeutic efficacy
therapy
These data
translated
Treatment
uncontrolled
vaccination
Viral load
Viral protein
Viral proteins
waning immunity
[DOI] 10.1101/2021.09.13.460111 PMC 바로가기 [Article Type] Article
[DOI] 10.1101/2021.09.13.460111 PMC 바로가기 [Article Type] Article