SARS-CoV-2 attenuates corticosteroid sensitivity by suppressing DUSP1 expression and activating p38 MAPK pathwaySARS-CoV-2는 DUSP1 발현을 억제하고 p38 MAPK 경로를 활성화하여 코르티코스테로이드 감수성을 약화시킵니다Observational Study Published on 2021-10-052022-09-11 Journal: European journal of pharmacology [Category] SARS, 유전자 메커니즘, 임상, [키워드] activating Activation attenuate Chloroquine Corticosteroid Corticosteroids COVID-19 data set data sets downregulate downregulation DUSP1 Efficacy expected expression IMPROVE in vitro experiments induce lung tissue MAPK mechanism nasopharyngeal swabs p38 MAPK pathway. pathway reported required SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections sensitivity significantly steroid steroid treatment Treatment [DOI] 10.1016/j.ejphar.2021.174374 PMC 바로가기 [Article Type] Observational Study
In-Depth Investigation of Conjunctival Swabs and Tear Fluid of Symptomatic COVID-19 Patients, an Observational Cohort StudyCOVID-19 증상 환자의 결막 면봉 및 눈물액에 대한 심층 조사, 관찰 코호트 연구Observational Study Published on 2021-10-042022-09-11 Journal: Translational vision science & technology [Category] SARS, 임상, 치료기술, [키워드] analyzed Chain Reaction Conjunctiva conjunctival Conjunctival swab conjunctival swabs correlation COVID-19 COVID-19 disease COVID-19 patient COVID-19 patients Ct values cycle cycle threshold cytokine cytokine level Cytokines determine disease onset elevated examined first visit healthcare worker Healthcare workers healthy control healthy controls hospitalized COVID-19 patient identify IL-1β IL-6 immunoassays investigation laboratory-confirmed large cohort majority multicenter multiplex Nasopharyngeal swab nasopharyngeal swabs nasopharynx Next-generation sequencing no correlation ocular Ocular surface performed Phylogenetic analysis polymerase chain polymerase chain reaction positive reverse transcription reverse transcription polymerase chain reaction risk SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 viral RNA Sequencing Sequencing analysis significantly higher specimen Swab symptomatic Tear threshold tissue tropism viral strain viral strains virus strain [DOI] 10.1167/tvst.10.12.32 PMC 바로가기 [Article Type] Observational Study
An ultrafast SARS-CoV-2 virus enrichment and extraction method compatible with multiple modalities for RNA detectionRNA 검출을 위한 다중 양식과 호환되는 초고속 SARS-CoV-2 바이러스 농축 및 추출 방법Randomized Controlled Trial Published on 2021-10-022022-09-11 Journal: Analytica chimica acta [Category] MERS, SARS, 임상, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus affinity Affinity nanoparticles alternative method alternative methods amplification Analysis Chain Reaction characterization characterized clinical samples clinically comparable compatibility Concordance coronavirus Coronavirus-2 COVID-19 pandemic demonstrated diagnoses Dilution dilutions double-blind study Enzymatic extraction form isothermal amplification Laboratory LAMP Loop-mediated amplification (LAMP) Loop-mediated isothermal amplification miniaturization nasopharyngeal swabs Particle pathogenicity polymerase polymerase chain polymerase chain reaction Polymerase chain reaction (PCR) positive recombinase polymerase amplification Recombinase polymerase amplification (RPA) respiratory reverse transcription reverse transcription real-time polymerase chain reaction RNA RNA eluate RNA isolation RNA virus RPA RT-PCR Saliva SARS-CoV-2 SARS-CoV-2 viral SARS-CoV-2 virus Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe acute respiratory syndrome coronavirus-2 Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) solution Stage the stage transmission rate Viral viral titer viral titers viral transport media VTM zoonotic [DOI] 10.1016/j.aca.2021.338846 PMC 바로가기 [Article Type] Randomized Controlled Trial
