PBMC – Page 17 – Communicable Diseases Research

A New ERAP2/Iso3 Isoform Expression Is Triggered by Different Microbial Stimuli in Human Cells. Could It Play a Role in the Modulation of SARS-CoV-2 Infection?

Article

Published on 2020-08-242022-10-31
Journal: Cells [Category] COVID-19, MERS,

[키워드] alternative splicing Analysis antigen processing antigen-presentation BAL Calu3 Cell cell line cellular CMV Concentration contributing to Cytokines determinant dose elements enzyme ERAP2 ERAP2/Iso3 expressing expression flu healthy subject HIV-1 host cell response Human immune response in vitro Infectious disease influenza infection interferon-stimulated genes isoforms LPS MDM MHC class I microbial infections modulation MOI mRNA mRNA expression New pathogen pathogenicity Pathogens PBMC PBMCs peptide Protein protein expression Result role SARS-CoV-2 SARS-CoV-2 antigen stimulated target to define translated variant viruses
[DOI] 10.3390/cells9091951 PMC 바로가기 [Article Type] Article

Adaptive immune responses to SARS-CoV-2 infection in severe versus mild individuals

Article

Published on 2020-08-142022-10-04
Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, MERS, 변종,

Anti-coagulation for COVID-19 treatment: both anti-thrombotic and anti-inflammatory?

Article

Published on 2020-07-062022-10-30
Journal: Journal of Thrombosis and Thrombolysis [Category] COVID-19,

[키워드] Acute inflammation acute respiratory distress acute respiratory syndrome addition Analysis ARDS autologous blood cell characterized chemokine chemokines Coagulation coagulation cascade coagulation factor Concentration Coronavirus-2 COVID-19 cytokine Cytokines different dose Diseases dose-dependent manner enzyme-linked immunosorbent events FIBRIN higher risk Infection Inflammation Influenza Mortality PBMC PBMCs plasma Previous studies pro-inflammatory cytokine reducing rising risk SARS-CoV-2 secretion Secretome serum significantly syndrome the cytokine storm thrombosis Thrombotic complications treated Treatment turn venous thromboembolic was measured
[DOI] 10.1007/s11239-020-02212-6 PMC 바로가기 [Article Type] Article

Impact of pantoprazole on absorption and disposition of hydroxychloroquine, a drug used in Corona Virus Disease-19 (Covid-19): A structured summary of a study protocol for a randomised controlled trial

Letter

Published on 2020-06-292022-10-29
Journal: Trials [Category] Coronavirus, SARS,

[키워드] 1:1 Absorption administration All participant anticipated Area assigned AUC C max center changes in clinical Concentration control group Corona Course COVID-19 CYP2D6 CYP3A4 dissemination dose drug drug-drug interaction element enrolment enzyme activity Enzymes EudraCT Germany HCQ Hydroxychloroquine Impact inhibitor investigator Microdosing Midazolam mononuclear cell not blinded number objective Open-label outcome P450 Pantoprazole parallel group participant Patient PBMC PBMCs performed Peripheral blood Phase I plasma PPI probe protocol randomisation list randomised randomised controlled trial Randomized receive recruitment Registered registry reported Sample size secondary single dose Standard status Study protocol target cell treated treatment group Trial trial protocol Two-arm university Volunteer website Whole blood Yohimbine
[DOI] 10.1186/s13063-020-04476-y PMC 바로가기 [Article Type] Letter

Neutrophils, Crucial, or Harmful Immune Cells Involved in Coronavirus Infection: A Bioinformatics Study

코로나바이러스 감염과 관련된 호중구, 결정적 또는 유해한 면역 세포: 생물정보학 연구

Genetics

Published on 2020-06-092022-08-13
Journal: Frontiers in Genetics [Category] 유전자 메커니즘,

