GSK-3 Inhibition as a Therapeutic Approach Against SARs CoV2: Dual Benefit of Inhibiting Viral Replication While Potentiating the Immune ResponseImmunology Published on 2020-06-262022-11-01 Journal: Frontiers in Immunology [Category] Coronavirus, MERS, SARS, [키워드] adaptive Against Analysis Anti-viral CD8+ CD8+: T lymphocyte subsets connection conserved COVID COVID-19 CTL cytolytic drug ENhance function GSK-3 Hypothesis immune response information inhibit inhibition inhibitor knowledge limit mice N protein natural killer NK cell pandemic Phosphorylation protein sequences question reducing reduction in Replication residue response responses SAR SARS-CoV2 SARS-CoV2 infection Serine small molecule inhibitor T-cell T-Cells (or lymphocytes) the N protein Therapeutic approach therapeutic approaches therapy Vaccine viral (or virus) viral infection viral replication virus while [DOI] 10.3389/fimmu.2020.01638 PMC 바로가기 [Article Type] Immunology
Flattening the COVID-19 Curve With Natural Killer Cell Based ImmunotherapiesImmunology Published on 2020-06-232022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] acute respiratory distress Cell circulating clinical trials coronavirus disease Coronavirus infection Coronavirus infections Coronaviruses COVID-19 Critical Curve exaggerated immune response flattening immunological immunopathological immunopathology Immunotherapy in viral Infection Inflammation innate immune Innate immunity insight interferon investigated Lung injury MERS morbidity and mortality natural NK cell NK cell response NK cells pathophysiology phenotype progression recommendation reduction in respond Responder responses responsible resulting SARS-CoV-2 severity severity of COVID-19 syndrome therapeutic therapeutic strategy viral clearance virus [DOI] 10.3389/fimmu.2020.01512 PMC 바로가기 [Article Type] Immunology
The inhibition of IL-2/IL-2R gives rise to CD8 + T cell and lymphocyte decrease through JAK1-STAT5 in critical patients with COVID-19 pneumoniaArticle Published on 2020-06-082022-10-04 Journal: Cell Death & Disease [Category] SARS, 치료기술, 치료법, [키워드] analyzed B cells CD8 controls Critical Critical case cytokine decrease develop elevated enrolled examined expression IL-2 immune response information Interleukins investigated JAK1 lymphocyte molecular mononuclear cell Mortality NK cell Patient patients patients with COVID-19 PBMC Peripheral blood plasma Pneumonia Prognosis qRT-PCR Severe patient signaling pathway significantly significantly lower T cell T cells three groups viral infection with COVID-19 [DOI] 10.1038/s41419-020-2636-4 PMC 바로가기 [Article Type] Article
Immune environment modulation in pneumonia patients caused by coronavirus: SARS-CoV, MERS-CoV and SARS-CoV-2Research Paper Published on 2020-05-152022-10-28 Journal: Aging (Albany NY) [Category] COVID-19, MERS, SARS, [키워드] 24 hours acute respiratory distress ARDS cause caused CD3+ CD4+ CD8+ T lymphocyte changes in chemokine coding Coronavirus infections COVID-19 Critical current cytokine cytokine profile Cytokine storm death demonstrated disease dry cough elevated fatigue Fever global pandemic highlight IFN-α2 IFN-γ IL-10 IL-1α IL-1β IL-6 IL-7 immune factor indicated infection process infiltration interferon lymphocyte Lymphocytes MERS-CoV modulation monocyte NK cell Patient patients with COVID-19 Pneumonia resulting SARS-CoV SARS-CoV-2 significantly syndrome T cells the cytokine storm treated Treatment [DOI] 10.18632/aging.103101 PMC 바로가기 [Article Type] Research Paper
