Robust innate responses to SARS-CoV-2 in children resolve faster than in adults without compromising adaptive immunity어린이의 SARS-CoV-2에 대한 강력한 타고난 반응은 적응 면역을 손상시키지 않으면서 성인보다 빠르게 해결됩니다.Article Published on 2021-10-052022-09-11 Journal: Cell Reports [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] activated Activation adaptive Adults Anti-viral antibodies antibody antiviral response B cell B cells Blood blood cell Cell changes in characterized children Clusters Course COVID-19 CXCL10 Cytokines dendritic cell dendritic cells disease course Effect faster gene profile GM-CSF immune signature Immunity Increases increases in Infection Inflammation initial viral load innate response innate responses interferon less longitudinal analysis mild infection monocyte Monocytes resolution. responses robust SARS-CoV-2 SARS-COV-2 infection Symptom Symptoms the disease the SARS-CoV-2 Viral [DOI] 10.1016/j.celrep.2021.109773 PMC 바로가기 [Article Type] Article
Single-cell analysis of COVID-19, sepsis, and HIV infection reveals hyperinflammatory and immunosuppressive signatures in monocytesCOVID-19, 패혈증 및 HIV 감염에 대한 단일 세포 분석은 단핵구에서 과염증 및 면역 억제 신호를 나타냅니다Article Published on 2021-10-052022-09-11 Journal: Cell Reports [Category] SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 caused Cell cellular and molecular coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients Cytokine storm Cytokine storms Guidance help heterogeneity HIV infection Hyperinflammatory identify Immunosuppression immunosuppressive IMPROVE Infection infections Infectious disease Infectious diseases Inflammation Inflammatory Inflammatory response Inflammatory responses Integrative analysis monocyte Monocytes mononuclear cell mortality risk other infectious diseases Patient patients with COVID-19 Peripheral blood Peripheral blood mononuclear cells provide reveal SARS-CoV-2 SARS-COV-2 infection Sepsis severe acute respiratory syndrome Coronavirus single-cell analysis single-cell transcriptome single-cell transcriptomes subset subtype the cytokine storm therapeutic Therapeutic strategies transcriptional difference Treatment understanding with HIV [DOI] 10.1016/j.celrep.2021.109793 PMC 바로가기 [Article Type] Article
The immune landscape of SARS-CoV-2-associated Multisystem Inflammatory Syndrome in Children (MIS-C) from acute disease to recoveryArticle Published on 2021-10-022022-10-30 Journal: iScience [Category] COVID-19, [키워드] Abstract Activated neutrophils Activation acute respiratory syndrome Atypical B-cell B-cells CD163 CD8+ children classical monocyte complement Complement inhibitor coronavirus COVID-19 deep disease disease severity feature Frequency Genomics identify IL-1 IL-6 IL6 immature neutrophil immune immune profiling immune response Immune system disorder immunology Infection Inflammatory inhibiting life-threatening memory MIS-C monocyte neutrophil Patient patients plasma plasmablast post treatment potential mechanism SARS-CoV-2 symptom resolution syndrome T-cells the disease therapeutic therapy TNF TNF-α treat [DOI] 10.1016/j.isci.2021.103215 PMC 바로가기 [Article Type] Article
Diagnostic Value of Hematological and Biochemical Parameters Combinations for Predicting Coronavirus Disease 2019 (COVID-19) in Suspected PatientsObservational Study Published on 2021-10-012022-10-05 Journal: The American journal of the medical sciences [Category] 임상, 진단, [키워드] Admission AMRI Analysis analyzed ANRI Aspartate aminotransferase AST AUC biochemical parameter characteristic Clinical data Combination control group control patient coronavirus disease COVID-19 COVID-19 patient Diagnosis evaluate Healthcare system hematological hospital hospital management IMPROVE independent risk factor Logistic regression monocyte multicenter negative RT-PCR neutrophil occurrence of COVID-19 parameter patients Predictive Predictive parameters predictor receiver retrospective ROC ROC Curve significantly Stratification Suspected Suspected cases suspected patient suspected patients value were used [DOI] 10.1016/j.amjms.2021.04.006 PMC 바로가기 [Article Type] Observational Study
Monocyte Chemotactic Protein-Induced Protein 1 (MCPIP-1): A Key Player of Host Defense and Immune RegulationImmunology Published on 2021-10-012022-11-01 Journal: Frontiers in Immunology [Category] Coronavirus, MERS, SARS, [키워드] Acute inflammation biological function blunt cardiovascular diseases cardiovascular system Cell clearance conserved COVID-19 dead cells Diseases effector Evidence expression Factor healthy highlight homeostasis Host immune function immunopathology Infection infections Infectious disease Inflammation Inflammatory Inflammatory diseases Inflammatory mediators Inflammatory response ischemic inflammation knock-out MCPIP-1 mechanism microbial microRNA miRNA monocyte mouse model mRNA neurodegenerative NFκB outlined Pleiotropic effects Protein public health recent Regulation Resolution signaling pathways stability syndrome target Therapeutic treatment tissue damage tissue injury tissue regeneration tissues transgenic viral infection virus [DOI] 10.3389/fimmu.2021.727861 PMC 바로가기 [Article Type] Immunology