Pooled SARS-CoV-2 antigen tests in asymptomatic children and their caregivers: Screening for SARS-CoV-2 in a pediatric emergency department무증상 아동 및 보호자를 대상으로 한 SARS-CoV-2 항원 통합 검사: 소아 응급실에서 SARS-CoV-2 선별 검사Article Published on 2021-10-012022-09-11 Journal: American journal of infection control [Category] SARS, 치료기술, [키워드] Admission Asymptomatic Chain Reaction Child children comparable contagious COVID-19 Critical Ct values effective evaluated extraction buffer False negative hospital Hospital infection identify individual individuals infectious Lateral Lateral flow test medium Mid-turbinate. nasopharyngeal swabs Oropharyngeal Outbreaks P-value PCR PCR swab PCR testing pediatric performed polymerase chain polymerase chain reaction Prevent Result SARS-CoV-2 SARS-CoV-2 antigen Screening Sensitivity and specificity significantly single-center study study period Swab swabbing Turbinate Universal was performed were used [DOI] 10.1016/j.ajic.2021.07.009 PMC 바로가기 [Article Type] Article
Discrepancy of SARS-CoV-2 PCR results due to the sample collection sites and possible improper sampling검체 채취 장소 및 부적절한 검체 채취로 인한 SARS-CoV-2 PCR 결과 불일치Case Reports Published on 2021-10-012022-09-11 Journal: Journal of infection and chemotherapy : official j [Category] SARS, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Affect Chain Reaction collected coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 case Diagnosis false False negative false-negative high viral load Infectivity Nasopharyngeal swab nasopharyngeal swab sample nasopharyngeal swabs neutralizing antibody oral cavity PCR PCR tests polymerase chain reaction positive RNA copies RNA copy SARS-CoV-2 SARS-CoV-2 PCR SARS-CoV-2 PCR test SARS-CoV-2 PCR tests serum serum sample severe acute respiratory syndrome Coronavirus sputum Sputum sample Swab swab sample swabs symptoms onset tongue Viral load Viral RNA viral RNA detection [DOI] 10.1016/j.jiac.2021.07.008 PMC 바로가기 [Article Type] Case Reports
Transmission event of SARS-CoV-2 delta variant reveals multiple vaccine breakthrough infectionsSARS-COV-2 델타 변형의 전염 사건은 다수의 백신 혁신 감염을 보여줍니다.Research Article Published on 2021-10-012022-09-10 Journal: BMC Medicine [Category] MERS, SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 allele allergy Alpha Alpha variant Amplicon Analysis B.1.617.2 BNT162b2 causal variant Chain Reaction circulating SARS-CoV-2 variants Cluster college coronavirus COVID-19 delta variant described determine filtered fraction funding GATK Genome global public health highest identify immune evasion Infection Infectious disease Infectious diseases Medicine Moderna mRNA-1273 nasopharyngeal swabs Panel Part Patient Pfizer polymerase chain polymerase chain reaction qPCR Quantitative quantitative polymerase chain reaction respiratory Result reveal risk SARS-CoV-2 SARS-CoV-2 delta SARS-CoV-2 strain SARS-CoV-2 variant sequenced Sequencing severe acute respiratory syndrome Coronavirus supplementary material supported Swab tested toolkit Transmissibility Vaccine vaccine breakthrough infection variant Viral [DOI] 10.1186/s12916-021-02103-4 PMC 바로가기 [Article Type] Research Article
Development of the RealTime SARS-CoV-2 quantitative Laboratory Developed Test and correlation with viral culture as a measure of infectivityRealTime SARS-CoV-2 정량 연구실 개발 감염성 측정을 위한 검사 및 바이러스 배양과의 상관관계 개발Article Published on 2021-10-012022-09-11 Journal: Journal of Clinical Virology [Category] MERS, SARS, 진단, 치료기술, [키워드] Abbott absence antiviral therapy Clinical use correlation CPE Culture demonstrated Developed development diagnosis of COVID-19 dynamic range Emergency use evaluated FDA Guidance highest implication individual inter- and intra-assay limit of detection log Lower molecular Nasopharyngeal swab nasopharyngeal swabs NPs public health Quantitative quarantine R 2 ranged reproducibility respiratory respiratory tract SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 viral load Test vaccine trial Vero CCL81 cells Viral viral culture Viral load viral shedding virus was determined while [DOI] 10.1016/j.jcv.2021.104945 PMC 바로가기 [Article Type] Article