Transplantation of ACE2 – Mesenchymal Stem Cells Improves the Outcome of Patients with COVID-19 PneumoniaOrginal Article Published on 2020-04-092022-10-06 Journal: Aging and Disease [Category] 진단, [키워드] ACE2 ACE2 negative addition adverse effect adverse effects Beijing C-reactive protein caused cell population cell transplantation change China clinical outcomes control group coronavirus COVID-19 COVID-19 infection discharged effective enrolled function recovery functional gene expression profile IL-10 Immune cell immune function immunomodulation immunomodulatory IMPROVE indicated Inflammatory injection intravenous mesenchymal stem cell Mesenchymal stem cells MSC MSCs NK cell novel coronavirus disease outbreak outcome Patient patients with COVID-19 peripheral lymphocyte Placebo Pneumonia Preventing Pulmonary function Regulatory Safe Seven Severe COVID-19 pneumonia Severe patient shown significantly STEM Symptom T cells the cytokine storm the patient TMPRSS2 TNF-α transplantation Treatment treatment group were assessed with COVID-19 Wuhan, China [DOI] 10.14336/AD.2020.0228 PMC 바로가기 [Article Type] Orginal Article
The Good and the Bad of Natural Killer Cells in Virus Control: Perspective for Anti-HBV TherapyReview Published on 2019-10-132023-06-03 Journal: International Journal of Molecular Sciences [Category] B형 간염, [키워드] Chronic HBV infection Immune-therapy NK cell NK-T cell interplay [DOI] 10.3390/ijms20205080 PMC 바로가기 [Article Type] Review
Kctd9 Deficiency Impairs Natural Killer Cell Development and Effector FunctionImmunology Published on 2019-04-102022-11-01 Journal: Frontiers in Immunology [Category] Coronavirus, MERS, [키워드] ameliorated caused CD11b Cell cytokine cytotoxicity deficiency degranulation development domain effector evidenced exhibited expressed expression fulminant hepatitis function granzyme B Hepatitis hepatitis B homologous identify IFN-γ Immune-mediated in vitro Infection investigated Kctd9 knockout mice Lineage liver Liver damage manifested maturation mechanism mice murine hepatitis virus natural natural killer NK cell NK cell function NK cells Patient phenotype potassium channel progression proliferative proportion reduction in Regulation selective supported survival transcription factors tumor cell wild-type [DOI] 10.3389/fimmu.2019.00744 PMC 바로가기 [Article Type] Immunology
Influenza Virus Infection Enhances Antibody-Mediated NK Cell Functions via Type I Interferon-Dependent PathwaysArticle Published on 2018-12-122023-06-14 Journal: Journal of Virology [Category] Fulltext, 신종인플루엔자, [키워드] ADCC Influenza interferons NK cell [DOI] 10.1128/JVI.02090-18 PMC 바로가기
Characterization of peritoneal cells from cats with experimentally-induced feline infectious peritonitis (FIP) using RNA-seqResearch Article Published on 2018-08-072022-10-28 Journal: Veterinary Research [Category] Coronavirus, [키워드] activated addition Allograft Alter Analysis APN Apoptosis Autoimmune disorders B cell Cell change characterization collected cytotoxicity DC-SIGN death deregulated disease Diseases dissemination down-regulated enrichment analysis Fever fold healthy Host immune complex indicated Interaction involved KEGG L-SIGN Laboratory less lymphopenia Macrophage mature macrophages MHC I mRNA mRNA expression NK cell other coronavirus pathogen pathway peritoneal macrophage populations receptor rejection RNA expression RNA-Seq serotype Signaling significantly Th1 Th2 transcript upregulated virus were infected [DOI] 10.1186/s13567-018-0578-y PMC 바로가기 [Article Type] Research Article
Interference with KCTD9 inhibits NK cell activation and ameliorates fulminant liver failure in miceResearch Article Published on 2018-06-252023-05-22 Journal: BMC Immunology [Category] B형 간염, Fulltext, [키워드] Kctd9 liver failure MHV-3 NK cell short hairpin RNA [DOI] 10.1186/s12865-018-0256-x PMC 바로가기 [Article Type] Research Article