Relative expression of proinflammatory molecules in COVID-19 patients who manifested disease severities질병 중증도를 나타내는 COVID-19 환자에서 전염증 분자의 상대적 발현Article Published on 2021-10-012022-09-11 Journal: Journal of medical virology [Category] SARS, 치료기술, 치료제, [키워드] ACE2 ACE2 expression Activation acute respiratory syndrome acute respiratory syndrome coronavirus 2 Aggressive angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Chain Reaction characterized chemokine chemokines convalescent stage coronavirus coronavirus disease Coronavirus disease 2019 correlation COVID-19 COVID-19 patient COVID-19 patients cytokine cytokine expression Cytokines Day diagnosed disease disease severities disease severity expressed expression expression level expression levels expressions female patient Female patients groups healthy volunteer help IL-12 IL-6 immune response immune system immune systems Inflammatory interleukin investigated leukocyte leukocytes log Macrophage management manifested Mild moderate monocyte monocyte chemotactic protein-1 nasal swab Necrosis nine onset of symptom opposite overexpressed participated Patient patients PCR method performed polymerase chain polymerase chain reaction positive correlation positively correlated post-COVID-19 patient proinflammatory proinflammatory molecule proinflammatory molecules Quantitative RANTES real-time RT-PCR regulated relative relative expression relative expression. RNA secreted semi-quantified severe acute respiratory syndrome Coronavirus severe cases significantly SPSS SPSS 24.0 statistical test Statistical tests T cell the patient therapy TNF-α Tumor tumor necrosis tumor necrosis factor tumor necrosis factor-α upregulated Viral load [DOI] 10.1002/jmv.27112 PMC 바로가기 [Article Type] Article
Single-cell transcriptomes of peripheral blood cells indicate and elucidate severity of COVID-19말초 혈액 세포의 단일 세포 전사체는 COVID-19의 심각성을 나타내고 설명합니다.Article Published on 2021-10-012022-09-11 Journal: Science China. Life sciences [Category] SARS, 유전자 메커니즘, [키워드] accumulated activities addition Blood CD8 Cell cell interaction cell interactions cellular cellular and molecular Characteristics conducted coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients COVID-19 severity Critical critical cases critical COVID-19 patients cytokine Cytokines cytotoxicity declined discrepancy disease severity effector T cell exhibited healthy donors heterogeneous immune Immune cell immune function immune functions immune response immune responses immune system infected patient Inflammatory cytokine Inflammatory cytokines moderate monocyte Monocytes mononuclear cell natural killer pathogenic mechanisms patients PBMCs Peripheral blood peripheral blood cell Peripheral blood mononuclear cells proliferative quantity reduced regulatory network severity severity of COVID-19 significantly single-cell RNA-seq single-cell transcriptome single-cell transcriptomes stages T cells T/NK cell transcription factor transcriptional Transcriptome Treatment Variation variations weakened with COVID-19 [DOI] 10.1007/s11427-020-1880-y PMC 바로가기 [Article Type] Article
A Single Dose of a Hybrid hAdV5-Based Anti-COVID-19 Vaccine Induces a Long-Lasting Immune Response and Broad Coverage against VOCArticle Published on 2021-09-292022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] Adenovirus Administered Alpha antibody approved B.1 B.1.617.2 cells chimeric clinical trials COVID vaccine COVID-19 D614G dendritic cell domain ENhance expressed expressing expression fiber Humoral immunity hybrid hybrid adenovirus vector immune response immunodominance Infection mice monocyte MOST mRNA neutralize P.1 prefusion conformation promoter pseudovirus regimen replacing response SARS-CoV-2 single dose spike T-cell immunity the Spike Vaccine variants of concern VoC wild type [DOI] 10.3390/vaccines9101106 PMC 바로가기 [Article Type] Article
Effect of ORF7 of SARS-CoV-2 on the Chemotaxis of Monocytes and Neutrophils In VitroResearch Article Published on 2021-09-282022-10-31 Journal: Disease Markers [Category] COVID-19, SARS, [키워드] A549 A549 cell acute respiratory syndrome caused CCL2 Cell chemokine chemotaxis component coronavirus Coronavirus disease 2019 COVID-19 Cytokine storm demonstrated Effect exacerbate examined expression Frame function Genome IL-6 IL-8 Immune cell immunological change Infection infiltration local inflammation lung Lung inflammation monocyte Monocytes Neutrophils ORF pathogenesis of COVID-19 Pneumonia promote public health threat recruit recruitment reduced SARS-CoV-2 severe COVID-19 Specific specific effect suggested the SARS-CoV-2 virus tissue Type II pneumocyte [DOI] 10.1155/2021/6803510 PMC 바로가기 [Article Type] Research Article
Case Report: Successful Treatment of Five Critically Ill Coronavirus Disease 2019 Patients Using Combination Therapy With Etoposide and CorticosteroidsMedicine Published on 2021-09-232022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] activated Activation acute respiratory distress (ARDS) age anti-inflammatory agents Antiviral ARDS Case series characterized clinical trial combination therapy contribute coronavirus disease Corticosteroid Corticosteroids Course COVID-19 COVID-19-associated ARDS distress drugs effective Efficacy and safety etoposide evaluate Fever FIVE hospitalized patient hyperinflammation Ill induce Infection Inflammation Inflammatory inflammatory mediator Invasive mechanical ventilation Japan lung Macrophage marker monocyte Mortality Multiple myeloma Patient patients reflected reported required SARS-CoV-2 second dose severe adverse event Steroids syndrome therapeutic strategy Therapies tissue injury treated treating COVID-19 patient Treatment underlying diseases [DOI] 10.3389/fmed.2021.718641 PMC 바로가기 [Article Type] Medicine