“The effectiveness of rapid antigen test-based for SARS-CoV-2 detection in nursing homes in Valencia, Spain”"스페인 발렌시아 요양원에서 SARS-CoV-2 검출을 위한 신속한 항원 검사 기반의 효과"Article Published on 2021-10-012022-09-11 Journal: Journal of Clinical Virology [Category] SARS, 치료기술, [키워드] analyzed Antigen benefit can be used collected Concordance conducted COVID-19 cut-off value diagnostic diagnostic test Effectiveness enrolled False negative false negative results group individual infected individuals Nasopharyngeal samples nasopharyngeal swabs Pandemics population groups positive positive RT-PCR Rapid Rapid techniques Rapid test returned RT-PCR RT-PCR testing SARS-CoV-2 SARS-CoV-2 detection SARS-CoV-2 infected individual SARS-CoV-2 infected individuals SARS-COV-2 infection sensitivity Sensitivity and specificity Swab tested turnaround times Valencia Viral load was used would increase [DOI] 10.1016/j.jcv.2021.104941 PMC 바로가기 [Article Type] Article
First COVID-19 cases with high secondary infection among health workers, Sana’a capital, April 2020: Lessons learned and future opportunities2020년 4월 수도 사나, 의료 종사자들 사이에서 2차 감염이 높은 첫 번째 COVID-19 사례: 교훈과 미래 기회Article Published on 2021-10-012022-09-11 Journal: International Journal of Infectious Diseases [Category] SARS, 치료기술, [키워드] attack rate Capital chain Chain Reaction collected confirmation Contact Contact tracing COVID-19 COVID-19 case COVID-19 outbreak detect died discharged had no Health health worker health workers hospital Hospitalization Infection infection control lesson male Mask measure Measures nasopharyngeal swabs National outbreak Patient PCR physical distancing polymerase chain reaction promoted public health reaction respond secondary attack rate Swab Symptom the patient the WHO Travel Yemen [DOI] 10.1016/j.ijid.2021.04.022 PMC 바로가기 [Article Type] Article
Asymptomatic and Mild SARS-CoV-2 Infections Elicit Lower Immune Activation and Higher Specific Neutralizing Antibodies in Children Than in Adults무증상 및 경증의 SARS-CoV-2 감염은 성인보다 어린이의 면역 활성화를 낮추고 특정 중화 항체를 더 많이 유발합니다Immunology Published on 2021-09-302022-09-11 Journal: Frontiers in Immunology [Category] SARS, 진단, 치료기술, [키워드] activated Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adults age analyzed anti-SARS-CoV-2 antibody baseline blood sample Blood samples Breg children Clinical outcome contribute coronavirus coronavirus disease Coronavirus disease 2019 correlated CoV COVID-19 COVID-19 children COVID-19 group COVID-19 patient COVID-19 patients enrolled Exhaustion expression first positive flow cytometry greater immune activation Immune profile immune response Infection interquartile investigated Lower median NAb NAbs Nasopharyngeal swab nasopharyngeal swabs neutralization test Neutralizing antibodies neutralizing antibodies (NAbs) Non-COVID-19 not differ Patient PCR pediatric plaque reduction neutralization Plaque reduction neutralization test positively correlated quantified reduce regulatory cell regulatory cells respiratory Result SARS-CoV-2 senescence senescent cell serology severe acute respiratory syndrome Coronavirus Specific subjects symptom onset Treg Tregs Tregs and Bregs Viral Viral load virus virus detection [DOI] 10.3389/fimmu.2021.741796 PMC 바로가기 [Article Type] Immunology