Comparative analysis of machine learning-based approaches for identifying therapeutic peptides targeting SARS-CoV-2SARS-CoV-2를 표적으로 하는 치료 펩타이드 식별을 위한 기계 학습 기반 접근 방식의 비교 분석Comparative Study Published on 2022-01-172022-09-11 Journal: Briefings in Bioinformatics [Category] SARS, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Algorithm Algorithms anticipated Antiviral antiviral peptides approach approaches AVP bioinformatics Comparative analysis computational tool conducted coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 COVID-19 pandemic COVID-19 therapeutics Critical datasets develop disadvantage Disadvantages epitope Epitopes evaluate evaluated evaluation metrics Guidance IL-6 IL-6 inducing peptides impacted in silico independent machine learning peptide peptide-based peptides performance assessment. predictor public health robustness SARS-CoV-2 scalability Scientific community Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus therapeutic [DOI] 10.1093/bib/bbab412 PMC 바로가기 [Article Type] Comparative Study
The β-NGF/TrkA Signalling Pathway Is Associated With the Production of Anti-Nucleoprotein IgG in Convalescent COVID-19β-NGF/TrkA 신호 전달 경로는 회복기 COVID-19에서 항핵단백질 IgG의 생산과 관련이 있습니다Immunology Published on 2022-01-142022-09-12 Journal: Frontiers in Immunology [Category] 진단, [키워드] β-NGF age analysed antibody antibody production Asymptomatic CD4 convalescent correlated COVID-19 Cytokines defined discrepancy ELISPOT expressed Factor First wave flow cytometry high variability Host IC50 IFN-γ IgG IgG level IL-1α Infection Inflammation mild SARS-CoV-2 infection molecular mechanism neutralising antibody pandemic pathway PBMC PCR-confirmed peptides positive positive correlation Production receptor Regulation reported Result SARS-CoV-2 SARS-COV-2 infection selected serum severe COVID-19 shown significantly specific antibody subject subjects T cell T cells titre undetectable virus-specific T cell Volunteer was determined were measured while [DOI] 10.3389/fimmu.2021.813300 PMC 바로가기 [Article Type] Immunology
The Broad-Spectrum Antiviral Potential of the Amphibian Peptide AR-23Article Published on 2022-01-142022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS, [키워드] activity Amphibian antimicrobial peptide antimicrobial peptides antiviral activity antiviral agent Antiviral agents antiviral drug antiviral drugs antiviral molecule antiviral therapy contrary coronavirus DNA DNA and RNA drugs early stage effective evaluated exhibited greater HCoV-229E HSV-1 identify inactive indicated Infection inhibitory activity investigated peptide peptides performed Potential reported RNA SARS-CoV-2 secretion strain therapeutic effect therapeutic options variety viral infections virus viruses [DOI] 10.3390/ijms23020883 PMC 바로가기 [Article Type] Article
Large-Scale Structure-Based Screening of Potential T Cell Cross-Reactivities Involving Peptide-Targets From BCG Vaccine and SARS-CoV-2BCG 백신 및 SARS-CoV-2의 펩티드 표적과 관련된 잠재적 T 세포 교차 반응성의 대규모 구조 기반 스크리닝Immunology Published on 2022-01-132022-09-11 Journal: Frontiers in Immunology [Category] 변종, [키워드] acute respiratory syndrome coronavirus Affect arising Bacillus Bacillus Calmette-Guérin BCG BCG vaccination bcg vaccine can be used caused clinical trials computational method conducted coronavirus coronavirus 2 Coronaviruses country Coverage COVID-19 cases COVID-19 pandemic cross-reactive cross-reactivity dataset death driving Evidence expand Heterologous high-density highlight HLA human leukocyte antigen Human Leukocyte Antigens identify Immunity immunogenic in silico in some infected cells involved Involving leukocyte list Lymphocytes other coronaviruses pandemic peptide peptides Potential produced provided recognize reduced reservoir respiratory responsible risk SARS-CoV-2 screened Screening severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severity of COVID-19 Spread structural bioinformatics Structure structure-based screening suggested T cell target targets therapeutic strategy vaccination Vaccine Vaccine development variant variants Viral [DOI] 10.3389/fimmu.2021.812176 PMC 바로가기 [Article Type] Immunology
Emerging Roles of Vitamin D-Induced Antimicrobial Peptides in Antiviral Innate Immunity항바이러스 선천 면역에서 비타민 D 유도 항균 펩티드의 새로운 역할Review Published on 2022-01-112022-09-10 Journal: Nutrients [Category] 유전자 메커니즘, 치료제, [키워드] 25-hydroxyvitamin D active form AMP AMPs antibacterial activity antibacterial immunity antimicrobial antimicrobial peptide antimicrobial peptides antiviral immunity antiviral responses Bacterial binding calcifediol calcitriol CAMP caries Cathelicidin characterized circulating component components contribute coronavirus COVID-19 COVID-19 pandemic cytokine cytokine network Cytokines defensin Dental caries elements etiological agent Evidence Gene Expression Human immune Immune cell immune cells in vitro in vivo increased risk indication induce Infection Innate Innate immune cells Innate immunity LL-37 pathogen Pattern recognition Pattern recognition receptors peptide peptides potential mechanism potential mechanisms provided regulate role SARS-CoV2 secondary structures secretion Signaling stimulated Transcription transcription factor urinary tract infections VDR Viral Vitamin Vitamin D vitamin D deficiency Vitamin D receptor β-defensin [DOI] 10.3390/nu14020284 PMC 바로가기 [Article Type] Review
