The effect of the E484K mutation of SARS-CoV-2 on the neutralizing activity of antibodies from BNT162b2 vaccinated individualsSARS-CoV-2의 E484K 돌연변이가 BNT162b2 백신을 접종한 개인의 항체 중화 활성에 미치는 영향Article Published on 2022-03-182022-09-11 Journal: Vaccine [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] antibody Antibody titer Antibody titers Beta Beta variant BNT162b2 BNT162b2 vaccine caused collected E484K E484K mutation Efficacy FIVE geometric geometric mean healthy humoral Humoral immunity Japanese Lineage N501Y mutation Neutralization antibody neutralization titer Neutralizing activity participant receiving reduced responsible SARS-CoV-2 SARS-CoV-2 variants second dose Serum Neutralization serum sample serum samples strain the SARS-CoV-2 thought vaccinated individual Vaccine vaccine efficacy variant was measured weakened were measured [DOI] 10.1016/j.vaccine.2022.02.047 PMC 바로가기 [Article Type] Article
In vitro evaluation of therapeutic antibodies against a SARS-CoV-2 Omicron B.1.1.529 isolateSARS-CoV-2 Omicron B.1.1.529 분리주에 대한 치료 항체의 시험관 내 평가Article Published on 2022-03-182022-09-11 Journal: Scientific Reports [Category] SARS, 변종, 진단, [키워드] analyzed antibodies antibody B.1 B.1.1.529 BavPat1 cilgavimab Clinical efficacy combination therapies combination therapy D614G dose doses Efficacy eight evaluated loss of activity modify monoclonal antibodies monoclonal antibody neutralize Neutralizing Neutralizing activity omicron Omicron variant reduction reduction in resulting SARS-CoV-2 Sotrovimab spike glycoprotein Spread Substitution the antibody therapeutic therapeutic antibodies Tixagevimab Vaccine variant variant of SARS-CoV-2 [DOI] 10.1038/s41598-022-08559-5 PMC 바로가기 [Article Type] Article
mRNA-encoded HIV-1 Env trimer ferritin nanoparticles induce monoclonal antibodies that neutralize heterologous HIV-1 isolates in micemRNA로 인코딩된 HIV-1 Env 삼량체 페리틴 나노입자는 생쥐에서 이종 HIV-1 분리물을 중화시키는 단클론 항체를 유도합니다Article Published on 2022-03-152022-09-12 Journal: Cell Reports [Category] MERS, 진단, [키워드] acquisition antigenic autologous B cell broadly neutralizing antibodies complex COVID-19 vaccine Critical demonstrated expression ferritin Heterologous HIV-1 immunogen induce isolate knock-in mice lineages Lipid nanoparticle Lipid nanoparticles mice monoclonal antibody mRNA mRNA-LNP mutations neutralize Neutralizing Neutralizing activity neutralizing antibody nucleoside-modified mRNA precursor priming Protein Sequencing serum trimer Vaccine Vaccine development [DOI] 10.1016/j.celrep.2022.110514 PMC 바로가기 [Article Type] Article
Natural SARS-CoV-2 Infection Affects Neutralizing Activity in Saliva of VaccineesOriginal Research Published on 2022-03-112023-06-16 Journal: Frontiers in Immunology [Category] MERS, SARS, [키워드] antibodies Neutralizing activity Saliva SARS-CoV-2 variants [DOI] 10.3389/fimmu.2022.820250 PMC 바로가기 [Article Type] Original Research
Anti-SARS-CoV-2 IgG and IgA antibodies in COVID-19 convalescent plasma do not enhance viral infectionCOVID-19 회복기 혈장의 항-SARS-CoV-2 IgG 및 IgA 항체는 바이러스 감염을 강화하지 않습니다Research Article Published on 2022-03-082022-09-12 Journal: PLoS ONE [Category] MERS, SARS, 진단, [키워드] absence ACE2 addressed ADE Alpha analyzed anti-S IgG antibodies antibody Antibody-dependent enhancement approach cause CCP clinical outcomes convalescent plasma correlated COVID-19 death elicit ENhance expressing Fc receptor Fc receptors IgA IgA antibody IgG IgM response IgM responses immunization Infection isotype monoclonal antibody neutralization activity Neutralizing activity Neutralizing titer not affected Novel coronavirus observation pandemic passive immunization passive transfer Prophylactic protective immune response question receptor SARS-CoV-2 Spike protein Support target cell target cells the spike protein theoretical risk therapeutic use therapy transfer transfusion Treatment vaccination Vaccine vaccine platform viral infection Virus neutralization virus receptor while [DOI] 10.1371/journal.pone.0257930 PMC 바로가기 [Article Type] Research Article
Neutralizing Antibody Activity Against the B.1.617.2 (delta) Variant Before and After a Third BNT162b2 Vaccine Dose in Hemodialysis Patients혈액 투석 환자에서 세 번째 BNT162b2 백신 접종 전후의 B.1.617.2(델타) 변이체에 대한 중화 항체 활성Article Published on 2022-03-042022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 변종, 진단, [키워드] activity addition Against Anti-RBD antibodies Anti-RBD antibody B.1.617.2 BNT162b2 correlation COVID-19 COVID-19 vaccination delta variant demonstrated determined by dialysis Epitopes Hemodialysis high risk Humoral immunity IgG IgG antibodies IgG antibody Immune escape Immunity immunocompromised individuals IQR Live virus median neutralization Neutralizing Neutralizing activity Patient SARS-CoV-2 SARS-CoV-2 epitope SARS-CoV-2 epitopes second vaccination seroconversion rate seroconverted Seropositivity severe COVID-19 significantly higher the strongest vaccination vaccine dose variant variants variants of concern was performed [DOI] 10.3389/fimmu.2022.840136 PMC 바로가기 [Article Type] Article