[키워드] activated biological processe analyzed ARG1 arginase Arginase inhibitor Arginase inhibitors basophilia bioinformatics BPI CAMP cause caused Cell co-expression network analysis Coronaviridae Coronaviridae family coronavirus disease Coronavirus disease 2019 CoV infection COVID-19 COVID-19 patients CXCL1 death deconvolution analysis DEFA4 demonstrated disease ELANE evaluated followed by GEO2R GEO2R analysis global health GO analysis GSE1739 GSE1739 microarray dataset Health infect inhibitor inhibitors involved Lower respiratory tract lymphopenia molecular mechanism most activated biological processes network analysis neutrophil neutrophil activation neutrophil degranulation neutrophilia new virus ORM2 pandemic PBMC Pneumonia predicted preserved respiratory respiratory tract respiratory tract cells RETN SARS infection SARS-CoV SARS-CoV infection SARS-CoV-2 SARS-positive patients SARS-positive PBMC serpin serpins severe acute respiratory tract syndrome significantly similarity suggested survival syndrome the Coronaviridae the disease turquoise module WGCNA
[DOI] 10.3389/fgene.2020.00641 PMC 바로가기 [Article Type] Genetics

The inhibition of IL-2/IL-2R gives rise to CD8 + T cell and lymphocyte decrease through JAK1-STAT5 in critical patients with COVID-19 pneumonia

Article

Published on 2020-06-082022-10-04
Journal: Cell Death & Disease [Category] SARS, 치료기술, 치료법,

Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients

코로나19 환자에서 기관지폐포세척액과 말초혈액 단핵세포의 전사적 특성

Article

Published on 2020-03-312022-09-06
Journal: Emerging Microbes & Infections [Category] Communicable Disease, COVID-19, MERS, SARS,

[키워드] Activation Anti-inflammatory Apoptosis association BALF Bronchoalveolar lavage fluid carried caused CCL2 CCL2/MCP-1 CCL3 CCL3/MIP-1A CCL4 CCL4/MIP1B Characteristics China country COVID-19 COVID-19 outbreak COVID-19 pathogenesis COVID-19 patient COVID-19 patients CXCL10 CXCL10/IP-10 cytokine cytokine release effort fatal disease Guidance HCoV highlight Host Host immune response host inflammatory response host response identify Infection Inflammation Inflammatory cytokine inflammatory cytokine profile IP-10 lymphocyte Lymphocytes lymphopenia medication molecular mononuclear cell mononuclear cells Mortality P53 signalling pathway Pathogenesis patients PBMC Peripheral blood Peripheral blood mononuclear cells public health RNA RNAs SARS-CoV-2 SARS-COV-2 infection Sequencing specimen therapeutic drug transcriptional Transcriptome transcriptome dataset transcriptome profiling transcriptome sequencing Treatment valuable resource
[DOI] 10.1080/22221751.2020.1747363 PMC 바로가기 [Article Type] Article

Plasma levels of interleukin 27 in falciparum malaria is increased independently of co-infection with HIV: potential immune-regulatory role during malaria

팔수파룸 말라리아에서 인터루킨 27의 혈장 수치는 HIV와의 동시 감염과 무관하게 증가하며, 말라리아 동안 면역 조절 역할을 할 가능성이 있다.

Research Article

Published on 2020-01-212024-08-11
Journal: BMC Infectious Diseases [Category] 말라리아,

[키워드] endothelial cells falciparum malaria Hemozoin HIV IL-27 Interleukins PBMC
[DOI] 10.1186/s12879-020-4783-8 PMC 바로가기 [Article Type] Research Article

Presence of Precore (C)/C Promoter Mutants in Peripheral Blood Mononuclear Cells of Chronic Hepatitis B (CHB) Carriers During Pregnancy Does Not Correlate with Increased Risk of Liver Disease in 4 Years of Follow-Up

Article

Published on 2020-01-012023-06-13
Journal: Digestive diseases and sciences [Category] B형 간염,

[키워드] Chronic Hepatitis B HBV genomes HBV variants Long-term follow-up PBMC Pregnancy
[DOI] 10.1007/s10620-019-05745-w

Low prevalence of occult hepatitis B virus infection in chronic haemodialysis and kidney transplant patients

Multicenter Study

Published on 2019-02-012023-06-18
Journal: Liver international : official journal of the Inte [Category] B형 간염,

[키워드] Haemodialysis Kidney transplantation Occult Hepatitis B PBMC Prevalence
[DOI] 10.1111/liv.13951 [Article Type] Multicenter Study