T-CoV: a comprehensive portal of HLA-peptide interactions affected by SARS-CoV-2 mutationsT-CoV: SARS-CoV-2 돌연변이의 영향을 받는 HLA-펩티드 상호작용의 종합 포털AcademicSubjects/SCI00010 Published on 2022-01-072022-09-10 Journal: Nucleic Acids Research [Category] SARS, 변종, [키워드] (alpha Affect affected affinity alleles Alpha Alter alteration Atla atlas binding affinities CD4 T-cell CD8 clinician COVID-19 Delta dependent on Diversity Epitopes evade example Genotype help highlight HLA HLA allele HLA alleles HLA class I HLA molecule HLA molecules HLA-B In silico methods individual Infection Interaction peptide peptides portal predict researcher responses SARS-CoV-2 mutation SARS-CoV-2 mutations severity susceptibility T cell T cell epitopes T-cell T-cell responses variant variants variants of SARS-CoV-2 viral peptide viral peptides virus virus variant were assessed Wuhan [DOI] 10.1093/nar/gkab701 PMC 바로가기 [Article Type] AcademicSubjects/SCI00010
Neutralization of SARS-CoV-2 requires antibodies against conformational receptor-binding domain epitopesSARS-CoV-2의 중화에는 구조적 수용체 결합 도메인 에피토프에 대한 항체가 필요합니다Article Published on 2022-01-012022-09-11 Journal: Allergy [Category] SARS, 변종, 진단, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analyzed angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antibody antibody repertoire Antibody Response Antibody responses clinically conformational conformational epitopes coronavirus correlated COVID-19 Critical determinant determinants domain effective vaccine Effective vaccines epitope Epitopes exposure to humoral immune response IgG IgG antibodies IgG antibody Immunity immunization Immunoglobulin Immunoglobulin G increasingly induce likelihood Mild natural infection Neutralizing antibodies Patient peptide peptide epitope peptide epitopes peptides polyclonal polyclonal antibody Prevent Protective protective immunity RBD RBD binding RBD-specific IgG receptor Receptor-binding domain required respiratory SARS-CoV-2 SARS-CoV-2 proteins SARS-CoV-2-neutralizing antibodies SARS-CoV-2-neutralizing antibody sera severe acute respiratory syndrome Coronavirus severe COVID-19 Spike protein sterilizing immunity suppression the receptor-binding domain the SARS-CoV-2 vaccination Vaccine Vaccines variant virus Virus neutralization virus variants virus-neutralizing [DOI] 10.1111/all.15066 PMC 바로가기 [Article Type] Article
SARS-CoV-2 peptides bind to NKG2D and increase NK cell activitySARS-CoV-2 펩타이드는 NKG2D에 결합하여 NK 세포 활성을 증가시킵니다Article Published on 2022-01-012022-09-12 Journal: Cellular immunology [Category] MERS, SARS, 진단, [키워드] Activation acute respiratory syndrome binding cells coronavirus coronavirus disease COVID-19 cytotoxicity dysregulation Genes IFN-γ in silico analysis induce innate immune cell innate immune system Interaction interferon gamma lung cancer modulation natural killer NK NK cell NK cells NKG2D Patient peptide peptides Phosphorylation receptor receptors response SARS-CoV-2 SARS-CoV-2 peptide SARS-CoV-2 S protein screened severe lung inflammation stimulated therapeutic target [DOI] 10.1016/j.cellimm.2021.104454 PMC 바로가기 [Article Type] Article
A promiscuous T cell epitope-based HIV vaccine providing redundant population coverage of the HLA class II elicits broad, polyfunctional T cell responses in nonhuman primatesResearch article Published on 2022-01-012022-10-05 Journal: Vaccine [Category] 비임상, [키워드] alleles Antigen approach BALB/c binding CD4+ CD4+ T cell CD8+ T cell cellular immunity conserved costly Coverage COVID-19 described Diseases DNA vaccine Electroporation elicit elicited ENCODE epitope Epitope-based vaccine Epitopes Evidence facilitate generate HIV HIV vaccine HLA class II HLA-DR immune response immunization immunized immunodominant immunogen in vivo Increasing induce less MHC mice multiple epitopes Multiple HLA-binding epitopes neutralizing antibody over patients peptides platform Populational vaccine response Result rhesus macaque rhesus macaques shown T cell T cell epitope T cell response transgenic Vaccine Vaccines viral disease viral infections [DOI] 10.1016/j.vaccine.2021.11.076 [Article Type] Research article
Cross-reactive and mono-reactive SARS-CoV-2 CD4+ T cells in prepandemic and COVID-19 convalescent individuals전염병 및 COVID-19 회복기 개인의 교차 반응성 및 단일 반응성 SARS-CoV-2 CD4+ T 세포Research Article Published on 2021-12-292022-09-10 Journal: PLoS Pathogens [Category] SARS, 치료기술, 치료법, [키워드] Activation allele Amino acid amino acid sequence Amino acid sequences Analysis assays Author CD4+ T cell class common cold common cold coronavirus common cold Coronaviruses common cold virus common cold viruses contributed convalescent convalescent individual convalescent individuals coronavirus COVID-19 cross-react cross-reactive cross-reactivity defined demonstrated Direct dominant epitope DPB1 elicit elicited Endemic epitope Epitopes Ex vivo frequencies Frequency functional HLA-DP HLA-DR identify immunodominant low frequency marker membrane MHC-II naïve individuals nucleocapsid Nucleocapsid proteins overlapping PBMC peptide peptides Potential prevalent Previous studies previous study proportion protective immunity Protein reactive reagent recognizing SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 antigens SARS-CoV-2 epitope SARS-CoV-2 epitopes sequence identity shown spike staining stratified subjects suggested T cell T cell epitope T cell epitopes T cell response T cell responses T cells the Spike to define unlikely viruses was used were used world population [DOI] 10.1371/journal.ppat.1010203 PMC 바로가기 [Article Type] Research Article