Vaccination-infection interval determines cross-neutralization potency to SARS-CoV-2 Omicron after breakthrough infection by other variants백신 접종-감염 간격은 다른 변이체에 의한 돌발성 감염 후 SARS-CoV-2 Omicron에 대한 교차 중화 효능을 결정합니다.Clinical and Translational Report Published on 2022-03-042022-09-14 Journal: Med (New York, N.Y.) [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] Abstract acute respiratory syndrome AMED ancestors antibodies antibody approach blood sample BNT162b2 mRNA vaccine breadth Breakthrough infection breakthrough infections collected Combination complex complicate Context coronavirus correlated COVID-19 COVID-19 vaccine cross-neutralization Delta demonstrated determine development finding funding heterogeneity immune immune evasion Immune profile Immunity individual Infection Japan magnitude mRNA mRNA vaccine much higher neutralization Neutralizing activity neutralizing antibody omicron Omicron variant other variant overcome population immunity protective immunity resistance to infection robust SARS-CoV-2 sera several variants Significance significantly spike mutations suffered supported susceptibility time interval vaccinated individual vaccination Vaccine vaccinee variant variants [DOI] 10.1016/j.medj.2022.02.006 PMC 바로가기 [Article Type] Clinical and Translational Report
Immunogenicity and protective efficacy of a recombinant protein subunit vaccine and an inactivated vaccine against SARS-CoV-2 variants in non-human primates비인간 영장류에서 SARS-CoV-2 변이체에 대한 재조합 단백질 소단위 백신 및 불활성화 백신의 면역원성 및 보호 효능Article Published on 2022-03-032022-09-10 Journal: Signal Transduction and Targeted Therapy [Category] MERS, SARS, 변종, 진단, [키워드] ADCC Alpha antibody Antibody titers antibody-dependent cellular cytotoxicity B.1.351 Beta Beta variant binding Breakthrough infection circulating variant COVID-19 vaccine cytokine declined Delta demonstrated domain downregulated effective Efficacy followed by immune memory immunized immunogenicity inactivated Inactivated vaccine increase in Infection Inflammatory cytokine involved lung tissue lung tissues Neutralizing activity Neutralizing antibodies neutralizing antibody Neutralizing antibody titer non-human primate omicron Omicron variants Other pathological changes post vaccination Protective protective effect protective mechanism Protein subunit protein subunit vaccine prototype provided RBD Receptor-binding domain reduction respiratory respiratory tracts rhesus macaque rhesus macaques SARS-CoV-2 variant sera significantly Strains Vaccine Vaccines variant Viral Viral load virus VOCs was reduced [DOI] 10.1038/s41392-022-00926-y PMC 바로가기 [Article Type] Article
Three doses of an inactivation-based COVID-19 vaccine induces cross-neutralizing immunity against the SARS CoV-2 Omicron variant비활성화 기반 COVID-19 백신의 3회 용량은 SARS CoV-2 Omicron 변이체에 대한 교차 중화 면역을 유도합니다Coronaviruses Published on 2022-03-032022-09-10 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 B.1.1.529 collected coronavirus COVID-19 vaccine cross-neutralizing delta variant demonstrated dose enrolled fold geometric mean geometric mean titer geometric mean titers GMT immune Immunity immunization immunized induce natural infection neutralization activity Neutralizing activity neutralizing antibody omicron Omicron variant positive prototype pseudotyped Pseudotyped virus recipient reported respiratory SARS CoV SARS CoV-2 SARS-CoV-2 sera serum sample serum samples severe acute respiratory syndrome Coronavirus sustained the vaccine vaccination Vaccine variant was determined [DOI] 10.1080/22221751.2022.2044271 PMC 바로가기 [Article Type] Coronaviruses
Previous Infection with SARS-CoV-2 Correlates with Increased Protective Humoral Responses after a Single Dose of an Inactivated COVID-19 VaccineSARS-CoV-2에 대한 이전 감염은 비활성화된 COVID-19 백신의 1회 투여 후 증가된 보호 체액 반응과 관련이 있습니다Article Published on 2022-03-022022-09-11 Journal: Viruses [Category] SARS, 변종, 치료기술, [키워드] anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody anti-SARS-CoV-2 humoral antibodies antibody antibody kinetics antibody levels Antibody Response Antibody responses assays both viruses CoronaVac COVID-19 COVID-19 vaccine detectable dose elicited ELISA evaluate FIVE Gamma had no immunization inactivated Inactivated vaccine increase in Increased indicated individual induce Lineage lineage B.1 naïve individuals Neutralizing activity neutralizing assays plaque Previous studies previous study PRNT Protective antibody protective antibody response protective antibody responses response retained SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccine second dose sera specific antibodies subject vaccinated individual vaccinated individuals vaccination vaccine dose vaccinees variant were measured [DOI] 10.3390/v14030510 PMC 바로가기 [Article Type] Article